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1.发明授权
公开(公告)号：US4270920A
公开(公告)日：1981-06-02
申请号：US71618
申请日：1979-08-31
申请人： Asaji Kondo , Fuminori Arai , Masao Kitajima
发明人： Asaji Kondo , Fuminori Arai , Masao Kitajima
CPC分类号： G01N31/22 , G01N33/525
摘要： An integrated material for chemical analysis comprising three or more reagent layer units on a support and a porous spreading layer, said units containing reagents for different chemical analyses and being proximately arranged on a support such that approximately equal portions thereof are within a spreading circle defined by the diffusion of a liquid sample as it passes through the porous spreading layer, and a method for analyzing blood using the same.
摘要翻译： 一种用于化学分析的综合材料，其包括在支撑体上的三个或更多个试剂层单元和多孔扩散层，所述单元包含用于不同化学分析的试剂，并且近似地布置在支撑体上，使得其大致相等的部分在由 液体样品在通过多孔扩散层时的扩散，以及使用其分析血液的方法。
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公开(公告)号：US4256693A
公开(公告)日：1981-03-17
申请号：US46125
申请日：1979-06-06
申请人： Asaji Kondo , Masao Kitajima
发明人： Asaji Kondo , Masao Kitajima
CPC分类号： G01N33/525 , Y10S435/805
摘要： A multilayered integral chemical analysis element for the blood comprising a filter layer capable of removing formed components from the blood, a water-proof layer having at least one small opening therein, a porous spreading layer and a reagent layer laminated in this order.
摘要翻译： 一种用于血液的多层整体化学分析元件，包括能够从血液中除去形成的成分的过滤层，其中具有至少一个小开口的防水层，多孔扩散层和试剂层。
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公开(公告)号：US4255384A
公开(公告)日：1981-03-10
申请号：US66363
申请日：1979-08-14
申请人： Masao Kitajima , Fuminori Arai , Asaji Kondo
发明人： Masao Kitajima , Fuminori Arai , Asaji Kondo
CPC分类号： G01N33/525
摘要： An integral multilayered element for the chemical analysis of the blood comprising a combination of a porous spreading layer, a reagent layer, and a radiation-blocking layer, said radiation-blocking layer being water-permeable and containing at least one elemental metal or an alloy thereof.
摘要翻译： 一种用于血液化学分析的整体多层元件，包括多孔扩散层，试剂层和辐射阻挡层的组合，所述辐射阻挡层是透水性的并且包含至少一种元素金属或合金 其中。
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公开(公告)号：US4292272A
公开(公告)日：1981-09-29
申请号：US157737
申请日：1980-06-09
申请人： Masao Kitajima , Fuminori Arai , Asaji Kondo
发明人： Masao Kitajima , Fuminori Arai , Asaji Kondo
CPC分类号： G01N33/525
摘要： A multilayer analysis sheet for analyzing liquid samples is described, comprising, in sequence, a light transmitting hydrophobic support having on one side thereof at least one layer containing at least one reagent in a binder and a liquid sample spreading layer made of fabric, which layers are laminated to form an integral unit together with the support, wherein said fabric has the ability to supply a liquid sample placed on the surface thereof to the reagent-containing layer at a substantially constant volume per unit area, which ability is conferred upon the fabric by rendering it hydrophilic; the multilayer analysis sheet can be economically manufactured without variations in quality, and improves the spreading capability of liquid samples.
摘要翻译： 描述了用于分析液体样品的多层分析片，其中依次包括透光性疏水性支持体，其透光性疏水性支持体的一面上具有至少一层含有粘合剂中的至少一种试剂和由织物构成的液体样品扩散层， 层叠以与支撑体一起形成整体单元，其中所述织物具有以每单位面积基本上恒定的体积供应将其表面上的液体样品供应到含有试剂的层的能力，该能力被赋予织物 通过使其亲水; 可以经济地制造多层分析片而不产生质量变化，并提高液体样品的铺展能力。
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公开(公告)号：US3951851A
公开(公告)日：1976-04-20
申请号：US364478
申请日：1973-05-29
申请人： Masao Kitajima , Asaji Kondo , Fuminori Arai
发明人： Masao Kitajima , Asaji Kondo , Fuminori Arai
CPC分类号： A61K9/5047 , A61K31/60 , A61K9/5089 , Y10T428/2989
摘要： Process of producing aspirin-containing capsules which comprises (1) dispersing aspirin particles in a solution of a cellulose derivative in an organic solvent partially miscible with water; (2) adding the dispersion to an encapsulation medium comprising water containing organic solvent(s) partially miscible with water with or without aspirin; (3) stirring the mixture to form a fine dispersion of the aspirin; and (4) evaporating off the organic solvent to deposit the cellulose derivative around the aspirin particles.
摘要翻译： 制备含阿司匹林胶囊的方法，其包括（1）将阿司匹林颗粒分散在纤维素衍生物在与水部分混溶的有机溶剂中的溶液中; （2）将分散体加入到包含含有有机溶剂的水的包封介质中，所述有机溶剂与或不与阿斯匹林部分混溶; （3）搅拌混合物形成阿司匹林的精细分散体; 和（4）蒸发掉有机溶剂以将纤维素衍生物沉积在阿司匹林颗粒周围。
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公开(公告)号：US4981805A
公开(公告)日：1991-01-01
申请号：US682478
申请日：1984-12-17
申请人： Kenichiro Yazawa , Masao Kitajima , Asaji Kondo
发明人： Kenichiro Yazawa , Masao Kitajima , Asaji Kondo
CPC分类号： B01L3/508 , G01N21/8483 , G01N33/525 , G02B21/34 , B01L2200/142 , B01L2300/041 , B01L2300/048 , B01L2300/069 , B01L2300/0822 , B01L2400/0406
摘要： A method of using a chemical analysis slide comprising a slide frame and a sheet-like or film-like chemical analysis element for colorimetric determination of a specific component in an aqueous liquid sample, which comprisesapplying an aqueous liquid sample to the chemical analysis element, andcovering the upper face of the side of the slide frame to which the sample is applied with a sheet-like, plate-like or block or brick-like cover to thereby ensure a space between the chemical analysis element and the cover and to prevent evaporation of water or to control evaporation rate of water.
