公开(公告)号：US07722664B2

公开(公告)日：2010-05-25

申请号：US11735180

申请日：2007-04-13

申请人： David J. Zarbatany ,  Ari Moskowitz ,  Fergus Quigley ,  Lukas J. Hijlkema

发明人： David J. Zarbatany ,  Ari Moskowitz ,  Fergus Quigley ,  Lukas J. Hijlkema

IPC分类号： A61F2/06

CPC分类号： A61F2/86 ,  A61F2/064 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/065 ,  A61F2002/067 ,  A61F2002/91558 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2250/0018 ,  A61F2250/0036

摘要： A modular elongated stent having an overlap region where two modular components fit together, the overlap region being relatively stiff as compared to another more flexible region of the stent when the stent is in an assembled configuration, the stent further comprising a mimic region that has a stiffness essentially equivalent to the stiffness of the overlap region, to provide kink resistance. A stent having such a mimic region or otherwise stiff region and a flexible region may have a transition region between the stiff and flexible regions, also to provide kink resistance. A stent may have relatively stiff regions and relatively flexible regions positioned to align the flexible regions with curved regions of a body lumen when deployed within the body lumen. The stiffness of the stiff, flexible, and transition regions may be controlled by varying the cross-sectional area of the stent components and/or by varying the stent architecture.

摘要翻译： 一种模块化细长支架，其具有两个模块化部件装配在一起的重叠区域，当所述支架处于组装构型时，所述重叠区域与所述支架的另一更柔性区域相比是相对刚性的，所述支架还包括模具区域， 刚度基本上等于重叠区域的刚度，以提供扭结阻力。 具有这种模拟区域或其他刚性区域和柔性区域的支架可以在刚性区域和柔性区域之间具有过渡区域，也提供扭结阻力。 支架可以具有相对刚性的区域和相对柔性的区域，其定位成当部署在体腔内时将柔性区域与体腔的弯曲区域对准。 可以通过改变支架部件的横截面面积和/或通过改变支架结构来控制刚性，柔性和过渡区域的刚度。

公开(公告)号：US20070185563A1

公开(公告)日：2007-08-09

申请号：US11735180

申请日：2007-04-13

申请人： David Zarbatany ,  Ari Moskowitz ,  Fergus Quigley ,  Lukas Hijlkema

发明人： David Zarbatany ,  Ari Moskowitz ,  Fergus Quigley ,  Lukas Hijlkema

IPC分类号： A61F2/06

CPC分类号： A61F2/86 ,  A61F2/064 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/065 ,  A61F2002/067 ,  A61F2002/91558 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2250/0018 ,  A61F2250/0036

摘要： A modular elongated stent having an overlap region where two modular components fit together, the overlap region being relatively stiff as compared to another more flexible region of the stent when the stent is in an assembled configuration, the stent further comprising a mimic region that has a stiffness essentially equivalent to the stiffness of the overlap region, to provide kink resistance. A stent having such a mimic region or otherwise stiff region and a flexible region may have a transition region between the stiff and flexible regions, also to provide kink resistance. A stent may have relatively stiff regions and relatively flexible regions positioned to align the flexible regions with curved regions of a body lumen when deployed within the body lumen. The stiffness of the stiff, flexible, and transition regions may be controlled by varying the cross-sectional area of the stent components and/or by varying the stent architecture.

摘要翻译： 一种模块化细长支架，其具有两个模块化部件装配在一起的重叠区域，当所述支架处于组装构型时，所述重叠区域与所述支架的另一更柔性区域相比是相对刚性的，所述支架还包括模具区域， 刚度基本上等于重叠区域的刚度，以提供扭结阻力。 具有这种模拟区域或其他刚性区域和柔性区域的支架可以在刚性区域和柔性区域之间具有过渡区域，也提供扭结阻力。 支架可以具有相对刚性的区域和相对柔性的区域，其定位成当部署在体腔内时将柔性区域与体腔的弯曲区域对准。 可以通过改变支架部件的横截面面积和/或通过改变支架结构来控制刚性，柔性和过渡区域的刚度。

公开(公告)号：US07556643B2

公开(公告)日：2009-07-07

申请号：US10202542

申请日：2002-07-24

申请人： Thomas V. Casey, II ,  Kristoff Nelson ,  Fergus Quigley

发明人： Thomas V. Casey, II ,  Kristoff Nelson ,  Fergus Quigley

IPC分类号： A61F2/06

CPC分类号： A61F2/07 ,  A61F2/89 ,  A61F2/90 ,  A61F2002/075

摘要： An endoluminal self-expanding prosthesis for placement in a blood vessel, duct or lumen, to hold it open. The prosthesis includes a stent with a graft extending within the stent. The stent is an elongated self-expanding stent with an open tubular wall structure. The graft is an elongated compressible generally tubular graft. One end of the graft is secured to the inside of the stent and the graft extends therethrough. The stent is deployed allowing the free flow of blood through the open-celled structure, and the graft is freely deployed secondarily within the stent by the blood flowing therethrough. The present invention is not subject to significant distal migration during delivery and placement of the prosthesis.

