公开(公告)号：US20140234354A1

公开(公告)日：2014-08-21

申请号：US13800413

申请日：2013-03-13

申请人： Arun V. IYER ,  Dianna M. Murphy JORDAN ,  Abby Rae PATTERSON ,  Michael B. ROOF ,  Eric Martin VAUGHN ,  Joseph Gilbert VICTORIA ,  Callie Ann VISEK

发明人： Arun V. IYER ,  Dianna M. Murphy JORDAN ,  Abby Rae PATTERSON ,  Michael B. ROOF ,  Eric Martin VAUGHN ,  Joseph Gilbert VICTORIA ,  Callie Ann VISEK

IPC分类号： C12N7/00

CPC分类号： A61K39/23 ,  A61K2039/53 ,  C07K14/005 ,  C12N7/00 ,  C12N2750/14321 ,  C12N2750/14322 ,  C12N2750/14334 ,  G01N33/56983 ,  G01N2333/015 ,  G01N2469/10

摘要： The present invention provides novel nucleotides sequences, protein sequences, immunogenic compositions, vaccines, and methods that relate to making and using new porcine parvovirus 5B (PPV5B) that infects, inter alia, domestic swine. The compositions and methods provide for the detection of infections by said new virus, monitoring genetic changes in the viral sequences in wild and domestic animals and herds, and making and using novel vaccines for protecting animals from infection by the virus.

摘要翻译： 本发明提供新颖的核苷酸序列，蛋白质序列，免疫原性组合物，疫苗和涉及制造和使用感染尤其是家猪的新型猪细小病毒5B（PPV5B）的方法。 组合物和方法提供了用于检测所述新病毒的感染，监测野生和家畜和猪群中的病毒序列的遗传变化，以及制备和使用新型疫苗以保护动物免受病毒感染。

公开(公告)号：US20140170180A1

公开(公告)日：2014-06-19

申请号：US13796621

申请日：2013-03-12

申请人： Arun V. IYER ,  Dianna M. Murphy JORDAN ,  Abby Rae PATTERSON ,  Michael B. ROOF ,  Eric Martin VAUGHN ,  Joseph Gilbert VICTORIA ,  Callie Ann VISEK

发明人： Arun V. IYER ,  Dianna M. Murphy JORDAN ,  Abby Rae PATTERSON ,  Michael B. ROOF ,  Eric Martin VAUGHN ,  Joseph Gilbert VICTORIA ,  Callie Ann VISEK

IPC分类号： A61K39/23 ,  G01N33/68

CPC分类号： A61K39/23 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/552 ,  C07K14/005 ,  C12N7/00 ,  C12N2750/14021 ,  C12N2750/14022 ,  C12N2750/14034 ,  G01N33/6893

摘要： The present invention provides novel nucleotides sequences, protein sequences, immunogenic compositions, vaccines, and methods that relate to making and using new porcine parvovirus 5A (PPV5A) that infects, inter alia, domestic swine. The compositions and methods provide for the detection of infections by said new virus, monitoring genetic changes in the viral sequences in wild and domestic animals and herds, and making and using novel vaccines for protecting animals from infection by the virus.

摘要翻译： 本发明提供新颖的核苷酸序列，蛋白质序列，免疫原性组合物，疫苗以及涉及制造和使用感染尤其是家猪的新型猪细小病毒5A（PPV5A）的方法。 组合物和方法提供了用于检测所述新病毒的感染，监测野生和家畜和猪群中的病毒序列的遗传变化，以及制备和使用新型疫苗以保护动物免受病毒感染。

公开(公告)号：US20140271698A1

公开(公告)日：2014-09-18

申请号：US14206283

申请日：2014-03-12

申请人： Dianna M. Murphy JORDAN ,  Brian Thomas MARTINSON ,  Michael B. ROOF ,  Eric Martin VAUGHN ,  Joseph Gilbert VICTORIA

发明人： Dianna M. Murphy JORDAN ,  Brian Thomas MARTINSON ,  Michael B. ROOF ,  Eric Martin VAUGHN ,  Joseph Gilbert VICTORIA

IPC分类号： A61K39/12 ,  C07K14/005 ,  C07K16/10

CPC分类号： A61K39/12 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/552 ,  C07K14/005 ,  C07K16/10 ,  C12N7/00 ,  C12N2770/10021 ,  C12N2770/10022 ,  C12N2770/10034 ,  C12N2770/10064

摘要： The present invention relates to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) mutant strains having increased stability; compositions containing the strains or antigens derived therefrom; vaccines containing the strains, including killed, attenuated or subunit vaccines; nucleic acids encoding PRRSV polypeptides, polypeptides encoded by the nucleic acids, including antigenic fragments thereof; antibodies which specifically bind to said polypeptides, and methods making and using thereof.

