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公开(公告)号：US08129530B2
公开(公告)日：2012-03-06
申请号：US12193979
申请日：2008-08-19
IPC分类号： A61K31/4353 , C07D487/00
CPC分类号： C07D491/04 , C07D209/60 , C07D221/06
摘要： The present invention relates to novel catecholamine derivatives of Formula I, to processes for their preparation, pharmaceutical compositions containing them and to their use in therapy.
摘要翻译： 本发明涉及式I的新型儿茶酚胺衍生物，其制备方法，含有它们的药物组合物及其在治疗中的用途。
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![METHODS OF ADMINISTERING (4AR,10AR)-1-N-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO [G] QUINOLINE-6,7-DIOL AND RELATED COMPOUNDS ACROSS THE ORAL MUCOSA, THE NASAL MUCOSA OR THE SKIN AND PHARMACEUTICAL COMPOSITIONS THEREOF](/abs-image/US/2012/03/29/US20120077836A1/abs.jpg.150x150.jpg)
2.发明申请METHODS OF ADMINISTERING (4AR,10AR)-1-N-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO [G] QUINOLINE-6,7-DIOL AND RELATED COMPOUNDS ACROSS THE ORAL MUCOSA, THE NASAL MUCOSA OR THE SKIN AND PHARMACEUTICAL COMPOSITIONS THEREOF 审中-公开（4AR，10AR）-1-N-PROPLL-1,2,3,4,4A，5,10,10A-OCTAHYDROBENZO [G]喹啉-7,7-二醇及其相关化合物的方法通过口服粘蛋白， NASAL MUCOSA或其皮肤和药物组合物公开(公告)号：US20120077836A1
公开(公告)日：2012-03-29
申请号：US13202590
申请日：2010-02-26
申请人： Håkan Wikström , Morten Jorgensen , Niels Mork , Jennifer Larsen , Benny Bang-Andersen , Thomas Nikolaj Sager , Ask Püschl , Lars Torup
发明人： Håkan Wikström , Morten Jorgensen , Niels Mork , Jennifer Larsen , Benny Bang-Andersen , Thomas Nikolaj Sager , Ask Püschl , Lars Torup
IPC分类号： A61K31/473 , A61P25/16
CPC分类号： A61K31/473 , A61K9/0019 , A61K9/0056 , A61K9/006
摘要： Disclosed are pharmaceutical compositions and methods for the administration of (4aR,10aR)-1-n-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol or a pharmaceutically acceptable salt thereof and related compounds for the treatment of neurological disorder such as Parkinson's disease and restless leg syndrome.
摘要翻译： 公开了用于（4aR，10aR）-1-正丙基-1,2,3,4,4a，5,10,10a-八氢 - 苯并[g]喹啉-6,7-二酮的药物组合物和方法， 二醇或其药学上可接受的盐和用于治疗神经障碍的相关化合物，例如帕金森病和不宁腿综合征。
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公开(公告)号：US20120196889A1
公开(公告)日：2012-08-02
申请号：US13202579
申请日：2010-02-24
申请人： Benny Bang-Andersen , Mogens Larsen , Klaus Gundertofte , Morten Jorgensen , Jennifer Larsen , Niels Mork , HåKan Wikström
发明人： Benny Bang-Andersen , Mogens Larsen , Klaus Gundertofte , Morten Jorgensen , Jennifer Larsen , Niels Mork , HåKan Wikström
IPC分类号： A61K31/4741 , A61K31/407 , C07D209/80 , C07D491/056 , C07D221/06 , A61K31/473 , A61K31/404
CPC分类号： C07D221/10 , C07D491/08
摘要： The present invention relates to novel catecholamine derivatives of Formula I, to processes for their preparation, pharmaceutical compositions containing them and to their use in therapy.
摘要翻译： 本发明涉及式I的新型儿茶酚胺衍生物，其制备方法，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：US08067410B2
公开(公告)日：2011-11-29
申请号：US12490610
申请日：2009-06-24
IPC分类号： C07D265/38 , C07D498/02 , C07D413/06 , A61K31/536 , A61K31/5365
CPC分类号： C07D265/34 , C07D413/06 , C07D498/04
摘要： The present invention relates to novel phenolic and catecholic amines of Formula I, to processes for their preparation, pharmaceutical compositions containing them, to their use in therapy and to their use in radiolabeled form as PET- or SPECT ligands.
