公开(公告)号：US20100029631A1

公开(公告)日：2010-02-04

申请号：US12551860

申请日：2009-09-01

申请人： Atsushi Naganawa ,  Maki Iwahashi ,  Atsushi Kinoshita ,  Atsushi Shimabukuro ,  Seiji Ogawa ,  Koji Yano ,  Kaoru Kobayashi ,  Yutaka Okada ,  Yoko Kishida ,  Shouji Kawauchi ,  Kohki Tsukamoto ,  Yoko Matsunaga ,  Fumio Nambu

发明人： Atsushi Naganawa ,  Maki Iwahashi ,  Atsushi Kinoshita ,  Atsushi Shimabukuro ,  Seiji Ogawa ,  Koji Yano ,  Kaoru Kobayashi ,  Yutaka Okada ,  Yoko Kishida ,  Shouji Kawauchi ,  Kohki Tsukamoto ,  Yoko Matsunaga ,  Fumio Nambu

IPC分类号： A61K31/538 ,  C07D265/36 ,  A61P37/08 ,  A61P11/06

CPC分类号： C07D307/80 ,  A61K31/343 ,  A61K31/538 ,  C07D265/36 ,  C07D317/48

摘要： A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.

摘要翻译： 由式（I）表示的化合物，其中式中的符号与说明书中的符号相同，其盐，溶剂合物或其前药与DP受体结合并显示DP受体的拮抗活性。 因此，它可用于预防和/或治疗过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有全身性肥大细胞活化的病症，过敏性休克， 支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），伴随瘙痒的行为的结果产生的疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍）（例如， 搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿关节炎，胸膜炎，溃疡性结肠炎等。由于其特异性结合DP受体并且弱结合到其他前列腺素受体，它们可以是具有 小副作用。

公开(公告)号：US07601712B2

公开(公告)日：2009-10-13

申请号：US10572578

申请日：2004-09-16

申请人： Atsushi Naganawa ,  Maki Iwahashi ,  Atsushi Kinoshita ,  Atsushi Shimabukuro ,  Seiji Ogawa ,  Koji Yano ,  Kaoru Kobayashi ,  Yutaka Okada ,  Yoko Kishida ,  Shouji Kawauchi ,  Kohki Tsukamoto ,  Yoko Matsunaga ,  Fumio Nambu

发明人： Atsushi Naganawa ,  Maki Iwahashi ,  Atsushi Kinoshita ,  Atsushi Shimabukuro ,  Seiji Ogawa ,  Koji Yano ,  Kaoru Kobayashi ,  Yutaka Okada ,  Yoko Kishida ,  Shouji Kawauchi ,  Kohki Tsukamoto ,  Yoko Matsunaga ,  Fumio Nambu

IPC分类号： A61K31/535 ,  A61K31/36 ,  A61K31/34 ,  A61K31/335 ,  C07D265/36 ,  C07D317/44 ,  C07D307/00 ,  C07D319/14

CPC分类号： C07D307/80 ,  A61K31/343 ,  A61K31/538 ,  C07D265/36 ,  C07D317/48

摘要： A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.

摘要翻译： 由式（I）表示的化合物，其中式中的符号与说明书中的符号相同，其盐，溶剂合物或其前药与DP受体结合并显示DP受体的拮抗活性。 因此，它可用于预防和/或治疗过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有全身性肥大细胞活化的病症，过敏性休克， 支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），伴随瘙痒的行为的结果产生的疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍）（例如， 搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿关节炎，胸膜炎，溃疡性结肠炎等。由于其特异性结合DP受体并且弱结合到其他前列腺素受体，它们可以是具有 小副作用。

公开(公告)号：US08138335B2

公开(公告)日：2012-03-20

申请号：US12551860

申请日：2009-09-01

申请人： Atsushi Naganawa ,  Maki Iwahashi ,  Atsushi Kinoshita ,  Atsushi Shimabukuro ,  Seiji Ogawa ,  Koji Yano ,  Kaoru Kobayashi ,  Yutaka Okada ,  Yoko Kishida ,  Shouji Kawauchi ,  Kohki Tsukamoto ,  Yoko Matsunaga ,  Fumio Nambu

发明人： Atsushi Naganawa ,  Maki Iwahashi ,  Atsushi Kinoshita ,  Atsushi Shimabukuro ,  Seiji Ogawa ,  Koji Yano ,  Kaoru Kobayashi ,  Yutaka Okada ,  Yoko Kishida ,  Shouji Kawauchi ,  Kohki Tsukamoto ,  Yoko Matsunaga ,  Fumio Nambu

IPC分类号： C07D265/36 ,  A61K31/535

CPC分类号： C07D307/80 ,  A61K31/343 ,  A61K31/538 ,  C07D265/36 ,  C07D317/48

摘要： A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.

