公开(公告)号：US11254679B2

公开(公告)日：2022-02-22

申请号：US16631915

申请日：2018-07-19

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Burcu Selin Aytar ,  Alina Borovika ,  Collin Chan ,  Joerg Deerberg ,  Nathan R. Domagalski ,  Martin D. Eastgate ,  Yu Fan ,  Michael David Bengt Fenster ,  Robert V. Forest ,  Francisco Gonzalez-Bobes ,  Rebecca A. Green ,  Matthew R. Hickey ,  Nathaniel David Kopp ,  Thomas E. La Cruz ,  Kathleen Lauser ,  Hong Geun Lee ,  David K. Leahy ,  Helen Y. Luo ,  Thomas M. Razler ,  Scott A. Savage ,  Chris Sfouggatakis ,  Maxime C. D. Soumeillant ,  Serge Zaretsky ,  Bin Zheng ,  Ye Zhu

IPC: C07D487/04

Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.

公开(公告)号：US11649226B2

公开(公告)日：2023-05-16

申请号：US17131718

申请日：2020-12-22

Applicant: Bristol-Myers Squibb Company

Inventor： Bahar Inankur ,  Sergei Kolotuchin ,  Maxime C. D. Soumeillant ,  Daniel S. Treitler

IPC: C07D249/08 ,  C07D403/12 ,  C07C211/09 ,  C07D237/24

CPC classification number: C07D403/12 ,  C07C211/09 ,  C07D237/24 ,  C07D249/08 ,  C07B2200/13

Abstract: The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula:




Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.