公开(公告)号：US20070072846A1

公开(公告)日：2007-03-29

申请号：US10576689

申请日：2004-10-22

申请人： B. Vishnuvajjala ,  Paul Liu ,  Kenneth Snader ,  David Thurston ,  Philip Howard ,  Luke Hsiao ,  Gregory Turner

发明人： B. Vishnuvajjala ,  Paul Liu ,  Kenneth Snader ,  David Thurston ,  Philip Howard ,  Luke Hsiao ,  Gregory Turner

IPC分类号： A61K31/551 ,  C07D487/04

CPC分类号： C07D487/04

摘要： Disclosed are compounds of Formula (I) wherein X, Y, Ri-R7,T1, T2, Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula (I) and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula (I); a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula (I); a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula (I); and a method of preparing a compound of Formula (I) as described herein.

摘要翻译： 公开了式（I）的化合物，其中X，Y，R 1 -R 7，T 1，T 2，Z和p是 如本文所述; 包含式（I）化合物和载体的药物组合物; 抑制细胞生长的方法，该方法包括以有效抑制生长的量施用式（I）化合物; 一种治疗哺乳动物癌症的方法，该方法包括以有效治疗癌症的量施用式（I）化合物; 治疗细胞的病毒，寄生或细菌感染的方法，所述方法包括以有效治疗病毒，寄生或细菌感染的量施用式（I）化合物; 和制备本文所述的式（I）化合物的方法。

公开(公告)号：US20080039448A1

公开(公告)日：2008-02-14

申请号：US11336623

申请日：2006-01-20

申请人： Paul Liu ,  B. Vishnuvajjala ,  Kenneth Snader ,  David Thurston ,  Philip Howard ,  Stephen Gregson

发明人： Paul Liu ,  B. Vishnuvajjala ,  Kenneth Snader ,  David Thurston ,  Philip Howard ,  Stephen Gregson

IPC分类号： A61K31/5517 ,  A61P43/00 ,  C07D487/04

CPC分类号： C07D487/04

摘要： A compound of formula I: or solvate thereof, wherein n is 1 to 10, and M and M′ are independently selected from monovalent pharmaceutically acceptable cations, or together represent a divalent pharmaceutically acceptable cation.

摘要翻译： 式I化合物或其溶剂化物，其中n为1-10，M和M'独立地选自一价药学上可接受的阳离子，或一起代表二价药学上可接受的阳离子。

公开(公告)号：US20060270661A1

公开(公告)日：2006-11-30

申请号：US11129207

申请日：2005-05-13

申请人： Paul Liu ,  B. Vishnuvajjala ,  Kenneth Snader ,  David Thurston ,  Philip Howard ,  Stephen Gregson

发明人： Paul Liu ,  B. Vishnuvajjala ,  Kenneth Snader ,  David Thurston ,  Philip Howard ,  Stephen Gregson

IPC分类号： A61K31/551 ,  C07D487/04

CPC分类号： C07D487/04

摘要： A compound of formula I: or solvate thereof, wherein n is 1 to 10, and M and M′ are independently selected from monovalent pharmaceutically acceptable cations, or together represent a divalent pharmaceutically acceptable cation.

摘要翻译： 式I化合物或其溶剂化物，其中n为1-10，M和M'独立地选自一价药学上可接受的阳离子，或一起代表二价药学上可接受的阳离子。

公开(公告)号：US20100073554A1

公开(公告)日：2010-03-25

申请号：US12272789

申请日：2008-11-18

申请人： Paul Liu

发明人： Paul Liu

IPC分类号： H04N5/225

CPC分类号： G03B15/03

摘要： A digital image acquiring and transforming apparatus is provided. The digital image acquiring and transforming apparatus is adapted for acquiring and transforming images of stereoscopic and plane objects. The digital image acquiring and transforming apparatus includes a housing, a compensatory light source, an image acquiring unit and a rotatable plate. The housing is designed to have a semi-closed configuration. The rotatable plate is pivotally coupled to an unclosed end of the housing. Facilitated by the rotatable plate, the housing can achieve an entirely closed configuration. The image acquiring unit is disposed inside the housing and opposite to the rotatable plate. The compensatory light source is disposed inside the housing. The compensatory light source and the image acquiring unit, in combination, are adapted for effectively acquiring an image of an object disposed on the rotatable plate, and transforming the image into a digital file for saving.

