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1.发明申请ENDOLUMINAL STENT HAVING A MATCHED STIFFNESS REGION AND/OR A STIFFNESS GRADIENT 有权具有匹配刚度区域和/或强度梯度的内支架公开(公告)号：US20070185563A1
公开(公告)日：2007-08-09
申请号：US11735180
申请日：2007-04-13
申请人： David Zarbatany , Ari Moskowitz , Fergus Quigley , Lukas Hijlkema
发明人： David Zarbatany , Ari Moskowitz , Fergus Quigley , Lukas Hijlkema
IPC分类号： A61F2/06
CPC分类号： A61F2/86 , A61F2/064 , A61F2/91 , A61F2/915 , A61F2002/065 , A61F2002/067 , A61F2002/91558 , A61F2220/005 , A61F2220/0058 , A61F2250/0018 , A61F2250/0036
摘要： A modular elongated stent having an overlap region where two modular components fit together, the overlap region being relatively stiff as compared to another more flexible region of the stent when the stent is in an assembled configuration, the stent further comprising a mimic region that has a stiffness essentially equivalent to the stiffness of the overlap region, to provide kink resistance. A stent having such a mimic region or otherwise stiff region and a flexible region may have a transition region between the stiff and flexible regions, also to provide kink resistance. A stent may have relatively stiff regions and relatively flexible regions positioned to align the flexible regions with curved regions of a body lumen when deployed within the body lumen. The stiffness of the stiff, flexible, and transition regions may be controlled by varying the cross-sectional area of the stent components and/or by varying the stent architecture.
摘要翻译： 一种模块化细长支架，其具有两个模块化部件装配在一起的重叠区域，当所述支架处于组装构型时，所述重叠区域与所述支架的另一更柔性区域相比是相对刚性的，所述支架还包括模具区域， 刚度基本上等于重叠区域的刚度，以提供扭结阻力。 具有这种模拟区域或其他刚性区域和柔性区域的支架可以在刚性区域和柔性区域之间具有过渡区域，也提供扭结阻力。 支架可以具有相对刚性的区域和相对柔性的区域，其定位成当部署在体腔内时将柔性区域与体腔的弯曲区域对准。 可以通过改变支架部件的横截面面积和/或通过改变支架结构来控制刚性，柔性和过渡区域的刚度。
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公开(公告)号：US08252005B2
公开(公告)日：2012-08-28
申请号：US11174357
申请日：2005-06-30
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B17/0467 , A61B17/0469 , A61B2017/00243 , A61B2017/00575 , A61B2017/0445 , A61B2017/0451 , A61B2017/0464 , A61B2017/0488
摘要： A tissue fastening device includes a suture clip holder and a suture cutter. A suture clip can be releasably secured to the suture clip holder, and a suture line or lines can pass through the clip and adjacent the suture cutter. A first movement of a control handle causes the suture clip to be released from the suture clip holder, and a second movement of the control handle causes the suture cutter to cut the suture line or lines. The first movement is different from the second movement. The first movement can be rotational, with the second movement being longitudinal. Alternatively, the first movement can be longitudinal, with the second movement being rotational. The device may include a main body, an inner body, and an outer body.
摘要翻译： 组织固定装置包括缝合夹夹持器和缝合线切割器。 缝线夹可以可释放地固定到缝合夹保持器，并且缝合线或线可以穿过夹子并且邻近缝合线切割器。 控制手柄的第一运动使得缝合夹从缝合夹夹持器释放，并且控制手柄的第二运动使得缝合线切割器切割缝合线或线。 第一动作不同于第二动作。 第一运动可以是旋转的，第二运动是纵向的。 或者，第一运动可以是纵向的，第二运动是旋转的。 该装置可以包括主体，内部主体和外部主体。
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公开(公告)号：US08226666B2
公开(公告)日：2012-07-24
申请号：US12552972
申请日：2009-09-02
申请人： David Zarbatany , Tai Tieu , Ponaka Pung , Joseph Videll , Ken Perry , John Krumme , Maurice Buchbinder
发明人： David Zarbatany , Tai Tieu , Ponaka Pung , Joseph Videll , Ken Perry , John Krumme , Maurice Buchbinder
IPC分类号： A61B17/04
CPC分类号： A61B17/0469 , A61B17/0467 , A61B17/0482 , A61B17/0487 , A61B2017/00243 , A61B2017/00371 , A61B2017/00783 , A61B2017/0445 , A61B2017/0451 , A61B2017/0464 , A61B2017/0472 , A61B2017/0488 , A61B2017/22052 , A61B2017/22069 , A61B2017/306 , A61F2/2442
摘要： The present invention is various systems for repairing tissue within the heart of a patient. The system of the present invention includes a guide catheter, a therapy catheter, and a fastener catheter. The therapy catheter and the fastener catheter are capable of traversing the internal lumen of the guide catheter. The fastener catheter is capable of introducing a suture clip to a desired position along suture line, deploying the suture clip to secure the suture and cutting excess suture. In addition, the present invention discloses various methods for repairing tissue.
