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    SUBSTITUTED OXAZOLIDINONE DERIVATIVES
    1.
    发明申请
    SUBSTITUTED OXAZOLIDINONE DERIVATIVES 审中-公开
    取代的氧杂环丁酮衍生物

    公开(公告)号：US20090247545A1

    公开(公告)日：2009-10-01

    申请号：US11577083

    申请日：2004-12-28

    申请人： Mukund Keshao Gurjar ,  Madhusudan Nagorao Deshmukh ,  Anita Mehta ,  Sudershan Kumar Arora ,  Ashok Rattan

    发明人： Mukund Keshao Gurjar ,  Madhusudan Nagorao Deshmukh ,  Anita Mehta ,  Sudershan Kumar Arora ,  Ashok Rattan

    IPC分类号： A61K31/496 ,  C07D413/10 ,  A61P31/04

    CPC分类号： C07D263/20 ,  C07D413/10

    摘要： The present invention provides substituted oxazolidinone derivatives, which can be used as antimicrobial agents. Compounds disclosed can be used for the treatment or prevention of a condition caused by or contributed to by bacteria, such as, inter alia, multiply-resistant Staphylococci, Streptococci, Enterococci, Bacterioides spp., Clostridium spp., Mycobacterium spp. Bacillus spp., Corynebacterium spp. Heptoslreptacoccus spp. Listeria spp., Legionella spp., Haemophilus influenza, Moraxella, Eschericia faecalis, and Eschericia coli. Processes for the preparation of disclosed compounds, pharmaceutical compositions thereof, and method of treating microbial infection are provided.

    摘要翻译： 本发明提供了可用作抗微生物剂的取代的恶唑烷酮衍生物。 所公开的化合物可用于治疗或预防由细菌引起的或由细菌引起的病症，例如多重耐药葡萄球菌，链球菌，肠球菌，细菌属，梭菌属，分枝杆菌属。 芽孢杆菌属，棒状杆菌属 肝细胞线粒体 利斯特氏菌属（Listeria spp。），军团菌属（Legionella spp。），嗜血杆菌流感，流感嗜血杆菌，大肠埃希氏菌和大肠埃希氏菌。 提供了制备所公开化合物的方法，其药物组合物，以及治疗微生物感染的方法。

    Dipyrano-quinolinones useful as anti viral agents and a process for preparing the same
    7.
    发明授权
    Dipyrano-quinolinones useful as anti viral agents and a process for preparing the same 有权
    可用作抗病毒剂的二亚氨基 - 喹啉酮及其制备方法

    公开(公告)号：US06191279B1

    公开(公告)日：2001-02-20

    申请号：US09321851

    申请日：1999-05-28

    申请人： Mukund Keshao Gurjar ,  Gangavaram Vasantha Madhava Sharma ,  Aindivelu Ilangovan ,  Ven Narayanan

    发明人： Mukund Keshao Gurjar ,  Gangavaram Vasantha Madhava Sharma ,  Aindivelu Ilangovan ,  Ven Narayanan

    IPC分类号： C07D49112

    CPC分类号： C07D491/14 ,  A61K31/436 ,  Y10S436/815

    摘要： The invention relates to novel dipyrano-quinolinone class of compounds having the general formula: Wherein R is hydrogen, alkyl optionally substituted about C-1 to C-10 alkenyl optionally substituted about C-1 to C-10 with one or more double bounds, alkynyl optionally substituted about C-1 to C-10 with one or more triple bonds, aryl, hetero aryl, carbocyclic aryl, alkyl aryl, alcyclic compounds, C-1 to C-6 alkyl with terminal dialkyl amino group, thio alkyl, hydroxyl alkyl groups; R1 is H, lower dialkyl amino alkyls such as methyl, ethyl, propyl, and other alkyl groups or b-amino acid moieties, hydroxy alkyl groups having optionally substituted about C-1 to C-10 carbons, acid amides such as aliphatic acids, aromatic acids, sulphonic acids trihalo acids. x—x is either a carbon-carbon single bond or a carbon-carbon double bond; R2 and R3, R4 and R5 are each independently hydrogen and methyl there by resulting the cis and trans diastereomers as well as enantiomers; R4 and R5 are each independently hydrogen and methyl while R6 and R7 are each independently hydrogen and hydroxyl/—OR8, where R8 is independently alkyl, aryl alkyl, amino alkyl, hydroxy alkyl with C-1 to C-10 carbons, sugars which include mono saccharides both in the furanose form as well as pyranose form, amino sugars, disaccharides, amino acids, small peptides through lower alkyl spacer groups, thereby resulting the cis and trans diastereomers as well as enantiomers; and a process for producing the above novel dipyrano-quinolinone class of compounds.

    摘要翻译： 本发明涉及具有以下通式的新颖的二吡喹烷 - 喹啉酮类化合物：其中R是氢，任选取代有C1-至C-10烯基的烷基，该C 1至C 10链烯基具有一个或多个双重界限的C-1至C-10， 芳基，杂芳基，碳环芳基，烷基芳基，异环化合物，具有末端二烷基氨基的C 1至C 6烷基，硫代烷基，羟基，C 1 -C 6烷基， 烷基; R 1为H，低级二烷基氨基烷基如甲基，乙基，丙基和其它烷基或b-氨基酸部分，具有任选取代为C-1至C-10碳原子的羟基烷基，酰胺如 脂肪酸，芳香酸，磺酸三卤酸.xx是碳 - 碳单键或碳 - 碳双键; R2和R3，R4和R5各自独立地为氢和甲基，得到顺式和反式非对映异构体 以及对映体; R4和R5各自独立 氢和甲基，而R6和R7各自独立地为氢和羟基-OR8，其中R8独立地是烷基，芳基烷基，氨基烷基，具有C-1至C-10碳的羟基烷基，包括单糖的糖， 呋喃糖形式以及吡喃糖形式，氨基糖，二糖，氨基酸，通过低级烷基间隔基团的小肽，从而得到顺式和反式非对映体以及对映异构体; 以及制备上述新型双吡喃 - 喹啉酮类化合物的方法。