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公开(公告)号：US20210317128A1
公开(公告)日：2021-10-14
申请号：US16759262
申请日：2018-10-18
发明人： Marcus KOPPITZ , Holger SIEBENEICHER , Nico BRÄUER , Elisabeth POOK , Andrea ROTGERI , Roland NEUHAUS , Oliver Martin FISCHER , Jens NAGEL , Adam James DAVENPORT , James Lindsay CARR , Robert James TOWNSEND , Nina CONNELLY URSINYOVA , Shelley Anne PARROTT
IPC分类号： C07D487/14
摘要： The present invention covers substituted. Pyrazolo-pyrrolo-pyrimidine-dione (PPPD) compounds of general formula (I): in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neurogenic diseases, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20190388410A1
公开(公告)日：2019-12-26
申请号：US16428669
申请日：2019-05-31
发明人： Ulrich BOTHE , Antje Margret WENGNER , Holger SIEBENEICHER , Nicole SCHMIDT , Reinhard NUBBEMEYER , Ulf BÖMER , Judith GÜNTHER , Holger STEUBER , Martin LANGE , Christian STEGMANN , Andreas SUTTER , Roland NEUHAUS
IPC分类号： A61K31/4439 , A61K45/06 , A61P35/00 , A61K31/519
摘要： The present application relates to novel combinations of at least two components, component A and component B: component A is an IRAK4-inhibiting compound of the formula (I) as defined herein, or a diastereomer, an enantiomer, a metabolite, a salt, a solvate or a solvate of a salt thereof; component B is a BTK-inhibiting compound, or a pharmaceutically acceptable salt thereof; and, optionally, one or more components C which are pharmaceutical products; in which one or two of the above-defined compounds A and B are optionally present in pharmaceutical formulations ready for simultaneous, separate or sequential administration, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis, lymphoma, macular degeneration, COPD, neoplastic disorders and psoriasis.
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公开(公告)号：US20170197921A1
公开(公告)日：2017-07-13
申请号：US15118154
申请日：2015-02-10
发明人： Hartmut REHWINKEL , Olaf PANKNIN , Sven RING , Sonja ANLAUF , Holger SIEBENEICHER , Duy NGUYEN , Wolfgang SCHWEDE , Marcus BAUSER , Katja ZIMMERMANN , Stefan KAULFUSS , Roland NEUHAUS , Paul Matthew BLANEY
IPC分类号： C07D235/30 , A61K31/4439 , C07D401/12 , A61K31/4184 , A61K45/06
CPC分类号： C07D235/30 , A61K31/4184 , A61K31/4439 , A61K45/06 , C07D401/12
摘要： The present invention relates to benzimidazol-2-amines of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20230174508A1
公开(公告)日：2023-06-08
申请号：US17869673
申请日：2022-07-20
发明人： Ulrich BOTHE , Holger SIEBENEICHER , Nicole SCHMIDT , Reinhard NUBBEMEYER , Ulf BÖMER , Judith GÜNTHER , Holger STEUBER , Martin LANGE , Christian STEGMANN , Andreas SUTTER , Alexandra RAUSCH , Christian FRIEDRICH , Peter HAUFF
IPC分类号： C07D401/12 , C07F7/18 , A61P19/02 , A61K31/4439 , C07D405/14
CPC分类号： C07D401/12 , C07F7/1804 , A61P19/02 , A61K31/4439 , C07D405/14
摘要： The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.
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公开(公告)号：US20190233395A1
公开(公告)日：2019-08-01
申请号：US16377025
申请日：2019-04-05
发明人： Ulrich BOTHE , Holger SIEBENEICHER , Nicole SCHMIDT , Reinhard NUBBEMEYER , Ulf BÖMER , Judith GÜNTHER , Holger STEUBER , Martin LANGE , Christian STEGMANN , Andreas SUTTER , Alexandra RAUSCH , Christian FRIEDRICH , Peter HAUFF
IPC分类号： C07D401/12 , C07F7/18 , A61P19/02 , A61K31/4439 , C07D405/14
摘要： The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.
