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    Apparatus and method for catheterizing the dura of a patient using a dural patch
    4.
    发明申请
    Apparatus and method for catheterizing the dura of a patient using a dural patch 审中-公开
    使用硬脑膜贴片导管患者硬膜的装置和方法

    公开(公告)号：US20050096633A1

    公开(公告)日：2005-05-05

    申请号：US10698952

    申请日：2003-10-31

    申请人： Ari Moskowitz

    发明人： Ari Moskowitz

    IPC分类号： A61M27/00 ,  A61M31/00

    CPC分类号： A61M27/006

    摘要： A method and apparatus for catheterizing a dura of a patient through a burr hole and through a hole in a dura. A catheter having a lumen is adapted for placement into the cranium through the burr hole and through a hole in the dura. A dural seal patch having a hole sized for and adapted to pass the catheter is adapted to be placed proximate the dura.

    摘要翻译： 用于通过毛刺孔和硬脑膜中的孔导管患者的硬膜的方法和装置。 具有内腔的导管适于通过毛刺孔和硬脑膜中的孔放置到颅骨中。 具有尺寸适于并适于通过导管的孔的硬脑膜密封贴片适于放置在硬脑膜附近。

    Apparatus and method for making a hole in the dura
    5.
    发明授权
    Apparatus and method for making a hole in the dura 有权
    在硬脑膜中形成孔的装置和方法

    公开(公告)号：US07300434B2

    公开(公告)日：2007-11-27

    申请号：US10699586

    申请日：2003-10-31

    申请人： Ari Moskowitz ,  Jeff Bertrand

    发明人： Ari Moskowitz ,  Jeff Bertrand

    IPC分类号： A61B18/18

    CPC分类号： A61B18/1492 ,  A61B2018/00446

    摘要： An apparatus and method of making a hole of a first predetermined diameter in a dura of a patient for the insertion of a catheter having a second predetermined diameter. A burr hole is created in the cranium of the patient, if necessary. A stylet is inserted into the lumen of a catheter with an end of the stylet formed with a tip having a diameter having a predetermined relationship with the first predetermined diameter such that the distal end of the stylet is proximate to a distal end of the catheter. The end of the catheter is inserted into the burr hole of the cranium. An electrical current is applied to the stylet in order to cauterize the dura creating a hole in the dura approximately equal to the diameter of the tip.

    摘要翻译： 在患者的硬脑膜中制造第一预定直径的孔以插入具有第二预定直径的导管的装置和方法。 如果有必要，在患者的颅骨中产生一个钻孔。 探针插入到导管的内腔中，探针的端部形成有具有与第一预定直径具有预定关系的直径的尖端，使得探针的远端靠近导管的远端。 导管的末端插入颅骨的钻孔中。 将电流施加到探针，以便硬化硬脑膜，在硬膜中产生大致等于尖端直径的孔。

    Endoluminal stent having a matched stiffness region and/or a stiffness gradient and methods for providing stent kink resistance
    6.
    发明授权
    Endoluminal stent having a matched stiffness region and/or a stiffness gradient and methods for providing stent kink resistance 失效
    具有匹配刚度区域和/或刚度梯度的腔内支架和用于提供支架扭结阻力的方法

    公开(公告)号：US07214241B2

    公开(公告)日：2007-05-08

    申请号：US10612110

    申请日：2003-07-02

    申请人： David J. Zarbatany ,  Ari Moskowitz ,  Fergus P. Quigley ,  Lukas J. Hijlkema

    发明人： David J. Zarbatany ,  Ari Moskowitz ,  Fergus P. Quigley ,  Lukas J. Hijlkema

    IPC分类号： A61F2/06

    CPC分类号： A61F2/86 ,  A61F2/064 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/065 ,  A61F2002/067 ,  A61F2002/91558 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2250/0018 ,  A61F2250/0036

    摘要： A modular elongated stent having an overlap region where two modular components fit together, the overlap region being relatively stiff as compared to another more flexible region of the stent when the stent is in an assembled configuration, the stent further comprising a mimic region that has a stiffness essentially equivalent to the stiffness of the overlap region, to provide kink resistance. A stent having such a mimic region or otherwise stiff region and a flexible region may have a transition region between the stiff and flexible regions, such as a bridging material attached to the stent, also to provide kink resistance. A stent may have relatively stiff regions and relatively flexible regions positioned to align the flexible regions with curved regions of a body lumen when deployed within the body lumen. The stiffness of the stiff, flexible, and transition regions may be controlled by attaching material to the stent, varying the cross-sectional area of the stent components, varying the metallurgical properties thereof, and/or by varying the stent architecture. Methods for providing kink resistance by controlling stent stiffness are also disclosed. A stent having regions of different metallurgical properties is also disclosed, as are methods for creating such a stent.

