公开(公告)号：US09376417B2

公开(公告)日：2016-06-28

申请号：US14686886

申请日：2015-04-15

Applicant: BAYER INTELLECTUAL PROPERTY GMBH

Inventor： Thomas Himmler ,  Lukas J. Goossen ,  Felix Rudolphi ,  Bingrui Song

IPC: C07D333/24 ,  C07C67/343 ,  C07C319/20 ,  C07C253/30 ,  C07C201/12

CPC classification number: C07D333/24 ,  C07C67/343 ,  C07C201/12 ,  C07C253/30 ,  C07C319/20 ,  C07C255/57 ,  C07C323/62 ,  C07C205/56 ,  C07C69/612 ,  C07C69/734 ,  C07C69/616 ,  C07C69/738 ,  C07C69/65 ,  C07C69/76 ,  C07C323/52

Abstract: The invention relates to a process for preparing aryl- and heteroarylacetic acids and derivatives thereof by reaction of aryl or heteroaryl halides with malonic diesters in the presence of a palladium catalyst, of one or more bases and optionally of a phase transfer catalyst. This process enables the preparation of a multitude of functionalized aryl- and heteroarylacetic acids and derivatives thereof, especially also the preparation of arylacetic acids with sterically demanding substituents.