摘要翻译： 本发明是用于修复患者心脏内的组织的各种系统。 本发明的系统包括导向导管，治疗导管和紧固导管。 治疗导管和紧固导管能够穿过引导导管的内腔。 紧固导管能够沿着缝合线将缝合夹引入到期望的位置，展开缝线夹以固定缝合线并切割多余的缝线。 此外，本发明公开了修复组织的各种方法。
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公开(公告)号：US07381210B2
公开(公告)日：2008-06-03
申请号：US10389721
申请日：2003-03-14
申请人： David Zarbatany , Tai Tieu , Ponaka Pung , Joseph Videll , Ken Perry , John Krumme , Maurice Buchbinder
发明人： David Zarbatany , Tai Tieu , Ponaka Pung , Joseph Videll , Ken Perry , John Krumme , Maurice Buchbinder
CPC分类号： A61B17/0469 , A61B17/0467 , A61B17/0482 , A61B17/0487 , A61B2017/00243 , A61B2017/00371 , A61B2017/00783 , A61B2017/0445 , A61B2017/0451 , A61B2017/0464 , A61B2017/0472 , A61B2017/0488 , A61B2017/22052 , A61B2017/22069 , A61B2017/306 , A61F2/2442
摘要： The present invention is directed to various systems for repairing tissue within the heart of a patient. The mitral valve repair system of the present invention comprises a guide catheter having a proximal end, a distal end, and at least one internal lumen formed therein, a therapy catheter capable of applying a suture to the tissue, and a fastener catheter capable of attaching a fastener to the suture. The therapy catheter and the fastener catheter are capable of traversing the internal lumen of the guide catheter. In addition, the present invention discloses various methods for repairing tissue within the heart of a patient.
摘要翻译： 本发明涉及用于修复患者心脏内的组织的各种系统。 本发明的二尖瓣修复系统包括具有近端，远端和形成在其中的至少一个内腔的引导导管，能够将缝合线施加到组织上的治疗导管，以及能够附接 紧固件到缝合线。 治疗导管和紧固导管能够穿过引导导管的内腔。 此外，本发明公开了用于修复患者心脏内的组织的各种方法。
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公开(公告)号：US20070005079A1
公开(公告)日：2007-01-04
申请号：US11174143
申请日：2005-06-30
申请人： David Zarbatany , Tai Tieu
发明人： David Zarbatany , Tai Tieu
IPC分类号： A61B17/10
CPC分类号： A61B17/0482 , A61B17/0057 , A61B17/0467 , A61B17/0487 , A61B2017/00243 , A61B2017/00575 , A61B2017/0445 , A61B2017/0451 , A61B2017/0464 , A61B2017/0472 , A61B2017/0488 , A61B2017/0496 , A61B2017/306
摘要： An apparatus and method for repairing septal defects includes advancing a catheter to the site of the defect, grasping opposing edges of the defect, passing one or more suture lines through the opposing edges, and tightening the suture lines. The catheter can include one or more vacuum ports, with the vacuum ports being sized and configured to grasp opposing edges of the defect when vacuum is applied thereto. The vacuum ports may be positioned longitudinally distant from each other along the catheter, and may also be on different sides of the catheter. The vacuum ports may have vacuum applied via independent control. The catheter can also include suture deploying structure that prevents the suture line from becoming entangled in the catheter.