    摘要翻译： 一种模块化细长支架，其具有两个模块化部件装配在一起的重叠区域，当所述支架处于组装构型时，所述重叠区域与所述支架的另一更柔性区域相比是相对刚性的，所述支架还包括模具区域， 刚度基本上等于重叠区域的刚度，以提供扭结阻力。 具有这种模拟区域或其他刚性区域和柔性区域的支架可以在刚性区域和柔性区域之间具有过渡区域，例如连接到支架的桥接材料，也提供扭结阻力。 支架可以具有相对刚性的区域和相对柔性的区域，其定位成当部署在体腔内时将柔性区域与体腔的弯曲区域对准。 可以通过将材料附接到支架，改变支架部件的横截面面积，改变其冶金特性和/或通过改变支架结构来控制刚性，柔性和过渡区域的刚度。 还公开了通过控制支架刚度提供扭结阻力的方法。 还公开了具有不同冶金特性的区域的支架，以及用于产生这种支架的方法。

    Ventriculo-sinus shunting for disease treatment
    7.
    发明申请
    Ventriculo-sinus shunting for disease treatment 审中-公开
    用于疾病治疗的心室窦分流

    公开(公告)号：US20050256510A1

    公开(公告)日：2005-11-17

    申请号：US10833810

    申请日：2004-04-28

    申请人： Ari Moskowitz ,  William Bertrand

    发明人： Ari Moskowitz ,  William Bertrand

    IPC分类号： A61M1/00 ,  A61M5/00 ,  A61M27/00

    CPC分类号： A61M27/006

    摘要： A method for treating a disease associated with increased concentration of an undesirable and/or deleterious agent in a central nervous system (CNS) is disclosed. A catheter having no flow restrictor member is placed is used to shunt cerebrospinal fluid (CSF) from a patient's cerebral ventricle to a venous sinus within the patient's head. Physiologically based pressure differential and control mechanisms between the ventricle and the venous sinus are exploited to control ventriculo-sinus flow of CSF.

    摘要翻译： 公开了一种治疗与中枢神经系统（CNS）中不期望的和/或有害药物浓度增加相关的疾病的方法。 放置没有限流器的导管用于将患者脑室的脑脊液（CSF）分流到患者头部内的静脉窦。 利用生理基础上的心室和静脉窦之间的压力差异和控制机制来控制CSF的脑室窦流量。

    Endoluminal stent having a matched stiffness region and/or a stiffness gradient
    8.
    发明授权
    Endoluminal stent having a matched stiffness region and/or a stiffness gradient 有权
    具有匹配刚度区域和/或刚度梯度的腔内支架

    公开(公告)号：US07722664B2

    公开(公告)日：2010-05-25

    申请号：US11735180

    申请日：2007-04-13

    申请人： David J. Zarbatany ,  Ari Moskowitz ,  Fergus Quigley ,  Lukas J. Hijlkema

    发明人： David J. Zarbatany ,  Ari Moskowitz ,  Fergus Quigley ,  Lukas J. Hijlkema

    IPC分类号： A61F2/06

    CPC分类号： A61F2/86 ,  A61F2/064 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/065 ,  A61F2002/067 ,  A61F2002/91558 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2250/0018 ,  A61F2250/0036

    摘要： A modular elongated stent having an overlap region where two modular components fit together, the overlap region being relatively stiff as compared to another more flexible region of the stent when the stent is in an assembled configuration, the stent further comprising a mimic region that has a stiffness essentially equivalent to the stiffness of the overlap region, to provide kink resistance. A stent having such a mimic region or otherwise stiff region and a flexible region may have a transition region between the stiff and flexible regions, also to provide kink resistance. A stent may have relatively stiff regions and relatively flexible regions positioned to align the flexible regions with curved regions of a body lumen when deployed within the body lumen. The stiffness of the stiff, flexible, and transition regions may be controlled by varying the cross-sectional area of the stent components and/or by varying the stent architecture.

