公开(公告)号：US20090087064A1

公开(公告)日：2009-04-02

申请号：US12243830

申请日：2008-10-01

申请人： Mladen Barbic ,  Axel Scherer

发明人： Mladen Barbic ,  Axel Scherer

IPC分类号： G06K9/00

CPC分类号： A61B6/504 ,  G01R33/3415 ,  G01R33/345 ,  G01R33/4824

摘要： Tomographic imaging using an imaging sensor that has a stripe-like shape is disclosed where a stripe sensor is mechanically scanned over a sample at different angles. For a single stripe detector imaging, linear motion and angular rotation are required. Single stripe sensor imaging may be performed using an elongated inductive coil detector. By utilizing an array of parallel stripe sensors that can be individually addressed, two-dimensional imaging can be performed with rotation only, eliminating the requirement for linear motion, e.g. with parallel coils array. Imaging with a stripe-type sensor of particular width and thickness (where width is much larger than thickness) is resolution limited only by the thickness (smaller parameter) of the sensor. Multiple sensor families can be produced where this imaging technique may be beneficial such as magneto-resistive, inductive, SQUID, and Hall effect sensors, and particularly in the field of magnetic resonance imaging (MRI).

摘要翻译： 公开了使用具有条状形状的成像传感器的层析成像，其中条纹传感器以不同的角度机械扫描样品。 对于单个条纹检测器成像，需要线性运动和角旋转。 可以使用细长的感应线圈检测器来执行单条纹传感器成像。 通过利用可以单独寻址的平行条纹传感器阵列，可以仅旋转执行二维成像，消除对线性运动的需求，例如， 具有并联线圈阵列。 具有特定宽度和厚度（宽度远大于厚度）的条纹型传感器的成像是仅由传感器的厚度（较小参数）限制的分辨率。 可以制造多个传感器系列，其中该成像技术可能是有益的，例如磁阻，感应，SQUID和霍尔效应传感器，特别是在磁共振成像（MRI）领域。

公开(公告)号：US06828786B2

公开(公告)日：2004-12-07

申请号：US10346811

申请日：2003-01-17

申请人： Axel Scherer ,  Mladen Barbic

发明人： Axel Scherer ,  Mladen Barbic

IPC分类号： G01V300

CPC分类号： G01R33/5604 ,  B82Y15/00 ,  G01R33/285

摘要： The invention combines (A) capabilities in fabrication, characterization, and manipulation of single domain magnetic nanostructures, with (B) the use of binding chemistry of biological molecules to modify the magnetic nanostructures into magnetic sensors and magnetically controllable nanoprobes. A biological characterization scheme is realized by combining nanomanipulation and observation of small magnetic structures in fluids. By coating nanomagnets with biological molecules, ultra-small, highly sensitive and robust biomagnetic devices are defined, and molecular electronics and spin electronics are combined. When these nano-sensors are integrated into microfluidic channels, highly efficient single-molecule detection chips for rapid diagnosis and analysis of biological agents are constructed.

摘要翻译： 本发明结合了（A）制造，表征和操纵单畴磁性纳米结构的能力，（B）使用生物分子的结合化学将磁性纳米结构改性为磁性传感器和磁性可控的纳米探针。 通过组合纳米操作和观察流体中的小磁性结构来实现生物表征方案。 通过用生物分子涂覆纳米磁体，定义了超小型，高灵敏度和鲁棒的生物磁性器件，并结合了分子电子学和自旋电子学。 当这些纳米传感器集成到微流体通道中时，构建了用于快速诊断和分析生物制剂的高效单分子检测芯片。

公开(公告)号：US08201765B2

公开(公告)日：2012-06-19

申请号：US12554817

申请日：2009-09-04

申请人： Aditya Rajagopal ,  Axel Scherer ,  Mladen Barbic

发明人： Aditya Rajagopal ,  Axel Scherer ,  Mladen Barbic

IPC分类号： B02C17/10

CPC分类号： C12N13/00 ,  C12M47/06 ,  C12N1/066

摘要： Methods and arrangements to lyse a biological sample are described. The arrangements comprise a lysis tube containing the sample, one or more electromagnets generating a magnetic field, and one or more permanent magnets inside the lysis tube. The permanent magnets move and lyse the sample when a magnetic field is generated by the electromagnets.

