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    Mechanical lysis arrangements and methods
    1.
    发明授权
    Mechanical lysis arrangements and methods 有权
    机械裂解布置和方法

    公开(公告)号：US08201765B2

    公开(公告)日：2012-06-19

    申请号：US12554817

    申请日：2009-09-04

    申请人： Aditya Rajagopal ,  Axel Scherer ,  Mladen Barbic

    发明人： Aditya Rajagopal ,  Axel Scherer ,  Mladen Barbic

    IPC分类号： B02C17/10

    CPC分类号： C12N13/00 ,  C12M47/06 ,  C12N1/066

    摘要： Methods and arrangements to lyse a biological sample are described. The arrangements comprise a lysis tube containing the sample, one or more electromagnets generating a magnetic field, and one or more permanent magnets inside the lysis tube. The permanent magnets move and lyse the sample when a magnetic field is generated by the electromagnets.

    摘要翻译： 描述了裂解生物样品的方法和布置。 该装置包括含有样品的裂解管，产生磁场的一个或多个电磁体和裂解管内的一个或多个永磁体。 当电磁铁产生磁场时，永久磁铁移动并裂开样品。

    Mechanical lysis arrangements and methods
    2.
    发明授权
    Mechanical lysis arrangements and methods 有权
    机械裂解布置和方法

    公开(公告)号：US08356763B2

    公开(公告)日：2013-01-22

    申请号：US13427672

    申请日：2012-03-22

    申请人： Aditya Rajagopal ,  Axel Scherer ,  Mladen Barbic

    发明人： Aditya Rajagopal ,  Axel Scherer ,  Mladen Barbic

    IPC分类号： B02C17/10

    CPC分类号： C12N13/00 ,  C12M47/06 ,  C12N1/066

    摘要： Methods and arrangements to lyse a biological sample are described. The arrangements comprise a lysis tube containing the sample, one or more electromagnets generating a magnetic field, and one or more permanent magnets inside the lysis tube. The permanent magnets move and lyse the sample when a magnetic field is generated by the electromagnets.

    摘要翻译： 描述了裂解生物样品的方法和布置。 该装置包括含有样品的裂解管，产生磁场的一个或多个电磁体和裂解管内的一个或多个永磁体。 当电磁铁产生磁场时，永久磁铁移动并裂开样品。

    MECHANICAL LYSIS ARRANGEMENTS AND METHODS
    3.
    发明申请
    MECHANICAL LYSIS ARRANGEMENTS AND METHODS 有权
    机械灵敏度安排和方法

    公开(公告)号：US20100068781A1

    公开(公告)日：2010-03-18

    申请号：US12554817

    申请日：2009-09-04

    申请人： Aditya Rajagopal ,  Axel Scherer ,  Mladen Barbic

    发明人： Aditya Rajagopal ,  Axel Scherer ,  Mladen Barbic

    IPC分类号： C12N13/00 ,  C12M1/42

    CPC分类号： C12N13/00 ,  C12M47/06 ,  C12N1/066

    摘要： Methods and arrangements to lyse a biological sample are described. The arrangements comprise a lysis tube containing the sample, one or more electromagnets generating a magnetic field, and one or more permanent magnets inside the lysis tube. The permanent magnets move and lyse the sample when a magnetic field is generated by the electromagnets.

    摘要翻译： 描述了裂解生物样品的方法和布置。 该装置包括含有样品的裂解管，产生磁场的一个或多个电磁体和裂解管内的一个或多个永磁体。 当电磁铁产生磁场时，永久磁铁移动并裂开样品。

    TOMOGRAPHIC IMAGING WITH A STRIPE-LIKE SHAPED SENSOR
    4.
    发明申请
    TOMOGRAPHIC IMAGING WITH A STRIPE-LIKE SHAPED SENSOR 有权
    带条状形状传感器的图像成像

