公开(公告)号：US07550272B2

公开(公告)日：2009-06-23

申请号：US11463870

申请日：2006-08-10

申请人： Asuka Ito ,  Tadashi Kohno ,  Isaburo Hosoi ,  Junko Hirayama ,  Kunihiko Shibata ,  Kenji Maeda

发明人： Asuka Ito ,  Tadashi Kohno ,  Isaburo Hosoi ,  Junko Hirayama ,  Kunihiko Shibata ,  Kenji Maeda

IPC分类号： C12Q1/44 ,  A61K47/42 ,  A61K51/02 ,  G01N33/483 ,  C07K14/76 ,  A61M36/04

CPC分类号： A61K49/0043 ,  A61K49/00 ,  A61K49/0004 ,  A61K49/006 ,  A61K49/1815

摘要： A preparation for the diagnosis of pancreatic exocrine function by determining the amount in which a substance administered to a subject or a degradation product or metabolite thereof migrates into the blood and/or is excreted out of the body, wherein the substance is carried by a carrier and released from the carrier when exposed to the action of a pancreatic exocrine function-related factor.

摘要翻译： 一种胰腺外分泌功能的诊断准备，其通过确定给予受试者或其降解产物或代谢物的物质迁移到血液中和/或从身体排出的量，其中所述物质由载体携带 并且当暴露于胰腺外分泌功能相关因子的作用时从载体释放。

公开(公告)号：US20070086945A1

公开(公告)日：2007-04-19

申请号：US11565514

申请日：2006-11-30

申请人： Asuka ITO ,  Tadashi Kohno ,  Isaburo Hosoi ,  Junko Hirayama ,  Kunihiko Shibata ,  Kenji Maeda

发明人： Asuka ITO ,  Tadashi Kohno ,  Isaburo Hosoi ,  Junko Hirayama ,  Kunihiko Shibata ,  Kenji Maeda

IPC分类号： A61K49/00 ,  A61K38/54

CPC分类号： A61K49/0043 ,  A61K49/00 ,  A61K49/0004 ,  A61K49/006 ,  A61K49/1815

摘要： A preparation for the diagnosis of pancreatic exocrine function by determining the amount in which a substance administered to a subject or a degradation product or metabolite thereof migrates into the blood and/or is excreted out of the body, wherein the substance is carried by a carrier and released from the carrier when exposed to the action of a pancreatic exocrine function-related factor.

摘要翻译： 一种胰腺外分泌功能的诊断准备，其通过确定给予受试者或其降解产物或代谢物的物质迁移到血液中和/或从体外排出的量，其中所述物质由载体携带 并且当暴露于胰腺外分泌功能相关因子的作用时从载体释放。

公开(公告)号：US07572598B2

公开(公告)日：2009-08-11

申请号：US11565514

申请日：2006-11-30

申请人： Asuka Ito ,  Tadashi Kohno ,  Isaburo Hosoi ,  Junko Hirayama ,  Kunihiko Shibata ,  Kenji Maeda

发明人： Asuka Ito ,  Tadashi Kohno ,  Isaburo Hosoi ,  Junko Hirayama ,  Kunihiko Shibata ,  Kenji Maeda

IPC分类号： C12Q1/44 ,  A61K47/42 ,  G01N33/483 ,  C07K14/76 ,  A61M36/04 ,  A61K51/02

CPC分类号： A61K49/0043 ,  A61K49/00 ,  A61K49/0004 ,  A61K49/006 ,  A61K49/1815

摘要： A preparation for the diagnosis of pancreatic exocrine function by determining the amount in which a substance administered to a subject or a degradation product or metabolite thereof migrates into the blood and/or is excreted out of the body, wherein the substance is carried by a carrier and released from the carrier when exposed to the action of a pancreatic exocrine function-related factor.

