公开(公告)号：US10722572B2

公开(公告)日：2020-07-28

申请号：US16708787

申请日：2019-12-10

Applicant: INSERM (Institut National de la Sante et de la Recherche Medicale) ,  Baylor Research Institute ,  Universite Paris Est Creteil Val De Marne ,  Assistance Publique Hopitaux de Paris

Inventor： Yves Levy ,  Gerard Zurawski ,  Sandra Zurawski ,  Anne-Laure Flamar

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  A61K39/12 ,  A61K39/21 ,  C07K14/005 ,  C12N7/00 ,  C07K16/10 ,  A61P31/18

Abstract: Methods and compositions are provided that can be used to vaccinate against and treat HIV. Specifically contemplated are vaccine compositions and methods of using these compositions treat HIV in patients. Aspects of the disclosure relate to an anti-CD40 antibody-HIV antigen fusion protein comprising (i) an anti-CD40 heavy chain (HCD40)-HIV antigen (Ag) fusion protein comprising the formula: HCD40-Ag, wherein Ag is a polypeptide with at least 80% sequence identity to SEQ ID NO:1; and (ii) an anti-CD40 light chain (LCD40).

公开(公告)号：US09885017B2

公开(公告)日：2018-02-06

申请号：US14152448

申请日：2014-01-10

Applicant: Baylor Research Institute ,  Institut National de la Sante et de la Recherche Medicale (INSERM)

Inventor： Helene Dutartre ,  Yves Levy ,  Jacques Banchereau ,  Gerard Zurawski

IPC: A61K39/395 ,  A61K39/00 ,  C07K16/28 ,  A61P37/04 ,  C12N5/0784 ,  A61K39/29 ,  A61K39/12 ,  C07K14/005

CPC classification number: C12N5/0639 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/6056 ,  C07K14/005 ,  C07K16/2851 ,  C07K16/2878 ,  C07K2319/00 ,  C07K2319/33 ,  C12N2770/24222 ,  C12N2770/24234

Abstract: Compositions comprising viral antigens and antigenic peptides corresponding to or derived from Hepatitis C virus (HCV) proteins or fragments thereof, fused to heavy and/or light chain of antibodies, or fragments thereof specific for dendritic cells (DCs) are described herein. Included herein are immunostimulatory compositions (HCV vaccines, HCV antigen presenting dendritic cells, etc.) and methods for increasing effectiveness of HCV antigen presentation by an antigen presenting cell, for a treatment, a prophylaxis or a combination thereof against hepatitis C in a human subject, and methods of providing immunostimulation by activation of one or more dendritic cells, methods to treat or prevent hepatitis C.

公开(公告)号：US11219683B2

公开(公告)日：2022-01-11

申请号：US16946390

申请日：2020-06-19

Applicant: INSERM (Institut National de la Santé et de la Recherche Mêdicale) ,  Baylor Research Institute ,  Universite Paris Est Creteil Val De Marne ,  Assistance Publique Hopitaux de Paris

Inventor： Yves Levy ,  Gerard Zurawski ,  Sandra Zurawski ,  Anne-Laure Flamar

IPC: A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61P31/18 ,  C07K14/005 ,  C12N7/00 ,  C07K16/28 ,  C07K16/10

Abstract: Methods and compositions are provided that can be used to vaccinate against and treat HIV. Specifically contemplated are vaccine compositions and methods of using these compositions treat HIV in patients. Aspects of the disclosure relate to an anti-CD40 antibody-HIV antigen fusion protein comprising (i) an anti-CD40 heavy chain (HCD40)-HIV antigen (Ag) fusion protein comprising the formula: HCD40-Ag, wherein Ag is a polypeptide with at least 80% sequence identity to SEQ ID NO:1; and (ii) an anti-CD40 light chain (LCD40).

公开(公告)号：US20190184008A1

公开(公告)日：2019-06-20

申请号：US16141157

申请日：2018-09-25

Applicant: INSERM (Institut National de la Santé et de la Recherche Mêdicale ,  Baylor Research Institute ,  Universite Paris Est Creteil Val De Marne ,  Assistance Publique Hopitaux de Paris

Inventor： Yves Levy ,  Gerard Zurawski ,  Sandra Zurawski ,  Anne-Laure Flamar

IPC: A61K39/21 ,  C07K16/28 ,  A61P31/18 ,  C07K14/005 ,  C12N7/00

CPC classification number: A61K39/21 ,  A61K2039/505 ,  A61K2039/572 ,  A61K2039/575 ,  A61K2039/6056 ,  A61K2039/627 ,  A61P31/18 ,  C07K14/005 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2319/02 ,  C07K2319/40 ,  C12N7/00 ,  C12N2740/16134 ,  C12N2740/16171

Abstract: Methods and compositions are provided that can be used to vaccinate against and treat HIV. Specifically contemplated are vaccine compositions and methods of using these compositions treat HIV in patients. Aspects of the disclosure relate to an anti-CD40 antibody-HIV antigen fusion protein comprising (i) an anti-CD40 heavy chain (HCD40)-HIV antigen (Ag) fusion protein comprising the formula: HCD40-Ag, wherein Ag is a polypeptide with at least 80% sequence identity to SEQ ID NO:1; and (ii) an anti-CD40 light chain (LCD40).

