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公开(公告)号：US07723352B2
公开(公告)日：2010-05-25
申请号：US10571870
申请日：2004-09-17
申请人： B. Wesley Trotter , Christopher Claiborne , Gerald S. Ponticello , Charles J. McIntyre , Nigel Liverton , David A. Claremon
发明人： B. Wesley Trotter , Christopher Claiborne , Gerald S. Ponticello , Charles J. McIntyre , Nigel Liverton , David A. Claremon
IPC分类号： C07D471/02 , A61K31/47
CPC分类号： C07D217/24 , C07D455/04 , C07D471/04
摘要： The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
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公开(公告)号：US08338449B2
公开(公告)日：2012-12-25
申请号：US12753572
申请日：2010-04-02
申请人： B. Wesley Trotter , Christopher Claiborne , Gerald S. Ponticello , Charles J. McIntyre , Nigel Liverton , David A. Claremon
发明人： B. Wesley Trotter , Christopher Claiborne , Gerald S. Ponticello , Charles J. McIntyre , Nigel Liverton , David A. Claremon
IPC分类号： C07D471/02 , A61K31/47
CPC分类号： C07D217/24 , C07D455/04 , C07D471/04
摘要： The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
摘要翻译： 本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构的化合物等。
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公开(公告)号：US20100256698A1
公开(公告)日：2010-10-07
申请号：US12753572
申请日：2010-04-02
申请人： B. Wesley Trotter , Christopher Claiborne , Gerald S. Ponticello , Charles J. McIntyre , Nigel Liverton , David A. Claremon
发明人： B. Wesley Trotter , Christopher Claiborne , Gerald S. Ponticello , Charles J. McIntyre , Nigel Liverton , David A. Claremon
IPC分类号： A61N1/36 , C07D217/24 , A61K31/4745 , A61K31/4704 , A61K31/70 , A61K31/616 , A61K31/727 , A61K31/4365 , A61P9/00
CPC分类号： C07D217/24 , C07D455/04 , C07D471/04
摘要： The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
摘要翻译： 本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构的化合物等。
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公开(公告)号：US20070149568A1
公开(公告)日：2007-06-28
申请号：US10559153
申请日：2004-03-10
IPC分类号： A61K31/445 , A61K31/40
CPC分类号： C07D401/12 , C07D417/12
摘要： Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are effective as NMD NR2B antagonists useful for treating conditions such as, for example, Parkinson's disease, Alzheimer's disease, migraine, epilepsy and pain.
摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐作为可用于治疗诸如帕金森病，阿尔茨海默氏病，偏头痛，癫痫和疼痛的病症的NMD NR2B拮抗剂是有效的。
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公开(公告)号：US20070027177A1
公开(公告)日：2007-02-01
申请号：US10571870
申请日：2004-09-17
申请人： B. Trotter , Christopher Claiborne , Gerald Ponticello , Charles McIntyre , Nigel Liverton , David Claremon
发明人： B. Trotter , Christopher Claiborne , Gerald Ponticello , Charles McIntyre , Nigel Liverton , David Claremon
IPC分类号： A61K31/4741 , A61K31/4704 , C07D217/22
CPC分类号： C07D217/24 , C07D455/04 , C07D471/04
摘要： The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
摘要翻译： 本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构（I）的化合物等。
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公开(公告)号：US20110249999A1
公开(公告)日：2011-10-13
申请号：US12798569
申请日：2010-04-07
申请人： Andrew Boer , Christopher Claiborne
发明人： Andrew Boer , Christopher Claiborne
IPC分类号： B41J5/00
CPC分类号： G06F3/0219 , G06F3/0235
摘要： An apparatus and layout for manual text entry on a small form factor information processing device provides a keyboard for data entry located on the back side of the device, opposite the side of the device facing the user. The keyboard assembly is further laid out as a split of the layout of the conventional standard form factor keyboard adapted to touch-typing, enabling users to employ touch-typing expertise acquired on standard keyboards on the small form-factor device.
