公开(公告)号：US11959077B2

公开(公告)日：2024-04-16

申请号：US16418515

申请日：2019-05-21

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： Rachel R. Spurbeck ,  Richard Mon Che Chou ,  Anthony D. Duong

IPC: C12N15/10 ,  C12N15/113 ,  C12Q1/6869 ,  C12Q1/6876

CPC classification number: C12N15/1089 ,  C12N15/113 ,  C12Q1/6869 ,  C12Q1/6876 ,  C12Q2563/185 ,  C12Q2600/166

Abstract: The invention relates to control compositions for sequencing and for chemical analyses, such as analytical chemistry analyses. More particularly, the invention relates to control compositions for sequencing and for chemical analyses having at least one barcode sequence fragment and at least one universal sequence fragment, and to methods of their use.

公开(公告)号：US11702653B2

公开(公告)日：2023-07-18

申请号：US16418521

申请日：2019-05-21

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： Rachel R. Spurbeck ,  Richard Mon Che Chou ,  Anthony D. Duong

IPC: C12N15/10 ,  C12N15/113 ,  C12Q1/6869 ,  C12Q1/6876

CPC classification number: C12N15/1089 ,  C12N15/113 ,  C12Q1/6869 ,  C12Q1/6876 ,  C12Q2563/185 ,  C12Q2600/166

Abstract: The invention relates to control compositions for sequencing and for chemical analyses, such as analytical chemistry analyses. More particularly, the invention relates to control compositions for sequencing and for chemical analyses having at least one barcode sequence fragment and at least one universal sequence fragment, and to methods of their use.

公开(公告)号：US11441176B2

公开(公告)日：2022-09-13

申请号：US16714125

申请日：2019-12-13

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： Rachel R. Spurbeck

IPC: C12Q1/6851 ,  C12Q1/6818 ,  C12Q1/6823 ,  C12Q1/686

Abstract: The invention relates to control compositions for a quantitative polymerase chain reaction. More particularly, the invention relates to control compositions for a quantitative polymerase chain reaction having at least one barcode sequence fragment and at least a first and a second primer binding site fragment, and to methods of their use.

公开(公告)号：US20210350877A1

公开(公告)日：2021-11-11

申请号：US17313707

申请日：2021-05-06

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： Rachel R. Spurbeck ,  Christopher Johnson ,  Jacob Lilly ,  Jared M. Schuetter ,  Patrick H. Wilson

IPC: G16B50/00 ,  G16B25/00 ,  C12Q1/70 ,  B01L3/00 ,  B01L3/02 ,  B01L7/00 ,  A61F13/38 ,  G01N33/18 ,  G01N21/78 ,  G16H10/40 ,  G16H50/20

Abstract: A point of care device, comprises a chamber configured to contain a swab. Once a swab is loaded, the device introduces a buffer into the chamber, then lyses cells collected by the swab. Probes such as padlock probes target a specified content such as a virus (e.g., SARS-CoV-2 RNA) and will bind, splint ligate, and rapidly isothermally amplify (e.g., using rolling circle amplification). Also described is a wastewater pathogen tracking dashboard and schema for detecting and tracking pathogen spread within communities by monitoring microbial and viral RNA.