摘要翻译： 本发明涉及式I的新型酚类和儿茶胺，其制备方法，含有它们的药物组合物，其在治疗中的用途及其作为PET或SPECT配体的放射标记形式的用途。
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5.发明授权4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors 有权4-（2-苯硫基 - 苯基） - 哌啶衍生物作为血清素再摄取抑制剂公开(公告)号：US07732463B2
公开(公告)日：2010-06-08
申请号：US10551883
申请日：2004-04-02
IPC分类号： A61K31/445 , C07D211/20
CPC分类号： C07D405/12 , C07D211/20 , C07D211/24
摘要： The invention provides compounds represented by the general formula (I) wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译： 本发明提供由通式（I）表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。
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6.发明申请4-(2-Phenylsulfanyl-phenyl)-piperidine derivates as serotonin reuptake inhibitors 有权4-（2-苯硫基 - 苯基） - 哌啶衍生物作为血清素再摄取抑制剂公开(公告)号：US20060100242A1
公开(公告)日：2006-05-11
申请号：US10551883
申请日：2004-04-02
IPC分类号： A61K31/445 , C07D211/20
CPC分类号： C07D405/12 , C07D211/20 , C07D211/24
摘要： The invention provides compounds represented by the general formula (I) wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译： 本发明提供由通式（I）表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。
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7.发明申请4-(2-Phenylsulfanyl-phenyl)-1,2,3,6- tetrahydropyridine derivatives as serotonin reuptake inhibitors 审中-公开4-（2-苯硫基 - 苯基）-1,2,3,6-四氢吡啶衍生物作为血清素再摄取抑制剂公开(公告)号：US20070173522A1
公开(公告)日：2007-07-26
申请号：US10551869
申请日：2004-04-02
申请人： Ask Puschl , Benny Bang-Andersen , Morten Jorgensen , Karsten Juhl , Thomas Ruhland , Kim Andersen , Jan Kehler
发明人： Ask Puschl , Benny Bang-Andersen , Morten Jorgensen , Karsten Juhl , Thomas Ruhland , Kim Andersen , Jan Kehler
IPC分类号： A61K31/44 , C07D211/70
CPC分类号： C07D211/70 , C07D405/12
摘要： The invention provides compounds represented by the general formula (I) wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译： 本发明提供由通式（I）表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。
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公开(公告)号：US20120108624A1
公开(公告)日：2012-05-03
申请号：US13202768
申请日：2010-02-26
申请人： Håkan Wikström , Morten Jørgensen , Niels Mork , Jennifer Larsen , Lars Torup , Benny Bang-Andersen
发明人： Håkan Wikström , Morten Jørgensen , Niels Mork , Jennifer Larsen , Lars Torup , Benny Bang-Andersen
IPC分类号： A61K31/473 , A61P25/16 , A61P25/14 , A61K31/4741
CPC分类号： A61K31/473 , A61K31/4741
摘要： Disclosed herein are methods of treating Parkinsons disease while maintaining a low dyskinesia induction profile and methods of reversing dyskinesias comprising administering a therapeutically effective amount of a compound of the invention. The present invention further relates to uses and pharmaceutical compositions of said compounds in the manufacture of medicaments in treating the same.
摘要翻译： 本文公开了治疗帕金森病的方法，同时维持低运动障碍诱导曲线和逆转运动障碍的方法，其包括施用治疗有效量的本发明化合物。 本发明还涉及所述化合物在制备药物中的用途和药物组合物。
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公开(公告)号：US07148238B2
公开(公告)日：2006-12-12
申请号：US11296836
申请日：2005-12-06
申请人： Thomas Ruhland , Benny Bang-Andersen , Ask Puschl
发明人： Thomas Ruhland , Benny Bang-Andersen , Ask Puschl
IPC分类号： A61K31/451 , C07D211/22
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
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公开(公告)号：US07144884B2
公开(公告)日：2006-12-05
申请号：US10488280
申请日：2002-10-02
申请人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
发明人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
IPC分类号： A61K31/495 , C07D295/096 , C07D241/04 , C07D211/54 , C07D211/70
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder
摘要翻译： 本发明提供由通式I表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症和恐慌症以及强迫症
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