摘要翻译： 用于放置在血管，管道或管腔中的腔内自扩张假体以保持其开放。 假体包括具有在支架内延伸的移植物的支架。 支架是具有开放管状壁结构的细长自扩张支架。 移植物是细长的可压缩的大体管状移植物。 移植物的一端固定到支架的内侧，并且移植物延伸穿过其中。 支架被部署允许血液通过开孔结构自由流动，并且移植物通过血液流过支架而自由地部署在支架内。 本发明在假体的输送和放置期间不会受到显着的远端移动。

公开(公告)号：US20060142840A1

公开(公告)日：2006-06-29

申请号：US11025826

申请日：2004-12-28

申请人： John Sherry ,  Fergus Quigley

发明人： John Sherry ,  Fergus Quigley

IPC分类号： A61F2/06

CPC分类号： A61F2/86 ,  A61F2002/075 ,  A61F2210/0076 ,  A61F2230/0054

摘要： A low profile, implantable prosthesis includes (a) a tubular graft including opposed open ends and having yarns in a textile pattern to define a textile wall having a luminal surface and an exterior surface; and (b) a tubular, radially extensible member including a portion arranged in a closed zig-zag pattern, the pattern having a series of angled bends at proximal and distal ends thereof, and longitudinally extending members having opposed proximal and distal ends, the distal ends being disposed from the angled bends of the proximal end; the longitudinally extending members having a plurality of detents for securing the yarns within the textile pattern at one of the opposed open ends, wherein the yarns of the textile patterns are securably disposed to the detents. The detents may be holes, inwardly extending notches, outwardly extending protuberances, or combinations thereof in the longitudinally extending members. The textile pattern of the graft may be a braided textile pattern, a woven textile pattern, a knitted textile pattern, and combinations thereof. Desirably, the zigzag portion of the radially extensible member is disposed beyond the open end of the graft. The radially extensible member may be a stent or may be an anchoring device for securing the prosthesis against the wall of a bodily lumen.

摘要翻译： 低度可植入的假体包括（a）管状移植物，其包括相对的开放端并且具有织物图案中的纱线以限定具有腔表面和外表面的织物壁; 和（b）管状的可径向延伸的构件，其包括以闭合的之字形图案布置的部分，所述图案在其近端和远端具有一系列成角度的弯曲部，以及具有相对的近端和远端的纵向延伸构件， 端部从近端的成角度的弯曲部设置; 纵向延伸部件具有多个棘爪，用于将织物图案中的纱线固定在相对的开口端中的一个处，其中织物图案的纱线牢固地设置在棘爪上。 棘爪可以是纵向延伸的构件中的孔，向内延伸的凹口，向外延伸的突起或其组合。 移植物的纺织图案可以是编织织物图案，纺织织物图案，针织织物图案及其组合。 期望地，可径向延伸的构件的锯齿形部分设置在移植物的开口端之外。 可径向延伸的构件可以是支架，也可以是用于将假体固定在体腔壁上的锚定装置。

公开(公告)号：US20110130655A1

公开(公告)日：2011-06-02

申请号：US12956820

申请日：2010-11-30

申请人： Eric D. Nielson ,  Steven C. Dimmer ,  David N. Krag ,  Timothy P. Mate ,  Roland Perez ,  Fergus Quigley

发明人： Eric D. Nielson ,  Steven C. Dimmer ,  David N. Krag ,  Timothy P. Mate ,  Roland Perez ,  Fergus Quigley

IPC分类号： A61B5/05

CPC分类号： A61N5/1049 ,  A61N2005/1051

摘要： Implantable devices and methods for external beam radiation treatments are disclosed. One embodiment of an implantable device for guided radiation therapy comprises an active marker configured to be positioned within the patient and to transmit a non-ionizing wireless signal in response to a non-ionizing wirelessly transmitted source energy. The device further includes a fastening unit coupled to the active marker and configured to (a) hold the marker within a desired distance of a target in the tissue and (b) inhibit deformation of tissue from moving the active marker relative to the target.

