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    Freeze-dried fibrin matrices and methods for preparation thereof
    2.
    发明授权
    Freeze-dried fibrin matrices and methods for preparation thereof 有权
    冻干纤维蛋白基质及其制备方法

    公开(公告)号：US08618258B2

    公开(公告)日：2013-12-31

    申请号：US13465452

    申请日：2012-05-07

    申请人： Avner Yayon ,  Malkit Azachi ,  Micha Gladnikoff

    发明人： Avner Yayon ,  Malkit Azachi ,  Micha Gladnikoff

    IPC分类号： A61K35/14

    CPC分类号： A61K9/0024 ,  A61F2/30756 ,  A61K9/2063 ,  A61K31/727 ,  A61K31/728 ,  A61K35/12 ,  A61K38/1825 ,  A61L27/225 ,  A61L27/3852 ,  A61L27/56 ,  C07K14/75 ,  C12N5/0068 ,  C12N5/0655 ,  C12N2533/56

    摘要： Methods for treating diseased or injured tissue by implanting into the tissue at a site of the disease or injury a porous freeze-dried fibrin matrix formed from plasma proteins. The proteins include fibrinogen cleaved by the action of thrombin at varying concentrations sufficient to cleave the fibrinogen and Factor XIII. The matrix has less than 10% residual moisture and is devoid of exogenous anti-fibrinolytic agents, plasminogen and of organic chelating agents. Alternatively, the plasma proteins comprise partially purified plasma proteins that are devoid of plasminogen.

    摘要翻译： 通过在血液蛋白质形成的多孔冷冻干燥的纤维蛋白基质中在疾病或损伤部位植入组织来治疗患病或损伤的组织的方法。 蛋白质包括纤维蛋白原，其通过凝血酶的作用以不同的浓度切割，足以切割纤维蛋白原和因子XIII。 该基质具有少于10％的残留水分，没有外源抗纤维蛋白溶解剂，纤溶酶原和有机螯合剂。 或者，血浆蛋白质包含没有纤溶酶原的部分纯化的血浆蛋白质。

    Freeze-dried fibrin matrices and methods for preparation thereof
    4.
    发明授权
    Freeze-dried fibrin matrices and methods for preparation thereof 有权
    冻干纤维蛋白基质及其制备方法

    公开(公告)号：US07714107B2

    公开(公告)日：2010-05-11

    申请号：US11190387

    申请日：2005-07-26

    申请人： Avner Yayon ,  Malkit Azachi ,  Micha Gladnikoff

    发明人： Avner Yayon ,  Malkit Azachi ,  Micha Gladnikoff

    IPC分类号： A61K35/14

    CPC分类号： A61K9/0024 ,  A61F2/30756 ,  A61K9/2063 ,  A61K31/727 ,  A61K31/728 ,  A61K35/12 ,  A61K38/1825 ,  A61L27/225 ,  A61L27/3852 ,  A61L27/56 ,  C07K14/75 ,  C12N5/0068 ,  C12N5/0655 ,  C12N2533/56

    摘要： The present invention relates to porous freeze-dried fibrin matrices substantially devoid of external anti-fibrinolytic agents, and methods of producing such matrices. Resilient matrices, also known as sponges, that are particularly beneficial for supporting three dimensional cell growth are obtained from plasma proteins substantially devoid of plasminogen or from partially purified plasma proteins, thus obviating the need for exogenous anti-fibrinolytic agents. Furthermore, incorporation of glycosaminoglycans and bioactive agents during the formation of the matrix results in a sponge having advantageous biological, mechanical and physical properties. The compositions of the present invention are useful clinically, without cells or as a cell bearing implants.

    摘要翻译： 本发明涉及基本上不含外部抗纤维蛋白溶解剂的多孔冷冻干燥的纤维蛋白基质，以及制备这种基质的方法。 特别有利于支持三维细胞生长的弹性基质，也称为海绵，从基本上不含纤溶酶原的血浆蛋白质或部分纯化的血浆蛋白质中获得，从而避免需要外源性抗纤维蛋白溶解剂。 此外，在形成基质期间掺入糖胺聚糖和生物活性剂可形成具有有利的生物，机械和物理性质的海绵。 本发明的组合物在临床上是有用的，没有细胞或作为携带细胞的植入物。

    Freeze-dried fibrin matrices and methods for preparation thereof
    5.
    发明授权
    Freeze-dried fibrin matrices and methods for preparation thereof 有权
    冻干纤维蛋白基质及其制备方法

    公开(公告)号：US08193317B2

    公开(公告)日：2012-06-05

    申请号：US12731356

    申请日：2010-03-25

    申请人： Avner Yayon ,  Malkit Azachi ,  Micha Gladnikoff

    发明人： Avner Yayon ,  Malkit Azachi ,  Micha Gladnikoff

    IPC分类号： A61K35/14

    CPC分类号： A61K9/0024 ,  A61F2/30756 ,  A61K9/2063 ,  A61K31/727 ,  A61K31/728 ,  A61K35/12 ,  A61K38/1825 ,  A61L27/225 ,  A61L27/3852 ,  A61L27/56 ,  C07K14/75 ,  C12N5/0068 ,  C12N5/0655 ,  C12N2533/56

    摘要： Methods for producing porous freeze-dried fibrin matrices substantially devoid of external anti-fibrinolytic agents. Resilient matrices, also known as sponges, that are particularly beneficial for supporting three dimensional cell growth are obtained from plasma proteins substantially devoid of plasminogen or from partially purified plasma proteins, thus obviating the need for exogenous anti-fibrinolytic agents. Furthermore, incorporation of glycosaminoglycans and bioactive agents during the formation of the matrix results in a sponge having advantageous biological, mechanical and physical properties. The compositions made by the method of the present invention are useful clinically or as cell-bearing implants.