摘要翻译： 在小尺寸信息处理装置上的用于手动文本输入的装置和布局提供了一种键盘，用于位于设备背面的数据输入，与面向用户的设备相对。 键盘组件进一步布置成适于触摸打字的常规标准形状因子键盘的布局，使得用户能够在小尺寸设备上采用在标准键盘上获得的触摸式专业技术。
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7.发明申请Pyridobenzazepine compounds and methods for inhibiting mitotic progression 有权吡啶并苯并吖嗪化合物和抑制有丝分裂进展的方法公开(公告)号：US20080045501A1
公开(公告)日：2008-02-21
申请号：US11890406
申请日：2007-08-06
IPC分类号： A61K31/55 , A61P35/00 , C07D471/04
CPC分类号： C07D471/04
摘要： This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
摘要翻译： 本发明涉及治疗癌症的化合物和方法。 特别地，本发明提供抑制极光激酶的化合物，包含该化合物的药物组合物，以及使用该化合物治疗癌症的方法。
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公开(公告)号：US20080051404A1
公开(公告)日：2008-02-28
申请号：US11890338
申请日：2007-08-06
申请人： Christopher Claiborne , Stephen Critchley , Courtney Cullis , Steven Langston , Hiro Mizutani , Edward Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel Weatherhead
发明人： Christopher Claiborne , Stephen Critchley , Courtney Cullis , Steven Langston , Hiro Mizutani , Edward Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel Weatherhead
IPC分类号： C07D473/32 , A61K31/44 , A61K31/4965 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/53 , C12N9/99 , A61P35/00 , A61P37/00 , C07D211/92 , C07D239/24 , C07D251/48
CPC分类号： C07D239/42 , A61K31/53 , C07D213/56 , C07D213/69 , C07D213/74 , C07D213/81 , C07D213/82 , C07D239/36 , C07D239/48 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D471/08 , C07D473/30 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
摘要翻译： 本发明涉及抑制E1活化酶的化合物，包含该化合物的药物组合物和使用该化合物的方法。 该化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎症和神经变性疾病; 和与感染和恶病质相关的炎症。
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公开(公告)号：US20060100194A1
公开(公告)日：2006-05-11
申请号：US11242413
申请日：2005-10-03
申请人： Christopher Blackburn , Christopher Claiborne , Courtney Cullis , Natalie Dales , Michael Patane , Matthew Stirling , Omar Stradella , Gabriel Weatherhead
发明人： Christopher Blackburn , Christopher Claiborne , Courtney Cullis , Natalie Dales , Michael Patane , Matthew Stirling , Omar Stradella , Gabriel Weatherhead
IPC分类号： A61K31/554 , A61K31/55 , C07D498/02
CPC分类号： C07D491/14 , C07D471/14 , C07D487/04 , C07D495/14
摘要： The present invention provides novel compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
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公开(公告)号：US20050256102A1
公开(公告)日：2005-11-17
申请号：US11127855
申请日：2005-05-12
申请人： Christopher Claiborne , Lloyd Payne , Richard Boyce , Todd Sells , Stephen Stroud , Stuart Travers , Tricia Vos , Gabriel Weatherhead
发明人： Christopher Claiborne , Lloyd Payne , Richard Boyce , Todd Sells , Stephen Stroud , Stuart Travers , Tricia Vos , Gabriel Weatherhead
IPC分类号： A61K31/55 , C07D487/00 , C07D487/04 , C07D487/14 , C07D491/14 , C07D495/14 , C07D498/14 , C07D513/14 , C07D519/00
CPC分类号： C07D487/04 , C07D487/14 , C07D491/14 , C07D495/14 , C07D513/14
摘要： This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
摘要翻译： 本发明涉及治疗癌症的化合物和方法。 特别地，本发明提供抑制极光激酶的化合物，包含该化合物的药物组合物，以及使用该化合物治疗癌症的方法。
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