摘要翻译： 一种胰腺外分泌功能的诊断准备，其通过确定给予受试者或其降解产物或代谢物的物质迁移到血液中和/或从体外排出的量，其中所述物质由载体携带 并且当暴露于胰腺外分泌功能相关因子的作用时从载体释放。

公开(公告)号：US20070154394A1

公开(公告)日：2007-07-05

申请号：US11716273

申请日：2007-03-08

申请人： Tadashi Kohno ,  Isaburo Hosoi ,  Asuka Ito ,  Junko Hirayama ,  Kenji Maeda

发明人： Tadashi Kohno ,  Isaburo Hosoi ,  Asuka Ito ,  Junko Hirayama ,  Kenji Maeda

IPC分类号： A61K49/12 ,  C07K5/06

CPC分类号： G01N33/60 ,  A61K49/00

摘要： A diagnostic agent for pancreatic exocrine function comprising a dipeptide represented by the following formula (I): X1—R113 Y1  (I) or a pharmaceutically acceptable salt thereof, wherein X1 is a protecting group, R1 is a phenylalanine, glutamine, valine, tyrosine, methionine, serine or threonine residue, and Y1 is a 13C-labeled alanine molecule optionally having a protecting group.

摘要翻译： 胰腺外分泌功能的诊断剂，其包含由下式（I）表示的二肽：<？in-line-formula description =“In-line formula”end =“lead”？> X＆lt; 1＆lt; （I）<？in-line-formula description =“In-line Formulas”end =“tail”？>或其药学上可接受的盐 其中X 1是保护基，R 1是苯丙氨酸，谷氨酰胺，缬氨酸，酪氨酸，甲硫氨酸，丝氨酸或苏氨酸残基，并且Y 1是< 13 C-标记的丙氨酸分子，任选具有保护基。

公开(公告)号：US07404945B2

公开(公告)日：2008-07-29

申请号：US10503557

申请日：2003-02-20

申请人： Asuka Ito ,  Tadashi Kohno ,  Isaburo Hosoi ,  Junko Hirayama ,  Kenji Maeda

发明人： Asuka Ito ,  Tadashi Kohno ,  Isaburo Hosoi ,  Junko Hirayama ,  Kenji Maeda

IPC分类号： A61K51/00

CPC分类号： G01N33/5008 ,  A61K51/0406 ,  A61K51/0491 ,  A61K51/1206 ,  C12Q1/34 ,  C12Q1/37 ,  C12Q1/40 ,  C12Q1/527 ,  G01N2500/00

摘要： A diagnostic reagent for use in the evaluation of a pharmacological effect of a medicine containing a pharmaceutical agent including an enzyme, an enzyme inhibitor or a receptor ligand or a prodrug of the pharmaceutical agent is provided. Further, a method of screening pharmaceutical agents each comprising an enzyme, an enzyme inhibitor or a receptor ligand and/or prodrugs of the pharmaceutical agents is provided.

摘要翻译： 提供了用于评估含有酶，酶抑制剂或受体配体或药物前药的​​药剂的药物的药理作用的诊断试剂。 另外，提供了各自包含酶，酶抑制剂或受体配体和/或药剂前药的药物的筛选方法。

公开(公告)号：US20050147557A1

公开(公告)日：2005-07-07

申请号：US10482571

申请日：2002-02-22

申请人： Tadashi Kohno ,  Isaburo Hosoi ,  Asuka Ito ,  Junko Hirayama ,  Kenji Maeda

发明人： Tadashi Kohno ,  Isaburo Hosoi ,  Asuka Ito ,  Junko Hirayama ,  Kenji Maeda

IPC分类号： A61K49/00 ,  A61K51/08 ,  G01N33/60 ,  C07K5/04

CPC分类号： G01N33/60 ,  A61K49/00

摘要： A diagnostic agent for pancreatic exocrine function comprising a dipeptide represented by the following formula (I): X1—R1—Y‘  (I) or a pharmaceutically acceptable salt thereof, wherein X1 is a protecting group, R1 is a phenylalanine, glutamine, valine, tyrosine, methionine, serine or threonine residue, and Y1 is a 13C-labeled alanine molecule optionally having a protecting group.

