公开(公告)号：US12031127B2

公开(公告)日：2024-07-09

申请号：US16091913

申请日：2017-04-05

Applicant: Cold Spring Harbor Laboratory

Inventor： Anthony Zador ,  Justus Kebschull

IPC: C12N15/10 ,  C07K14/18 ,  C12N5/0793 ,  C12N15/09 ,  C12Q1/6806 ,  C40B70/00

CPC classification number: C12N15/1065 ,  C07K14/1808 ,  C12N5/0619 ,  C12N15/09 ,  C12N15/10 ,  C12N15/102 ,  C12Q1/6806 ,  C40B70/00 ,  C12N2770/36143 ,  C12Q1/6806 ,  C12Q2522/101 ,  C12Q2525/161 ,  C12Q2535/122 ,  C12Q2563/179 ,  C12Q2565/514 ,  C12N15/102 ,  C12Q2535/122

Abstract: The present invention provides a composition comprising a plurality of labeled neurons, each of which is labeled by an expression construct that encodes a unique barcoded nucleic acid.

公开(公告)号：US11744887B2

公开(公告)日：2023-09-05

申请号：US17196889

申请日：2021-03-09

Applicant: Arcturus Therapeutics, Inc.

Inventor： Sean Michael Sullivan ,  Daiki Matsuda ,  Kiyoshi Tachikawa ,  Padmanabh Chivukula ,  Priya Prakash Karmali ,  Jared Henry Davis ,  Yanjie Bao ,  Amit Sagi

IPC: A61K39/215 ,  C07K14/005 ,  C12N15/86 ,  A61K47/20 ,  A61K47/26 ,  A61K47/10 ,  A61K9/51 ,  A61K39/12 ,  C07K14/18 ,  C12N7/00 ,  A61K39/00 ,  A61K38/00

CPC classification number: A61K39/215 ,  A61K9/5123 ,  A61K39/12 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  C07K14/005 ,  C07K14/1808 ,  C12N7/00 ,  C12N15/86 ,  A61K38/00 ,  A61K2039/53 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/36122 ,  C12N2770/36134 ,  C12N2830/42 ,  C12N2830/50

Abstract: Provided herein are nucleic acid molecules encoding viral replication proteins and antigenic coronavirus proteins or fragments thereof. Also provided herein are compositions that include nucleic acid molecules encoding viral replication and antigenic proteins, and lipids. Nucleic acid molecules provided herein are useful for inducing immune responses.

公开(公告)号：US20140065178A1

公开(公告)日：2014-03-06

申请号：US13983279

申请日：2012-02-01

Applicant: Ilya Frolov ,  Elena Frolova

Inventor： Ilya Frolov ,  Elena Frolova

IPC: A61K39/12 ,  C12N7/00

CPC classification number: A61K39/12 ,  A61K35/76 ,  C07K14/005 ,  C07K14/1808 ,  C12N7/00 ,  C12N2770/36111 ,  C12N2770/36121 ,  C12N2770/36122 ,  C12N2770/36123 ,  C12N2770/36134 ,  G01N2333/181 ,  Y02A50/382

Abstract: The present invention provides pseudoinfectious alphavirus particles and methods of making them and using them to produce an immune response to an alphavirus in a subject.

Abstract translation: 本发明提供假感染性甲病毒颗粒及其制备方法，并使用它们产生受试者中甲病毒的免疫应答。

公开(公告)号：US20240115691A1

公开(公告)日：2024-04-11

申请号：US18345893

申请日：2023-06-30

Applicant: Arcturus Therapeutics, Inc.

Inventor： Sean Michael SULLIVAN ,  Daiki MATSUDA ,  Kiyoshi TACHIKAWA ,  Padmanabh CHIVUKULA ,  Priya Prakash KARMALI ,  Jared Henry DAVIS ,  Yanjie BAO ,  Amit SAGI

IPC: A61K39/215 ,  A61K9/51 ,  A61K39/12 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  C07K14/005 ,  C07K14/18 ,  C12N7/00 ,  C12N15/86

CPC classification number: A61K39/215 ,  A61K9/5123 ,  A61K39/12 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  C07K14/005 ,  C07K14/1808 ,  C12N7/00 ,  C12N15/86 ,  A61K2039/53

Abstract: Provided herein are nucleic acid molecules encoding viral replication proteins and antigenic coronavirus proteins or fragments thereof. Also provided herein are compositions that include nucleic acid molecules encoding viral replication and antigenic proteins, and lipids. Nucleic acid molecules provided herein are useful for inducing immune responses.

公开(公告)号：US20230219996A1

公开(公告)日：2023-07-13

申请号：US17816243

申请日：2022-07-29

Applicant: Arcturus Therapeutics, Inc.

