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公开(公告)号：US09331113B2
公开(公告)日：2016-05-03
申请号：US13695267
申请日：2011-04-25
申请人： Aydogan Ozcan , Ahmet F. Coskun , Ikbal Sencan , Ting-Wei Su
发明人： Aydogan Ozcan , Ahmet F. Coskun , Ikbal Sencan , Ting-Wei Su
IPC分类号： G01J1/04 , H01J3/14 , H01L27/00 , H01L27/146 , G01N21/64
CPC分类号： H01L27/14625 , G01N21/64 , G01N21/6456 , G01N21/648 , G01N2021/6471 , G01N2021/6482 , G01N2021/6484 , G01N2201/0833
摘要： An imaging device uses a fiber optic faceplate (FOF) with a compressive sampling algorithm for the fluorescent imaging of a sample over an large field-of-view without the need for any lenses or mechanical scanning. The imaging device includes a sample holder configured to hold a sample and a prism or hemispherical glass surface disposed adjacent the sample holder on a side opposite the lower surface of the sample holder. A light source is configured to illuminate the sample via the prism or the hemispherical surface, wherein substantially all of the light is subject to total internal reflection at the lower surface of the sample holder. The FOF is disposed adjacent to the lower surface of the sample holder, the fiber optic array having an input side and an output side. The device includes an imaging sensor array disposed adjacent to the output side of the fiber optic array.
摘要翻译： 成像装置使用具有压缩采样算法的光纤面板（FOF），用于在大视野范围内的样品的荧光成像，而不需要任何透镜或机械扫描。 成像装置包括：样本保持器，其被配置为保持样本和邻近样本保持器设置在与样本保持器的下表面相对的一侧的棱镜或半球形玻璃表面。 光源被配置为经由棱镜或半球形表面照射样品，其中基本上所有的光在样品保持器的下表面处受到全内反射。 FOF设置在样品架的下表面附近，光纤阵列具有输入侧和输出侧。 该装置包括邻近光纤阵列的输出侧设置的成像传感器阵列。
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公开(公告)号：US20130092821A1
公开(公告)日：2013-04-18
申请号：US13695267
申请日：2011-04-25
申请人： Aydogan Ozcan , Ahmet F. Coskun , Ikbal Sencan , Ting-Wei Su
发明人： Aydogan Ozcan , Ahmet F. Coskun , Ikbal Sencan , Ting-Wei Su
IPC分类号： H01L27/146 , G01N21/64
CPC分类号： H01L27/14625 , G01N21/64 , G01N21/6456 , G01N21/648 , G01N2021/6471 , G01N2021/6482 , G01N2021/6484 , G01N2201/0833
摘要： An imaging device uses a fiber optic faceplate (FOF) with a compressive sampling algorithm for the fluorescent imaging of a sample over an large field-of-view without the need for any lenses or mechanical scanning. The imaging device includes a sample holder configured to hold a sample and a prism or hemispherical glass surface disposed adjacent the sample holder on a side opposite the lower surface of the sample holder. A light source is configured to illuminate the sample via the prism or the hemispherical surface, wherein substantially all of the light is subject to total internal reflection at the lower surface of the sample holder. The FOF is disposed adjacent to the lower surface of the sample holder, the fiber optic array having an input side and an output side. The device includes an imaging sensor array disposed adjacent to the output side of the fiber optic array.