摘要翻译： 用于修复间隔缺损的装置和方法包括将导管推进到缺损部位，抓住缺损的相对边缘，使一条或多条缝合线穿过相对边缘，并收紧缝合线。 导管可以包括一个或多个真空端口，其中真空端口的尺寸和构造被设计成在将真空施加到其上时抓住缺陷的相对边缘。 真空端口可以沿着导管相对于彼此纵向地定位，并且也可以在导管的不同侧面上。 真空端口可以通过独立控制来施加真空。 导管还可以包括防止缝合线缠结在导管中的缝线展开结构。
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公开(公告)号：US20090318871A1
公开(公告)日：2009-12-24
申请号：US12552972
申请日：2009-09-02
申请人： David Zarbatany , Tai Tieu , Ponaka Pung , Joseph Videll , Ken Perry , John Krumme , Maurice Buchbinder
发明人： David Zarbatany , Tai Tieu , Ponaka Pung , Joseph Videll , Ken Perry , John Krumme , Maurice Buchbinder
CPC分类号： A61B17/0469 , A61B17/0467 , A61B17/0482 , A61B17/0487 , A61B2017/00243 , A61B2017/00371 , A61B2017/00783 , A61B2017/0445 , A61B2017/0451 , A61B2017/0464 , A61B2017/0472 , A61B2017/0488 , A61B2017/22052 , A61B2017/22069 , A61B2017/306 , A61F2/2442
摘要： The present invention is directed to various systems for repairing tissue within the heart of a patient. The mitral valve repair system of the present invention comprises a guide catheter having a proximal end, a distal end, and at least one internal lumen formed therein, a therapy catheter capable of applying a suture to the tissue, and a fastener catheter capable of attaching a fastener to the suture. The therapy catheter and the fastener catheter are capable of traversing the internal lumen of the guide catheter. In addition, the present invention discloses various methods for repairing tissue within the heart of a patient. In one embodiment, the method of repairing heart valve tissue includes advancing a guide catheter through a circulatory pathway to a location in the heart proximate to a heart valve, advancing a therapy catheter through the guide catheter to the heart valve, stabilizing a first leaflet with the therapy catheter, deploying a first suture into the stabilized first leaflet, disengaging the first leaflet from the therapy catheter while leaving the first suture attached thereto, stabilizing a second leaflet with the therapy catheter, deploying a second suture into the second leaflet, disengaging the second leaflet from the therapy catheter while leaving the second suture attached thereto, and joining the first and second leaflets by reducing the distance between the first and second sutures.
摘要翻译： 本发明涉及用于修复患者心脏内的组织的各种系统。 本发明的二尖瓣修复系统包括具有近端，远端和形成在其中的至少一个内腔的引导导管，能够将缝合线施加到组织的治疗导管，以及能够附接 紧固件到缝合线。 治疗导管和紧固导管能够穿过引导导管的内腔。 此外，本发明公开了用于修复患者心脏内的组织的各种方法。 在一个实施例中，修复心脏瓣膜组织的方法包括使引导导管通过循环路径前进到靠近心脏瓣膜的心脏中的位置，将治疗导管通过引导导管推进到心脏瓣膜，使第一传单与 所述治疗导管将第一缝合线部署到所述稳定化的第一小叶中，使所述第一传播带与所述治疗导管脱离接合，同时使所述第一缝合线附接到所述导管，使所述治疗导管稳定第二传播片，将第二缝合线部署到所述第二传单中， 第二传单，同时离开附接到其上的第二缝合线，并且通过减小第一和第二缝合线之间的距离来接合第一和第二小叶。
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公开(公告)号：US07628797B2
公开(公告)日：2009-12-08
申请号：US11345208
申请日：2006-01-31
申请人： Tai Tieu , Joshua Benjamin , David Zarbatany
发明人： Tai Tieu , Joshua Benjamin , David Zarbatany
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B17/0467 , A61B17/0469 , A61B2017/00243 , A61B2017/00575 , A61B2017/00867 , A61B2017/0451 , A61B2017/0454 , A61B2017/0464 , A61B2017/0488 , A61B2017/0496 , Y10T24/3916
摘要： A clip for securing suture includes a generally tubular body, with one or more tabs cut from the wall of the generally tubular. The tab in an open configuration has the tabs in general alignment with the tab out wall, and the tab in a closed configuration has the tabs bent or otherwise positioned to extend into and at least partially obstruct the inner lumen. The tab may be formed as a generally horse-shoe shaped cut out, and may include a generally elliptical portion having a width and length. The tab may have a width generally the same size as the diameter of the inner lumen. The clip can be formed from memory material such as nitinol, and the clip may be biased toward its closed configuration.
摘要翻译： 用于固定缝合线的夹子包括大致管状的主体，其中一个或多个突出部从大致管状的壁切割。 处于打开构型的突片具有与突片外壁大致对准的突出部，并且处于闭合构型的突片具有弯曲或以其他方式定位成延伸到并至少部分地阻碍内腔的突舌。 突片可以形成为大致为马鞋形切口，并且可以包括具有宽度和长度的大致椭圆形部分。 突片的宽度通常与内腔直径相同。 夹子可以由诸如镍钛诺的记忆材料形成，并且夹子可以朝向其闭合构型偏置。
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公开(公告)号：US20070239154A1
公开(公告)日：2007-10-11
申请号：US11728010
申请日：2007-03-22
CPC分类号： A61F2/2445 , A61F2/2466 , A61F2250/0001
摘要： An activation device for applying energy to an implanted annuloplasty ring is described. In some embodiments, the activation device includes an outer elongate member having an outer elongate member distal end and an outer elongate member proximal end, and a lumen therebetween. In some embodiments, the activation device further includes an inner elongate member having a inner elongate member distal end and a inner elongate member proximal end, and a lumen therebetween, wherein the inner elongate member is slidably insertable through the lumen of the outer elongate member. In some embodiments, the activation device further includes at least one adjustable spline having spline proximal and spline distal ends, the spline distal end connected to the inner tubular member distal end and the spline proximal end connected to the outer tubular member distal end, wherein the adjustable spline is configured to flex as the inner tubular member distal end is drawn proximally toward the outer tubular member distal end while the inner elongate member resides in the lumen of the outer elongate member. In some embodiments, the activation device further includes at least one energy-transfer element coupled to the adjustable spline.
