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公开(公告)号：US20090062324A1
公开(公告)日：2009-03-05
申请号：US12193979
申请日：2008-08-19
IPC分类号： A61K31/4355 , C07D221/06 , A61K31/435 , C07D209/56 , A61P25/00 , A61K31/403 , C07D491/02
CPC分类号： C07D491/04 , C07D209/60 , C07D221/06
摘要： The present invention relates to novel catecholamine derivatives of Formula I, to processes for their preparation, pharmaceutical compositions containing them and to their use in therapy.
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公开(公告)号：US08067410B2
公开(公告)日：2011-11-29
申请号：US12490610
申请日：2009-06-24
IPC分类号： C07D265/38 , C07D498/02 , C07D413/06 , A61K31/536 , A61K31/5365
CPC分类号： C07D265/34 , C07D413/06 , C07D498/04
摘要： The present invention relates to novel phenolic and catecholic amines of Formula I, to processes for their preparation, pharmaceutical compositions containing them, to their use in therapy and to their use in radiolabeled form as PET- or SPECT ligands.
摘要翻译： 本发明涉及式I的新型酚类和儿茶胺，其制备方法，含有它们的药物组合物，其在治疗中的用途及其作为PET或SPECT配体的放射标记形式的用途。
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3.发明授权4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors 有权4-（2-苯硫基 - 苯基） - 哌啶衍生物作为血清素再摄取抑制剂公开(公告)号：US07732463B2
公开(公告)日：2010-06-08
申请号：US10551883
申请日：2004-04-02
IPC分类号： A61K31/445 , C07D211/20
CPC分类号： C07D405/12 , C07D211/20 , C07D211/24
摘要： The invention provides compounds represented by the general formula (I) wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译： 本发明提供由通式（I）表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。
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公开(公告)号：US20090124651A1
公开(公告)日：2009-05-14
申请号：US12194022
申请日：2008-08-19
申请人： Morten Jorgensen , Benny Bang- Andersen , Ask Puschl , Niels Mork , Jennifer Larsen , Hakan Vilhelm Wikstrom
发明人： Morten Jorgensen , Benny Bang- Andersen , Ask Puschl , Niels Mork , Jennifer Larsen , Hakan Vilhelm Wikstrom
IPC分类号： A61K31/473 , C07D209/56 , A61K31/403 , A61P25/00 , C07D221/06
CPC分类号： C07D491/04 , C07D209/60 , C07D221/06
摘要： The present invention relates to novel catecholamine derivatives of Formula I, to processes for their preparation, pharmaceutical compositions containing them and to their use in therapy.
摘要翻译： 本发明涉及式I的新型儿茶酚胺衍生物，其制备方法，含有它们的药物组合物及其在治疗中的用途。
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5.发明申请4-(2-Phenylsulfanyl-phenyl)-piperidine derivates as serotonin reuptake inhibitors 有权4-（2-苯硫基 - 苯基） - 哌啶衍生物作为血清素再摄取抑制剂公开(公告)号：US20060100242A1
公开(公告)日：2006-05-11
申请号：US10551883
申请日：2004-04-02
IPC分类号： A61K31/445 , C07D211/20
CPC分类号： C07D405/12 , C07D211/20 , C07D211/24
摘要： The invention provides compounds represented by the general formula (I) wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译： 本发明提供由通式（I）表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。
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公开(公告)号：US08129530B2
公开(公告)日：2012-03-06
申请号：US12193979
申请日：2008-08-19
IPC分类号： A61K31/4353 , C07D487/00
CPC分类号： C07D491/04 , C07D209/60 , C07D221/06
摘要： The present invention relates to novel catecholamine derivatives of Formula I, to processes for their preparation, pharmaceutical compositions containing them and to their use in therapy.
摘要翻译： 本发明涉及式I的新型儿茶酚胺衍生物，其制备方法，含有它们的药物组合物及其在治疗中的用途。
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7.发明申请4-(2-Phenylsulfanyl-phenyl)-1,2,3,6- tetrahydropyridine derivatives as serotonin reuptake inhibitors 审中-公开4-（2-苯硫基 - 苯基）-1,2,3,6-四氢吡啶衍生物作为血清素再摄取抑制剂公开(公告)号：US20070173522A1
公开(公告)日：2007-07-26
申请号：US10551869
申请日：2004-04-02
申请人： Ask Puschl , Benny Bang-Andersen , Morten Jorgensen , Karsten Juhl , Thomas Ruhland , Kim Andersen , Jan Kehler
发明人： Ask Puschl , Benny Bang-Andersen , Morten Jorgensen , Karsten Juhl , Thomas Ruhland , Kim Andersen , Jan Kehler
IPC分类号： A61K31/44 , C07D211/70
CPC分类号： C07D211/70 , C07D405/12
摘要： The invention provides compounds represented by the general formula (I) wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译： 本发明提供由通式（I）表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。
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公开(公告)号：US07148238B2
公开(公告)日：2006-12-12
申请号：US11296836
申请日：2005-12-06
申请人： Thomas Ruhland , Benny Bang-Andersen , Ask Puschl
发明人： Thomas Ruhland , Benny Bang-Andersen , Ask Puschl
IPC分类号： A61K31/451 , C07D211/22
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
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公开(公告)号：US08110567B2
公开(公告)日：2012-02-07
申请号：US12700521
申请日：2010-02-04
申请人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ejner Knud Moltzen , Kim Andersen , Ask Puschl
发明人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ejner Knud Moltzen , Kim Andersen , Ask Puschl
IPC分类号： A61P25/22 , A61K31/55 , C07D403/00 , C07D243/00
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译： 本发明提供由通式I表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。
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公开(公告)号：US20070060574A1
公开(公告)日：2007-03-15
申请号：US11551188
申请日：2006-10-19
申请人： Thomas Ruhland , Garrick Smith , Benny Bang-Andersen , Ask Puschl , Ejner Moltzen , Kim Andersen
发明人： Thomas Ruhland , Garrick Smith , Benny Bang-Andersen , Ask Puschl , Ejner Moltzen , Kim Andersen
IPC分类号： A61K31/551 , A61K31/496 , C07D241/04 , C07D243/08
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译： 本发明提供由通式I表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。
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