Inventor： Daiki MATSUDA ,  Sean Michael Sullivan ,  Kiyoshi Tachikawa ,  Padmanabh Chivukula ,  Priya Prakash Karmali ,  Yanjie Bao ,  Amit Sagi ,  Rajesh Mukthavaram

IPC: C07H21/02 ,  C07K14/18 ,  C07K14/165 ,  C07K14/11 ,  A61K9/127 ,  A61K47/14 ,  A61K47/28 ,  A61K9/19

CPC classification number: C07H21/02 ,  A61K9/19 ,  A61K9/127 ,  A61K47/14 ,  A61K47/28 ,  C07K14/11 ,  C07K14/165 ,  C07K14/1808

Abstract: Provided herein are RNA molecules encoding viral replication proteins and antigenic proteins or fragments thereof. Also provided herein are compositions that include RNA molecules encoding viral replication proteins and antigenic proteins or fragments thereof, and lipids. RNA molecules and compositions including them are useful for inducing immune responses.

公开(公告)号：US09402890B2

公开(公告)日：2016-08-02

申请号：US13983279

申请日：2012-02-01

Applicant: Ilya Frolov ,  Elena Frolova

Inventor： Ilya Frolov ,  Elena Frolova

IPC: A61K39/12 ,  C07K14/005 ,  C12N7/00 ,  A61K35/76 ,  C07K14/18 ,  C07K14/08

CPC classification number: A61K39/12 ,  A61K35/76 ,  C07K14/005 ,  C07K14/1808 ,  C12N7/00 ,  C12N2770/36111 ,  C12N2770/36121 ,  C12N2770/36122 ,  C12N2770/36123 ,  C12N2770/36134 ,  G01N2333/181 ,  Y02A50/382

Abstract: The present invention provides pseudoinfectious alphavirus particles and methods of making them and using them to produce an immune response to an alphavirus in a subject.

Abstract translation: 本发明提供假感染性甲病毒颗粒及其制备方法，并使用它们产生受试者中甲病毒的免疫应答。

公开(公告)号：US20240115692A1

公开(公告)日：2024-04-11

申请号：US18351392

申请日：2023-07-12

Applicant: Arcturus Therapeutics, Inc.

Inventor： Sean Michael SULLIVAN ,  Daiki MATSUDA ,  Kiyoshi TACHIKAWA ,  Padmanabh CHIVUKULA ,  Priya Prakash KARMALI ,  Jared Henry DAVIS ,  Yanjie BAO

IPC: A61K39/215 ,  A61K9/51 ,  A61K39/12 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  C07K14/005 ,  C07K14/18 ,  C12N7/00 ,  C12N15/86

CPC classification number: A61K39/215 ,  A61K9/5123 ,  A61K39/12 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  C07K14/005 ,  C07K14/1808 ,  C12N7/00 ,  C12N15/86 ,  A61K2039/53

Abstract: Provided herein are nucleic acid molecules encoding viral replication proteins and antigenic proteins or fragments thereof. Also provided herein are compositions that include nucleic acid molecules encoding viral replication and antigenic proteins, and lipids. Nucleic acid molecules provided herein are useful for inducing immune responses.

公开(公告)号：US11759515B2

公开(公告)日：2023-09-19

申请号：US17196890

申请日：2021-03-09

Applicant: Arcturus Therapeutics, Inc.

Inventor： Sean Michael Sullivan ,  Daiki Matsuda ,  Kiyoshi Tachikawa ,  Padmanabh Chivukula ,  Priya Prakash Karmali ,  Jared Henry Davis ,  Yanjie Bao

IPC: A61K39/215 ,  C07K14/005 ,  C12N15/86 ,  A61K47/20 ,  A61K47/26 ,  A61K47/10 ,  A61K9/51 ,  A61K39/12 ,  C07K14/18 ,  C12N7/00 ,  A61K39/00 ,  A61K38/00

CPC classification number: A61K39/215 ,  A61K9/5123 ,  A61K39/12 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  C07K14/005 ,  C07K14/1808 ,  C12N7/00 ,  C12N15/86 ,  A61K38/00 ,  A61K2039/53 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/36122 ,  C12N2770/36134 ,  C12N2830/42 ,  C12N2830/50

Abstract: Provided herein are nucleic acid molecules encoding viral replication proteins and antigenic proteins or fragments thereof. Also provided herein are compositions that include nucleic acid molecules encoding viral replication and antigenic proteins, and lipids. Nucleic acid molecules provided herein are useful for inducing immune responses.

公开(公告)号：US20230256083A1

公开(公告)日：2023-08-17

申请号：US18001912

申请日：2021-06-18

Applicant: Ziphius Vaccines

Inventor： Itishri SAHU ,  Ashiqul HAQUE A K M ,  Sean MC CAFFERTY ,  Christiaan CARDON ,  Niek SANDERS

IPC: A61K39/215 ,  C07K14/18 ,  A61P31/14

CPC classification number: A61K39/215 ,  C07K14/1808 ,  A61P31/14 ,  A61K2039/53

Abstract: The present invention relates self-replicating RNA molecules comprising a sequence encoding nonstructural alphavirus proteins and a sequence encoding a SARS-CoV-2 protein antigen.