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公开(公告)号：US12129509B2
公开(公告)日：2024-10-29
申请号：US17241991
申请日：2021-04-27
Applicant: Avails Medical, Inc.
Inventor： Oren S. Knopfmacher , Meike Herget , Nitin K. Rajan , Ashraf M. Wahba
IPC: C12Q1/18 , G01N27/30 , G01N27/327
CPC classification number: C12Q1/18 , G01N27/3275 , G01N27/302
Abstract: Various methods, devices, and systems for determining the susceptibility of infectious agents to anti-infectives are disclosed herein. A method comprises introducing an inoculum solution comprising the infectious agent into a sample receiving space of a diagnostic device. The sample receiving space comprises a plurality of growth control wells devoid of the anti-infective and a plurality of active electrode wells comprising the anti-infective at differing concentrations. A water immiscible liquid can be introduced into the sample receiving space to seal the plurality of wells and the diagnostic device can be incubated for a period of time. The minimum inhibitory concentration (MIC) of the anti-infective on the infectious agent can be determined by monitoring and comparing one or more solution characteristics of the inoculum solution within the active electrode wells with the one or more solution characteristics of the inoculum solution with the growth control wells.
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2.发明授权公开(公告)号：US11385200B2
公开(公告)日：2022-07-12
申请号：US16716945
申请日：2019-12-17
Applicant: Avails Medical, Inc.
Inventor： Oren S. Knopfmacher , Meike Herget , August Estabrook , Nitin K. Rajan , Michael D. Laufer
IPC: C12Q1/18 , G01N27/416
Abstract: Various devices, systems and methods of detecting a susceptibility of one or more infectious agents to one or more anti-infectives are described herein. In one embodiment, a method of detecting the susceptibility of the infectious agents to the anti-infectives involves introducing a sample comprising the infectious agents to a filter comprising a filter surface. The filter surface can be configured to capture the infectious agents in the sample. The method can also involve introducing a solution to the filter surface such that the solution is in fluid communication with the infectious agents captured on the filter surface. The solution can comprise nutrients and one or more anti-infectives. The method can further involve monitoring an oxidation reduction potential (ORP) of the solution using one or more parameter analyzers coupled to a sensor currently in fluid communication with the solution to assess the susceptibility of the infectious agents to the anti-infectives.
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公开(公告)号：US10883135B2
公开(公告)日：2021-01-05
申请号：US15917266
申请日：2018-03-09
Applicant: Avails Medical, Inc.
Inventor： Oren S. Knopfmacher , Meike Herget , Michael D. Laufer , August Estabrook
IPC: C12M1/18 , C12M1/02 , G01N33/50 , G01N27/414 , G01N27/327 , C12Q1/18 , C12Q1/04 , C12Q1/02 , C12M3/06
Abstract: Various devices, systems and methods for detecting a susceptibility of an infectious agent to an anti-infective are described herein. A method comprises introducing a fluid sample to a first surface and a second surface; exposing the first surface to a first solution; exposing the second surface to a second solution, wherein the second surface comprises an anti-infective; sampling the first solution after exposing the first solution to the first surface; sampling the second solution after exposing the second solution to the second surface; monitoring a first electrical characteristic of a first sensor exposed to the first solution sampled; monitoring a second electrical characteristic of a second sensor exposed to the second solution sampled; and comparing the first electrical characteristic and the second electrical characteristic to assess the susceptibility of the infectious agent to the anti-infective.
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公开(公告)号：US12275982B2
公开(公告)日：2025-04-15
申请号：US18423077
申请日：2024-01-25
Applicant: Avails Medical, Inc.
Inventor： Oren S. Knopfmacher , Meike Herget , Michael D. Laufer , August Estabrook
Abstract: Various devices, systems and methods for detecting infectious agents or determining a susceptibility of an infectious agent to an anti-infective are described herein. One example method comprises introducing a fluid sample to a surface; exposing the surface to a solution; sampling the solution after exposing the solution to the surface; and detecting a change in an electrical characteristic of a sensing device exposed to the solution sampled corresponding to a presence of the infectious agent in the fluid sample.
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公开(公告)号：US12275981B2
公开(公告)日：2025-04-15
申请号：US18301121
申请日：2023-04-14
Applicant: Avails Medical, Inc.
Inventor： Oren S. Knopfmacher , Meike Herget , Nitin K. Rajan , Michael D. Laufer
IPC: C12Q1/18 , C12Q1/06 , G01N27/416
Abstract: Various methods, devices, and systems for determining the concentration of microorganisms in a sample and determining the susceptibility of such microorganisms to one or more antibiotics or other types of anti-infectives are disclosed herein. More specifically, methods for quantifying microorganisms based on redox reactions are disclosed along with systems and devices for quantifying such microorganisms using certain oxidation reduction potential (ORP) sensors. Moreover, methods for determining the susceptibility and the degree of susceptibility of microorganisms to one or more anti-infectives are disclosed along with multiplex systems for such assays.
