公开(公告)号：US06174701B1

公开(公告)日：2001-01-16

申请号：US08455741

申请日：1995-05-31

申请人： Arnon Rosenthal ,  John W. Winslow

发明人： Arnon Rosenthal ,  John W. Winslow

IPC分类号： C12N1500

CPC分类号： C07K14/475 ,  A61K38/00

摘要： A novel polypeptide, designated neuronal factor (NF), has been identified by PCR amplification of human genomic DNA. Provided herein is nucleic acid encoding NF useful in diagnostics and in the recombinant preparation of NF. NF is used in the treatment of nerve cells and in diagnostic assays.

摘要翻译： 已经通过人类基因组DNA的PCR扩增鉴定了一种新的多肽，称为神经元因子（NF）。 本文提供了可用于诊断和NF重组制备中的NF的核酸。 NF用于治疗神经细胞和诊断测定。

公开(公告)号：US08101571B2

公开(公告)日：2012-01-24

申请号：US12254458

申请日：2008-10-20

申请人： Leonard G. Presta ,  Roman Urfer ,  John W. Winslow

发明人： Leonard G. Presta ,  Roman Urfer ,  John W. Winslow

IPC分类号： A61K38/18

CPC分类号： C07K14/48 ,  A61K38/00

摘要： NGF variants which have trkC-binding activity and trkC-signal inducing activity are provided. The variants optionally have trkA or trkB binding and signal induction activity. The NGF variants of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the NGF variant neurotrophins are also provided.

摘要翻译： 提供具有trkC结合活性和trkC信号诱导活性的NGF变体。 变体任选具有trkA或trkB结合和信号诱导活性。 本发明的NGF变体可用于治疗神经元疾病。 还提供了编码NGF变体神经营养蛋白的核酸和表达载体。

公开(公告)号：US07452863B1

公开(公告)日：2008-11-18

申请号：US09066619

申请日：1998-04-24

申请人： Leonard G. Presta ,  Roman Urfer ,  John W. Winslow

发明人： Leonard G. Presta ,  Roman Urfer ,  John W. Winslow

IPC分类号： A61K38/18 ,  C07K14/48

CPC分类号： C07K14/48 ,  A61K38/00

摘要： NGF variants which have trkC-binding activity and trkC-signal inducing activity are provided. The variants optionally have trkA or trkB binding and signal induction activity. The NGF variants of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the NGF variant neurotrophins are also provided.

摘要翻译： 提供具有trkC结合活性和trkC信号诱导活性的NGF变体。 变体任选具有trkA或trkB结合和信号诱导活性。 本发明的NGF变体可用于治疗神经元疾病。 还提供了编码NGF变体神经营养蛋白的核酸和表达载体。

公开(公告)号：US07935671B2

公开(公告)日：2011-05-03

申请号：US12401483

申请日：2009-03-10

申请人： Roman Urfer ,  Leonard G. Presta ,  John W. Winslow

发明人： Roman Urfer ,  Leonard G. Presta ,  John W. Winslow

IPC分类号： A61K38/18 ,  C07K14/475 ,  C07K14/48

CPC分类号： A61K38/185 ,  C07K14/475 ,  C07K14/48 ,  C12N15/11

摘要： Pantropic neurotrophic factors which have multiple neurotrophic specificities are provided. The pantropic neurotrophic factors of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the pantropic neurotrophins are also provided.

摘要翻译： 提供了具有多种神经营养特异性的泛性神经营养因子。 本发明的泛素神经营养因子可用于治疗神经元疾病。 还提供了编码泛素神经营养因子的核酸和表达载体。

公开(公告)号：US07528233B2

公开(公告)日：2009-05-05

申请号：US11443576

申请日：2006-05-30

申请人： Roman Urfer ,  Leonard G. Presta ,  John W. Winslow

发明人： Roman Urfer ,  Leonard G. Presta ,  John W. Winslow

IPC分类号： A61K38/18 ,  C07K14/475 ,  C07K14/48

CPC分类号： A61K38/185 ,  C07K14/475 ,  C07K14/48 ,  C12N15/11

摘要： Pantropic neurotrophic factors which have multiple neurotrophic specificities are provided. The pantropic neurotrophic factors of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the pantropic neurotrophins are also provided.

