公开(公告)号：US09376417B2

公开(公告)日：2016-06-28

申请号：US14686886

申请日：2015-04-15

Applicant: BAYER INTELLECTUAL PROPERTY GMBH

Inventor： Thomas Himmler ,  Lukas J. Goossen ,  Felix Rudolphi ,  Bingrui Song

IPC: C07D333/24 ,  C07C67/343 ,  C07C319/20 ,  C07C253/30 ,  C07C201/12

CPC classification number: C07D333/24 ,  C07C67/343 ,  C07C201/12 ,  C07C253/30 ,  C07C319/20 ,  C07C255/57 ,  C07C323/62 ,  C07C205/56 ,  C07C69/612 ,  C07C69/734 ,  C07C69/616 ,  C07C69/738 ,  C07C69/65 ,  C07C69/76 ,  C07C323/52

Abstract: The invention relates to a process for preparing aryl- and heteroarylacetic acids and derivatives thereof by reaction of aryl or heteroaryl halides with malonic diesters in the presence of a palladium catalyst, of one or more bases and optionally of a phase transfer catalyst. This process enables the preparation of a multitude of functionalized aryl- and heteroarylacetic acids and derivatives thereof, especially also the preparation of arylacetic acids with sterically demanding substituents.

公开(公告)号：US09272997B2

公开(公告)日：2016-03-01

申请号：US14472754

申请日：2014-08-29

Applicant: Bayer Intellectual Property GmbH

Inventor： Reiner Fischer ,  Thomas Himmler

IPC: C07D209/54 ,  C07D207/36 ,  C07D491/107 ,  C07D491/113 ,  C07C235/74 ,  C07C255/46 ,  C07D307/22 ,  C07D317/72

CPC classification number: C07D207/36 ,  C07C235/74 ,  C07C255/46 ,  C07D209/54 ,  C07D307/22 ,  C07D317/72 ,  C07D491/107 ,  C07D491/113

Abstract: The present invention relates to a novel process for the preparation of 1-H-pyrrolidine-2,4-dione derivatives and to novel intermediates and to a process for their preparation.

Abstract translation: 本发明涉及一种制备1 H-吡咯烷-2,4-二酮衍生物和新型中间体的新方法及其制备方法。

公开(公告)号：US20140256956A1

公开(公告)日：2014-09-11

申请号：US14350893

申请日：2012-10-10

Applicant: BAYER INTELLECTUAL PROPERTY GMBH

Inventor： Thomas Himmler ,  Thomas Geller ,  Lars Rodefeld ,  Frank Volz

IPC: C07D495/14 ,  C07D207/46 ,  C07D207/456

CPC classification number: C07D495/14 ,  C07D207/456 ,  C07D207/46 ,  C07D495/04

Abstract: The present invention relates to a new process for preparing dithiine-tetracarboximides.

Abstract translation: 本发明涉及一种制备二硫代四甲酰亚胺的新方法。

公开(公告)号：US09365586B2

公开(公告)日：2016-06-14

申请号：US14385648

申请日：2013-03-18

Applicant: BAYER CROPSCIENCE AG ,  BAYER INTELLECTUAL PROPERTY GMBH

Inventor： Thomas Himmler ,  Thomas Geller ,  Lars Rodefeld ,  Mark James Ford ,  Guenter Hoemberger ,  Dieter Heinz

IPC: C07D495/14

CPC classification number: C07D495/14

Abstract: The present invention relates to a process for preparing dithiinetetracarboximides by reaction of succinic monoamides with thionyl chloride, with continuous performance of at least one of the process steps.

Abstract translation: 本发明涉及通过琥珀酰单酰胺与亚硫酰氯的反应制备二硫代四羧酰亚胺的方法，连续地进行至少一个工艺步骤。

公开(公告)号：US09969717B2

公开(公告)日：2018-05-15

申请号：US15493087

申请日：2017-04-20

Applicant: BAYER INTELLECTUAL PROPERTY GMBH

Inventor： Thomas Himmler ,  Sergii Pazenok ,  Frank Volz ,  Norbert Lui

IPC: C07D401/00 ,  C07D401/14

CPC classification number: C07D401/14 ,  C07C253/30 ,  C07C255/60

Abstract: The present invention relates to a process for preparing substituted anthranilic acid derivatives of the formula (I) in which R1, R2, R3 and R4 are each as defined in the description, by conversion of compounds of the general formula (IV) in the presence of a palladium catalyst and carbon monoxide. The present invention likewise relates to compounds of the general formula (IV).

公开(公告)号：US09670182B2

公开(公告)日：2017-06-06

申请号：US14924889

申请日：2015-10-28

Applicant: BAYER INTELLECTUAL PROPERTY GMBH

Inventor： Thomas Himmler ,  Sergii Pazenok ,  Frank Volz ,  Norbert Lui

IPC: C07D401/00 ,  C07D401/14 ,  C07C255/60 ,  C07C253/30

CPC classification number: C07D401/14 ,  C07C253/30 ,  C07C255/60

Abstract: The present invention relates to a process for preparing substituted anthranilic acid derivatives of the formula (I) in which R1, R2, R3 and R4 are each as defined in the description, by conversion of compounds of the general formula (IV) in the presence of a palladium catalyst and carbon monoxide. The present invention likewise relates to compounds of the general formula (IV).

公开(公告)号：US20150011772A1

公开(公告)日：2015-01-08

申请号：US14375496

申请日：2013-02-06

Applicant: BAYER INTELLECTUAL PROPERTY GMBH

Inventor： Thomas Himmler ,  Sergii Pazenok ,  Frank Volz ,  Norbert Lui

IPC: C07C253/30 ,  C07D401/14 ,  C07C255/60

CPC classification number: C07D401/14 ,  C07C253/30 ,  C07C255/60

Abstract: The present invention relates to a process for preparing substituted anthranilic acid derivatives of the formula (I) in which R1, R2, R3 and R4 are each as defined in the description, by conversion of compounds of the general formula (IV) in the presence of a palladium catalyst and carbon monoxide. The present invention likewise relates to compounds of the general formula (IV).

Abstract translation: 本发明涉及一种制备式（I）的取代的邻氨基苯甲酸衍生物的方法，其中R 1，R 2，R 3和R 4各自如说明书中所定义，通过在存在下转化通式（Ⅳ）的化合物 的钯催化剂和一氧化碳。 本发明同样涉及通式（IV）的化合物。