公开(公告)号：US20080300196A1

公开(公告)日：2008-12-04

申请号：US11866542

申请日：2007-10-03

申请人： Ashwani Kumar Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Rajkumar Shirumalla ,  Abhijit Ray

发明人： Ashwani Kumar Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Rajkumar Shirumalla ,  Abhijit Ray

IPC分类号： A61K31/7052 ,  C07H17/02 ,  A61K31/70 ,  A61P9/00 ,  A61P37/00 ,  A61P35/00 ,  A61P29/00 ,  C07H15/00

CPC分类号： C07H3/02 ,  C07H9/04 ,  C07H15/00

摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory, cancer, cardiovascular and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type-I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, pruritis or allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating diseases such as bronchial asthma, rheumatoid arthritis, type-I diabetes, multiple sclerosis, cancer, cardiovascular diseases, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, pruritis or allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文公开的化合物可用于抑制和预防炎症和相关病理，包括炎症，癌症，心血管和自身免疫性疾病如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病， 溃疡性结肠炎，痤疮，动脉粥样硬化，瘙痒或过敏性鼻炎。 包含本文公开的化合物的药理学组合物和治疗诸如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化症，癌症，心血管疾病，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，瘙痒症 或使用该化合物的过敏性鼻炎和其它炎症和/或自身免疫性疾病。

公开(公告)号：US07790689B2

公开(公告)日：2010-09-07

申请号：US11755164

申请日：2007-05-30

申请人： Ashwani Kumar Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Abhijit Ray ,  Rajkumar Shirumalla

发明人： Ashwani Kumar Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Abhijit Ray ,  Rajkumar Shirumalla

IPC分类号： A61K31/7008 ,  A61K31/7012 ,  A61K31/34 ,  C07H5/04 ,  C07H5/06 ,  C07D323/02 ,  C07D317/00

CPC分类号： C07H13/12 ,  C07H9/04

摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文公开的化合物可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮， 动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。 含有本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性 还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

公开(公告)号：US20070287673A1

公开(公告)日：2007-12-13

申请号：US11755164

申请日：2007-05-30

申请人： Ashwani Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Abhijit Ray ,  Rajkumar Shirumalla

发明人： Ashwani Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Abhijit Ray ,  Rajkumar Shirumalla

IPC分类号： A61K31/7008

CPC分类号： C07H13/12 ,  C07H9/04

摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文公开的化合物可用于抑制和预防炎症和相关病理学，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植物排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮， 动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。 含有本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性 还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

公开(公告)号：US07674811B2

公开(公告)日：2010-03-09

申请号：US11685892

申请日：2007-03-14

申请人： Ashwani Kumar Verma ,  Sanjay Malhotra ,  Abhijit Ray ,  Shirumalla Raj Kumar

发明人： Ashwani Kumar Verma ,  Sanjay Malhotra ,  Abhijit Ray ,  Shirumalla Raj Kumar

IPC分类号： C07D249/08 ,  A61K31/4196

CPC分类号： C07D405/12 ,  C07D405/14 ,  C07D413/14

摘要： The present invention relates to 5-lipoxygenase inhibitors. Compounds disclosed herein can be useful in the treatment of bronchial asthma, chronic obstructive pulmonary disorder, arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, urticaria, atopic dermatitis, allergic rhinitis, other inflammatory, and autoimmune diseases. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as 5-lipoxygenase inhibitors are also provided.

摘要翻译： 本发明涉及5-脂氧合酶抑制剂。 本文公开的化合物可用于治疗支气管哮喘，慢性阻塞性肺病，关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒症，荨麻疹，特应性 皮炎，过敏性鼻炎，其他炎症和自身免疫性疾病。 还提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物及其作为5-脂氧合酶抑制剂的用途。

公开(公告)号：US20080114031A1

公开(公告)日：2008-05-15

申请号：US11692362

申请日：2007-03-28

申请人： Viswajanani Sattigeri ,  Sudershan Arora ,  Mohammad Salman ,  Venkata Palle ,  Ashis Mukherji ,  Ashwani Verna ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Abhijit Ray ,  Raj Shirumalla

