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1.发明申请公开(公告)号：US20100029631A1
公开(公告)日：2010-02-04
申请号：US12551860
申请日：2009-09-01
申请人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , Seiji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
发明人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , Seiji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
IPC分类号： A61K31/538 , C07D265/36 , A61P37/08 , A61P11/06
CPC分类号： C07D307/80 , A61K31/343 , A61K31/538 , C07D265/36 , C07D317/48
摘要： A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.
摘要翻译： 由式（I）表示的化合物，其中式中的符号与说明书中的符号相同，其盐，溶剂合物或其前药与DP受体结合并显示DP受体的拮抗活性。 因此，它可用于预防和/或治疗过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有全身性肥大细胞活化的病症，过敏性休克， 支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），伴随瘙痒的行为的结果产生的疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍）（例如， 搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿关节炎，胸膜炎，溃疡性结肠炎等。由于其特异性结合DP受体并且弱结合到其他前列腺素受体，它们可以是具有 小副作用。
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2.发明授权Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient 有权羧酸化合物和含有与活性成分相同的药物组合物公开(公告)号：US07601712B2
公开(公告)日：2009-10-13
申请号：US10572578
申请日：2004-09-16
申请人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , Seiji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
发明人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , Seiji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
IPC分类号： A61K31/535 , A61K31/36 , A61K31/34 , A61K31/335 , C07D265/36 , C07D317/44 , C07D307/00 , C07D319/14
CPC分类号： C07D307/80 , A61K31/343 , A61K31/538 , C07D265/36 , C07D317/48
摘要： A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.
摘要翻译： 由式（I）表示的化合物，其中式中的符号与说明书中的符号相同，其盐，溶剂合物或其前药与DP受体结合并显示DP受体的拮抗活性。 因此，它可用于预防和/或治疗过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有全身性肥大细胞活化的病症，过敏性休克， 支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），伴随瘙痒的行为的结果产生的疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍）（例如， 搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿关节炎，胸膜炎，溃疡性结肠炎等。由于其特异性结合DP受体并且弱结合到其他前列腺素受体，它们可以是具有 小副作用。
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3.发明授权Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient 有权羧酸化合物和含有与活性成分相同的药物组合物公开(公告)号：US08138335B2
公开(公告)日：2012-03-20
申请号：US12551860
申请日：2009-09-01
申请人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , Seiji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
发明人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , Seiji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
IPC分类号： C07D265/36 , A61K31/535
CPC分类号： C07D307/80 , A61K31/343 , A61K31/538 , C07D265/36 , C07D317/48
摘要： A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.
摘要翻译： 由式（I）表示的化合物，其中式中的符号与说明书中的符号相同，其盐，溶剂合物或其前药与DP受体结合并显示DP受体的拮抗活性。 因此，它可用于预防和/或治疗过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有全身性肥大细胞活化的病症，过敏性休克， 支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），伴随瘙痒的行为的结果产生的疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍）（例如， 搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿关节炎，胸膜炎，溃疡性结肠炎等。由于其特异性结合DP受体并且弱结合到其他前列腺素受体，它们可以是具有 小副作用。
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4.发明申请Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient 有权羧酸化合物和含有与活性成分相同的药物组合物公开(公告)号：US20070004716A1
公开(公告)日：2007-01-04
申请号：US10572578
申请日：2004-09-16
申请人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , SeijiKoji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
发明人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , SeijiKoji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
IPC分类号： A61K31/538 , C07D265/36
CPC分类号： C07D307/80 , A61K31/343 , A61K31/538 , C07D265/36 , C07D317/48
摘要： A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.
摘要翻译： 由式（I）表示的化合物，其中式中的符号与说明书中的符号相同，其盐，溶剂合物或其前药与DP受体结合并显示DP受体的拮抗活性。 因此，它可用于预防和/或治疗过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有全身性肥大细胞活化的病症，过敏性休克， 支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），伴随瘙痒的行为的结果产生的疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍）（例如， 搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿关节炎，胸膜炎，溃疡性结肠炎等。由于其特异性结合DP受体并且弱结合到其他前列腺素受体，它们可以是具有 小副作用。
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公开(公告)号：US09266195B2
公开(公告)日：2016-02-23
申请号：US14008177
申请日：2011-04-28
申请人： Koji Yano , Hiroyuki Sumi
发明人： Koji Yano , Hiroyuki Sumi
CPC分类号： B23K26/32 , B23K26/0608 , B23K26/26 , B23K2103/04 , B23K2103/05 , B23K2103/50
摘要： A laser welding method includes emitting two laser beams along a weld line from an upper surface side of a workpiece, the two laser beams being transmitted through different optical fibers and having in-focus spot diameters of 0.3 mm or larger; emitting the laser beams such that a leading laser beam of the two laser beams and a trailing laser beam of the two laser beams are each inclined toward a direction in which welding proceeds at an incident angle with respect to a direction perpendicular to an upper surface of the workpiece, the leading laser beam being ahead of the trailing laser beam on the upper surface of the workpiece in the direction in which welding proceeds, the trailing laser beam being behind the leading laser beam; and setting the incident angle of the leading laser beam to be larger than the incident angle of the trailing laser beam.