摘要翻译： 提供了数字图像获取和变换装置。 数字图像获取和变换装置适于获取和变换立体和平面物体的图像。 数字图像获取和变换装置包括壳体，补偿光源，图像获取单元和可旋转板。 外壳设计为具有半封闭配置。 可旋转板枢转地联接到壳体的未闭合的端部。 通过可旋转板促进，壳体可以实现完全关闭的构造。 图像获取单元设置在壳体内并与可旋转板相对。 补偿光源设置在壳体内。 补偿光源和图像获取单元组合地适于有效地获取设置在可旋转板上的物体的图像，并且将图像转换成数字文件以进行保存。

公开(公告)号：US06304072B1

公开(公告)日：2001-10-16

申请号：US09492815

申请日：2000-01-28

申请人： Paul Liu

发明人： Paul Liu

IPC分类号： G01R516

CPC分类号： G01R7/06 ,  G01D11/16

摘要： A pointer resetting mechanism for a magnet disc operated gauge mainly adapted for use in vehicles is made up of a coil spring particularly housed together with a floatable magnet disc for protection in a sealed shelter case and at least an auxiliary magnet received in one of a tubular columns in a lower case of the shelter case. The spring has one end fixed to a pointer shaft and the other end secured to a retaining means disposed on the case. Around the sealed shelter case is wrapped around induction copper wires. When an electric current appears in the copper wires, the magnet disc floating in damping oil is forced by induced magnetism to rotate in the shelter case and when the electric current is removed the pointer can be automatically reset by way of the mechanical biasing force of the coil spring. Furthermore, the auxiliary magnet is used to make the pointer operate more stable at its initial position at where the coil spring can not produce enough tension to firmly hold the pointer in position. When the pointer is moved within or over a half circle range, the coil spring is extended in such a manner that it will produce larger tension to hold the pointer, the auxiliary magnet can constantly help the pointer to overcome the tension by attracting the magnet disc to spin clockwisely. When the pointer moves back to its initial position, the auxiliary magnet can also exert force on the magnet disc so as to help the pointer move smoothly backwards.

摘要翻译： 用于主要适用于车辆的磁盘操作量规的指针复位机构由特别容纳在一起的可旋转磁盘用于保护在密封防护罩中的螺旋弹簧和至少一个容纳在管状 列在小箱子的收容箱中。 弹簧的一端固定在指针轴上，另一端固定在设置在壳体上的保持装置上。 在密封的避风箱周围缠绕感应铜线。 当铜线中出现电流时，浮动在阻尼油中的磁盘被感应磁力强迫在遮蔽箱内转动，当电流消失时，指针可以通过机械偏置力自动复位 螺旋弹簧 此外，辅助磁体用于使指针在其初始位置更稳定，其中螺旋弹簧不能产生足够的张力以将指针牢固地保持在适当位置。 当指针在半圆范围内移动或超过半圆范围时，螺旋弹簧以这样的方式延伸，使得它将产生较大的张力来保持指示器，辅助磁体可以不断地帮助指针克服张力，通过吸引磁盘 顺时针旋转。 当指针回到其初始位置时，辅助磁体也可以对磁盘施加力，以帮助指针顺利地向后移动。

公开(公告)号：US5443551A

公开(公告)日：1995-08-22

申请号：US229785

申请日：1994-04-19

申请人： Paul Liu

发明人： Paul Liu

IPC分类号： G01L9/00 ,  G01L9/02 ,  G01L27/00

CPC分类号： G01L9/0057

摘要： A wiper actuating mechanism for use in an oil pressure measuring gague is equipped with an additional auxiliary spring plate and a push rod guide sleeve in addition to an improved two-arm wiper and a round diaphram board which is provided with a vertical flange on the periphery thereof for confining a rubber packing in place. The two-arm wiper can assure constant contact of the wiper with two sides of a winding board on which a resistive wire is attached; and the push rod guide sleeve can retain a slidable push rod in place which is not welded to the diaphram board and to move linearly so as to precisely pivot the two-arm wiper; the auxiliary spring plate disposed right under the diaphram board is also intended to reinforce the operation of the diaphram.

摘要翻译： 用于油压测量装置的刮水器执行机构除了改进的双臂刮水器和圆形双层板之外还配备有附加的辅助弹簧板和推杆导向套筒，该双层刮板和外围板在周边上设有垂直凸缘 用于限制橡胶包装到位。 双臂刮水器可以确保擦拭器与缠绕板的两侧连接的电阻丝的连续接触; 并且推杆引导套筒可以将可滑动的推杆保持在适当位置，该推杆未焊接到双层板并且线性移动，以便精确地枢转双臂刮水器; 设置在隔板下方的辅助弹簧板也用于加强堤坝的操作。

