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公开(公告)号：US09505786B2
公开(公告)日：2016-11-29
申请号：US14738148
申请日：2015-06-12
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Dieter Lang , Frank Wunder , Walter Hübsch , Alexandros Vakalopoulos , Adrian Tersteegen
IPC分类号： C07D471/04 , A61K31/53 , A61P9/10 , A61P9/12 , A61P7/02 , C07D519/00 , A61K31/519 , A61K45/06
CPC分类号： C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06 , C07D471/04
摘要： The present application relates to novel substituted fused pyrimidines and triazines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的稠合嘧啶和三嗪，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于生产药物用于治疗和/或预防 疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US09095582B2
公开(公告)日：2015-08-04
申请号：US13893344
申请日：2013-05-14
发明人： Peter Nell , Walter Hübsch , Barbara Albrecht-Küpper , Jorg Keldenich , Alexandros Vakalopoulos , Frank Süssmeier , Katja Zimmermann , Dieter Lang , Daniel Meibom
IPC分类号： C07D413/14 , A61K31/443 , A61K31/4439 , C07D413/12 , C07D419/14 , A61K31/695 , A61K45/06 , C07F7/10
CPC分类号： A61K31/4439 , A61K31/695 , A61K45/06 , C07D413/12 , C07D413/14 , C07D419/14 , C07F7/10
摘要： The present application relates to novel substituted aryloxazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular and metabolic disorders.
摘要翻译： 本申请涉及新型取代的芳氧唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ /或预防心血管和代谢紊乱。
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3.发明授权公开(公告)号：US09714242B2
公开(公告)日：2017-07-25
申请号：US14299750
申请日：2014-06-09
发明人： Timo Fleβner , Frank-Gerhard Böβ , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Dieter Lang , Joachim Luithle , Marja Van Kampen , Franz-Josef Van Der Staay
IPC分类号： C07D453/02
CPC分类号： C07D453/02
摘要： The invention relates to novel benzothiophene-, benzofuran-, and indole ureas and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning, and/or memory.
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公开(公告)号：US09023849B2
公开(公告)日：2015-05-05
申请号：US13736692
申请日：2013-01-08
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Dieter Lang , Frank Wunder , Holger Paulsen , Walter Hübsch , Alexandros Vakalopoulos , Adrian Tersteegen
IPC分类号： A61K31/5365 , C07D253/00 , C07D487/04 , C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06
CPC分类号： C07D487/04 , A61K31/519 , A61K31/53 , A61K45/06 , C07D519/00 , A61K2300/00
摘要： The present application relates to novel substituted fused imidazoles and pyrazoles, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof producing medicaments for the treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新颖的取代的稠合咪唑和吡唑，其制备方法，单独或组合用于治疗和/或预防疾病及其用于治疗和/或预防的药物的用途 的疾病，特别是用于治疗和/或预防心血管疾病。
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5.发明申请AZABICYCLIC CARBAMATES AND THEIR USE AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS 有权异丁烯酸碳酸酯及其作为ALPHA-7 NICOTINIC乙酰胆碱受体激动剂公开(公告)号：US20150065537A1
公开(公告)日：2015-03-05
申请号：US14299750
申请日：2014-06-09
发明人： Timo Flessner , Frank-Gerhard Boss , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Dieter Lang , Joachim Luithle , Marja Van Kampen , Franz-Josef Van Der Staay
IPC分类号： C07D453/02
CPC分类号： C07D453/02
摘要： The invention relates to novel benzothiophene-, benzofuran-, and indole ureas and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning, and/or memory.
摘要翻译： 本发明涉及新的苯并噻吩 - ，苯并呋喃和吲哚脲，以及其用于制备用于治疗和/或预防疾病和改善感知，集中，学习和/或记忆的药物的用途。
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公开(公告)号：US09498480B2
公开(公告)日：2016-11-22
申请号：US14382746
申请日：2013-03-05
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Alexandros Vakalopoulos , Dieter Lang , Frank Wunder , Walter Hübsch , Michael Hahn
IPC分类号： A61K31/519 , C07D487/04 , A61K31/522 , A61K45/06 , C07D519/00
CPC分类号： A61K31/519 , A61K31/522 , A61K45/06 , C07D487/04 , C07D519/00
摘要： The present application relates to novel substituted azabicycles, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的氮杂双环，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于制备用于治疗和/或预防疾病的药物的用途 特别用于治疗和/或预防心血管疾病。
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7.发明授权公开(公告)号：US10196388B2
公开(公告)日：2019-02-05
申请号：US15624227
申请日：2017-06-15
发明人： Timo Fleβner , Frank-Gerhard Böβ , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Dieter Lang , Joachim Luithle , Marja Van Kampen , Franz-Josef Van Der Staay
IPC分类号： C07D453/02
摘要： The invention relates to novel benzothiophene-, benzofuran-, and indole ureas and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning, and/or memory.
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8.发明授权Substituted triazine derivatives and use thereof as stimulators of soluble guanylate cyclase 有权取代的三嗪衍生物和其可用作可溶性鸟苷酸环化酶的刺激剂公开(公告)号：US09133191B2
公开(公告)日：2015-09-15
申请号：US14371054
申请日：2013-01-08
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Frank Wunder , Dieter Lang
IPC分类号： C07D471/04 , A61K31/53 , A61K45/06
CPC分类号： C07D471/04 , A61K31/53 , A61K45/06
摘要： The present application relates to novel substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的稠合嘧啶，其制备方法，其单独使用或组合用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途， 特别是用于治疗和/或预防心血管疾病。
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9.发明申请SUBSTITUTED TRIAZINE DERIVATIVES AND USE THEREOF AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE 有权取代的TRIAZINE衍生物及其作为可溶性葡萄糖循环的刺激物的用途公开(公告)号：US20150094308A1
公开(公告)日：2015-04-02
申请号：US14371054
申请日：2013-01-08
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Frank Wunder , Dieter Lang
IPC分类号： C07D471/04 , A61K45/06 , A61K31/53
CPC分类号： C07D471/04 , A61K31/53 , A61K45/06
摘要： The present application relates to novel substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的稠合嘧啶，其制备方法，其单独使用或组合用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途， 特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20150025090A1
公开(公告)日：2015-01-22
申请号：US14382746
申请日：2013-03-05
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Alexandros Vakalopoulos , Dieter Lang , Frank Wunder , Walter Hübsch , Michael Hahn
IPC分类号： A61K31/519 , A61K45/06 , A61K31/522 , C07D519/00
CPC分类号： A61K31/519 , A61K31/522 , A61K45/06 , C07D487/04 , C07D519/00
摘要： The present application relates to novel substituted azabicycles, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的氮杂双环，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于制备用于治疗和/或预防疾病的药物的用途 特别用于治疗和/或预防心血管疾病。
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