摘要翻译： 本发明涉及具有增加的稳定性的猪繁殖与呼吸综合征病毒（PRRSV）突变株; 含有源自其的菌株或抗原的组合物; 含有菌株的疫苗，包括杀死，减毒或亚单位疫苗; 编码PRRSV多肽的核酸，由核酸编码的多肽，包括其抗原性片段; 特异性结合所述多肽的抗体及其制备和使用方法。

公开(公告)号：US20110150770A1

公开(公告)日：2011-06-23

申请号：US12964073

申请日：2010-12-09

申请人： Elida BAUTISTA ,  Dianna M. Murphy JORDAN ,  Axel NEUBAUER ,  Abby Rae PATTERSON ,  Michael B. Roof ,  Eric M. VAUGHN ,  Joseph G. Victoria

发明人： Elida BAUTISTA ,  Dianna M. Murphy JORDAN ,  Axel NEUBAUER ,  Abby Rae PATTERSON ,  Michael B. Roof ,  Eric M. VAUGHN ,  Joseph G. Victoria

IPC分类号： A61K39/295 ,  A61K39/39 ,  A61K39/125 ,  A61K49/00 ,  A61P31/04 ,  A61P31/14 ,  B65D85/00

CPC分类号： A61K39/125 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/543 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/70 ,  C12N7/00 ,  C12N2750/10034 ,  C12N2770/10034 ,  C12N2770/32034

摘要： An immunogenic composition or vaccine, and method of treatment are provided by the present invention. The immunogenic composition is useful for treating, preventing, and lessening the severity of clinical symptoms associated with disease-causing organisms in swine, utilizing one or more Porcine Teschovirus antigen(s) along with an antigen of the other disease-causing organism in swine and a pharmaceutically acceptable carrier.

摘要翻译： 免疫原性组合物或疫苗以及治疗方法由本发明提供。 免疫原性组合物可用于治疗，预防和减轻与猪中的致病生物体相关的临床症状的严重性，利用一种或多种猪Teschovirus抗原以及猪中其他致病生物的抗原，以及 药学上可接受的载体。

公开(公告)号：US20140186393A1

公开(公告)日：2014-07-03

申请号：US14135791

申请日：2013-12-20

申请人： Dianna M. Murphy JORDAN ,  Brian Thomas MARTINSON ,  Christine Margaret MUEHLENTHALER ,  Axel NEUBAUER ,  Arun V. IYER

发明人： Dianna M. Murphy JORDAN ,  Brian Thomas MARTINSON ,  Christine Margaret MUEHLENTHALER ,  Axel NEUBAUER ,  Arun V. IYER

IPC分类号： A61K39/02 ,  A61K35/22

CPC分类号： A61K39/0241 ,  A61K35/22 ,  A61K2039/70

摘要： The present invention relates to an immunogenic composition comprising: a) one or more antigen of M. hyorhinis and one or more antigens of M. hyosynoviae; and b) a pharmaceutically acceptable carrier. Furthermore, the present invention relates to an immunogenic composition that comprises a) one or more mycoplasma antigens of mycoplasma bacteria selected from the group consisting of M. hyorhinis, M. hyopneumoniae and M. hyosynoviae; and b) one or more components of a eukaryotic cell system. Moreover, the present invention also provides an immunogenic composition obtained by a method comprising a) cultivation of a mycoplasma bacteria selected from the group consisting of M. hyorhinis, M. hyopneumoniae and M. hyosynoviae in a serum-reduced, eukaryotic cell system; b) obtaining an antigen of such mycoplasma bacteria; and c) addition of a pharmaceutically acceptable carrier.

摘要翻译： 本发明涉及一种免疫原性组合物，其包含：a）一种或多种羊水藓的抗原和一种或多种hy蛇科的抗原; 和b）药学上可接受的载体。 此外，本发明涉及免疫原性组合物，其包含a）一种或多种支原体细菌的支原体抗原，所述支原体抗原选自湿of属，猪肺炎支原体和hy蛇科; 和b）真核细胞系统的一种或多种组分。 此外，本发明还提供了一种通过以下方法获得的免疫原性组合物，所述方法包括：a）在血清还原的真核细胞系统中培养选自由猪肺炎支原体，猪肺炎支原体和猪hy属细菌组成的组的支原体细菌; b）获得这种支原体细菌的抗原; 和c）加入药学上可接受的载体。

公开(公告)号：US20140186394A1

公开(公告)日：2014-07-03

申请号：US14135796

申请日：2013-12-20

申请人： Dianna M. Murphy JORDAN ,  Brian Thomas MARTINSON ,  Christine Margaret MUEHLENTHALER ,  Axel NEUBAUER ,  Arun V. IYER

发明人： Dianna M. Murphy JORDAN ,  Brian Thomas MARTINSON ,  Christine Margaret MUEHLENTHALER ,  Axel NEUBAUER ,  Arun V. IYER

IPC分类号： C12N1/20 ,  A61K39/02

CPC分类号： A61K39/0241 ,  A61K2039/521 ,  A61K2039/552 ,  A61K2039/55566 ,  C12N1/20 ,  C12N1/36 ,  C12N5/0686 ,  C12N2502/70

摘要： The present invention relates to a method for the preparation of an immunogenic composition for the treatment and/or prophylaxis of mycoplasma infections in a subject comprising the cultivation of mycoplasma bacteria in a serum-reduced or swine serum-free, eukaryotic cell system; obtaining an antigen of the mycoplasma bacteria; and addition of a pharmaceutically acceptable carrier. Further, the present invention relates to the immunogenic composition obtainable by said method and a method for immunizing a subject comprising the administration of said immunogenic composition to a subject.

摘要翻译： 本发明涉及一种制备用于治疗和/或预防受试者支原体感染的免疫原性组合物的方法，包括在血清还原或猪血清的真核细胞系统中培养支原体细菌; 获得支原体细菌的抗原; 并加入药学上可接受的载体。 此外，本发明涉及可通过所述方法获得的免疫原性组合物和包括向受试者施用所述免疫原性组合物的受试者的免疫方法。