公开(公告)号：US20190102757A1

公开(公告)日：2019-04-04

申请号：US15719818

申请日：2017-09-29

申请人： Paul Liu

发明人： Paul Liu

IPC分类号： G06Q20/06 ,  G06Q20/36

摘要： A method of constructing scalable blockchain by using KanBan to update off-chain transactions' statesA KanBan is a collection of data or data-tables managed as in memory database to maintain live states of a blockchain's off-chain transactions or off-chain accounts, it runs in a blockchain node computer or a separate computer connects to blockchain node, it resides either in computer's normal memory or GPU memory.In a blockchain system, usually transactions are collected by blockchain nodes and included in a block to lock by consensus, however, due to consensus protocol as well as node computer's performance and network bandwidth limit, a blockchain system usually has low transaction process ability, for example, Bitcoin blockchain can process no more than 7 transactions per second only.The so called off-chain transaction is a transaction that is not submitted to main blockchain only hold in local system temporarily until final submitting.Off-chain transactions can be very large volume, two participants can perform multiple transactions back and forth before submitting to main blockchain for settlement, update and maintain accurate states in a global decentralized way for every off-chain account or address is important for banning double spend.KanBan is dedicated for this purpose, when an off-chain transaction happens, it is sent to all KanBan nodes immediately, so that states of participants accounts or addresses are updated immediately in the blockchain wide.With KanBan feature, a blockchain eco-system consists of main blockchain and localized nodes or side-chains in a unified value system can perform giant amount of transactions in a safe, reliable way, it enables a blockchain system to achieve great scalability.

公开(公告)号：US09031861B1

公开(公告)日：2015-05-12

申请号：US13242772

申请日：2011-09-23

申请人： Lili Liu ,  Chao Cai ,  Paul Liu ,  Sissie Ling-le Hsiao ,  Karl Pfleger

发明人： Lili Liu ,  Chao Cai ,  Paul Liu ,  Sissie Ling-le Hsiao ,  Karl Pfleger

IPC分类号： G06Q30/00 ,  G06Q30/02

CPC分类号： G06Q30/0205

摘要： Methods, systems, and computer program products are provided for measuring effectiveness of content items included in a campaign. One example method includes providing a corpus of campaigns, where a campaign defines parameters for presentation that specify circumstances under which content items are presented to users in response to requests. The corpus is filtered by identifying one or more candidate campaigns, where each of the identified candidate campaigns is associated with a geographic region and includes one or more constraints that permit pausing distribution of content items without compromising campaign goals. For each candidate campaign, one or more experimental geographic locations included in the geographic region are determined that are substantially representative of the region. Presentation of at least one of the content items is paused for a time period, and content item effectiveness is measured by comparing resource conversions for experimental and control geographic locations.

摘要翻译： 提供了方法，系统和计算机程序产品，用于衡量活动中包含的内容项目的有效性。 一种示例性方法包括提供广告系列语料库，其中活动定义用于呈现的参数，其指定响应于请求将内容项呈现给用户的情况。 通过识别一个或多个候选活动来筛选语料库，其中每个所识别的候选活动与地理区域相关联，并且包括允许在不影响活动目标的情况下暂停分配内容项目的一个或多个约束。 对于每个候选活动，确定包括在地理区域中的一个或多个实验地理位置，其基本上代表该区域。 至少一个内容项的呈现暂停一段时间，通过比较实验和控制地理位置的资源转换来测量内容项有效性。

公开(公告)号：USD596964S1

公开(公告)日：2009-07-28

申请号：US29324116

申请日：2008-09-05

申请人： Steven Wang ,  Paul Liu ,  Gary Yang ,  Levi Geadelmann ,  Daniel Sullivan

设计人： Steven Wang ,  Paul Liu ,  Gary Yang ,  Levi Geadelmann ,  Daniel Sullivan

公开(公告)号：US5152170A

公开(公告)日：1992-10-06

申请号：US780499

申请日：1991-10-22

申请人： Paul Liu

发明人： Paul Liu

IPC分类号： G01F23/32 ,  G01F23/36

CPC分类号： G01F23/36 ,  G01F23/32

摘要： An universal fuel measuring device including an adjusting stem and an adjusting block having a sensor; the adjusting stem is formed with reinforcing grooves on its two sides and a slot at its middle portion; the adjusting block is connected with the adjusting stem and movable along the slot thereof; the sensor has a slide seat connected with a rod member; one end of the rod member is fitted with a float, whereby the adjusting block can slide along the slot of the adjusting stem to provide various specifications to suit any types of fuel tanks, and the reinforcing grooves of the adjusting stem strengthen the same to prevent the same from being distorted by vibration of a car or rushing fuel flow supplied from a fuel gun.

摘要翻译： 一种通用燃料测量装置，包括调节杆和具有传感器的调节块; 调节杆在其两侧形成有加强槽，在其中间部分形成有槽; 所述调节块与所述调节杆连接并且可沿着所述调节杆移动; 传感器具有与杆构件连接的滑动座; 杆构件的一端装有浮子，由此调节块可以沿调节杆的槽滑动，以提供适合任何类型的燃料箱的各种规格，并且调节杆的加强槽加强以防止 同样的，由于汽车的振动或从燃料枪供应的冲燃燃料流而变形。