    摘要翻译： 制备基本上不含外部抗纤维蛋白溶解剂的多孔冻干纤维蛋白基质的方法。 特别有利于支持三维细胞生长的弹性基质，也称为海绵，从基本上不含纤溶酶原的血浆蛋白质或部分纯化的血浆蛋白质中获得，从而避免需要外源性抗纤维蛋白溶解剂。 此外，在形成基质期间掺入糖胺聚糖和生物活性剂可形成具有有利的生物，机械和物理性质的海绵。 通过本发明的方法制备的组合物在临床上或作为细胞承载植入物是有用的。

    Freeze-dried fibrin matrices and methods for preparation thereof
    6.
    发明申请
    Freeze-dried fibrin matrices and methods for preparation thereof 有权
    冻干纤维蛋白基质及其制备方法

    公开(公告)号：US20060172008A1

    公开(公告)日：2006-08-03

    申请号：US11190387

    申请日：2005-07-26

    申请人： Avner Yayon ,  Malkit Azachi ,  Micha Gladnikoff

    发明人： Avner Yayon ,  Malkit Azachi ,  Micha Gladnikoff

    IPC分类号： A61K38/37 ,  A61K38/18 ,  A61K31/727 ,  A61K31/728 ,  A61K9/14

    CPC分类号： A61K9/0024 ,  A61F2/30756 ,  A61K9/2063 ,  A61K31/727 ,  A61K31/728 ,  A61K35/12 ,  A61K38/1825 ,  A61L27/225 ,  A61L27/3852 ,  A61L27/56 ,  C07K14/75 ,  C12N5/0068 ,  C12N5/0655 ,  C12N2533/56

    摘要： The present invention relates to porous freeze-dried fibrin matrices substantially devoid of external anti-fibrinolytic agents, and methods of producing such matrices. Resilient matrices, also known as sponges, that are particularly beneficial for supporting three dimensional cell growth are obtained from plasma proteins substantially devoid of plasminogen or from partially purified plasma proteins, thus obviating the need for exogenous anti-fibrinolytic agents. Furthermore, incorporation of glycosaminoglycans and bioactive agents during the formation of the matrix results in a sponge having advantageous biological, mechanical and physical properties. The compositions of the present invention are useful clinically, per se or as cell-bearing implants.

    摘要翻译： 本发明涉及基本上不含外部抗纤维蛋白溶解剂的多孔冷冻干燥的纤维蛋白基质，以及制备这种基质的方法。 特别有利于支持三维细胞生长的弹性基质，也称为海绵，从基本上不含纤溶酶原的血浆蛋白质或部分纯化的血浆蛋白质中获得，从而避免需要外源性抗纤维蛋白溶解剂。 此外，在形成基质期间掺入糖胺聚糖和生物活性剂可形成具有有利的生物，机械和物理性质的海绵。 本发明的组合物在临床上本身或作为细胞承载植入物是有用的。

    Removal of plasmin or plasminogen from cryoprecipitate
    9.
    发明授权
    Removal of plasmin or plasminogen from cryoprecipitate 有权
    从冷沉淀物中去除纤溶酶或纤溶酶原

    公开(公告)号：US08563288B2

    公开(公告)日：2013-10-22

    申请号：US12289499

    申请日：2008-10-29

    申请人： Israel Nur ,  Liliana Bar ,  Malkit Azachi

    发明人： Israel Nur ,  Liliana Bar ,  Malkit Azachi

    IPC分类号： C12N9/66 ,  A61K35/16

    CPC分类号： C12N9/6435 ,  C07K1/22 ,  C12Y304/21007

    摘要： A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6-8 Angstroms, preferably about 7 Angstroms apart and the rigid amino acid is covalently bound to the support via the amino group of the amino acid.

    摘要翻译： 一种通过使混合物与刚性氨基酸接触的方法，其特征在于从含有纤维蛋白溶酶（ogen）或纤溶酶的混合物中除去或分离纤维蛋白原（纤维蛋白原）存在下的纤维蛋白溶酶或纤溶酶，其中氨基酸和羧基的氨基 氨基酸约6-8埃，优选约7埃，刚性氨基酸通过氨基酸的氨基与载体共价结合。

    Removal of plasmin(ogen) from protein solutions
    10.
    发明申请
    Removal of plasmin(ogen) from protein solutions 有权
    从蛋白质溶液中去除纤溶酶（ogen）

    公开(公告)号：US20090176293A1

    公开(公告)日：2009-07-09

    申请号：US12289499

    申请日：2008-10-29

    申请人： Israel Nur ,  Liliana Bar ,  Malkit Azachi

    发明人： Israel Nur ,  Liliana Bar ,  Malkit Azachi

    IPC分类号： C12N9/68

    CPC分类号： C12N9/6435 ,  C07K1/22 ,  C12Y304/21007

    摘要： A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6-8 Angstroms, preferably about 7 Angstroms apart and the rigid amino acid is covalently bound to the support via the amino group of the amino acid.

    摘要翻译： 一种通过使混合物与刚性氨基酸接触的方法，其特征在于从含有纤维蛋白溶酶（ogen）或纤溶酶的混合物中除去或分离纤维蛋白原（纤维蛋白原）存在下的纤维蛋白溶酶或纤溶酶，其中氨基酸和羧基的氨基 氨基酸约6-8埃，优选约7埃，刚性氨基酸通过氨基酸的氨基与载体共价结合。