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Patent Agency Ranking
公开(公告)号：US11021732B2
公开(公告)日：2021-06-01
申请号：US16241691
申请日：2019-01-07
Applicant: Avails Medical, Inc.
Inventor： Oren S. Knopfmacher , Meike Herget , Michael D. Laufer , August Estabrook
IPC: G01N27/27 , C12Q1/18 , C12Q1/02 , C12Q1/04 , G01N27/416 , G01N27/327 , G01N33/50 , C12Q1/00 , B01L3/00
Abstract: Various devices, systems and methods for detecting infectious agents or determining a susceptibility of an infectious agent to an anti-infective are described herein. One example method comprises introducing a fluid sample to a surface; exposing the surface to a solution; sampling the solution after exposing the solution to the surface; and detecting a change in an electrical characteristic of a sensing device exposed to the solution sampled corresponding to a presence of the infectious agent in the fluid sample.
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公开(公告)号：US09377456B1
公开(公告)日：2016-06-28
申请号：US14599190
申请日：2015-01-16
Applicant: Avails Medical, Inc.
Inventor： Meike Herget , Oren S. Knopfmacher
IPC: G01N15/06 , G01N33/00 , G01N33/48 , G01N33/543
CPC classification number: G01N27/4145 , G01N27/60 , G01N33/54353 , G01N33/54373 , G01N33/54386
Abstract: Various devices, systems and methods for determining a parameter of and/or detecting chemical and biological substances in bodily fluid are described herein. A device or system may include a substrate. An active sensor having an electrical characteristic and/or a control sensor may be disposed on the substrate. In certain variations, a differential between a first signal from the active sensor, and a second signal from the control sensor may be used to determine a parameter of the chemical or biological substance in the sample of bodily fluid.
Abstract translation: 本文描述了用于确定体液中的化学和生物物质参数和/或检测体液中的化学和生物物质的各种装置，系统和方法。 设备或系统可以包括基板。 具有电特性的有源传感器和/或控制传感器可以设置在基板上。 在某些变化中，可以使用来自有源传感器的第一信号与来自控制传感器的第二信号之间的差分来确定体液样品中的化学或生物物质的参数。
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8.发明授权公开(公告)号：US12276634B2
公开(公告)日：2025-04-15
申请号：US17806206
申请日：2022-06-09
Applicant: Avails Medical, Inc.
Inventor： Oren S. Knopfmacher , Meike Herget , August Estabrook , Nitin K. Rajan , Michael D. Laufer
IPC: C12Q1/18 , G01N27/416
Abstract: Various devices, systems and methods of detecting a susceptibility of one or more infectious agents to one or more anti-infectives are described herein. In one embodiment, a method of detecting the susceptibility of the infectious agents to the anti-infectives involves introducing a sample comprising the infectious agents to a filter comprising a filter surface. The filter surface can be configured to capture the infectious agents in the sample. The method can also involve introducing a solution to the filter surface such that the solution is in fluid communication with the infectious agents captured on the filter surface. The solution can comprise nutrients and one or more anti-infectives. The method can further involve monitoring an oxidation reduction potential (ORP) of the solution using one or more parameter analyzers coupled to a sensor currently in fluid communication with the solution to assess the susceptibility of the infectious agents to the anti-infectives.
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公开(公告)号：US12007350B2
公开(公告)日：2024-06-11
申请号：US18057622
申请日：2022-11-21
Applicant: Avails Medical, Inc.
Inventor： Creighton T. Buie , Hima Shah , Nitin K. Rajan , Ashraf M. Wahba , Oren S. Knopfmacher , Meike Herget
IPC: G01N27/30 , B01L3/00 , G01N27/12 , G01N27/416
CPC classification number: G01N27/301 , B01L3/5023 , G01N27/125 , G01N27/302 , G01N27/4167 , G01N27/4168 , B01L2300/042 , B01L2300/0645 , B01L2300/161 , B01L2300/165
Abstract: Various apparatus, systems, and methods for measuring a solution characteristic of a sample comprising microorganisms are disclosed. In one embodiment, a sensor apparatus is disclosed comprising a sample container comprising a sample chamber configured to receive the sample and a reference sensor component comprising a reference conduit having a reference conduit cavity defined therein. The reference conduit cavity can be at least partially filled with a reference buffer gel, buffer solution, or wicking component. A segment of the reference conduit can extend into the sample chamber. A reference electrode material can be positioned at a proximal end of the wicking component or extend partially into the reference conduit cavity. The sensor apparatus can also comprise an active sensor component having an active electrode in fluid contact with the sample. The sample in the sample chamber can be aerated through an aeration port defined along a surface of the sample container.
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公开(公告)号：USD907795S1
公开(公告)日：2021-01-12
申请号：US29719607
申请日：2020-01-06
Applicant: Avails Medical, Inc.
Designer： Creighton T. Buie , Oren S. Knopfmacher , Meike Herget
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