公开(公告)号：US20150299329A1

公开(公告)日：2015-10-22

申请号：US14610456

申请日：2015-01-30

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Gerard Zurawski ,  Jacques F. Banchereau ,  Anne-Laure Flamar ,  Yves Levy ,  Monica Montes

IPC: C07K16/28 ,  C07K16/00 ,  C07K14/005

CPC classification number: C07K16/2878 ,  A61K39/00 ,  A61K39/385 ,  A61K2039/6056 ,  A61K2039/627 ,  A61K2039/64 ,  C07K14/005 ,  C07K16/00 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/77 ,  C07K2317/80 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/40 ,  C07K2319/91 ,  C12N2740/16222 ,  C12N2740/16322 ,  C12N2760/16122 ,  C12N2770/24222 ,  C12N2770/24234 ,  G01N33/6863 ,  Y02A50/39 ,  Y02A50/464 ,  Y02A50/466

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

Abstract translation: 本发明包括用于表达，分泌和使用用作例如疫苗和抗原递送载体的用于将抗原递送至抗原呈递细胞的组合物和方法。 在一个实施方案中，载体是抗CD40抗体或其片段，以及与抗-CD40抗体或其片段（包括人源化抗体）连接的一个或多个抗原肽。

公开(公告)号：US10988544B2

公开(公告)日：2021-04-27

申请号：US15787425

申请日：2017-10-18

Applicant: Baylor Research Institute

Inventor： Gerard Zurawski ,  Jacques F. Banchereau ,  Anne-Laure Flamar ,  Yves Levy ,  Monica Montes

IPC: C07K16/28 ,  C07K14/005 ,  A61K39/385 ,  G01N33/68 ,  C07K16/00 ,  A61K39/00

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

公开(公告)号：US20180094071A1

公开(公告)日：2018-04-05

申请号：US15787425

申请日：2017-10-18

Applicant: Baylor Research Institute

Inventor： Gerard Zurawski ,  Jacques F. Banchereau ,  Anne-Laure Flamar ,  Yves Levy ,  Monica Montes

IPC: C07K16/28 ,  G01N33/68 ,  C07K14/005

CPC classification number: C07K16/2878 ,  A61K39/00 ,  A61K39/385 ,  A61K2039/6056 ,  A61K2039/627 ,  A61K2039/64 ,  C07K14/005 ,  C07K16/00 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/77 ,  C07K2317/80 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/40 ,  C07K2319/91 ,  C12N2740/16222 ,  C12N2740/16322 ,  C12N2760/16122 ,  C12N2770/24222 ,  C12N2770/24234 ,  G01N33/6863 ,  Y02A50/39 ,  Y02A50/464 ,  Y02A50/466

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

公开(公告)号：US20210221904A1

公开(公告)日：2021-07-22

申请号：US17301118

申请日：2021-03-25

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Gerard ZURAWSKI ,  Jacques F. Banchereau ,  Anne-Laure FLAMAR ,  Yves Levy ,  Monica Montes

IPC: C07K16/28 ,  C07K14/005 ,  A61K39/385 ,  G01N33/68 ,  C07K16/00

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.