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公开(公告)号：US20250060311A1
公开(公告)日：2025-02-20
申请号：US18709215
申请日：2021-11-12
Applicant: BGI SHENZHEN
Inventor： Zeyu Su , Yuanqing Liang , Mengzhe Shen , Jielei Ni
IPC: G01N21/64 , C12Q1/6869
Abstract: Disclosed are a method for increasing a sequencing resolution, and a sequencing device and system. The method includes carrying out irradiation and excitation on a sample to be tested containing a fluorescent dye with at least one type of excitation light to generate a fluorescence signal, where a maximum wavelength in the excitation light is smaller than a wavelength of red light; and the transmitting the generated fluorescence signal through an optical path, and collecting and imaging the signal.
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2.发明授权公开(公告)号：US12276809B2
公开(公告)日：2025-04-15
申请号：US17769428
申请日：2020-03-09
Applicant: BGI SHENZHEN
Inventor： Jielei Ni , Ming Ni , Fan Zhou , Zeyu Su , Ke Ji , Dong Wei , Mengzhe Shen , Yuanqing Liang , Mei Li , Xun Xu
Abstract: Disclosed are a super-resolution imaging system (1, 41, 51), a super-resolution imaging method, a biological sample identification system (4, 61) and method, a nucleic acid sequencing imaging system (5) and method, and a nucleic acid identification system (6) and method. The super-resolution imaging system (1, 41, 51) includes an illumination system (A) and an imaging system (B). The illumination system (A) outputs excitation light to irradiate a biological sample to generate excited light, and the imaging system (B) collects and records the excited light to generate an excited light image. The illumination system (A) includes an excitation light source (10, 10a) and a structured light generation and modulation device (11, 11a). The excitation light source (10, 10a) outputs the excitation light, and the structured light generation and modulation device (11, 11a) modulates the excitation light into structured light to irradiate the biological sample to generate the excited light.
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