摘要翻译： 公开了用于外部束辐射处理的可植入装置和方法。 用于引导放射治疗的可植入装置的一个实施例包括被配置为定位在患者体内并且响应于非电离无线发射的源能发射非电离无线信号的活动标记。 该装置还包括紧固单元，其联接到主动标记并且被配置为（a）将标记保持在组织中的目标的期望距离内，并且（b）抑制组织相对于目标移动主动标记物的变形。

公开(公告)号：US08579961B2

公开(公告)日：2013-11-12

申请号：US11657140

申请日：2007-01-24

申请人： Thomas V. Casey, II ,  Kristoff Nelson ,  Fergus Quigley

发明人： Thomas V. Casey, II ,  Kristoff Nelson ,  Fergus Quigley

IPC分类号： A61F2/06

CPC分类号： A61F2/07 ,  A61F2/06 ,  A61F2/89

摘要： The present invention provides a sectional crimped graft that allows graft flexibility where required and limits the overall longitudinal extension. The present invention overcomes the disadvantage of fully crimped grafts by controlling the number of crimps per unit length, crimp height, crimp geometry and their location along the graft wall, dependent on the particular end-use application. In so doing, flexibility and elongation can be controllably tailored only in areas where significant anatomical angulation is present. It may also be useful in applications other than stent grafts such as surgical grafts for aortic and peripheral areas. Limiting the overall graft longitudinal extension also facilitates the deployment of the stent-graft into the blood vessel.

摘要翻译： 本发明提供了一种在需要时允许移植物柔性并限制整个纵向延伸的截面卷曲移植物。 根据特定的最终用途，本发明通过控制每单位长度的卷曲数量，卷曲高度，卷曲几何形状及其沿着移植物壁的位置克服了完全卷曲移植物的缺点。 在这样做时，灵活性和伸长率可以仅在存在显着解剖角度的区域中被可控地定制。 它也可用于除支架移植物以外的应用，例如用于主动脉和外周区域的手术移植物。 限制整个移植物纵向延伸也有助于将支架移植物部署到血管中。

公开(公告)号：US20100298858A1

公开(公告)日：2010-11-25

申请号：US12665498

申请日：2008-06-19

申请人： Steven C. Dimmer ,  Fergus Quigley ,  Eric D. Nielson

发明人： Steven C. Dimmer ,  Fergus Quigley ,  Eric D. Nielson

IPC分类号： A61M29/00

CPC分类号： A61N5/1015 ,  A61B2090/3958 ,  A61N5/1049 ,  A61N2005/1051

摘要： Apparatus and methods for external beam radiation treatments of resection cavities are described. One embodiment of such an apparatus comprises a stabilization device having an expandable member configured to (a) be implanted in a patient and (b) move from a first position for insertion into a resection cavity within the patient to a second position for stabilizing tissue of the cavity. The apparatus further includes an active marker coupled to the stabilization device and an electrically conductive line connected to the active marker. The active marker is configured to transmit a signal. The electrically conductive line has an internal portion coupled to the stabilization device and an external portion configured to be coupled to a signal generator and/or a signal processor located outside of the patient.

摘要翻译： 描述了用于切除腔的外部束辐射治疗的装置和方法。 这种装置的一个实施例包括具有可扩张构件的稳定装置，所述可扩张构件构造成（a）植入患者体内，并且（b）从用于插入患者体内切除腔的第一位置移动到第二位置，以稳定组织 空腔。 该装置还包括耦合到稳定装置的有源标记和连接到有源标记的导电线。 活动标记被配置为发送信号。 导电线具有连接到稳定装置的内部部分和被配置为耦合到位于病人外部的信号发生器和/或信号处理器的外部部分。

公开(公告)号：US20070208421A1

公开(公告)日：2007-09-06

申请号：US11365325

申请日：2006-03-01

申请人： Fergus Quigley

发明人： Fergus Quigley

IPC分类号： A61F2/06

CPC分类号： A61F2/07 ,  A61F2/89 ,  A61F2/90 ,  A61F2/915 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2250/0028 ,  A61F2250/0029

摘要： A stent-graft or prosthesis (10) with enhanced flexibility, in particular enhanced bending flexibility, includes a radially distensible stent (24) and at least one continuously uninterrupted ePTFE tubular graft or covering (18) having a node and fibril structure. The tubular stent (24) includes opposed open ends (12′, 14′) and a stent wall structure (26) having opposed exterior (28) and luminal surfaces (30). The ePTFE covering (18) is securably disposed to at least one of the stent surfaces (28, 30). The ePTFE graft or covering (18) includes a tubular wall (16) that is continuously uninterrupted and desirably substantially free of slits, apertures and folds. The ePTFE graft (18) further includes a first region (20) and a second region (22), where the first region (20) has a different bending flexibility from the second region (22).