摘要翻译： 描述了裂解生物样品的方法和布置。 该装置包括含有样品的裂解管，产生磁场的一个或多个电磁体和裂解管内的一个或多个永磁体。 当电磁铁产生磁场时，永久磁铁移动并裂开样品。

公开(公告)号：US08170316B2

公开(公告)日：2012-05-01

申请号：US12243830

申请日：2008-10-01

申请人： Mladen Barbic ,  Axel Scherer

发明人： Mladen Barbic ,  Axel Scherer

IPC分类号： G06K9/00

CPC分类号： A61B6/504 ,  G01R33/3415 ,  G01R33/345 ,  G01R33/4824

摘要： Tomographic imaging using an imaging sensor that has a stripe-like shape is disclosed where a stripe sensor is mechanically scanned over a sample at different angles. For a single stripe detector imaging, linear motion and angular rotation are required. Single stripe sensor imaging may be performed using an elongated inductive coil detector. By utilizing an array of parallel stripe sensors that can be individually addressed, two-dimensional imaging can be performed with rotation only, eliminating the requirement for linear motion, e.g. with parallel coils array. Imaging with a stripe-type sensor of particular width and thickness (where width is much larger than thickness) is resolution limited only by the thickness (smaller parameter) of the sensor. Multiple sensor families can be produced where this imaging technique may be beneficial such as magneto-resistive, inductive, SQUID, and Hall effect sensors, and particularly in the field of magnetic resonance imaging (MRI).

摘要翻译： 公开了使用具有条状形状的成像传感器的层析成像，其中条纹传感器以不同的角度机械扫描样品。 对于单个条纹检测器成像，需要线性运动和角旋转。 可以使用细长的感应线圈检测器来执行单条纹传感器成像。 通过利用可以单独寻址的平行条纹传感器阵列，可以仅旋转执行二维成像，消除对线性运动的需求，例如， 具有并联线圈阵列。 具有特定宽度和厚度（宽度远大于厚度）的条纹型传感器的成像是仅由传感器的厚度（较小参数）限制的分辨率。 可以制造多个传感器系列，其中该成像技术可能是有益的，例如磁阻，感应，SQUID和霍尔效应传感器，特别是在磁共振成像（MRI）领域。

公开(公告)号：US20100068781A1

公开(公告)日：2010-03-18

申请号：US12554817

申请日：2009-09-04

申请人： Aditya Rajagopal ,  Axel Scherer ,  Mladen Barbic

发明人： Aditya Rajagopal ,  Axel Scherer ,  Mladen Barbic

IPC分类号： C12N13/00 ,  C12M1/42

CPC分类号： C12N13/00 ,  C12M47/06 ,  C12N1/066

摘要： Methods and arrangements to lyse a biological sample are described. The arrangements comprise a lysis tube containing the sample, one or more electromagnets generating a magnetic field, and one or more permanent magnets inside the lysis tube. The permanent magnets move and lyse the sample when a magnetic field is generated by the electromagnets.

摘要翻译： 描述了裂解生物样品的方法和布置。 该装置包括含有样品的裂解管，产生磁场的一个或多个电磁体和裂解管内的一个或多个永磁体。 当电磁铁产生磁场时，永久磁铁移动并裂开样品。

公开(公告)号：US08356763B2

公开(公告)日：2013-01-22

申请号：US13427672

申请日：2012-03-22

申请人： Aditya Rajagopal ,  Axel Scherer ,  Mladen Barbic

发明人： Aditya Rajagopal ,  Axel Scherer ,  Mladen Barbic

IPC分类号： B02C17/10

CPC分类号： C12N13/00 ,  C12M47/06 ,  C12N1/066

摘要： Methods and arrangements to lyse a biological sample are described. The arrangements comprise a lysis tube containing the sample, one or more electromagnets generating a magnetic field, and one or more permanent magnets inside the lysis tube. The permanent magnets move and lyse the sample when a magnetic field is generated by the electromagnets.

摘要翻译： 描述了裂解生物样品的方法和布置。 该装置包括含有样品的裂解管，产生磁场的一个或多个电磁体和裂解管内的一个或多个永磁体。 当电磁铁产生磁场时，永久磁铁移动并裂开样品。

公开(公告)号：US20070238971A1

公开(公告)日：2007-10-11

申请号：US11649643

申请日：2007-01-04

申请人： Mladen Barbic ,  Axel Scherer

发明人： Mladen Barbic ,  Axel Scherer

IPC分类号： G01V3/00

CPC分类号： G01R33/48 ,  G01R33/30 ,  G01R33/3808 ,  G01R33/383

摘要： Systems and methods for obtaining two- and three-dimensional magnetic resonance images by using azimuthally symmetric dipolar magnetic fields from magnetic spheres. A complete two- or three-dimensional structured rendering of a sample can be obtained without the motion of the sample relative to the sphere. Magnetic spheres in the range of 100 μm and 100 nm are used with samples that are approximately one-tenth as large as the magnetic sphere. Sequential positioning of the integrated sample-sphere system in an external magnetic field at various angular orientations provides all the required imaging slices for successful computerized tomographic image reconstruction. The requirement to scan the sample relative to the magnetic tip is eliminated. Resolutions approaching atomic dimensions are expected to be obtained.

