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公开(公告)号：US20210317128A1
公开(公告)日：2021-10-14
申请号：US16759262
申请日：2018-10-18
发明人： Marcus KOPPITZ , Holger SIEBENEICHER , Nico BRÄUER , Elisabeth POOK , Andrea ROTGERI , Roland NEUHAUS , Oliver Martin FISCHER , Jens NAGEL , Adam James DAVENPORT , James Lindsay CARR , Robert James TOWNSEND , Nina CONNELLY URSINYOVA , Shelley Anne PARROTT
IPC分类号： C07D487/14
摘要： The present invention covers substituted. Pyrazolo-pyrrolo-pyrimidine-dione (PPPD) compounds of general formula (I): in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neurogenic diseases, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20180148418A1
公开(公告)日：2018-05-31
申请号：US15571414
申请日：2016-05-02
发明人： Knut EIS , Jens ACKERSTAFF , Sarah WAGNER , Philipp BUCHGRABER , Detlev SÜLZLE , Simon HOLTON , Eckhard BENDER , Volkhart LI , Ningshu LIU , Franziska SIEGEL , Philip LIENAU , Michaela BAIRLEIN , Franz VON NUSSBAUM , Simon Anthony HERBERT , Marcus KOPPITZ
IPC分类号： C07D233/90 , C07D495/10 , A61P35/04 , C07D487/10 , C07D487/04 , C07D417/12 , C07D405/14 , C07D405/12 , C07D403/14 , C07D403/06 , C07D401/14 , C07D401/12 , C07D263/34 , A61K45/06 , A61K31/554 , A61K31/5377 , A61K31/519 , A61K31/5025 , A61K31/454 , A61K31/4439 , A61K31/421 , A61K31/4178 , A61K31/4164 , A61K31/4155 , A61P35/00 , C07D491/107
CPC分类号： C07D233/90 , A61K31/4155 , A61K31/4164 , A61K31/4178 , A61K31/421 , A61K31/4439 , A61K31/454 , A61K31/5025 , A61K31/519 , A61K31/5377 , A61K31/554 , A61K45/06 , A61P35/00 , A61P35/04 , C07D233/54 , C07D263/34 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/06 , C07D417/12 , C07D487/04 , C07D487/10 , C07D487/14 , C07D491/107 , C07D495/10
摘要： The present invention relates to amido-substituted cyclohexane compounds of general formula (I), in which A, R4, R6, R7, R8, R9, R10 and R11 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredient.
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公开(公告)号：US20190142812A1
公开(公告)日：2019-05-16
申请号：US16067830
申请日：2017-01-06
发明人： Ulrich LÜCKING , Marcus KOPPITZ , Julien LEFRANC , Lars WORTMANN , Antje Margret WENGNER , Gerhard SIEMEISTER , Ulf BÖMER , Benjamin BADER , Philip LIENAU , Hans SCHICK
IPC分类号： A61K31/4375 , A61P35/00 , A61K45/06
摘要： The present invention relates to 5-substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
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METHANONES](/abs-image/US/2020/03/19/US20200085791A1/abs.jpg.150x150.jpg)
公开(公告)号：US20200085791A1
公开(公告)日：2020-03-19
申请号：US16470495
申请日：2017-12-15
发明人： Marcus KOPPITZ , Holger SIEBENEICHER , Holger STEUBER , Antonius TER LAAK , Reinhard NUBBEMEYER , Antje ROTTMANN , Horst IRLBACHER , Benjamin BADER , Michaele PETERS , Andrea WAGENFELD
IPC分类号： A61K31/4192 , A61K45/06 , A61K31/704 , C07D487/18
摘要： The present invention covers [(phenylsulfonyl)octahydro-epiminoisoindol-yl](1H-1,2,3-triazol-5-yl)methanone compounds of general formula (I), in which Q, R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of disorders, in particular of gynecological disorders, hyperproliferative disorders, metabolic disorders, or inflammatory disorders as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20180256591A1
公开(公告)日：2018-09-13
申请号：US15974536
申请日：2018-05-08
发明人： Lars WORTMANN , Ulrich LÜCKING , Julien LEFRANC , Hans BRIEM , Marcus KOPPITZ , Knut EIS , Franz VON NUSSBAUM , Benjamin BADER , Antje Margret WENGNER , Gerhard SIEMEISTER , Wilhelm BONE , Philip LIENAU , Joanna GRUDZINSKA-GOEBEL , Dieter MOOSMAYER , Uwe EBERSPÄCHER , Hans SCHICK
IPC分类号： A61K31/541 , A61K31/55 , A61K31/5377 , A61K31/5386 , C07D471/04 , A61K31/675 , A61K45/06 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
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6.发明申请公开(公告)号：US20170354620A1
公开(公告)日：2017-12-14
申请号：US15537280
申请日：2015-12-16
发明人： Nico BRÄUER , Jens NAGEL , Horst IRLBACHER , Andrea ROTGERI , Wolfgang SCHWEDE , Henrik DAHLLÖF , Marcus KOPPITZ , Michaele PETERS , Anne-Marie GODINHO-COELHO
IPC分类号： A61K31/167 , C07D213/61 , C07D213/56 , A61K31/44
CPC分类号： A61K31/167 , A61K31/44 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/84 , C07D405/12
摘要： The present invention relates to substituted Pyridyl-cycloalkyl-carboxylic acids of general formula (I), to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular in mammals, such as diseases associated with pains, or for the treatment or prophylaxis of pain syndromes (acute and chronic), inflammatory-induced pain, pelvic pain, cancer-associated pain, endometriosis-associated pain as well as endometriosis and adenomyosis as such, cancer as such, and proliferative diseases as such like endometriosis.
