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公开(公告)号：US09993484B2
公开(公告)日：2018-06-12
申请号：US15501079
申请日：2015-08-03
发明人： Lars Wortmann , Ulrich Lücking , Julien LeFranc , Hans Briem , Marcus Koppitz , Knut Eis , Franz Von Nussbaum , Benjamin Bader , Antje Margret Wengner , Gerhard Siemeister , Wilhelm Bone , Philip Lienau , Joanna Grudzinska-Goebel , Dieter Moosmayer , Uwe Eberspächer , Hans Schick
IPC分类号： C07D471/04 , C07D413/04 , C07D295/02 , C07D403/14 , A61K31/5377 , A61K31/4375 , A61K31/4025 , A61K31/4155 , A61K31/541 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D491/22 , C07D519/00 , C07F9/6561
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (1b), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
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公开(公告)号：US10772893B2
公开(公告)日：2020-09-15
申请号：US15974536
申请日：2018-05-08
发明人： Lars Wortmann , Ulrich Lücking , Julien Lefranc , Hans Briem , Marcus Koppitz , Knut Eis , Franz Von Nussbaum , Benjamin Bader , Antje Margret Wengner , Gerhard Siemeister , Wilhelm Bone , Philip Lienau , Joanna Grudzinska-Goebel , Dieter Moosmayer , Uwe Eberspächer , Hans Schick
IPC分类号： C07D471/04 , C07D413/14 , A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
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![Substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-A]pyridine-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-C][1,2,4]triazol-3-ones, and use thereof](/abs-image/US/2020/07/28/US10722501B2/abs.jpg.150x150.jpg)
公开(公告)号：US10722501B2
公开(公告)日：2020-07-28
申请号：US16300480
申请日：2017-05-08
发明人： Nicole Biber , Damian Brockschnieder , Kersten Matthias Gericke , Florian Kölling , Klemens Lustig , Jörg Meding , Heinrich Meier , Thomas Neubauer , Martina Schäfer , Andreas Timmermann , Dmitry Zubov , Carsten Terjung , Niels Lindner , Volker Badock , Dieter Moosmayer , Hideki Miyatake Ondozabal , Stephen Moore , Alexander Schulz
IPC分类号： A61K31/437 , A61K31/506 , C07D471/04 , A61K31/4375 , A61K31/4709 , A61K31/497 , C07D519/00 , A61K45/06 , A61K31/444 , A61P11/00 , A61P29/00
摘要： The present application relates to novel substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazol-3-ones of formula (I), to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of lung inflammation disorders.
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公开(公告)号：US09549932B2
公开(公告)日：2017-01-24
申请号：US15159548
申请日：2016-05-19
发明人： Lars Wortmann , Ulrich Lücking , Julien Lefranc , Hans Briem , Franz Von Nussbaum , Benjamin Bader , Gerhard Siemeister , Wilhelm Bone , Philip Lienau , Dieter Moosmayer , Uwe Eberspächer , Hans Schick , Knut Eis , Marcus Koppitz , Antje Margret Wengner , Joanna Grudzinska-Goebel
IPC分类号： A61K31/5377 , A61K31/675 , A61K31/541 , A61K31/5386 , A61K45/06 , C07D471/04 , C07D491/22 , C07F9/6561 , C07D519/00 , A61K31/55
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
摘要翻译： 制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合，以及所述化合物用于制备用于治疗或预防疾病，特别是过度增殖的药物组合物的用途 疾病作为唯一的代理或与其他活性成分组合。
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公开(公告)号：US11529356B2
公开(公告)日：2022-12-20
申请号：US16999832
申请日：2020-08-21
发明人： Lars Wortmann , Ulrich Lücking , Julien Lefranc , Hans Briem , Marcus Koppitz , Knut Eis , Franz Von Nussbaum , Benjamin Bader , Antje Margret Wengner , Gerhard Siemeister , Wilhelm Bone , Philip Lienau , Joanna Grudzinska-Goebel , Dieter Moosmayer , Uwe Eberspächer , Hans Schick
IPC分类号： A61K31/4375 , A61K31/5377 , A61K31/4155 , C07D471/04 , C07D519/00 , C07D413/14 , A61P35/00 , A61P35/02 , A61K31/541 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D491/22 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
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![4H-pyrrolo[3,2-c]pyridin-4-one derivatives](/abs-image/US/2022/05/24/US11339157B1/abs.jpg.150x150.jpg)
公开(公告)号：US11339157B1
公开(公告)日：2022-05-24
申请号：US16758018
申请日：2018-10-23
申请人： Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , Dana-Farber Cancer Institute, Inc. , The Broad Institute, Inc.
发明人： Stephan Siegel , Franziska Siegel , Volker Schulze , Markus Berger , Keith Graham , Ulrich Klar , Knut Eis , Detlev Sülzle , Ulf Bömer , Daniel Korr , Kirstin Petersen , Ursula Mönning , Uwe Eberspächer , Dieter Moosmayer , Matthew Meyerson , Heidi Greulich , Bethany Kaplan , Hassan Youssef Harb , Phi Manh Dinh
IPC分类号： C07D471/04 , A61P35/00 , A61K45/06
摘要： Compounds of formula (I) processes for their production and their use as pharmaceuticals.
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公开(公告)号：US20160287604A1
公开(公告)日：2016-10-06
申请号：US15159548
申请日：2016-05-19
发明人： Lars Wortmann , Ulrich Lücking , Julien Lefranc , Hans Briem , Franz Von Nussbaum , Benjamin Bader , Gerhard Siemeister , Wilhelm Bone , Philip Lienau , Dieter Moosmayer , Uwe Eberspächer , Hans Schick , Knut Eis , Marcus Koppitz , Antje Margret Wengner , Joanna Grudzinska-Goebel
IPC分类号： A61K31/5377 , C07D471/04 , C07F9/6561 , A61K31/55 , A61K31/541 , C07D519/00 , A61K31/5386 , C07D491/22 , A61K45/06 , A61K31/675
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
摘要翻译： 制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合，以及所述化合物用于制备用于治疗或预防疾病，特别是过度增殖的药物组合物的用途 疾病作为唯一的代理或与其他活性成分组合。
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