摘要翻译： 通过使用磁球的方位角对称偶极磁场获得二维和三维磁共振图像的系统和方法。 可以获得样品的完整的二维或三维结构渲染，而不需要样品相对于球体的运动。 使用范围为100um和100nm的磁性球体，其尺寸约为磁性球体的十分之一。 集成样品球系统在各种角度取向的外部磁场中的顺序定位为成功的计算机断层图像重建提供了所有所需的成像切片。 消除了相对于磁头扫描样品的要求。 预计将获得接近原子尺寸的分辨率。

公开(公告)号：US20090092509A1

公开(公告)日：2009-04-09

申请号：US12229975

申请日：2008-08-28

申请人： Mladen Barbic ,  Jack J. Mock ,  Andrew P. Gray

发明人： Mladen Barbic ,  Jack J. Mock ,  Andrew P. Gray

IPC分类号： F04B17/03 ,  B25J15/02 ,  H02K1/14

CPC分类号： B01F13/0818 ,  B01F13/0059 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2400/0475 ,  B01L2400/0633 ,  G01N2035/1034

摘要： Apparatus and method for manipulating particles on a micro- or nano-scale. An embodiment of the present invention includes a magnetic micro-manipulation technique that utilizes micro-coils and soft magnetic microscopic wires for localized manipulation of particles. Another embodiment of the present invention uses magneto-static interaction between two magnetic microscopic wires to mechanically manipulate particles. Yet another embodiment of the present invention combines a magnetic particle with a magnetic manipulator or other device for generating magnetic fields to operate as a micro-fluidic micro-motor. Other embodiments of the present invention employ a magnetic separation system employing porous membranes partially filled with magnetic wires.

摘要翻译： 用于在微尺度或纳米尺度上操纵颗粒的装置和方法。 本发明的一个实施例包括利用微线圈和软磁微细线来微粒化的局部操纵的磁微操作技术。 本发明的另一个实施例使用两个磁性微细线之间的静电相互作用来机械地操纵颗粒。 本发明的另一个实施例将磁性颗粒与磁性机械手或其他用于产生磁场的装置组合起来以作为微流体微型电动机运行。 本发明的其他实施例采用使用部分填充有磁性线的多孔膜的磁选机。

公开(公告)号：US06980004B2

公开(公告)日：2005-12-27

申请号：US10976559

申请日：2004-10-29

申请人： Mladen Barbic

发明人： Mladen Barbic

IPC分类号： G01R20060101 ,  G01V3/00

CPC分类号： G01R33/3808 ,  G01R33/341 ,  G01R33/381 ,  G01R33/421

摘要： A magnetic-resonance imaging system including a magnetic-resonance sensor including at least one magneto-resistive element; and a sample disposed adjacent to the magnetic-resonance sensor and configurable to generate a magnetic-resonance signal, wherein the magneto-resistive element is configured to generate a magnetic field in response to a current driven through the magneto-resistive element, the magnetic field being configured to polarize spins of the sample, and detect a magnetic-resonance signal from precession of the spins.

摘要翻译： 一种磁共振成像系统，包括包含至少一个磁阻元件的磁共振传感器; 以及与所述磁共振传感器相邻设置的并且可配置为产生磁共振信号的样本，其中所述磁阻元件被配置为响应于驱动通过所述磁阻元件的电流产生磁场，所述磁场 被配置为偏振样品的旋转，并且检测来自旋转进动的磁共振信号。

公开(公告)号：US20050275494A1

公开(公告)日：2005-12-15

申请号：US11137853

申请日：2005-05-24

申请人： Morteza Gharib ,  Derek Rinderknecht ,  Mladen Barbic

发明人： Morteza Gharib ,  Derek Rinderknecht ,  Mladen Barbic

IPC分类号： F04B19/00 ,  F04B43/04 ,  F04B43/12 ,  H02K7/09 ,  H02K7/14 ,  H02K41/03

CPC分类号： H02K41/031 ,  A61M2205/0244 ,  F04B19/006 ,  F04B43/043 ,  F04B43/12 ,  H02K7/14 ,  H02K33/16 ,  H02K99/20

摘要： An electromagnetic actuator for a microfluidic pump of the type that causes periodic pinching and releasing against the walls of a fluidic channel, e.g., a tube. At least one permanent magnet is placed against the walls of the fluidic channel, and located in an area with magnetic fields, produced by coils that are radially symmetric to the channel. The permanent magnet is cause to press and release against the wall of the fluid channel to cause a fluid flow through the channel.

摘要翻译： 用于微流体泵的电磁致动器，其导致周期性地夹持和释放抵靠流体通道（例如管）的壁。 至少一个永磁体被放置在流体通道的壁上，并且位于具有与通道径向对称的线圈产生的具有磁场的区域中。 导致永久磁铁压迫和释放流体通道的壁，使流体流过通道。