摘要翻译： 一种使用包括滑动框架和片状或膜状化学分析元件的化学分析载玻片的方法，用于比色测定水性液体样品中的特定组分，其包括将水性液体样品施加到化学分析元件， 并且将覆盖样品的滑动框架的侧面的上表面覆盖有片状，板状或块状或砖状的盖，从而确保化学分析元件与盖之间的空间，并防止 蒸发水或控制水的蒸发速率。
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公开(公告)号：US4870005A
公开(公告)日：1989-09-26
申请号：US787713
申请日：1985-10-16
申请人： Yutaka Akiyoshi , Asaji Kondo , Masao Kitajima
发明人： Yutaka Akiyoshi , Asaji Kondo , Masao Kitajima
IPC分类号： G01N33/543
CPC分类号： G01N33/54386 , Y10S435/805 , Y10S435/97 , Y10S436/81
摘要： A dry type multilayer analysis element comprises at least one porous medium layer comprising a membrane filter, to which an antigen (or antibody) is immobilized, and at least one reagent layer through which a substance(s) which did not participate in an antigen-antibody reaction can permeate.The multilayer analysis element is effective for assaying components present in body fluids, blood, urine, etc., in a simple manner.
摘要翻译： 干式多层分析元件包括至少一个多孔介质层，该多孔介质层包括固定有抗原（或抗体）的膜过滤器，以及至少一个试剂层，通过该试剂层不参与抗原 - 抗体反应可以渗透。 该多层分析元件以简单的方式有效地测定体液，血液，尿液等中存在的成分。
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8.发明授权
公开(公告)号：US4248829A
公开(公告)日：1981-02-03
申请号：US101385
申请日：1979-12-07
申请人： Masao Kitajima , Asaji Kondo , Fuminori Arai
发明人： Masao Kitajima , Asaji Kondo , Fuminori Arai
CPC分类号： G01N33/525 , G01N31/22 , Y10S435/805
摘要： An integrated material for chemically analyzing a liquid sample comprising a supporting plate having provided thereon two or more different analytical units each comprising a reagent layer and a porous spreading layer or a portion of a common porous spreading layer, the units being disposed such that at least a portion of the reagent layers are in contact with or in close proximity to one another with the porous spreading layer(s) of the units being commonly covered with a liquid sample delivering patch.
摘要翻译： 一种用于化学分析液体样品的综合材料，包括其上设置有两个或更多个不同分析单元的支撑板，每个分析单元包括试剂层和多孔扩散层或共同的多孔扩散层的一部分，该单元被设置为使得至少 试剂层的一部分彼此接触或彼此靠近，单元的多孔扩散层通常被液体样品递送贴片覆盖。
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公开(公告)号：US4612290A
公开(公告)日：1986-09-16
申请号：US542569
申请日：1983-10-19
申请人： Kenichiro Yazawa , Osamu Seshimoto , Masao Kitajima , Asaji Kondo
发明人： Kenichiro Yazawa , Osamu Seshimoto , Masao Kitajima , Asaji Kondo
CPC分类号： G01N33/728 , Y10T436/146666 , Y10T436/255
摘要： A method for quantitative determination of bilirubin is disclosed. The method comprises bringing a bilirubin-containing aqueous liquid sample into contact with a hydrophobic bilirubin extracting composition containing a hydrophobic amine capable of extracting bilirubin. The amine extracts the bilirubin in said aqueous liquid sample. Photometry is then used to determine the concentration of bilirubin extracted with the bilirubin extracting composition. A device for use in this method is also disclosed. The device has a layer containing a hydrophobic bilirubin extracting composition containing a hydrophobic amine capable of extracting bilirubin.
摘要翻译： 公开了一种定量测定胆红素的方法。 该方法包括使含胆红素的含水液体样品与含有能够提取胆红素的疏水性胺的疏水性胆红素提取组合物接触。 胺提取所述含水液体样品中的胆红素。 然后使用光度测定法测定用胆红素提取组合物提取的胆红素的浓度。 还公开了一种用于该方法的装置。 该装置具有包含含有能够提取胆红素的疏水性胺的疏水性胆红素提取组合物的层。
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公开(公告)号：US4356149A
公开(公告)日：1982-10-26
申请号：US165444
申请日：1980-07-02
申请人： Masao Kitajima , Fuminori Arai , Asaji Kondo
发明人： Masao Kitajima , Fuminori Arai , Asaji Kondo
CPC分类号： C12Q1/58 , G01N33/526 , Y10S435/805
摘要： A multi-layer chemical analytical material comprising a support, a reagent layer on the support and a spreading layer on the reagent layer wherein the reagent layer is composed of a hydrophilic binder and fine hydrophobic particles dispersed in the hydrophilic binder, said hydrophobic particles containing a reagent capable of directly or indirectly reacting with the component being analyzed to produce a color change.
摘要翻译： 一种多层化学分析材料，包括载体，载体上的试剂层和试剂层上的扩散层，其中试剂层由亲水性粘合剂和分散在亲水性粘合剂中的细疏水性颗粒构成，所述疏水性颗粒含有 能够直接或间接地与被分析的组分反应以产生颜色变化的试剂。
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