    摘要翻译： 一种模块化细长支架，其具有两个模块化部件装配在一起的重叠区域，当所述支架处于组装构型时，所述重叠区域与所述支架的另一更柔性区域相比是相对刚性的，所述支架还包括模具区域， 刚度基本上等于重叠区域的刚度，以提供扭结阻力。 具有这种模拟区域或其他刚性区域和柔性区域的支架可以在刚性区域和柔性区域之间具有过渡区域，也提供扭结阻力。 支架可以具有相对刚性的区域和相对柔性的区域，其定位成当部署在体腔内时将柔性区域与体腔的弯曲区域对准。 可以通过改变支架部件的横截面面积和/或通过改变支架结构来控制刚性，柔性和过渡区域的刚度。

    ENDOLUMINAL STENT HAVING A MATCHED STIFFNESS REGION AND/OR A STIFFNESS GRADIENT
    9.
    发明申请
    ENDOLUMINAL STENT HAVING A MATCHED STIFFNESS REGION AND/OR A STIFFNESS GRADIENT 有权
    具有匹配刚度区域和/或强度梯度的内支架

    公开(公告)号：US20070185563A1

    公开(公告)日：2007-08-09

    申请号：US11735180

    申请日：2007-04-13

    申请人： David Zarbatany ,  Ari Moskowitz ,  Fergus Quigley ,  Lukas Hijlkema

    发明人： David Zarbatany ,  Ari Moskowitz ,  Fergus Quigley ,  Lukas Hijlkema

    IPC分类号： A61F2/06

    CPC分类号： A61F2/86 ,  A61F2/064 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/065 ,  A61F2002/067 ,  A61F2002/91558 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2250/0018 ,  A61F2250/0036

    摘要： A modular elongated stent having an overlap region where two modular components fit together, the overlap region being relatively stiff as compared to another more flexible region of the stent when the stent is in an assembled configuration, the stent further comprising a mimic region that has a stiffness essentially equivalent to the stiffness of the overlap region, to provide kink resistance. A stent having such a mimic region or otherwise stiff region and a flexible region may have a transition region between the stiff and flexible regions, also to provide kink resistance. A stent may have relatively stiff regions and relatively flexible regions positioned to align the flexible regions with curved regions of a body lumen when deployed within the body lumen. The stiffness of the stiff, flexible, and transition regions may be controlled by varying the cross-sectional area of the stent components and/or by varying the stent architecture.

    摘要翻译： 一种模块化细长支架，其具有两个模块化部件装配在一起的重叠区域，当所述支架处于组装构型时，所述重叠区域与所述支架的另一更柔性区域相比是相对刚性的，所述支架还包括模具区域， 刚度基本上等于重叠区域的刚度，以提供扭结阻力。 具有这种模拟区域或其他刚性区域和柔性区域的支架可以在刚性区域和柔性区域之间具有过渡区域，也提供扭结阻力。 支架可以具有相对刚性的区域和相对柔性的区域，其定位成当部署在体腔内时将柔性区域与体腔的弯曲区域对准。 可以通过改变支架部件的横截面面积和/或通过改变支架结构来控制刚性，柔性和过渡区域的刚度。

    Apparatus and method for making a hole in the dura
    10.
    发明申请
    Apparatus and method for making a hole in the dura 有权
    在硬脑膜中形成孔的装置和方法

    公开(公告)号：US20050096648A1

    公开(公告)日：2005-05-05

    申请号：US10699586

    申请日：2003-10-31

    申请人： Ari Moskowitz ,  Jeff Bertrand

    发明人： Ari Moskowitz ,  Jeff Bertrand

    IPC分类号： A61B18/14 ,  A61B18/18

    CPC分类号： A61B18/1492 ,  A61B2018/00446

    摘要： An apparatus and method of making a hole of a first predetermined diameter in a dura of a patient for the insertion of a catheter having a second predetermined diameter. A burr hole is created in the cranium of the patient, if necessary. A stylet is inserted into the lumen of a catheter with an end of the stylet formed with a tip having a diameter having a predetermined relationship with the first predetermined diameter such that the distal end of the stylet is proximate to a distal end of the catheter. The end of the catheter is inserted into the burr hole of the cranium. An electrical current is applied to the stylet in order to cauterize the dura creating a hole in the dura approximately equal to the diameter of the tip.

    摘要翻译： 在患者的硬脑膜中制造第一预定直径的孔以插入具有第二预定直径的导管的装置和方法。 如果有必要，在患者的颅骨中产生一个钻孔。 探针插入到导管的内腔中，探针的端部形成有具有与第一预定直径具有预定关系的直径的尖端，使得探针的远端靠近导管的远端。 导管的末端插入颅骨的钻孔中。 将电流施加到探针，以便硬化硬脑膜，在硬膜中产生大致等于尖端直径的孔。