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公开(公告)号：US20170216304A1
公开(公告)日：2017-08-03
申请号：US15501079
申请日：2015-08-03
发明人： Lars WORTMANN , Ulrich LÜCKING , Julien LEFRANC , Hans BRIEM , Marcus KOPPITZ , Knut EIS , Franz VON NUSSBAUM , Benjamin BADER , Antje Margret WENGNER , Gerhard SIEMEISTER , Wilhelm BONE , Philip LIENAU , Joanna GRUDZINSKA-GOEBEL , Dieter MOOSMAYER , Uwe EBERSPÄCHER , Hans SCHICK
IPC分类号： A61K31/541 , A61K31/5386 , A61K31/5377 , C07D491/22 , C07F9/6561 , C07D471/04 , C07D519/00 , A61K31/55 , A61K31/675
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
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METHANONES](/abs-image/US/2020/03/19/US20200087284A1/abs.jpg.150x150.jpg)
公开(公告)号：US20200087284A1
公开(公告)日：2020-03-19
申请号：US16469745
申请日：2017-12-15
发明人： Marcus KOPPITZ , Holger SIEBENEICHER , Holger STEUBER , Antonius TER LAAK , Reinhard NUBBEMEYER , Antje ROTTMANN , Horst IRLBACHER , Benjamin BADER , Michaele PETERS , Andrea WAGENFELD
IPC分类号： C07D403/06 , A61K31/704
摘要： The present invention covers [4-(phenylsulfonyl)piperazin-1-yl](1H-1,2,3-triazol-4-yl)methanone compounds of general formula (I), in which Q, R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of disorders, in particular of gynecological disorders, hyperproliferative disorders, metabolic disorders, or inflammatory disorders as a sole agent or in combination with other active ingredients.
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METHANONES](/abs-image/US/2020/03/12/US20200079758A1/abs.jpg.150x150.jpg)
公开(公告)号：US20200079758A1
公开(公告)日：2020-03-12
申请号：US16469861
申请日：2017-12-15
发明人： Marcus KOPPITZ , Holger SIEBENEICHER , Holger STEUBER , Antonius TER LAAK , Reinhard NUBBEMEYER , Antje ROTTMANN , Horst IRLBACHER , Benjamin BADER , Michaele PETERS , Andrea WAGENFELD
IPC分类号： C07D403/06 , A61K31/496 , A61K45/06 , A61K31/704 , C07D409/14 , C07D401/14 , C07D413/14 , C07D417/14 , C07D405/14 , A61P35/00
摘要： The present invention covers [4-(phenylsulfonyl)piperazin-1-yl](1H-1,2,3-triazol-4-yl)methanone compounds of general formula (I): (I), in which Q, R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of disorders, in particular of gynecological disorders, hyperproliferative disorders, metabolic disorders, or inflammatory disorders as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20190047980A1
公开(公告)日：2019-02-14
申请号：US16063370
申请日：2016-12-15
发明人： Volker SCHULZE , Tobias HEINRICH , Florian PRINZ , Julien LEFRANC , Jens SCHRÖDER , Anne MENGEL , Wilhelm BONE , Joszef BÁLINT , Antje Margret WENGNER , Knut EIS , Horst IRLBACHER , Marcus KOPPITZ , Ulf BÖMER , Benjamin BADER , Hans BRIEM , Philip LIENAU , Clara CHRIST , Detlef STÖCKIGT , Roman HILLIG
IPC分类号： C07D401/12 , A61P35/00 , C07D401/14 , C07D487/08 , C07D471/08 , C07D451/14 , C07D409/14 , C07D405/14
摘要： The present invention covers heteroarylbenzimidazole compounds of general formula (I) in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative and/or inflammatory disorders, as a sole agent or in combination with other active ingredients.
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