摘要翻译： 胰腺外分泌功能的诊断剂，其包含由下式（I）表示的二肽：<？in-line-formula description =“In-line formula”end =“lead”？> X＆lt; 1＆lt; （I）<？in-line-formula description =“In-line Formulas”end =“tail”？>或其药学上可接受的盐 其中X 1是保护基，R 1是苯丙氨酸，谷氨酰胺，缬氨酸，酪氨酸，甲硫氨酸，丝氨酸或苏氨酸残基，并且Y 1是< 13 C-标记的丙氨酸分子，任选具有保护基。

公开(公告)号：US20050079564A1

公开(公告)日：2005-04-14

申请号：US10503557

申请日：2003-02-20

申请人： Asuka Ito ,  Tadashi Kohno ,  Isaburo Hosoi ,  Junko Hirayama ,  Kenji Maeda

发明人： Asuka Ito ,  Tadashi Kohno ,  Isaburo Hosoi ,  Junko Hirayama ,  Kenji Maeda

IPC分类号： A61K51/12 ,  C12Q1/34 ,  C12Q1/37 ,  C12Q1/40 ,  C12Q1/527 ,  G01N33/50 ,  G01N33/53 ,  G01N33/537 ,  G01N33/543

CPC分类号： G01N33/5008 ,  A61K51/0406 ,  A61K51/0491 ,  A61K51/1206 ,  C12Q1/34 ,  C12Q1/37 ,  C12Q1/40 ,  C12Q1/527 ,  G01N2500/00

摘要： A diagnostic reagent for use in the evaluation of a pharmacological effect of a medicine containing a pharmaceutical agent including an enzyme, an enzyme inhibitor or a receptor ligand or a prodrug of the pharmaceutical agent; and a method of screening pharmaceutical agents each comprising an enzyme, an enzyme inhibitor or a receptor ligand and/or prodrugs of the pharmaceutical agents for one or ones having high medicative efficacy and/or a small side effect are provided. The diagnostic reagent and the reagent used in the method comprise: (a) a compound which serves as a substrate for the enzyme contained in the medicine or the pharmaceutical agent to be evaluated or for an enzyme generated from the prodrug contained in the medicine or the pharmaceutical agent to be evaluated, or a pharmaceutically acceptable salt thereof; (b) a compound which serves as a substrate for a different enzyme capable of exhibiting an alteration in activity by coupling to the effect of the enzyme in (a), or a pharmaceutically acceptable salt thereof; (c) a compound which serves as a substrate for an enzyme which is directly inhibited by the enzyme inhibitor contained in the medicine or the pharmaceutical agent to be evaluated or by an enzyme inhibitor generated from the prodrug contained in the medicine or the pharmaceutical agent to be evaluated, or a pharmaceutically acceptable salt thereof; (d) a compound which serves as a substrate for an enzyme capable of exhibiting an alteration in activity by coupling to the effect of the enzyme inhibitor in (c), or a pharmaceutically acceptable salt thereof; (e) a compound which serves as a substrate for an enzyme capable of exhibiting an alteration in activity by the binding between a receptor and the receptor ligand contained in the medicine or the pharmaceutical agent to be evaluated or a receptor ligand generated from the prodrug contained in the medicine or the pharmaceutical agent to be evaluated, or a pharmaceutically acceptable salt thereof; or (f) a labeled form of any one of the substances (a) to (e).