摘要翻译： 由式（I）表示的化合物，其中式中的符号与说明书中的符号相同，其盐，溶剂合物或其前药与DP受体结合并显示DP受体的拮抗活性。 因此，它可用于预防和/或治疗过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有全身性肥大细胞活化的病症，过敏性休克， 支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），伴随瘙痒的行为的结果产生的疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍）（例如， 搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿关节炎，胸膜炎，溃疡性结肠炎等。由于其特异性结合DP受体并且弱结合到其他前列腺素受体，它们可以是具有 小副作用。

公开(公告)号：US20070004716A1

公开(公告)日：2007-01-04

申请号：US10572578

申请日：2004-09-16

申请人： Atsushi Naganawa ,  Maki Iwahashi ,  Atsushi Kinoshita ,  Atsushi Shimabukuro ,  SeijiKoji Ogawa ,  Koji Yano ,  Kaoru Kobayashi ,  Yutaka Okada ,  Yoko Kishida ,  Shouji Kawauchi ,  Kohki Tsukamoto ,  Yoko Matsunaga ,  Fumio Nambu

发明人： Atsushi Naganawa ,  Maki Iwahashi ,  Atsushi Kinoshita ,  Atsushi Shimabukuro ,  SeijiKoji Ogawa ,  Koji Yano ,  Kaoru Kobayashi ,  Yutaka Okada ,  Yoko Kishida ,  Shouji Kawauchi ,  Kohki Tsukamoto ,  Yoko Matsunaga ,  Fumio Nambu

IPC分类号： A61K31/538 ,  C07D265/36

CPC分类号： C07D307/80 ,  A61K31/343 ,  A61K31/538 ,  C07D265/36 ,  C07D317/48

摘要： A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.

摘要翻译： 由式（I）表示的化合物，其中式中的符号与说明书中的符号相同，其盐，溶剂合物或其前药与DP受体结合并显示DP受体的拮抗活性。 因此，它可用于预防和/或治疗过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有全身性肥大细胞活化的病症，过敏性休克， 支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），伴随瘙痒的行为的结果产生的疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍）（例如， 搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿关节炎，胸膜炎，溃疡性结肠炎等。由于其特异性结合DP受体并且弱结合到其他前列腺素受体，它们可以是具有 小副作用。

公开(公告)号：US07355933B2

公开(公告)日：2008-04-08

申请号：US10635528

申请日：2003-08-07

申请人： Yutaka Okada

发明人： Yutaka Okada

IPC分类号： G11B7/00

CPC分类号： G11B7/1353 ,  G11B7/0903 ,  G11B7/123 ,  G11B7/1365 ,  G11B7/1381

摘要： Substantially all of the laser light emitted from laser chip(s) 11 toward optical disk(s) 17 may be transmitted through polarizing hologram(s) 13 and may thereafter be transmitted through quarter-wave plate(s) 15, and after being reflected at optical disk(s) 17, may again be transmitted through quarter-wave plate(s) 15 and be incident on polarizing hologram(s) 13. Accordingly, where laser light is transmitted twice through quarter-wave plate(s) 15, the direction(s) of polarization thereof may be rotated by 90 degrees before it is incident on polarizing hologram(s) 13. For this reason, even if laser light is p-polarized when it is transmitted through polarizing hologram(s) 13 from laser chip(s) 11, it may be s-polarized when it is again transmitted through polarizing hologram(s) 13 after being reflected from optical disk(s) 17. Laser light, after being made s-polarized, may be diffracted by polarizing hologram(s) 13, which diffracts only s-polarized light. Light of order ±1 produced as a result of diffraction of laser light by polarizing hologram(s) 13 may be incident on photodiode(s) 18.

摘要翻译： 从激光芯片11向光盘17发射的基本上所有的激光可以通过偏振全息图13传播，然后可以通过四分之一波片15传播，并且在被反射之后 在光盘17上，可以再次透过四分之一波片15并入射到偏振全息图13上。 因此，当激光通过四分之一波片15传输两次时，其偏振方向可以在入射到偏振全息图13之前旋转90度。因此，即使 当从激光芯片11透射偏振全息图13时，激光是p偏振光，当它从光盘反射后再次透过偏光全息图13时可以被s偏振（ s）17.激光在被s偏振后，可以通过仅衍射s偏振光的偏振全息图13衍射。 通过偏振全息图13衍射的激光产生的阶数±1的光可以入射到光电二极管18上。

