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公开(公告)号：US06670363B1
公开(公告)日：2003-12-30
申请号：US09575578
申请日：2000-05-22
IPC分类号： A61K31497
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared to known compounds such as fluconazole and itraconazole and the processes for the preparation thereof. This invention also relates to pharmaceutical compositions containing the compounds of the present invention and their use in treating and/or preventing fungal infections in mammals, preferably humans.
摘要翻译： 本发明涉及与已知的化合物如氟康唑和伊曲康唑相比具有改善的抗真菌活性的特殊取代的唑化合物的衍生物及其制备方法。 本发明还涉及含有本发明化合物的药物组合物及其用于治疗和/或预防哺乳动物，优选人类的真菌感染的用途。
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公开(公告)号：US06710049B2
公开(公告)日：2004-03-23
申请号：US10026235
申请日：2001-12-21
IPC分类号： A61K31496
CPC分类号： C07D249/12
摘要： The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared with presently available agents in this class and the processes for the preparation thereof. This invention also relates to pharmaceutical preparations containing the compounds of the present invention and their use in treating and/or preventing the fungal infections in mammals, preferably humans.
摘要翻译： 本发明涉及与本类目前可获得的试剂相比具有改善的抗真菌活性的特殊取代的唑化合物的衍生物及其制备方法。 本发明还涉及含有本发明化合物的药物制剂及其用于治疗和/或预防哺乳动物，优选人类的真菌感染的用途。
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公开(公告)号：US06956040B2
公开(公告)日：2005-10-18
申请号：US10051784
申请日：2002-01-17
申请人： Anita Mehta , Sudershan K. Arora , Bis{umlaut over (w)}ajit Das , Abhijit Ray , Sonali Rudra , Ashok Rattan
发明人： Anita Mehta , Sudershan K. Arora , Bis{umlaut over (w)}ajit Das , Abhijit Ray , Sonali Rudra , Ashok Rattan
IPC分类号： C07D413/12 , C07D413/14 , A61K31/496 , A61P31/04
CPC分类号： C07D413/12
摘要： The present invention relates to certain substituted phenyl piperazinyl oxazolidinones, for example, to those having the structure of Formula I with the variables as defined within, and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
摘要翻译： 本发明涉及某些取代的苯基哌嗪基恶唑烷酮，例如具有式I结构的具有变量的定义的那些，以及其合成方法。 本发明还涉及含有作为抗微生物剂的本发明化合物的药物组合物。 这些化合物是有用的抗微生物剂，对许多人类和兽医病原体有效，包括革兰氏阳性好氧细菌如多重耐药性葡萄球菌，链球菌和肠球菌以及厌氧生物如细菌属。 和梭菌属（Clostridia spp。） 物种和酸性快速生物如结核分枝杆菌，鸟分枝杆菌和分枝杆菌属。
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公开(公告)号：US20090247545A1
公开(公告)日：2009-10-01
申请号：US11577083
申请日：2004-12-28
申请人： Mukund Keshao Gurjar , Madhusudan Nagorao Deshmukh , Anita Mehta , Sudershan Kumar Arora , Ashok Rattan
发明人： Mukund Keshao Gurjar , Madhusudan Nagorao Deshmukh , Anita Mehta , Sudershan Kumar Arora , Ashok Rattan
IPC分类号： A61K31/496 , C07D413/10 , A61P31/04
CPC分类号： C07D263/20 , C07D413/10
摘要： The present invention provides substituted oxazolidinone derivatives, which can be used as antimicrobial agents. Compounds disclosed can be used for the treatment or prevention of a condition caused by or contributed to by bacteria, such as, inter alia, multiply-resistant Staphylococci, Streptococci, Enterococci, Bacterioides spp., Clostridium spp., Mycobacterium spp. Bacillus spp., Corynebacterium spp. Heptoslreptacoccus spp. Listeria spp., Legionella spp., Haemophilus influenza, Moraxella, Eschericia faecalis, and Eschericia coli. Processes for the preparation of disclosed compounds, pharmaceutical compositions thereof, and method of treating microbial infection are provided.