摘要翻译： 描述了一种用于向植入的瓣膜成形术环施加能量的激活装置。 在一些实施例中，激活装置包括具有外部细长构件远端和外部细长构件近端的外部细长构件和其间的内腔。 在一些实施例中，激活装置还包括具有内部细长构件远端和内部细长构件近端的内部细长构件和其间的内腔，其中内部细长构件可滑动地插入穿过外部细长构件的内腔。 在一些实施例中，激活装置还包括具有花键近端和花键远端的至少一个可调节花键，花键远端连接到内部管状构件远端，花键近端连接到外部管状构件远端，其中， 当内部细长构件驻留在外部细长构件的内腔中时，可调节花键构造成随着内部管状构件远端朝向外部管状构件远端被拉近而弯曲。 在一些实施例中，激活装置还包括耦合到可调节花键的至少一个能量传递元件。
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公开(公告)号：US20070179530A1
公开(公告)日：2007-08-02
申请号：US11345208
申请日：2006-01-31
申请人： Tai Tieu , Joshua Benjamin , David Zarbatany
发明人： Tai Tieu , Joshua Benjamin , David Zarbatany
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B17/0467 , A61B17/0469 , A61B2017/00243 , A61B2017/00575 , A61B2017/00867 , A61B2017/0451 , A61B2017/0454 , A61B2017/0464 , A61B2017/0488 , A61B2017/0496 , Y10T24/3916
摘要： A clip for securing suture includes a generally tubular body, with one or more tabs cut from the wall of the generally tubular. The tab in an open configuration has the tabs in general alignment with the tab out wall, and the tab in a closed configuration has the tabs bent or otherwise positioned to extend into and at least partially obstruct the inner lumen. The tab may be formed as a generally horse-shoe shaped cut out, and may include a generally elliptical portion having a width and length. The tab may have a width generally the same size as the diameter of the inner lumen. The clip can be formed from memory material such as nitinol, and the clip may be biased toward its closed configuration.
摘要翻译： 用于固定缝合线的夹子包括大致管状的主体，其中一个或多个突出部从大致管状的壁切割。 处于打开构型的突片具有与突片外壁大致对准的突出部，并且处于闭合构型的突片具有弯曲或以其他方式定位成延伸到并至少部分地阻碍内腔的突舌。 突片可以形成为大致为马鞋形切口，并且可以包括具有宽度和长度的大致椭圆形部分。 突片的宽度通常与内腔直径相同。 夹子可以由诸如镍钛诺的记忆材料形成，并且夹子可以朝向其闭合构型偏置。
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公开(公告)号：US09220555B2
公开(公告)日：2015-12-29
申请号：US12914297
申请日：2010-10-28
CPC分类号： A61B18/02 , A61B2017/00243 , A61B2017/00867 , A61B2018/0022 , A61B2018/00357 , A61B2018/0212 , A61B2018/1861 , A61M25/104 , A61M2025/0004 , A61M2025/0175
摘要： A medical system is provided, including a catheter body having a proximal portion and a distal portion; a shaft slidably disposed within a portion of the catheter body, the shaft defining a distal tip; a fluid injection tube coupled to the distal portion of the catheter body and the distal tip of the shaft, the fluid injection tube being transitionable from a first geometric configuration to a second geometric configuration; a membrane coupled to the shaft and enclosing at least a portion of the fluid injection tube therein; and a coolant source in fluid communication with the fluid injection tube. The first geometric configuration may be substantially linear, the second geometric configuration may be substantially helical, and the membrane may be tensioned across at least a portion of the fluid injection tube in the second geometric configuration.
摘要翻译： 提供了一种医疗系统，包括具有近端部分和远端部分的导管主体; 可滑动地设置在所述导管主体的一部分内的轴，所述轴限定远端; 流体注入管，其耦合到所述导管主体的远端部分和所述轴的远侧末端，所述流体注入管可从第一几何构型转换到第二几何构型; 膜，其联接到所述轴并且包围所述流体注入管的至少一部分; 以及与流体注入管流体连通的冷却剂源。 第一几何构型可以是基本上线性的，第二几何构型可以是基本上螺旋的，并且膜可以在第二几何构型中跨过流体注入管的至少一部分张紧。
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