摘要翻译： 成像装置使用具有压缩采样算法的光纤面板（FOF），用于在大视野范围内的样品的荧光成像，而不需要任何透镜或机械扫描。 成像装置包括：样本保持器，其被配置为保持样本和邻近样本保持器设置在与样本保持器的下表面相对的一侧的棱镜或半球形玻璃表面。 光源被配置为经由棱镜或半球形表面照射样品，其中基本上所有的光在样品保持器的下表面处受到全内反射。 FOF设置在样品架的下表面附近，光纤阵列具有输入侧和输出侧。 该装置包括邻近光纤阵列的输出侧设置的成像传感器阵列。
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3.发明申请COMPACT AUTOMATED SEMEN ANALYSIS PLATFORM USING LENS-FREE ON-CHIP MICROSCOPY 有权使用无镜头芯片显微镜的精简自动化分析平台公开(公告)号：US20120148141A1
公开(公告)日：2012-06-14
申请号：US13324941
申请日：2011-12-13
申请人： Aydogan Ozcan , Anthony F. Erlinger , Ting-Wei Su
发明人： Aydogan Ozcan , Anthony F. Erlinger , Ting-Wei Su
IPC分类号： G06K9/46
CPC分类号： G06K9/00127 , G01N15/1429 , G01N15/1434 , G01N15/1463 , G01N2015/1006 , G01N2015/1075 , G01N2015/1454 , G03H1/0443 , G03H2001/0447 , G03H2001/0816 , G03H2001/0825 , G03H2001/2655 , G06K9/0014 , G06T7/0012 , G06T2207/10016 , G06T2207/10056 , G06T2207/30242
摘要： A compact and light-weight lens-free platform to conduct automated semen analysis is disclosed. The device employs holographic on-chip imaging and does not require any lenses, lasers or other bulky optical components to achieve phase and amplitude imaging of sperm a relatively large field-of-view with an effective numerical aperture of approximately 0.2. A series of digital image frames is obtained of the sample. Digital subtraction of the consecutive lens-free frames, followed by processing of the reconstructed phase images, enables automated quantification of the count, the speed and the dynamic trajectories of motile sperm, while summation of the same frames permits counting of immotile sperm.
摘要翻译： 公开了一种紧凑且重量轻的无镜头自由精液分析平台。 该器件采用全息片上成像技术，并且不需要任何透镜，激光器或其他庞大的光学部件来实现具有大约0.2的有效数值孔径的相对较大的视野的精子的相位和振幅成像。 获得样品的一系列数字图像帧。 连续无镜头帧的数字减法，然后处理重建的相位图像，能够自动量化运动精子的计数，速度和动态轨迹，同时相同帧的总和允许计数无精子精子。
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4.发明授权Compact automated semen analysis platform using lens-free on-chip microscopy 有权紧凑型自动精液分析平台，采用无镜头芯片显微镜公开(公告)号：US08842901B2
公开(公告)日：2014-09-23
申请号：US13324941
申请日：2011-12-13
申请人： Aydogan Ozcan , Anthony F. Erlinger , Ting-Wei Su
发明人： Aydogan Ozcan , Anthony F. Erlinger , Ting-Wei Su
CPC分类号： G06K9/00127 , G01N15/1429 , G01N15/1434 , G01N15/1463 , G01N2015/1006 , G01N2015/1075 , G01N2015/1454 , G03H1/0443 , G03H2001/0447 , G03H2001/0816 , G03H2001/0825 , G03H2001/2655 , G06K9/0014 , G06T7/0012 , G06T2207/10016 , G06T2207/10056 , G06T2207/30242
摘要： A compact and light-weight lens-free platform to conduct automated semen analysis is disclosed. The device employs holographic on-chip imaging and does not require any lenses, lasers or other bulky optical components to achieve phase and amplitude imaging of sperm a relatively large field-of-view with an effective numerical aperture of approximately 0.2. A series of digital image frames is obtained of the sample. Digital subtraction of the consecutive lens-free frames, followed by processing of the reconstructed phase images, enables automated quantification of the count, the speed and the dynamic trajectories of motile sperm, while summation of the same frames permits counting of immotile sperm.