发明人： Viswajanani Sattigeri ,  Sudershan Arora ,  Mohammad Salman ,  Venkata Palle ,  Ashis Mukherji ,  Ashwani Verna ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Abhijit Ray ,  Raj Shirumalla

IPC分类号： A61K31/4525 ,  A61K31/34 ,  A61P17/00 ,  A61P29/00 ,  A61P3/10 ,  A61P35/00 ,  A61P37/00 ,  A61P9/00 ,  C07D307/20 ,  C07D405/02 ,  C07D405/14 ,  C07D413/02

CPC分类号： C07H9/04 ,  C07H3/02 ,  C07H15/00

摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, Ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, Ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文中的化合物障碍可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮， 动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。 包含本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植物排斥反应，炎症性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性 还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

公开(公告)号：US20090221600A1

公开(公告)日：2009-09-03

申请号：US12088538

申请日：2006-09-28

申请人： Ashwani Kumar Verma ,  Yogesh Bhaskarrao Waman ,  Venkata P. Palle ,  Atul Kondaskar ,  Abhijit Ray ,  Malini Bajpai ,  Geeta Sharma

发明人： Ashwani Kumar Verma ,  Yogesh Bhaskarrao Waman ,  Venkata P. Palle ,  Atul Kondaskar ,  Abhijit Ray ,  Malini Bajpai ,  Geeta Sharma

IPC分类号： A61K31/519 ,  C07D471/04 ,  A61P29/00

CPC分类号： C07D471/04

摘要： Provided are novel pyrido-pyrimidine derivatives, having the structure of Formula (I): which can be used as anti-inflammatory agents. Also provided are pharmaceutical compositions comprising one or more pyrido-pyrimidine derivatives, as well as methods of treating autoimmune diseases, inflammation or associated pathologies, including for example, sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis, comprising administering such compounds or pharmaceutical compositions comprising them.

摘要翻译： 提供具有式（I）结构的新型吡啶并嘧啶衍生物：其可用作抗炎剂。 还提供了包含一种或多种吡啶并嘧啶衍生物的药物组合物，以及治疗自身免疫性疾病，炎症或相关病理学的方法，包括例如败血症，类风湿性关节炎，炎性肠病，1型糖尿病，哮喘，慢性阻塞性 肺部疾病，器官移植排斥和牛皮癣，包括施用这样的化合物或包含它们的药物组合物。

公开(公告)号：US20100113371A9

公开(公告)日：2010-05-06

申请号：US11722573

申请日：2005-12-22

申请人： Viswajanani Jitendra Sattigeri ,  Sudershan K. Arora ,  Mohammad Salman ,  Venkata P. Palle ,  Muthukaman Nagarajan ,  Rajkumar Shirumalla ,  Gurpreet Kaur Aulakh ,  Abhijit Ray

发明人： Viswajanani Jitendra Sattigeri ,  Sudershan K. Arora ,  Mohammad Salman ,  Venkata P. Palle ,  Muthukaman Nagarajan ,  Rajkumar Shirumalla ,  Gurpreet Kaur Aulakh ,  Abhijit Ray

IPC分类号： A61K31/7008 ,  C07H15/04 ,  A61P29/00 ,  C07H15/12

CPC分类号： C07H3/02 ,  C07H15/02 ,  C07H15/18 ,  C07H15/26

摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds of this invention can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases, for example, bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection or psoriasis. The present invention also relates to pharmacological compositions containing these monosaccharide derivatives, as well as methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or auto immune disorders.

摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本发明的化合物可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植物排斥或银屑病。 本发明还涉及含有这些单糖衍生物的药物组合物，以及治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥和其它炎症和/或自身免疫的方法 疾病

公开(公告)号：US20100144801A1

公开(公告)日：2010-06-10

申请号：US12443838

申请日：2007-10-02

申请人： Naresh Kumar ,  Jaskiran Kaur ,  Abhijit Ray ,  Suman Gupta ,  Shivani Malhotra ,  Rajkumar Shirumalla

发明人： Naresh Kumar ,  Jaskiran Kaur ,  Abhijit Ray ,  Suman Gupta ,  Shivani Malhotra ,  Rajkumar Shirumalla

IPC分类号： A61K31/44 ,  C07D213/55 ,  C07D233/54 ,  A61K31/4164 ,  A61P11/00 ,  A61P13/00 ,  A61P1/00 ,  A61P3/00

CPC分类号： C07D233/64 ,  C07D211/70 ,  C07D213/30

摘要： The present invention generally relates to muscarinic receptor antagonists of formula I, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors. Formula (I) wherein Het: is heterocyclyl or heteroaryl X: O, S or NR1 and the other substituents are defined as in the claims.