公开(公告)号：US20150299329A1

公开(公告)日：2015-10-22

申请号：US14610456

申请日：2015-01-30

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Gerard Zurawski ,  Jacques F. Banchereau ,  Anne-Laure Flamar ,  Yves Levy ,  Monica Montes

IPC: C07K16/28 ,  C07K16/00 ,  C07K14/005

CPC classification number: C07K16/2878 ,  A61K39/00 ,  A61K39/385 ,  A61K2039/6056 ,  A61K2039/627 ,  A61K2039/64 ,  C07K14/005 ,  C07K16/00 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/77 ,  C07K2317/80 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/40 ,  C07K2319/91 ,  C12N2740/16222 ,  C12N2740/16322 ,  C12N2760/16122 ,  C12N2770/24222 ,  C12N2770/24234 ,  G01N33/6863 ,  Y02A50/39 ,  Y02A50/464 ,  Y02A50/466

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

Abstract translation: 本发明包括用于表达，分泌和使用用作例如疫苗和抗原递送载体的用于将抗原递送至抗原呈递细胞的组合物和方法。 在一个实施方案中，载体是抗CD40抗体或其片段，以及与抗-CD40抗体或其片段（包括人源化抗体）连接的一个或多个抗原肽。

公开(公告)号：US20210221904A1

公开(公告)日：2021-07-22

申请号：US17301118

申请日：2021-03-25

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Gerard ZURAWSKI ,  Jacques F. Banchereau ,  Anne-Laure FLAMAR ,  Yves Levy ,  Monica Montes

IPC: C07K16/28 ,  C07K14/005 ,  A61K39/385 ,  G01N33/68 ,  C07K16/00

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

公开(公告)号：US20180094071A1

公开(公告)日：2018-04-05

申请号：US15787425

申请日：2017-10-18

Applicant: Baylor Research Institute

Inventor： Gerard Zurawski ,  Jacques F. Banchereau ,  Anne-Laure Flamar ,  Yves Levy ,  Monica Montes

IPC: C07K16/28 ,  G01N33/68 ,  C07K14/005

CPC classification number: C07K16/2878 ,  A61K39/00 ,  A61K39/385 ,  A61K2039/6056 ,  A61K2039/627 ,  A61K2039/64 ,  C07K14/005 ,  C07K16/00 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/77 ,  C07K2317/80 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/40 ,  C07K2319/91 ,  C12N2740/16222 ,  C12N2740/16322 ,  C12N2760/16122 ,  C12N2770/24222 ,  C12N2770/24234 ,  G01N33/6863 ,  Y02A50/39 ,  Y02A50/464 ,  Y02A50/466

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

公开(公告)号：US20140199763A1

公开(公告)日：2014-07-17

申请号：US14152448

申请日：2014-01-10

Applicant: Institut National de la Sante et de la Recherche Medicale ( INSERM) ,  Baylor Research Institute

Inventor： Helene Dutartre ,  Yves Levy ,  Jacques Banchereau ,  Gerard Zurawski

IPC: C12N5/0784

CPC classification number: C12N5/0639 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/6056 ,  C07K14/005 ,  C07K16/2851 ,  C07K16/2878 ,  C07K2319/00 ,  C07K2319/33 ,  C12N2770/24222 ,  C12N2770/24234

Abstract: Compositions comprising viral antigens and antigenic peptides corresponding to or derived from Hepatitis C virus (HCV) proteins or fragments thereof, fused to heavy and/or light chain of antibodies, or fragments thereof specific for dendritic cells (DCs) are described herein. Included herein are immunostimulatory compositions (HCV vaccines, HCV antigen presenting dendritic cells, etc.) and methods for increasing effectiveness of HCV antigen presentation by an antigen presenting cell, for a treatment, a prophylaxis or a combination thereof against hepatitis C in a human subject, and methods of providing immunostimulation by activation of one or more dendritic cells, methods to treat or prevent hepatitis C.

Abstract translation: 本文描述了包含与针对树突状细胞（DC）特异性的抗体的重链和/或轻链或其片段融合的丙型肝炎病毒（HCV）蛋白或其片段的病毒抗原和抗原肽的组合物。 本文包括免疫刺激组合物（HCV疫苗，呈递树突细胞的HCV抗原等）以及用于增加抗原呈递细胞的HCV抗原呈递的有效性的方法，用于治疗，预防或其组合以抗人类受试者中的丙型肝炎 ，以及通过激活一种或多种树突状细胞提供免疫刺激的方法，治疗或预防丙型肝炎的方法。

公开(公告)号：US10988544B2

公开(公告)日：2021-04-27

申请号：US15787425

申请日：2017-10-18

Applicant: Baylor Research Institute

Inventor： Gerard Zurawski ,  Jacques F. Banchereau ,  Anne-Laure Flamar ,  Yves Levy ,  Monica Montes

IPC: C07K16/28 ,  C07K14/005 ,  A61K39/385 ,  G01N33/68 ,  C07K16/00 ,  A61K39/00

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.