    公开(公告)号：US20090087064A1

    公开(公告)日：2009-04-02

    申请号：US12243830

    申请日：2008-10-01

    申请人： Mladen Barbic ,  Axel Scherer

    发明人： Mladen Barbic ,  Axel Scherer

    IPC分类号： G06K9/00

    CPC分类号： A61B6/504 ,  G01R33/3415 ,  G01R33/345 ,  G01R33/4824

    摘要： Tomographic imaging using an imaging sensor that has a stripe-like shape is disclosed where a stripe sensor is mechanically scanned over a sample at different angles. For a single stripe detector imaging, linear motion and angular rotation are required. Single stripe sensor imaging may be performed using an elongated inductive coil detector. By utilizing an array of parallel stripe sensors that can be individually addressed, two-dimensional imaging can be performed with rotation only, eliminating the requirement for linear motion, e.g. with parallel coils array. Imaging with a stripe-type sensor of particular width and thickness (where width is much larger than thickness) is resolution limited only by the thickness (smaller parameter) of the sensor. Multiple sensor families can be produced where this imaging technique may be beneficial such as magneto-resistive, inductive, SQUID, and Hall effect sensors, and particularly in the field of magnetic resonance imaging (MRI).

    摘要翻译： 公开了使用具有条状形状的成像传感器的层析成像，其中条纹传感器以不同的角度机械扫描样品。 对于单个条纹检测器成像，需要线性运动和角旋转。 可以使用细长的感应线圈检测器来执行单条纹传感器成像。 通过利用可以单独寻址的平行条纹传感器阵列，可以仅旋转执行二维成像，消除对线性运动的需求，例如， 具有并联线圈阵列。 具有特定宽度和厚度（宽度远大于厚度）的条纹型传感器的成像是仅由传感器的厚度（较小参数）限制的分辨率。 可以制造多个传感器系列，其中该成像技术可能是有益的，例如磁阻，感应，SQUID和霍尔效应传感器，特别是在磁共振成像（MRI）领域。

    Method and apparatus for nanomagnetic manipulation and sensing
    5.
    发明授权
    Method and apparatus for nanomagnetic manipulation and sensing 失效
    用于纳米磁操纵和感测的方法和装置

    公开(公告)号：US06828786B2

    公开(公告)日：2004-12-07

    申请号：US10346811

    申请日：2003-01-17

    申请人： Axel Scherer ,  Mladen Barbic

    发明人： Axel Scherer ,  Mladen Barbic

    IPC分类号： G01V300

    CPC分类号： G01R33/5604 ,  B82Y15/00 ,  G01R33/285

    摘要： The invention combines (A) capabilities in fabrication, characterization, and manipulation of single domain magnetic nanostructures, with (B) the use of binding chemistry of biological molecules to modify the magnetic nanostructures into magnetic sensors and magnetically controllable nanoprobes. A biological characterization scheme is realized by combining nanomanipulation and observation of small magnetic structures in fluids. By coating nanomagnets with biological molecules, ultra-small, highly sensitive and robust biomagnetic devices are defined, and molecular electronics and spin electronics are combined. When these nano-sensors are integrated into microfluidic channels, highly efficient single-molecule detection chips for rapid diagnosis and analysis of biological agents are constructed.

    摘要翻译： 本发明结合了（A）制造，表征和操纵单畴磁性纳米结构的能力，（B）使用生物分子的结合化学将磁性纳米结构改性为磁性传感器和磁性可控的纳米探针。 通过组合纳米操作和观察流体中的小磁性结构来实现生物表征方案。 通过用生物分子涂覆纳米磁体，定义了超小型，高灵敏度和鲁棒的生物磁性器件，并结合了分子电子学和自旋电子学。 当这些纳米传感器集成到微流体通道中时，构建了用于快速诊断和分析生物制剂的高效单分子检测芯片。

    Apparatus and method for two-and three-dimensional magnetic resonance imaging using ferromagnetic spheres
    6.
    发明申请
    Apparatus and method for two-and three-dimensional magnetic resonance imaging using ferromagnetic spheres 审中-公开
    使用铁磁球的二维和三维磁共振成像的装置和方法