公开(公告)号：US07233137B2

公开(公告)日：2007-06-19

申请号：US10947425

申请日：2004-09-23

申请人： Junichi Nakamura ,  Masahiro Kawamura ,  Yutaka Okada ,  Takeshi Morimoto

发明人： Junichi Nakamura ,  Masahiro Kawamura ,  Yutaka Okada ,  Takeshi Morimoto

IPC分类号： H01F17/00 ,  H02M3/335

CPC分类号： G06F1/26 ,  H02J5/005 ,  H02J7/0068 ,  H02J7/025 ,  H02J50/10 ,  H02J50/60 ,  H02J50/80 ,  H02J50/90

摘要： A power supply system is provided, having: a primary side coil; a power transmission apparatus having a primary side circuit for feeding a pulse voltage resulted from switching a DC voltage which is obtained by rectifying and smoothing a commercial power supply to the primary side coil; a secondary side coil magnetically coupled to the primary side coil; and power reception equipment having a secondary side circuit for rectifying and smoothing voltage induced across the secondary side coil, wherein there is provided a power adjusting section for adjusting a level of power to be transmitted according to power required by the power reception equipment. The power adjusting section has, in the primary side circuit, a carrier wave oscillation circuit for supplying a carrier wave to the primary side coil, a demodulation circuit for demodulating a modulated signal transmitted from the secondary circuit and received by the primary side coil, and a power change-over section for selecting a level of power to be transmitted according to an information signal from the power reception equipment and demodulated by the demodulation circuit. The power adjusting section has, in the secondary side circuit, a modulation circuit for modulating the carrier wave fed from the carrier wave oscillation circuit and received by the secondary side coil with the information signal from the power reception equipment and transmitting the modulated signal.

摘要翻译： 提供一种电源系统，具有：一次侧线圈; 电力传输装置，具有：初级侧电路，用于馈送通过对通过对一次侧线圈进行商业电源的整流和平滑而获得的DC电压的切换而产生的脉冲电压; 磁耦合到初级侧线圈的次级侧线圈; 以及具有二次侧电路的电力接收设备，用于整流和平滑次级侧线圈两端感应的电压，其中设置有功率调节部分，用于根据电力接收设备所需的功率来调整要发送的功率电平。 功率调整部在初级侧电路中具有用于向一次侧线圈供给载波的载波振荡电路，用于解调从次级电路发送并由一次侧线圈接收的调制信号的解调电路，以及 功率转换部分，用于根据来自功率接收设备的信息信号选择要发送的功率电平，并由解调电路解调。 功率调节部在次级侧电路中具有调制电路，用于对来自载波振荡电路的二次侧线圈接收到的载波进行调制，并使用来自功率接收装置的信息信号，并发送调制信号。

公开(公告)号：US5859673A

公开(公告)日：1999-01-12

申请号：US880646

申请日：1997-06-23

申请人： Takayuki Kobayashi ,  David Wuertele ,  Yutaka Okada

发明人： Takayuki Kobayashi ,  David Wuertele ,  Yutaka Okada

IPC分类号： H04N19/50 ,  G06T7/20 ,  H03M7/30 ,  H03M7/40 ,  H04N5/14 ,  H04N19/102 ,  H04N19/105 ,  H04N19/134 ,  H04N19/136 ,  H04N19/137 ,  H04N19/167 ,  H04N19/176 ,  H04N19/189 ,  H04N19/192 ,  H04N19/196 ,  H04N19/42 ,  H04N19/503 ,  H04N19/51 ,  H04N19/57 ,  H04N9/64

CPC分类号： G06T7/202 ,  H04N19/43 ,  H04N19/51 ,  H04N5/145 ,  G06T2207/10016

摘要： Herein described are a motion estimation method and a motion estimation apparatus for calculating a motion vector to estimate a current picture based on a reference picture. The current picture is partially formed by a current block represented by pel values. The reference picture is partially formed by a search window represented by pel values and having a plurality of candidate blocks. There are provided processor elements and side register units arranged in the form of a matrix array. The pel values of the search window are fed to the processor elements and the side register units. The pel values of the current block are fed to the processor elements. Between the processor elements and the side register units, are shifted pel values of the search window. The processor elements are designed to calculate distortion values each indicative of a difference between the current block and each of the candidate blocks on the basis of the received pel values of the search window and the received pel values of the current block. The method and apparatus are characterized in that, at one of the adjoining two columns of the matrix array, the pel values of the search window are shifted only in an upward direction, while, at the other of the adjoining two columns of the matrix array, the pel values of the search window are shifted only in a downward direction.