摘要翻译： 具有增强的柔性，特别是增强的弯曲柔性的支架移植物或假体（10）包括径向扩张的支架（24）和至少一个具有节点和原纤结构的连续不间断的ePTFE管状移植物或覆盖物（18）。 管状支架（24）包括相对的开放端（12'，14'）和具有相对的外部（28）和腔表面（30）的支架壁结构（26）。 ePTFE覆盖物（18）被牢固地设置在至少一个支架表面（28,30）上。 ePTFE移植物或覆盖物（18）包括连续不间断且期望地基本上没有狭缝，孔和折叠的管状壁（16）。 ePTFE移植物（18）还包括第一区域（20）和第二区域（22），其中第一区域（20）具有与第二区域（22）不同的弯曲柔性。

公开(公告)号：US20130345561A1

公开(公告)日：2013-12-26

申请号：US13877257

申请日：2011-10-03

申请人： Fergus Quigley

发明人： Fergus Quigley

IPC分类号： A61M31/00

CPC分类号： A61M25/00 ,  A61B1/2676 ,  A61B90/39 ,  A61B2017/00867 ,  A61B2034/2051 ,  A61B2090/3987 ,  A61B2090/3991 ,  A61M25/0105 ,  A61M25/0108 ,  A61M25/09 ,  A61M31/005 ,  A61M2025/09166 ,  A61N5/1049

摘要： Systems and methods for treating a lung of a patient. One embodiment of a method comprises positioning a leadless marker in the lung of the patient relative to the target, and collecting position data of the marker. This method further comprises determining the location of the marker in an external reference frame outside of the patient based on the collected position data, and providing an objective output in the external reference frame that is responsive to movement of the marker. The objective output is provided at a frequency (i.e., periodicity) that results in a clinically acceptable tracking error. In addition, the objective output can also be provided at least substantially contemporaneously with collecting the position data used to determine the location of the marker.

摘要翻译： 用于治疗患者肺部的系统和方法。 一种方法的一个实施例包括将无引线标记物相对于靶标定位在患者的肺中，以及收集标记物的位置数据。 该方法还包括基于所收集的位置数据确定标记在患者外部的外部参考框架中的位置，以及响应于标记的移动而在外部参考框架中提供客观输出。 以导致临床上可接受的跟踪误差的频率（即，周期性）提供目标输出。 此外，目标输出还可以至少基本同时提供，收集用于确定标记位置的位置数据。

公开(公告)号：US08025693B2

公开(公告)日：2011-09-27

申请号：US11365325

申请日：2006-03-01

申请人： Fergus Quigley

发明人： Fergus Quigley

IPC分类号： A61F2/06

CPC分类号： A61F2/07 ,  A61F2/89 ,  A61F2/90 ,  A61F2/915 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2250/0028 ,  A61F2250/0029

摘要： A stent-graft or prosthesis (10) with enhanced flexibility, in particular enhanced bending flexibility, includes a radially distensible stent (24) and at least one continuously uninterrupted ePTFE tubular graft or covering (18) having a node and fibril structure. The tubular stent (24) includes opposed open ends (12′, 14′) and a stent wall structure (26) having opposed exterior (28) and luminal surfaces (30). The ePTFE covering (18) is securably disposed to at least one of the stent surfaces (28, 30). The ePTFE graft or covering (18) includes a tubular wall (16) that is continuously uninterrupted and desirably substantially free of slits, apertures and folds. The ePTFE graft (18) further includes a first region (20) and a second region (22), where the first region (20) has a different bending flexibility from the second region (22).

摘要翻译： 具有增强的柔性，特别是增强的弯曲柔性的支架移植物或假体（10）包括径向扩张的支架（24）和至少一个具有节点和原纤结构的连续不间断的ePTFE管状移植物或覆盖物（18）。 管状支架（24）包括相对的开放端（12'，14'）和具有相对的外部（28）和腔表面（30）的支架壁结构（26）。 ePTFE覆盖物（18）被牢固地设置在至少一个支架表面（28,30）上。 ePTFE移植物或覆盖物（18）包括连续不间断且期望地基本上没有狭缝，孔和折叠的管状壁（16）。 ePTFE移植物（18）还包括第一区域（20）和第二区域（22），其中第一区域（20）具有与第二区域（22）不同的弯曲柔性。