摘要翻译： 公开了一种紧凑且重量轻的无镜头自由精液分析平台。 该器件采用全息片上成像技术，并且不需要任何透镜，激光器或其他庞大的光学部件来实现具有大约0.2的有效数值孔径的相对较大的视野的精子的相位和振幅成像。 获得样品的一系列数字图像帧。 连续无镜头帧的数字减法，然后处理重建的相位图像，能够自动量化运动精子的计数，速度和动态轨迹，同时相同帧的总和允许计数无精子精子。
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公开(公告)号：US08244086B2
公开(公告)日：2012-08-14
申请号：US13187930
申请日：2011-07-21
IPC分类号： G02B6/42
CPC分类号： G02B6/02328 , G02B6/02052 , G02B6/02304 , G02B6/02347 , G02B6/02376 , G02B6/2552
摘要： An optical device and methods of using an optical device are provided. The optical device includes a hollow-core fiber including a first portion and a second portion. The first portion includes a hollow core having a first diameter. The second portion includes a hollow core having a second diameter smaller than the first diameter. The difference between the first diameter and the second diameter is less than 10% of the first diameter.
摘要翻译： 提供了光学装置和使用光学装置的方法。 光学装置包括中空纤维，其包括第一部分和第二部分。 第一部分包括具有第一直径的中空芯。 第二部分包括具有小于第一直径的第二直径的中空芯。 第一直径和第二直径之间的差小于第一直径的10％。
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公开(公告)号：US07746480B2
公开(公告)日：2010-06-29
申请号：US12343449
申请日：2008-12-23
IPC分类号： G01B9/02
CPC分类号： G02B6/0208 , G01M11/3145 , G01M11/3172 , G02B2006/02166
摘要： An apparatus characterizes at least one fiber Bragg grating. The apparatus includes a laser pulse source, an optical spectrum analyzer, and multiple optical paths. A first optical path includes a pulse stretcher and an attenuator. A second optical path optically coupled to the first optical path includes a mirror. A third optical path optically coupled to the first optical path includes a first fiber Bragg grating. A fourth optical path is optically coupled to the second optical path, the third optical path, and the optical spectrum analyzer. A fifth optical path optically coupled to the laser pulse source and the optical spectrum analyzer includes a delay line.
摘要翻译： 一种装置表征至少一个光纤布拉格光栅。 该装置包括激光脉冲源，光谱分析仪和多个光路。 第一光路包括脉冲展宽器和衰减器。 光耦合到第一光路的第二光路包括反射镜。 光学耦合到第一光路的第三光路包括第一光纤布拉格光栅。 第四光路光耦合到第二光路，第三光路和光谱分析仪。 光耦合到激光脉冲源和光谱分析仪的第五光路包括延迟线。
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公开(公告)号：US20090207414A1
公开(公告)日：2009-08-20
申请号：US12372225
申请日：2009-02-17
CPC分类号： A61B5/0066 , A61B5/0073 , A61B5/7257 , G01B9/02044 , G01B9/02083 , G01B9/02091 , G01N21/4795
摘要： An apparatus is provided for measuring a frequency-domain optical coherence tomography power spectrum from a sample. The apparatus includes a broadband light source, an optical spectrum analyzer, and a partially reflective element optically coupled to the light source, to the optical spectrum analyzer, and to the sample. A first portion of light from the light source is reflected by the partially reflective element and propagates to the optical spectrum analyzer. A second portion of light from the light source propagating through the partially reflective element, impinging the sample, reflecting from the sample, and propagating to the optical spectrum analyzer.
摘要翻译： 提供了一种用于从样本测量频域光学相干断层摄影功率谱的装置。 该装置包括宽带光源，光谱分析仪和与光源光耦合到光谱分析仪和样品的部分反射元件。 来自光源的光的第一部分被部分反射元件反射并传播到光谱分析仪。 来自光源的光的第二部分传播通过部分反射元件，撞击样品，从样品反射并传播到光谱分析仪。
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公开(公告)号：US20090207401A1
公开(公告)日：2009-08-20
申请号：US12343449
申请日：2008-12-23
IPC分类号： G01N21/00
CPC分类号： G02B6/0208 , G01M11/3145 , G01M11/3172 , G02B2006/02166
摘要： An apparatus characterizes at least one fiber Bragg grating. The apparatus includes a laser pulse source, an optical spectrum analyzer, and multiple optical paths. A first optical path includes a pulse stretcher and an attenuator. A second optical path optically coupled to the first optical path includes a mirror. A third optical path optically coupled to the first optical path includes a first fiber Bragg grating. A fourth optical path is optically coupled to the second optical path, the third optical path, and the optical spectrum analyzer. A fifth optical path optically coupled to the laser pulse source and the optical spectrum analyzer includes a delay line.
