公开(公告)号：US11714083B2

公开(公告)日：2023-08-01

申请号：US16612270

申请日：2018-05-04

Applicant: Arizona Board of Regents on behalf of Arizona State University ,  MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH ,  AXIM Biotechnologies, Inc.

Inventor： Jeffrey LaBelle ,  Garrett Repp ,  Chi Lin ,  Mark Spano ,  Jennifer Blain Christen ,  Hongwu Jiang ,  Marcus Smith ,  Andrew Penman ,  Pierce Youngbar ,  Mackenzie Honikel ,  Curtiss Cook

IPC: G01N33/543 ,  G01N27/02 ,  G01N27/327 ,  G01N33/487 ,  G01N33/53 ,  G01N33/569 ,  G01N33/66 ,  G01N35/00

CPC classification number: G01N33/5438 ,  G01N27/026 ,  G01N27/3276 ,  G01N33/48707 ,  G01N33/5308 ,  G01N33/56983 ,  G01N33/66 ,  G01N35/00029 ,  G01N2333/075

Abstract: The presence of analytes can be detected in the bodily fluid using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (ECS) in devices, such as handheld point-of-care devices. The devices, as well as systems and methods, utilize using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (EIS) in combination with an antibody or other target-capturing molecule on a working electrode. Imaginary impedance or phase shift, as well as background subtraction, also may be utilized.

公开(公告)号：US10939857B2

公开(公告)日：2021-03-09

申请号：US16011796

申请日：2018-06-19

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Jeffrey LaBelle ,  Anngela Adams ,  Garrett Repp

IPC: A61B5/1486 ,  C12Q1/00 ,  G01N27/327 ,  G01N33/66 ,  A61B5/145 ,  A61B5/15 ,  A61B5/00 ,  A61B5/157 ,  A61B5/1495 ,  G01N33/49

Abstract: A blood glucose sensing device includes a substrate, multiple three-dimensionally (3D) printed electrode leads comprising graphene arranged on or over the substrate, and glucose monitoring chemistry arranged in or on (e.g., adsorbed in) at least one of the 3D printed electrode leads. An end portion of a counter electrode lead may partially surround an end portion of a working electrode lead, and a reference lead may be further provided, Optionally, the 3D printed electrode leads may include a thermoplastic material, such as an aliphatic polyester. The glucose monitoring chemistry may include an enzyme.

公开(公告)号：US20210223196A1

公开(公告)日：2021-07-22

申请号：US16612270

申请日：2018-05-04

Applicant: Arizona Board of Regents on behalf of Arizona State University ,  MAYO FOUNDAION FOR MEDICAL EDUCATION AND RESEARCH

Inventor： Jeffrey LaBelle ,  Garrett Repp ,  Chi Lin ,  Mark Spano ,  Jennifer Blain Christen ,  Hongwu Jiang ,  Marcus Smith ,  Andrew Penman ,  Pierce Youngbar ,  Mackenzie Honikel ,  Curtiss Cook

IPC: G01N27/02 ,  G01N27/327 ,  G01N33/487 ,  G01N27/22 ,  G01N35/00 ,  G01N33/569 ,  G01N33/66 ,  G01N33/53

Abstract: The presence of analytes can be detected in the bodily fluid using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (ECS) in devices, such as handheld point-of-care devices. The devices, as well as systems and methods, utilize using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (EIS) in combination with an antibody or other target-capturing molecule on a working electrode. Imaginary impedance or phase shift, as well as background subtraction, also may be utilized.

公开(公告)号：US20190046092A1

公开(公告)日：2019-02-14

申请号：US16011796

申请日：2018-06-19

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Jeffrey LaBelle ,  Anngela Adams ,  Garrett Repp

IPC: A61B5/1486 ,  G01N33/66 ,  A61B5/145 ,  G01N27/327 ,  A61B5/15 ,  A61B5/00

Abstract: A blood glucose sensing device includes a substrate, multiple three-dimensionally (3D) printed electrode leads comprising graphene arranged on or over the substrate, and glucose monitoring chemistry arranged in or on (e.g., adsorbed in) at least one of the 3D printed electrode leads. An end portion of a counter electrode lead may partially surround an end portion of a working electrode lead, and a reference lead may be further provided, Optionally, the 3D printed electrode leads may include a thermoplastic material, such as an aliphatic polyester. The glucose monitoring chemistry may include an enzyme.