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1.发明授权公开(公告)号：US11385200B2
公开(公告)日：2022-07-12
申请号：US16716945
申请日：2019-12-17
Applicant: Avails Medical, Inc.
Inventor： Oren S. Knopfmacher , Meike Herget , August Estabrook , Nitin K. Rajan , Michael D. Laufer
IPC: C12Q1/18 , G01N27/416
Abstract: Various devices, systems and methods of detecting a susceptibility of one or more infectious agents to one or more anti-infectives are described herein. In one embodiment, a method of detecting the susceptibility of the infectious agents to the anti-infectives involves introducing a sample comprising the infectious agents to a filter comprising a filter surface. The filter surface can be configured to capture the infectious agents in the sample. The method can also involve introducing a solution to the filter surface such that the solution is in fluid communication with the infectious agents captured on the filter surface. The solution can comprise nutrients and one or more anti-infectives. The method can further involve monitoring an oxidation reduction potential (ORP) of the solution using one or more parameter analyzers coupled to a sensor currently in fluid communication with the solution to assess the susceptibility of the infectious agents to the anti-infectives.
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公开(公告)号：US10883135B2
公开(公告)日：2021-01-05
申请号：US15917266
申请日：2018-03-09
Applicant: Avails Medical, Inc.
Inventor： Oren S. Knopfmacher , Meike Herget , Michael D. Laufer , August Estabrook
IPC: C12M1/18 , C12M1/02 , G01N33/50 , G01N27/414 , G01N27/327 , C12Q1/18 , C12Q1/04 , C12Q1/02 , C12M3/06
Abstract: Various devices, systems and methods for detecting a susceptibility of an infectious agent to an anti-infective are described herein. A method comprises introducing a fluid sample to a first surface and a second surface; exposing the first surface to a first solution; exposing the second surface to a second solution, wherein the second surface comprises an anti-infective; sampling the first solution after exposing the first solution to the first surface; sampling the second solution after exposing the second solution to the second surface; monitoring a first electrical characteristic of a first sensor exposed to the first solution sampled; monitoring a second electrical characteristic of a second sensor exposed to the second solution sampled; and comparing the first electrical characteristic and the second electrical characteristic to assess the susceptibility of the infectious agent to the anti-infective.
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公开(公告)号：US12275982B2
公开(公告)日：2025-04-15
申请号：US18423077
申请日：2024-01-25
Applicant: Avails Medical, Inc.
Inventor： Oren S. Knopfmacher , Meike Herget , Michael D. Laufer , August Estabrook
Abstract: Various devices, systems and methods for detecting infectious agents or determining a susceptibility of an infectious agent to an anti-infective are described herein. One example method comprises introducing a fluid sample to a surface; exposing the surface to a solution; sampling the solution after exposing the solution to the surface; and detecting a change in an electrical characteristic of a sensing device exposed to the solution sampled corresponding to a presence of the infectious agent in the fluid sample.
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公开(公告)号：US12275981B2
公开(公告)日：2025-04-15
申请号：US18301121
申请日：2023-04-14
Applicant: Avails Medical, Inc.
Inventor： Oren S. Knopfmacher , Meike Herget , Nitin K. Rajan , Michael D. Laufer
IPC: C12Q1/18 , C12Q1/06 , G01N27/416
Abstract: Various methods, devices, and systems for determining the concentration of microorganisms in a sample and determining the susceptibility of such microorganisms to one or more antibiotics or other types of anti-infectives are disclosed herein. More specifically, methods for quantifying microorganisms based on redox reactions are disclosed along with systems and devices for quantifying such microorganisms using certain oxidation reduction potential (ORP) sensors. Moreover, methods for determining the susceptibility and the degree of susceptibility of microorganisms to one or more anti-infectives are disclosed along with multiplex systems for such assays.
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公开(公告)号：US11021732B2
公开(公告)日：2021-06-01
申请号：US16241691
申请日：2019-01-07
Applicant: Avails Medical, Inc.
Inventor： Oren S. Knopfmacher , Meike Herget , Michael D. Laufer , August Estabrook
IPC: G01N27/27 , C12Q1/18 , C12Q1/02 , C12Q1/04 , G01N27/416 , G01N27/327 , G01N33/50 , C12Q1/00 , B01L3/00
Abstract: Various devices, systems and methods for detecting infectious agents or determining a susceptibility of an infectious agent to an anti-infective are described herein. One example method comprises introducing a fluid sample to a surface; exposing the surface to a solution; sampling the solution after exposing the solution to the surface; and detecting a change in an electrical characteristic of a sensing device exposed to the solution sampled corresponding to a presence of the infectious agent in the fluid sample.