摘要翻译： 一种装置表征至少一个光纤布拉格光栅。 该装置包括激光脉冲源，光谱分析仪和多个光路。 第一光路包括脉冲展宽器和衰减器。 光耦合到第一光路的第二光路包括反射镜。 光学耦合到第一光路的第三光路包括第一光纤布拉格光栅。 第四光路光耦合到第二光路，第三光路和光谱分析仪。 光耦合到激光脉冲源和光谱分析仪的第五光路包括延迟线。
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9.发明授权Method for determining the complex scattering function of an optical coherence tomography sample 有权用于确定光学相干断层摄影样本的复散射函数的方法公开(公告)号：US07493227B2
公开(公告)日：2009-02-17
申请号：US11384170
申请日：2006-03-17
CPC分类号： A61B5/0066 , A61B5/0073 , A61B5/7257 , G01B9/02044 , G01B9/02083 , G01B9/02091 , G01N21/4795
摘要： A method determines the complex scattering function of a portion of a sample under analysis. The method includes providing a magnitude spectrum of a complex spatial Fourier transform of a complex intermediate function. The complex intermediate function is dependent on the complex scattering function of the sample. The magnitude spectrum is obtained from power spectrum data of frequency-domain optical coherence tomography of the sample. The method further includes providing an estimated phase term of the complex spatial Fourier transform. The method further includes multiplying the magnitude spectrum and the estimated phase term together to generate an estimated complex spatial Fourier transform. The method further includes calculating an inverse Fourier transform of the estimated complex spatial Fourier transform. The method further includes calculating an estimated intermediate function by applying at least one constraint to the inverse Fourier transform of the estimated complex spatial Fourier transform.
摘要翻译： 一种方法确定了一部分样品在分析中的复散射函数。 该方法包括提供复杂中间函数的复数空间傅里叶变换的幅度谱。 复杂的中间函数取决于样品的复散射函数。 幅度谱是从样本的频域光学相干断层扫描的功率谱数据获得的。 该方法还包括提供复数空间傅里叶变换的估计相位项。 该方法还包括将幅度谱和估计的相位项相乘以产生估计的复数空间傅里叶变换。 该方法还包括计算估计的复数空间傅立叶变换的逆傅里叶变换。 该方法还包括通过对估计的复数空间傅里叶变换的傅立叶逆变换应用至少一个约束来计算估计的中间函数。
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公开(公告)号：US07480034B2
公开(公告)日：2009-01-20
申请号：US12116871
申请日：2008-05-07
IPC分类号： G01N21/00
CPC分类号： G02B6/0208 , G01M11/3145 , G01M11/3172 , G02B2006/02166
摘要： An apparatus characterizes at least one fiber Bragg grating. The apparatus includes a laser pulse source, an optical spectrum analyzer, and multiple optical paths. A first optical path includes a pulse stretcher and an attenuator. A second optical path optically coupled to the first optical path includes a mirror. A third optical path optically coupled to the first optical path includes a first fiber Bragg grating. A fourth optical path is optically coupled to the second optical path, the third optical path, and the optical spectrum analyzer. A fifth optical path optically coupled to the laser pulse source and the optical spectrum analyzer includes a delay line.
摘要翻译： 一种装置表征至少一个光纤布拉格光栅。 该装置包括激光脉冲源，光谱分析仪和多个光路。 第一光路包括脉冲展宽器和衰减器。 光耦合到第一光路的第二光路包括反射镜。 光耦合到第一光路的第三光路包括第一光纤布拉格光栅。 第四光路光耦合到第二光路，第三光路和光谱分析仪。 光耦合到激光脉冲源和光谱分析仪的第五光路包括延迟线。
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