摘要翻译： 本发明提供了可用作抗微生物剂的取代的恶唑烷酮衍生物。 所公开的化合物可用于治疗或预防由细菌引起的或由细菌引起的病症，例如多重耐药葡萄球菌，链球菌，肠球菌，细菌属，梭菌属，分枝杆菌属。 芽孢杆菌属，棒状杆菌属 肝细胞线粒体 利斯特氏菌属（Listeria spp。），军团菌属（Legionella spp。），嗜血杆菌流感，流感嗜血杆菌，大肠埃希氏菌和大肠埃希氏菌。 提供了制备所公开化合物的方法，其药物组合物，以及治疗微生物感染的方法。
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公开(公告)号：US07592335B2
公开(公告)日：2009-09-22
申请号：US11911576
申请日：2006-04-12
申请人： Biswajit Das , Sonali Rudra , Sangita Sangita , Mohammad Salman , Ashok Rattan
发明人： Biswajit Das , Sonali Rudra , Sangita Sangita , Mohammad Salman , Ashok Rattan
IPC分类号： C07D498/04 , A61K31/5383
CPC分类号： Y02A50/478 , Y02P20/55
摘要： Provided herein are novel substituted phenyl oxazolidinones and to processes for the synthesis thereof. Also provided are pharmaceutical compositions comprising one or more compounds described herein The compounds described can be useful antimicrobial agents, which can be effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiple-resistant staphylococci, streptococci and enterococci, as well as, anaerobic organisms, such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms, such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
摘要翻译： 本文提供了新的取代的苯基恶唑烷酮，以及其合成方法。 还提供了包含本文所述的一种或多种化合物的药物组合物。所述化合物可以是有用的抗微生物剂，其可以对许多人和兽医病原体有效，包括革兰氏阳性好氧细菌如多重耐药性葡萄球菌，链球菌和肠球菌 ，以及厌氧生物，如细菌属。 和梭菌属（Clostridia spp。） 物种和酸性快速生物，如结核分枝杆菌，鸟分枝杆菌和分枝杆菌。
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公开(公告)号：US20080214565A1
公开(公告)日：2008-09-04
申请号：US10552322
申请日：2003-04-07
申请人： Anita Mehta , Sonali Rudra , Ajjarapu Venkata Subrahmanya Rajo Rao , Ajay Singh Yadav , Ashok Rattan
发明人： Anita Mehta , Sonali Rudra , Ajjarapu Venkata Subrahmanya Rajo Rao , Ajay Singh Yadav , Ashok Rattan
IPC分类号： A61K31/496 , C07D413/10 , A61P31/04
CPC分类号： C07D413/12 , C07D413/14
摘要： The present invention relates to certain substituted phenyl oxazolidinones of formula I and H and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
摘要翻译： 本发明涉及式I和H的某些取代的苯基恶唑烷酮及其合成方法。 本发明还涉及含有作为抗微生物剂的本发明化合物的药物组合物。 这些化合物是有用的抗微生物剂，对许多人类和兽医病原体有效，包括革兰氏阳性好氧细菌如多重耐药性葡萄球菌，链球菌和肠球菌以及厌氧生物作为细菌属。 和梭菌属（Clostridia spp。） 物种和酸性快速生物如结核分枝杆菌，鸟分枝杆菌和分枝杆菌属。
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公开(公告)号：US20070270484A1
公开(公告)日：2007-11-22
申请号：US10573275
申请日：2003-09-25
申请人： Biswajit Das , Mohammad Salman , Sachin Shelke , Atul Hajare , Sanjay Talukdar , Sujata Rathy , Arani Pal , Ashok Rattan
发明人： Biswajit Das , Mohammad Salman , Sachin Shelke , Atul Hajare , Sanjay Talukdar , Sujata Rathy , Arani Pal , Ashok Rattan
IPC分类号： A61K31/7048 , A61P31/04 , C07H17/08
CPC分类号： A61K31/7048 , Y02A50/473
摘要： This invention generally relates to macrolides, more particularly, the invention relates to 3-N-substituted-3-O-substituted erythronolide A derivatives, which are antibacterial agents effective against gram positive or gram negative bacteria and atypical pathogens. The compounds of this invention are more particularly effective against Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Haemophilus influenzae. The invention also relates to a process for the preparation of the compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods for treating bacterial infection.