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Patent Agency Ranking
6.发明授权公开(公告)号：US12276634B2
公开(公告)日：2025-04-15
申请号：US17806206
申请日：2022-06-09
Applicant: Avails Medical, Inc.
Inventor： Oren S. Knopfmacher , Meike Herget , August Estabrook , Nitin K. Rajan , Michael D. Laufer
IPC: C12Q1/18 , G01N27/416
Abstract: Various devices, systems and methods of detecting a susceptibility of one or more infectious agents to one or more anti-infectives are described herein. In one embodiment, a method of detecting the susceptibility of the infectious agents to the anti-infectives involves introducing a sample comprising the infectious agents to a filter comprising a filter surface. The filter surface can be configured to capture the infectious agents in the sample. The method can also involve introducing a solution to the filter surface such that the solution is in fluid communication with the infectious agents captured on the filter surface. The solution can comprise nutrients and one or more anti-infectives. The method can further involve monitoring an oxidation reduction potential (ORP) of the solution using one or more parameter analyzers coupled to a sensor currently in fluid communication with the solution to assess the susceptibility of the infectious agents to the anti-infectives.
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公开(公告)号：US10174356B2
公开(公告)日：2019-01-08
申请号：US15482307
申请日：2017-04-07
Applicant: Avails Medical, Inc.
Inventor： Oren S. Knopfmacher , Meike Herget , Michael D. Laufer , August Estabrook
Abstract: Various devices, systems and methods for detecting infectious agents or determining a susceptibility of an infectious agent to an anti-infective are described herein. One example method comprises introducing a fluid sample to a surface; exposing the surface to a solution; sampling the solution after exposing the solution to the surface; and detecting a change in an electrical characteristic of a sensing device exposed to the solution sampled corresponding to a presence of the infectious agent in the fluid sample.
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公开(公告)号：US12139742B2
公开(公告)日：2024-11-12
申请号：US17443990
申请日：2021-07-29
Applicant: Avails Medical, Inc.
Inventor： Meike Herget , Creighton T. Buie , Nitin K. Rajan , Andrew H. THeiss , Elizabeth Botbol Ponte , Oren S. Knopfmacher , Michael D. Laufer , Eszter Deak , Suzanne Putney
Abstract: Various apparatus, systems, and methods for measuring a solution characteristic of a sample comprising microorganisms are disclosed. The measured solution characteristic can be used to generate a standardized inoculum. In one embodiment, a sensor apparatus is disclosed comprising a sample container having a chamber lateral wall surrounding a chamber cavity configured receive the sample, a reference sensor fabricated as a container cap and comprising a reference electrode material and, and an active sensor made of a substrate covered in part by an active electrode layer. The active sensor can be coupled to at least part of the chamber lateral wall at a window opening defined along the chamber lateral wall. The solution characteristic can be measured using a reader configured to electrically couple to the sensor apparatus and measure the solution characteristic based on a potential difference between the active sensor and the active sensor.
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公开(公告)号：US11913058B2
公开(公告)日：2024-02-27
申请号：US17242810
申请日：2021-04-28
Applicant: Avails Medical, Inc.
Inventor： Oren S. Knopfmacher , Meike Herget , Michael D. Laufer , August Estabrook
CPC classification number: C12Q1/18 , C12Q1/006 , C12Q1/025 , C12Q1/04 , G01N27/27 , G01N27/3273 , G01N27/3275 , G01N33/5011 , B01L3/502715 , G01N27/3272
Abstract: Various devices, systems and methods for detecting infectious agents or determining a susceptibility of an infectious agent to an anti-infective are described herein. One example method comprises introducing a fluid sample to a surface; exposing the surface to a solution; sampling the solution after exposing the solution to the surface; and detecting a change in an electrical characteristic of a sensing device exposed to the solution sampled corresponding to a presence of the infectious agent in the fluid sample.
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公开(公告)号：US11655494B2
公开(公告)日：2023-05-23
申请号：US16814153
申请日：2020-03-10
Applicant: Avails Medical, Inc.
Inventor： Oren S. Knopfmacher , Meike Herget , Nitin K. Rajan , Michael D. Laufer
IPC: C12Q1/18 , C12Q1/06 , G01N27/416
CPC classification number: C12Q1/18 , C12Q1/06 , G01N27/4168
Abstract: Various methods, devices, and systems for determining the concentration of microorganisms in a sample and determining the susceptibility of such microorganisms to one or more antibiotics or other types of anti-infectives are disclosed herein. More specifically, methods for quantifying microorganisms based on redox reactions are disclosed along with systems and devices for quantifying such microorganisms using certain oxidation reduction potential (ORP) sensors. Moreover, methods for determining the susceptibility and the degree of susceptibility of microorganisms to one or more anti-infectives are disclosed along with multiplex systems for such assays.
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