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公开(公告)号：US20180289685A1
公开(公告)日：2018-10-11
申请号：US15570212
申请日：2016-04-29
发明人： Ulrich BOTHE , Antje Margret WENGNER , Holger SIEBENEICHER , Nicole SCHMIDT , Reinhard NUBBEMEYER , Ulf BÖMER , Judith GÜNTHER , Holger STEUBER , Martin LANGE , Christian STEGMANN , Andreas SUTTER , Roland NEUHAUS
IPC分类号： A61K31/4439 , A61K31/519 , A61K45/06 , A61P35/00
摘要： The present application relates to novel combinations of at least two components, component A and component B: ⋅component A is an IRAK4-inhibiting compound of the formula (I) as defined herein, or a diastereomer, an enantiomer, a metabolite, a salt, a solvate or a solvate of a salt thereof; ⋅component B is a BTK-inhibiting compound, or a pharmaceutically acceptable salt thereof; and, optionally, ⋅one or more components C which are pharmaceutical products; in which one or two of the above-defined compounds A and B are optionally present in pharmaceutical formulations ready for simultaneous, separate or sequential administration, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis, lymphoma, macular degeneration, COPD, neoplastic disorders and psoriasis.
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公开(公告)号：US20210053941A1
公开(公告)日：2021-02-25
申请号：US17009553
申请日：2020-09-01
发明人： Ulrich BOTHE , Holger SIEBENEICHER , Nicole SCHMIDT , Reinhard NUBBEMEYER , Ulf BÖMER , Judith GÜNTHER , Holger STEUBER , Martin LANGE , Christian STEGMANN , Andreas SUTTER , Alexandra RAUSCH , Christian FRIEDRICH , Peter HAUFF
IPC分类号： C07D401/12 , C07F7/18 , A61P19/02 , A61K31/4439 , C07D405/14
摘要： The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.
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METHANONES](/abs-image/US/2020/03/19/US20200085791A1/abs.jpg.150x150.jpg)
公开(公告)号：US20200085791A1
公开(公告)日：2020-03-19
申请号：US16470495
申请日：2017-12-15
发明人： Marcus KOPPITZ , Holger SIEBENEICHER , Holger STEUBER , Antonius TER LAAK , Reinhard NUBBEMEYER , Antje ROTTMANN , Horst IRLBACHER , Benjamin BADER , Michaele PETERS , Andrea WAGENFELD
IPC分类号： A61K31/4192 , A61K45/06 , A61K31/704 , C07D487/18
摘要： The present invention covers [(phenylsulfonyl)octahydro-epiminoisoindol-yl](1H-1,2,3-triazol-5-yl)methanone compounds of general formula (I), in which Q, R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of disorders, in particular of gynecological disorders, hyperproliferative disorders, metabolic disorders, or inflammatory disorders as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20220241261A1
公开(公告)日：2022-08-04
申请号：US17544641
申请日：2021-12-07
发明人： Ulrich BOTHE , Antje Margret WENGNER , Holger SIEBENEICHER , Nicole SCHMIDT , Reinhard NUBBEMEYER , Ulf BÖMER , Judith GÜNTHER , Holger STEUBER , Martin LANGE , Christian STEGMANN , Andreas SUTTER , Roland NEUHAUS
IPC分类号： A61K31/4439 , A61K31/519 , A61K31/497 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/55 , A61K31/506 , A61K31/454 , A61K31/505 , A61P35/00 , A61K45/06
摘要： The present application relates to novel combinations of at least two components, component A and component B: component A is an IRAK4-inhibiting compound of the formula (I) as defined herein, or a diastereomer, an enantiomer, a metabolite, a salt, a solvate or a solvate of a salt thereof; component B is a BTK-inhibiting compound, or a pharmaceutically acceptable salt thereof; and, optionally, one or more components C which are pharmaceutical products; in which one or two of the above-defined compounds A and B are optionally present in pharmaceutical formulations ready for simultaneous, separate or sequential administration, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis, lymphoma, macular degeneration, COPD, neoplastic disorders and psoriasis.
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公开(公告)号：US20190071432A1
公开(公告)日：2019-03-07
申请号：US16081209
申请日：2017-02-28
发明人： Ulrich BOTHE , Holger SIEBENEICHER , Nicole SCHMIDT , Judith GÜNTHER , Holger STEUBER , Ulf BÖMER , Martin LANGE , Reinhard NUBBEMEYER , Nicholas Charles RAY , Pascal SAVY
IPC分类号： C07D405/14 , C07D409/14 , C07D401/14 , C07D413/14 , C07D417/14 , C07D487/08
CPC分类号： C07D405/14 , A61P19/02 , A61P25/04 , A61P29/00 , A61P35/00 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/08
摘要： The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.
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