摘要翻译： 本发明一般涉及大环内酯类，更具体地说，本发明涉及3-N-取代-3-O-取代的红景天苷A衍生物，它们是对革兰氏阳性或革兰氏阴性细菌和非典型病原体有效的抗菌剂。 本发明的化合物对金黄色葡萄球菌，肺炎链球菌，粪肠球菌，大肠杆菌，铜绿假单胞菌，流感嗜血杆菌更为特别有效。 本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物和治疗细菌感染的方法。
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公开(公告)号：US06734307B2
公开(公告)日：2004-05-11
申请号：US09906215
申请日：2001-07-16
申请人： Anita Mehta , Arora K. Sudershan , Biswajit Das , Abhijit Ray , Sonali Rudra , Ashok Rattan
发明人： Anita Mehta , Arora K. Sudershan , Biswajit Das , Abhijit Ray , Sonali Rudra , Ashok Rattan
IPC分类号： C07D41314
CPC分类号： C07D413/10 , C07D413/12 , C07D413/14
摘要： The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
摘要翻译： 本发明涉及某些取代的苯基恶唑烷酮及其合成方法。 本发明还涉及含有作为抗微生物剂的本发明化合物的药物组合物。 这些化合物是有用的抗微生物剂，对许多人类和兽医病原体有效，包括革兰氏阳性好氧细菌如多重耐药性葡萄球菌，链球菌和肠球菌以及厌氧生物如细菌属。 和梭菌属（Clostridia spp。） 物种和酸性快速生物如结核分枝杆菌，鸟分枝杆菌和分枝杆菌属。
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公开(公告)号：US20080207536A1
公开(公告)日：2008-08-28
申请号：US11572754
申请日：2005-07-13
申请人： Biswajit Das , Rita Katoch , Atul Kashinath Hajare , Gobind Singh Kapkoti , Anish Bandyopadhyay , Ramadass Venkataramanan , Rajesh Kumar , Santosh Haribhau Kurhade , Sujata Rathy , Anjan Chakrabarti , Yogesh Baban Surase , Mohammad Salman , Ashok Rattan
发明人： Biswajit Das , Rita Katoch , Atul Kashinath Hajare , Gobind Singh Kapkoti , Anish Bandyopadhyay , Ramadass Venkataramanan , Rajesh Kumar , Santosh Haribhau Kurhade , Sujata Rathy , Anjan Chakrabarti , Yogesh Baban Surase , Mohammad Salman , Ashok Rattan
IPC分类号： A61K31/7048 , C07H17/08 , A61P31/04
CPC分类号： C07H17/08
摘要： The present invention provides acylide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for the treatment or prevention of a condition caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against bacterium such as Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Myobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Baccillus or Enterobactericeae. Processes for the preparation of disclosed compounds, pharmaceutical compositions thereof, and method of treating bacterial infections, are also provided.
摘要翻译： 本发明提供可用作抗菌剂的酰化物衍生物。 本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起的或由其贡献的病症，特别是针对细菌如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫萨拉氏菌，衣原体 肉豆蔻，军团菌属，Myobacterium，Helicobacter，Clostridium，拟杆菌属，棒状杆菌属，Baccillus或肠杆菌属。 还提供了制备所公开的化合物的方法，其药物组合物和治疗细菌感染的方法。
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公开(公告)号：US20080188470A1
公开(公告)日：2008-08-07
申请号：US11911576
申请日：2006-04-12
申请人： Biswajit Das , Sonali Rudra , Sangita Sangita , Mohammad Salman , Ashok Rattan
发明人： Biswajit Das , Sonali Rudra , Sangita Sangita , Mohammad Salman , Ashok Rattan
IPC分类号： A61K31/5383 , C07D498/04 , A61P31/04
CPC分类号： Y02A50/478 , Y02P20/55
摘要： Provided herein are novel substituted phenyl oxazolidinones and to processes for the synthesis thereof. Also provided are pharmaceutical compositions comprising one or more compounds described herein The compounds described can be useful antimicrobial agents, which can be effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiple-resistant staphylococci, streptococci and enterococci, as well as, anaerobic organisms, such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms, such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
摘要翻译： 本文提供了新的取代的苯基恶唑烷酮，以及其合成方法。 还提供了包含本文所述的一种或多种化合物的药物组合物。所述化合物可以是有用的抗微生物剂，其可以对许多人和兽医病原体有效，包括革兰氏阳性好氧细菌如多重耐药性葡萄球菌，链球菌和肠球菌 ，以及厌氧生物，如细菌属。 和梭菌属（Clostridia spp。） 物种和酸性快速生物，如结核分枝杆菌，鸟分枝杆菌和分枝杆菌。
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