公开(公告)号：US12276809B2

公开(公告)日：2025-04-15

申请号：US17769428

申请日：2020-03-09

Applicant: BGI SHENZHEN

Inventor： Jielei Ni ,  Ming Ni ,  Fan Zhou ,  Zeyu Su ,  Ke Ji ,  Dong Wei ,  Mengzhe Shen ,  Yuanqing Liang ,  Mei Li ,  Xun Xu

IPC: G01N21/00 ,  C12Q1/6869 ,  G01N21/64 ,  G02B21/14 ,  G02B21/16 ,  G02B21/36 ,  G02B27/28 ,  G02B27/58

Abstract: Disclosed are a super-resolution imaging system (1, 41, 51), a super-resolution imaging method, a biological sample identification system (4, 61) and method, a nucleic acid sequencing imaging system (5) and method, and a nucleic acid identification system (6) and method. The super-resolution imaging system (1, 41, 51) includes an illumination system (A) and an imaging system (B). The illumination system (A) outputs excitation light to irradiate a biological sample to generate excited light, and the imaging system (B) collects and records the excited light to generate an excited light image. The illumination system (A) includes an excitation light source (10, 10a) and a structured light generation and modulation device (11, 11a). The excitation light source (10, 10a) outputs the excitation light, and the structured light generation and modulation device (11, 11a) modulates the excitation light into structured light to irradiate the biological sample to generate the excited light.