摘要翻译： 提供了具有多种神经营养特异性的泛性神经营养因子。 本发明的泛素神经营养因子可用于治疗神经元疾病。 还提供了编码泛素神经营养因子的核酸和表达载体。

公开(公告)号：US5759775A

公开(公告)日：1998-06-02

申请号：US442248

申请日：1995-05-15

申请人： Ingrid W. Caras ,  John W. Winslow

发明人： Ingrid W. Caras ,  John W. Winslow

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K45/00 ,  A61P9/00 ,  A61P25/00 ,  A61P25/28 ,  A61P31/04 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07K14/47 ,  C07K14/52 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  C12N5/10 ,  C12N9/12 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12P19/34 ,  C07H21/04 ,  C07H21/02

CPC分类号： C12N9/1205 ,  C07K14/52 ,  C07K16/22 ,  C07K16/2863 ,  A61K38/00 ,  C07K2319/00

摘要： Provided are nucleic acids encoding AL-1 protein, as well as AL-1 protein produced by recombinant DNA methods. Such AL-1 protein is useful in preparing antibodies and in diagnosing and treating various neuronal disorders. The present invention provides methods to preferentially detect or amplify AL-1 nucleic acid in a sample using AL-1 nucleotide sequence probes.

摘要翻译： 提供编码AL-1蛋白的核酸，以及通过重组DNA方法产生的AL-1蛋白。 这样的AL-1蛋白质可用于制备抗体和诊断和治疗各种神经元疾病。 本发明提供了使用AL-1核苷酸序列探针优先检测或扩增样品中的AL-1核酸的方法。

公开(公告)号：US5728803A

公开(公告)日：1998-03-17

申请号：US440049

申请日：1995-05-12

申请人： Roman Urfer ,  Leonard G. Presta ,  John W. Winslow

发明人： Roman Urfer ,  Leonard G. Presta ,  John W. Winslow

IPC分类号： C12N15/09 ,  A61K38/18 ,  A61K38/27 ,  A61P25/00 ,  C07H21/04 ,  C07K14/475 ,  C07K14/48 ,  C12N5/10 ,  C12N15/11 ,  C12N15/18 ,  C12P21/02

CPC分类号： A61K38/185 ,  C07K14/475 ,  C07K14/48 ,  C12N15/11

摘要： Pantropic neurotrophic factors which have multiple neurotrophic specificities are provided. The pantropic neurotrophic factors of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the pantropic neurotrophins are also provided.

公开(公告)号：US07144983B1

公开(公告)日：2006-12-05

申请号：US10230865

申请日：2002-08-28

申请人： Roman Urfer ,  Leonard G. Presta ,  John W. Winslow

发明人： Roman Urfer ,  Leonard G. Presta ,  John W. Winslow

IPC分类号： C07K14/48 ,  A61K38/18

CPC分类号： C07K14/475 ,  C07K14/4756 ,  C07K14/48

摘要： Pantropic neurotrophic factors which have multiple neurotrophic specificities are provided. The pantropic neurotrophic factors of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the pantropic neurotrophins are also provided.

公开(公告)号：US06503728B1

公开(公告)日：2003-01-07

申请号：US08794028

申请日：1997-02-03

申请人： Roman Urfer ,  Leonard G. Presta ,  John W. Winslow

发明人： Roman Urfer ,  Leonard G. Presta ,  John W. Winslow

IPC分类号： C12P2102

CPC分类号： A61K38/185 ,  C07K14/475 ,  C07K14/48 ,  C12N15/11

摘要： Pantropic neurotrophic factors which have multiple neurotrophic specificities are provided. The pantropic neurotrophic factors of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the pantropic neurotrophins are also provided.

公开(公告)号：US06365373B2

公开(公告)日：2002-04-02

申请号：US09066065

申请日：1998-04-24

申请人： Leonard G. Presta ,  Roman Urfer ,  John W. Winslow

发明人： Leonard G. Presta ,  Roman Urfer ,  John W. Winslow

IPC分类号： C12N1518

CPC分类号： C07K14/48 ,  A61K38/00

摘要： NGF variants which have trkC-binding activity and trkC-signal inducing activity are provided. The variants optionally have trkA or trkB binding and signal induction activity. The NGF variants of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the NGF variant neurotrophins are also provided.

摘要翻译： 提供具有trkC结合活性和trkC信号诱导活性的NGF变体。 变体任选具有trkA或trkB结合和信号诱导活性。 本发明的NGF变体可用于治疗神经元疾病。 还提供了编码NGF变体神经营养蛋白的核酸和表达载体。