摘要翻译： 激光焊接方法包括沿着焊接线从工件的上表面侧发射两束激光束，两束激光束透过不同的光纤并具有0.3mm以上的焦点直径; 发射激光束，使得两个激光束的前导激光束和两个激光束的后退激光束各自朝着焊接相对于垂直于上表面的方向以入射角进行的方向倾斜 所述工件，所述前导激光束在所述工件的上表面上在所述焊接进行方向上位于所述尾部激光束之前，所述后激光束位于所述激光束的后面; 并且将前导激光束的入射角设定为大于后激光束的入射角。
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公开(公告)号：US08633865B2
公开(公告)日：2014-01-21
申请号：US13016264
申请日：2011-01-28
申请人： Tetsuya Miyagawa , Koji Yano
发明人： Tetsuya Miyagawa , Koji Yano
IPC分类号： H01Q1/42
摘要： This disclosure provides a radome to be installed on an emission face side of an antenna, which includes an outer wall having a side cross-section formed in a substantially semi-circular shape to include the antenna therein, and an inner wall arranged between the outer wall and the antenna, and formed in a shape to substantially conform to the outer wall. A gap between the outer wall and the inner wall is wider near both ends on the circumference of the substantially semi-circular shape than at a substantially midpoint on the circumference of the substantially semi-circular shape.
摘要翻译： 本公开内容提供了一种天线罩，其安装在天线的发射面侧，该天线罩包括具有形成为大致半圆形状的侧面截面的外壁，以在其中包括天线，以及设置在外部 壁和天线，并且形成为基本上符合外壁的形状。 外壁和内壁之间的间隙在基本上半圆形的圆周上的两端附近比在大致半圆形的圆周上的大致中点处更宽。
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公开(公告)号：US20110248902A1
公开(公告)日：2011-10-13
申请号：US13016264
申请日：2011-01-28
申请人： Tetsuya Miyagawa , Koji Yano
发明人： Tetsuya Miyagawa , Koji Yano
IPC分类号： H01Q1/42
摘要： This disclosure provides a radome to be installed on an emission face side of an antenna, which includes an outer wall having a side cross-section formed in a substantially semi-circular shape to include the antenna therein, and an inner wall arranged between the outer wall and the antenna, and formed in a shape to substantially conform to the outer wall. A gap between the outer wall and the inner wall is wider near both ends on the circumference of the substantially semi-circular shape than at a substantially midpoint on the circumference of the substantially semi-circular shape.
摘要翻译： 本公开内容提供了一种天线罩，其安装在天线的发射面侧，该天线罩包括具有形成为大致半圆形状的侧面截面的外壁，以在其中包括天线，以及设置在外部 壁和天线，并且形成为基本上符合外壁的形状。 外壁和内壁之间的间隙在基本上半圆形的圆周上的两端附近比在大致半圆形的圆周上的大致中点处更宽。
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公开(公告)号：US20110248883A1
公开(公告)日：2011-10-13
申请号：US13015909
申请日：2011-01-28
申请人： Tetsuya Miyagawa , Koji Yano , Makoto Oda , Takashi Omori , Motoji Kondo , Masato Sakamoto
发明人： Tetsuya Miyagawa , Koji Yano , Makoto Oda , Takashi Omori , Motoji Kondo , Masato Sakamoto
CPC分类号： H01Q1/42 , H01P5/12 , H01Q13/10 , H01Q19/06 , H01Q21/005
摘要： The disclosure provides an antenna device, which includes a waveguide antenna having wall surfaces and for emitting a radio wave in a direction substantially perpendicular to an emission face that is one of wall surfaces of the waveguide antenna extending in an elongated direction of the waveguide antenna, a plate-shape two-dimensional opening slots for beam formation formed in the waveguide antenna on the emission face side, a power feed waveguide module arranged in the rear face of the waveguide antenna opposite from the emission face and for supplying electric power to the waveguide antenna, and a cylindrical radome having a substantially circular cross-section of a diameter that is substantially equal to a length of the emission face in a direction perpendicular to the long-side direction so that the waveguide antenna is contained in the radome so as to be arranged at substantially the center of the radome.