摘要翻译： 本发明一般涉及式I的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。 式（I）其中Het：是杂环基或杂芳基X：O，S或NR1，其它取代基如权利要求中所定义。

公开(公告)号：US20100004215A1

公开(公告)日：2010-01-07

申请号：US12109752

申请日：2008-04-25

申请人： Abhijit Ray ,  Sunanda G. Dastidar ,  Rajkumar Shirumalla ,  Suman Gupta

发明人： Abhijit Ray ,  Sunanda G. Dastidar ,  Rajkumar Shirumalla ,  Suman Gupta

IPC分类号： A61K31/56 ,  A61K31/407 ,  A61K31/519 ,  A61K31/46

CPC分类号： A61K45/06 ,  A61K31/407 ,  A61K31/46 ,  A61K31/519 ,  A61K31/56 ,  A61K2300/00

摘要： Provided herein are pharmaceutical compositions comprising one or more phosphodiesterase inhibitors of type IV (“PDE-IV”), and at least one other active ingredient such as muscarinic receptor antagonists (MRA), β2-agonists, p38 MAP Kinase inhibitors, or corticosteroids and optionally one or more pharmaceutically acceptable excipients. In addition, methods of treating autoimmune, inflammatory or allergic diseases or disorders are provided.

摘要翻译： 本文提供包含一种或多种IV型磷酸二酯酶抑制剂（“PDE-IV”）和至少一种其它活性成分如毒蕈碱受体拮抗剂（MRA），β2-激动剂，p38 MAP激酶抑制剂或皮质类固醇的药物组合物，以及 任选地一种或多种药学上可接受的赋形剂。 此外，提供了治疗自身免疫性，炎性或过敏性疾病或病症的方法。

公开(公告)号：US20100120902A1

公开(公告)日：2010-05-13

申请号：US12532815

申请日：2008-03-24

申请人： Chandra Kant Katiyar ,  Anil Kanaujia ,  Rajeev Duggar ,  Satyapal Singh Yadav ,  Navin Sharma ,  Abhijit Ray ,  Rajkumar Shirumalla ,  Malini Bajpai ,  Gyanesh Shukla ,  Baddireddi Subhadra Lakshmi ,  Kontham Sanathkumar Vinaykumar

发明人： Chandra Kant Katiyar ,  Anil Kanaujia ,  Rajeev Duggar ,  Satyapal Singh Yadav ,  Navin Sharma ,  Abhijit Ray ,  Rajkumar Shirumalla ,  Malini Bajpai ,  Gyanesh Shukla ,  Baddireddi Subhadra Lakshmi ,  Kontham Sanathkumar Vinaykumar

IPC分类号： A61K31/352 ,  A61P29/00 ,  A61P19/02 ,  A61P19/00

CPC分类号： A61K36/185

摘要： The present invention relates to standardized extracts of Boerhaavia diffusa, wherein the extracts have anti inflammatory and analgesic activities. The present invention also includes bioassay guided fractionation of Boerhaavia diffusa leading to the identification of bioactive markers; processes for the isolation of the bioactive markers; processes for the preparation of the extracts enriched with bioactive markers from Boerhaavia diffusa; pharmaceutical compositions comprising bioactive markers, or standardized extracts of Boerhaavia diffusa and methods of standardization of the extracts.

摘要翻译： 本发明涉及双歧杆菌的标准化提取物，其中提取物具有抗炎和止痛活性。 本发明还包括生物测定引导分离的Boerhaavia diffusa，导致鉴定生物活性标记; 分离生物活性标记物的方法; 用于制备富含Boerhaavia diffusa的生物活性标记物的提取物的方法; 包含生物活性标记物或Boerhaavia diffusa的标准化提取物的药物组合物和提取物的标准化方法。