摘要翻译： 这里描述了一种运动估计方法和运动估计装置，用于基于参考图像计算运动矢量以估计当前图像。 当前图像部分地由由像素值表示的当前块形成。 参考图片由由像素值表示并具有多个候选块的搜索窗口部分地形成。 提供了以矩阵阵列的形式布置的处理器元件和侧面寄存器单元。 搜索窗口的像素值被馈送到处理器元件和侧寄存器单元。 当前块的像素值被馈送到处理器元件。 在处理器元件和侧面寄存器单元之间，是搜索窗口的偏移像素值。 处理器元件被设计为基于接收的搜索窗口的像素值和当前块的接收像素值来计算每个指示当前块和每个候选块之间的差异的失真值。 该方法和装置的特征在于，在矩阵阵列的相邻两列之一处，搜索窗口的像素值仅在向上方向移动，而在矩阵阵列的相邻两列中的另一列 搜索窗口的像素值仅向下移动。

公开(公告)号：US4433258A

公开(公告)日：1984-02-21

申请号：US245163

申请日：1981-03-18

申请人： Kenji Kaneko ,  Takahiro Okabe ,  Minoru Nagata ,  Yutaka Okada

发明人： Kenji Kaneko ,  Takahiro Okabe ,  Minoru Nagata ,  Yutaka Okada

IPC分类号： H03K19/082 ,  H03K19/091 ,  H03K19/092 ,  H03K19/088

CPC分类号： H03K19/0915 ,  H03K19/082

摘要： A logic circuit is provided which includes a plurality of basic circuits each of which has a pnp (or npn) transistor as a constant current load and at least one npn (or pnp) transistor each as a driver with a clamping Schottky diode. The base of the driver transistor is used as an input terminal and the collector thereof is used as an output terminal, for each basic circuit and the output terminal of the preceding stage basic circuit is coupled directly to the input terminal of the subsequent stage basic circuit. In order to prevent current hogging the load current supplied from the preceding stage constant current load transistor is set to operate the subsequent stage driver transistor in a saturation made when the subsequent stage driver transistor is in the ON state.

摘要翻译： 提供了一种逻辑电路，其包括多个基本电路，每个基本电路具有作为恒定电流负载的pnp（或npn）晶体管和每个具有钳位肖特基二极管的驱动器的至少一个npn（或pnp）晶体管）。 驱动晶体管的基极用作输入端子，其集电极用作输出端子，对于每个基本电路，前级基本电路的输出端子直接耦合到后级基本电路的输入端子 。 为了防止电流偏移，设定从前一级恒流负载晶体管提供的负载电流，以使后级级驱动晶体管处于导通状态时产生的饱和度使后级级驱动晶体管工作。

公开(公告)号：US4106998A

公开(公告)日：1978-08-15

申请号：US516826

申请日：1974-10-21

申请人： Yutaka Okada ,  Kyoji Sasaguri ,  Kazuo Ishihara

发明人： Yutaka Okada ,  Kyoji Sasaguri ,  Kazuo Ishihara

IPC分类号： C10B39/02 ,  C10B45/00 ,  C10B27/04

CPC分类号： C10B39/02

摘要： In a dry type quenching facility for red hot coke wherein an operation pressure at the upper portion of the quenching station is set up within the range of 0 to +10 mmH.sub.2 O, red hot coke is charged into said station under a reduced pressure of 0 to -30 mmH.sub.2 O, to prevent escape of dust and smoke from said station and thereby prevent polluting of the environment.

摘要翻译： 在用于红热焦炭的干式淬火设备中，其中淬火站上部的操作压力设定在0至+ 10mm 2 H 2 O的范围内，在0至+ 10mmH 2 O的范围内将红热焦炭加入所述工位， -30 mmH2O，以防止灰尘和烟雾从所述车站逃逸，从而防止污染环境。

公开(公告)号：US08794777B2

公开(公告)日：2014-08-05

申请号：US13127863

申请日：2009-11-10

申请人： Shin Ito ,  Yutaka Okada

发明人： Shin Ito ,  Yutaka Okada

IPC分类号： F21V5/04

CPC分类号： G02B19/0028 ,  G02B19/0061 ,  G02B2207/113 ,  G02F1/133603 ,  G02F2001/133607 ,  H01L33/54 ,  H01L2924/0002 ,  H01L2924/00

摘要： A light emitting device includes: a substrate; a semiconductor light emitting element provided on the substrate; a sealing member which covers the semiconductor light emitting element; and a lens having a plurality of convex parts and a concave part. The light emitting device emits light having a non-concentric luminance distribution made up of a plurality of bright regions and a plurality of dark regions, the non-concentric luminance distribution being observed on a plane which is parallel to the substrate. This makes it possible to provide (i) a display device which has a thin body and hardly causes unevenness in luminance and in chromaticity, and (ii) a light emitting device and (iii) a surface illuminant suitable, which are suitable for use in the display device.

摘要翻译： 发光装置包括：基板; 设置在所述基板上的半导体发光元件; 覆盖半导体发光元件的密封构件; 以及具有多个凸部和凹部的透镜。 发光器件发射具有由多个亮区域和多个暗区域组成的非同心亮度分布的光，在平行于衬底的平面上观察到非同心亮度分布。 这使得可以提供（i）具有薄体并且几乎不引起亮度和色度不均匀的显示装置，以及（ii）发光装置和（iii）适合于适用于 显示设备。