公开(公告)号：US07662857B2

公开(公告)日：2010-02-16

申请号：US11716273

申请日：2007-03-08

申请人： Tadashi Kohno ,  Isaburo Hosoi ,  Asuka Ito ,  Junko Hirayama ,  Kenji Maeda

发明人： Tadashi Kohno ,  Isaburo Hosoi ,  Asuka Ito ,  Junko Hirayama ,  Kenji Maeda

IPC分类号： A61K31/195 ,  C07K5/06 ,  C07K5/065 ,  C07K5/062 ,  C07K5/072

CPC分类号： G01N33/60 ,  A61K49/00

摘要： A diagnostic agent for pancreatic exocrine function comprising a dipeptide represented by the following formula (I): X1—R1—Y1  (I) or a pharmaceutically acceptable salt thereof, wherein X1 is a protecting group, R1 is a phenylalanine, glutamine, valine, tyrosine, methionine, serine or threonine residue, and Y1 is a 13C-labeled alanine molecule optionally having a protecting group.

摘要翻译： 1.一种胰外分泌功能诊断剂，其特征在于，含有下述式（I）表示的二肽：X1-R1-Y1（Ⅰ）或其药学上可接受的盐，其中X1为保护基，R1为苯丙氨酸，谷氨酰胺，缬氨酸， 酪氨酸，甲硫氨酸，丝氨酸或苏氨酸残基，Y1是任选具有保护基的13 C-标记的丙氨酸分子。

公开(公告)号：US07208525B2

公开(公告)日：2007-04-24

申请号：US10482571

申请日：2002-02-22

申请人： Tadashi Kohno ,  Isaburo Hosoi ,  Asuka Ito ,  Junko Hirayama ,  Kenji Maeda

发明人： Tadashi Kohno ,  Isaburo Hosoi ,  Asuka Ito ,  Junko Hirayama ,  Kenji Maeda

IPC分类号： A61K31/195 ,  C07K5/06 ,  C07K5/065 ,  C07K5/062 ,  C07K5/072

CPC分类号： G01N33/60 ,  A61K49/00

摘要： A diagnostic agent for pancreatic exocrine function comprising a dipeptide represented by the following formula (I): X1—R1—Y1  (I) or a pharmaceutically acceptable salt thereof, wherein X1 is a protecting group, R1 is a phenylalanine, glutamine, valine, tyrosine, methionine, serine or threonine residue, and Y1 is a 13C-labeled alanine molecule optionally having a protecting group.

摘要翻译： 胰腺外分泌功能的诊断剂，其包含由下式（I）表示的二肽：<？in-line-formula description =“In-line formula”end =“lead”？> X＆lt; 1＆lt; （I）<βin-line-formula description =“In-line Formulas”end =“tail”？>或其药学上可接受的盐 其中X 1是保护基，R 1是苯丙氨酸，谷氨酰胺，缬氨酸，酪氨酸，甲硫氨酸，丝氨酸或苏氨酸残基，并且Y 1是< 13 C-标记的丙氨酸分子，任选具有保护基。

公开(公告)号：US07125683B2

公开(公告)日：2006-10-24

申请号：US10362639

申请日：2001-08-31

申请人： Ito Asuka ,  Tadashi Kohno ,  Isaburo Hosoi ,  Junko Hirayama ,  Kunihiko Shibata ,  Kenji Maeda

发明人： Ito Asuka ,  Tadashi Kohno ,  Isaburo Hosoi ,  Junko Hirayama ,  Kunihiko Shibata ,  Kenji Maeda

IPC分类号： C12Q1/34 ,  C12Q1/40 ,  C12Q1/37 ,  A61K51/02 ,  A61K38/46 ,  A61K38/47 ,  A61K38/48 ,  A61M36/04

CPC分类号： A61K49/0043 ,  A61K49/00 ,  A61K49/0004 ,  A61K49/006 ,  A61K49/1815

摘要： A preparation for the diagnosis of pancreatic exocrine function by determining the amount in which a substance administered to a subject or a degradation product or metabolite thereof migrates into the blood and/or is excreted out of the body, wherein the substance is carried by a carrier and released from the carrier when exposed to the action of a pancreatic exocrine function-related factor.