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公开(公告)号：US20240408194A1
公开(公告)日：2024-12-12
申请号：US18701892
申请日：2022-10-20
Inventor： Nicholas Stephanopoulos , Yang Xu , Petr Sulc , Hao Yan , Rong Zheng
IPC: A61K39/215 , A61K39/00 , A61K39/385 , A61P37/04 , B82Y5/00
Abstract: The present disclosure relates to DNA nanocarriers and methods of use for stimulating an immune response in a host. In some embodiments, the DNA nanocarriers comprise SARS-CoV-2 surface glycoprotein.
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公开(公告)号：US11760774B2
公开(公告)日：2023-09-19
申请号：US16938474
申请日：2020-07-24
Inventor： Dongran Han , Hao Yan
Abstract: Novel compositions and methods for engineering wireframe architectures and scaffolds of increasing complexity by creating gridiron-like DNA structures (FIG. 1). A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects, can be assembled according the methods presented herein.
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公开(公告)号：US20190144491A1
公开(公告)日：2019-05-16
申请号：US16202841
申请日：2018-11-28
Inventor： Dongran Han , Hao Yan
Abstract: Novel compositions and methods for engineering wireframe architectures and scaffolds of increasing complexity by creating gridiron-like DNA structures (FIG. 1). A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects, can be assembled according the methods presented herein.
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公开(公告)号：US20230212681A1
公开(公告)日：2023-07-06
申请号：US17799755
申请日：2021-02-17
Inventor： Hao Yan , Rizal Hariadi , Swarup Dey
IPC: C12Q1/6886
CPC classification number: C12Q1/6886 , C12Q1/6818 , C12Q2600/178
Abstract: Disclosed herein is a transmembrane nanosensor device comprising a lipid conjugated DNA tweezer, and methods of using the same.
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公开(公告)号：US11168320B2
公开(公告)日：2021-11-09
申请号：US15673017
申请日：2017-08-09
Inventor： Hao Yan
IPC: C12N15/10 , C12N15/115
Abstract: Provided herein are methods and systems for structure-assisted evolution of multivalent aptamers using a single stranded DNA or single-stranded RNA nanostructure as a structural support. Also provided herein are methods for constructing ssDNA or ssRNA nanostructures as structural supports suitable for structure-assisted evolution of multivalent aptamers.
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Patent Agency Ranking
公开(公告)号：US10774107B2
公开(公告)日：2020-09-15
申请号：US16202841
申请日：2018-11-28
Inventor： Dongran Han , Hao Yan
Abstract: Novel compositions and methods for engineering wireframe architectures and scaffolds of increasing complexity by creating gridiron-like DNA structures (FIG. 1). A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects, can be assembled according the methods presented herein.
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公开(公告)号：US20250146021A1
公开(公告)日：2025-05-08
申请号：US18726078
申请日：2023-01-09
Inventor： Nicholas Stephanopoulos , Karen Sue Anderson , Petr Sulc , Skyler Jennifer Wray Henry , Liangxiao Chen , Erik Poppleton , Hao Yan
Abstract: Described herein is a DNA nanotechnology-based platform for the delivery of nucleic acids into cells. The delivery platform relies on compacting cargo mRNA and/or ssDNA into single folded nanostructures that act as the primary structural vehicle material for nanoparticle delivery to cells. The described compositions and methods provide an alternative to packaging mRNA or ssDNA into lipid nanoparticle vehicles, which have complex formulation properties. Also described herein are strategies for protecting mRNA and/or ssDNA cargo and helping these nucleic acid molecules escape the endosome into the cytoplasm using a cationic peptide-PEG coating.
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公开(公告)号：US20230038866A1
公开(公告)日：2023-02-09
申请号：US17814407
申请日：2022-07-22
Inventor： Xiaodong Qi , Hao Yan , Peter Nakaji , Joseph Georges , Xiaowei Liu
IPC: G01N33/53 , C12N15/115
Abstract: Disclosed are methods of detecting and treating suspected B-cell lymphoma.
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公开(公告)号：US11466267B2
公开(公告)日：2022-10-11
申请号：US15937371
申请日：2018-03-27
Inventor： Joseph Blattman , Hao Yan , Louis Schoettle , Xixi Wei
IPC: C12Q1/68 , C12N15/10 , C12Q1/6816 , C12Q1/6881 , C12Q1/6806 , B82Y5/00 , B82Y15/00
Abstract: Methods for construction of DNA origami nanostructures, as well as for binding, isolation, linking, and deep sequencing information, such as both of TCR alpha and beta CDR3 mRNA, from individual cells within a mixed population of cells without the need for single cell sorting (FIG. 1).
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公开(公告)号：US20180044663A1
公开(公告)日：2018-02-15
申请号：US15673017
申请日：2017-08-09
Inventor： Hao Yan
IPC: C12N15/10 , C12N15/115
CPC classification number: C12N15/1058 , C12N15/1013 , C12N15/115 , C12N2310/16 , C12N2320/13 , C12Q2531/113
Abstract: Provided herein are methods and systems for structure-assisted evolution of multivalent aptamers using a single stranded DNA or single-stranded RNA nanostructure as a structural support. Also provided herein are methods for constructing ssDNA or ssRNA nanostructures as structural supports suitable for structure-assisted evolution of multivalent aptamers.
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