摘要翻译： 本发明提供了一种天线装置，其包括具有壁面的波导天线，并且用于沿与波导天线的延伸方向延伸的波导天线的壁面之一基本垂直的发射面发射无线电波， 在发射面侧的波导天线中形成的用于波束形成的板状二维开口槽，布置在波导天线的与发射面相反的后表面并用于向波导供电的馈电波导模块 天线和具有基本上圆形截面的圆柱形天线罩，其直径基本上等于发射面在垂直于长边方向的方向上的长度，使得波导天线被包含在天线罩中，从而 布置在雷达罩的大致中心处。
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9.发明授权Method of manufacturing a single chip semiconductor integrated circuit device including a mask ROM in a short time 失效在短时间内制造包括掩模ROM的单芯片半导体集成电路器件的方法公开(公告)号：US07670875B2
公开(公告)日：2010-03-02
申请号：US11881223
申请日：2007-07-26
申请人： Koji Yano , Tomoki Segawa
发明人： Koji Yano , Tomoki Segawa
IPC分类号： H01L21/44 , H01L21/48 , H01L21/50 , H01L21/338
CPC分类号： H01L27/0207 , H01L23/49575 , H01L23/50 , H01L24/48 , H01L24/49 , H01L25/0657 , H01L27/105 , H01L27/112 , H01L27/11293 , H01L2223/5444 , H01L2224/05554 , H01L2224/05599 , H01L2224/16 , H01L2224/32145 , H01L2224/451 , H01L2224/48091 , H01L2224/48137 , H01L2224/48145 , H01L2224/48247 , H01L2224/4911 , H01L2224/49171 , H01L2224/85399 , H01L2225/06506 , H01L2225/0651 , H01L2924/00014 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01015 , H01L2924/01033 , H01L2924/01047 , H01L2924/01075 , H01L2924/01082 , H01L2924/014 , H01L2924/10161 , H01L2924/10162 , H01L2924/1306 , H01L2924/13091 , H01L2924/14 , H01L2924/181 , H01L2924/00 , H01L2224/45015 , H01L2924/207 , H01L2924/00012 , H01L2224/45099
摘要： In a state of a first semiconductor integrated circuit device on which a first semiconductor integrated circuit board including a first mask ROM and a programmable ROM are mounted, an ultimate program determined by using the programmable ROM is stored in a second ROM of a second semiconductor integrated circuit board which is substantially similar in structure to the first semiconductor integrated circuit board, thereby manufacturing a second semiconductor integrated circuit device as an ultimate product.
摘要翻译： 在其上安装有包括第一掩模ROM和可编程ROM的第一半导体集成电路板的第一半导体集成电路器件的状态下，通过使用可编程ROM确定的最终程序被存储在第二半导体集成的第二ROM中 电路板，其结构基本上与第一半导体集成电路板相似，从而制造第二半导体集成电路器件作为最终产品。
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公开(公告)号：US07345132B2
公开(公告)日：2008-03-18
申请号：US11037058
申请日：2005-01-19
申请人： Noriaki Saito , Ichishi Aizu , Nobuyuki Nakajima , Masahiro Fujiwara , Koji Yano
发明人： Noriaki Saito , Ichishi Aizu , Nobuyuki Nakajima , Masahiro Fujiwara , Koji Yano
IPC分类号： C08G14/04
摘要： Provided an industrially excellent method of producing a phenol novolak resin having an ortho ratio of 30% or more by: (1) a method of reacting a phenol and an aldehyde using an oxalic acid catalyst at 110 to 160° C. under pressure; or (2) a method of reacting a phenol and an aldehyde under pressure while removing the heat of reaction by a condenser with controlling a pressure so that water or an organic solvent present in the reaction system is refluxed.
摘要翻译： 本发明提供一种工业上优异的通过以下方法制造邻位比为30％以上的酚醛清漆树脂的方法：（1）使用草酸催化剂在110〜160℃下在压力下使苯酚与醛反应的方法; 或（2）在压力下使苯酚和醛反应的方法，同时通过冷凝器除去反应热，同时控制压力使得反应体系中存在的水或有机溶剂回流。
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