    公开(公告)号：US20070238971A1

    公开(公告)日：2007-10-11

    申请号：US11649643

    申请日：2007-01-04

    申请人： Mladen Barbic ,  Axel Scherer

    发明人： Mladen Barbic ,  Axel Scherer

    IPC分类号： G01V3/00

    CPC分类号： G01R33/48 ,  G01R33/30 ,  G01R33/3808 ,  G01R33/383

    摘要： Systems and methods for obtaining two- and three-dimensional magnetic resonance images by using azimuthally symmetric dipolar magnetic fields from magnetic spheres. A complete two- or three-dimensional structured rendering of a sample can be obtained without the motion of the sample relative to the sphere. Magnetic spheres in the range of 100 μm and 100 nm are used with samples that are approximately one-tenth as large as the magnetic sphere. Sequential positioning of the integrated sample-sphere system in an external magnetic field at various angular orientations provides all the required imaging slices for successful computerized tomographic image reconstruction. The requirement to scan the sample relative to the magnetic tip is eliminated. Resolutions approaching atomic dimensions are expected to be obtained.

    摘要翻译： 通过使用磁球的方位角对称偶极磁场获得二维和三维磁共振图像的系统和方法。 可以获得样品的完整的二维或三维结构渲染，而不需要样品相对于球体的运动。 使用范围为100um和100nm的磁性球体，其尺寸约为磁性球体的十分之一。 集成样品球系统在各种角度取向的外部磁场中的顺序定位为成功的计算机断层图像重建提供了所有所需的成像切片。 消除了相对于磁头扫描样品的要求。 预计将获得接近原子尺寸的分辨率。

    Tomographic imaging with a stripe-like shaped sensor
    7.
    发明授权
    Tomographic imaging with a stripe-like shaped sensor 有权
    具有条纹状传感器的断层成像

    公开(公告)号：US08170316B2

    公开(公告)日：2012-05-01

    申请号：US12243830

    申请日：2008-10-01

    申请人： Mladen Barbic ,  Axel Scherer

    发明人： Mladen Barbic ,  Axel Scherer

    IPC分类号： G06K9/00

    CPC分类号： A61B6/504 ,  G01R33/3415 ,  G01R33/345 ,  G01R33/4824

    摘要： Tomographic imaging using an imaging sensor that has a stripe-like shape is disclosed where a stripe sensor is mechanically scanned over a sample at different angles. For a single stripe detector imaging, linear motion and angular rotation are required. Single stripe sensor imaging may be performed using an elongated inductive coil detector. By utilizing an array of parallel stripe sensors that can be individually addressed, two-dimensional imaging can be performed with rotation only, eliminating the requirement for linear motion, e.g. with parallel coils array. Imaging with a stripe-type sensor of particular width and thickness (where width is much larger than thickness) is resolution limited only by the thickness (smaller parameter) of the sensor. Multiple sensor families can be produced where this imaging technique may be beneficial such as magneto-resistive, inductive, SQUID, and Hall effect sensors, and particularly in the field of magnetic resonance imaging (MRI).

    摘要翻译： 公开了使用具有条状形状的成像传感器的层析成像，其中条纹传感器以不同的角度机械扫描样品。 对于单个条纹检测器成像，需要线性运动和角旋转。 可以使用细长的感应线圈检测器来执行单条纹传感器成像。 通过利用可以单独寻址的平行条纹传感器阵列，可以仅旋转执行二维成像，消除对线性运动的需求，例如， 具有并联线圈阵列。 具有特定宽度和厚度（宽度远大于厚度）的条纹型传感器的成像是仅由传感器的厚度（较小参数）限制的分辨率。 可以制造多个传感器系列，其中该成像技术可能是有益的，例如磁阻，感应，SQUID和霍尔效应传感器，特别是在磁共振成像（MRI）领域。