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公开(公告)号：US20130217709A1
公开(公告)日：2013-08-22
申请号：US13810860
申请日：2011-07-28
申请人： Bayard R. Huck , Xiaoling Chen , Constantin Neagu , Reinaldo Jones , Yufang Xiao , Igor Mochalkin
发明人： Bayard R. Huck , Xiaoling Chen , Constantin Neagu , Reinaldo Jones , Yufang Xiao , Igor Mochalkin
IPC分类号： C07D403/12 , A61K31/4709 , C07D403/14 , C07D401/12 , C07D401/14 , C07D405/14 , A61K31/517 , A61K45/06
CPC分类号： C07D403/12 , A61K31/4709 , A61K31/517 , A61K45/06 , C07D233/90 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/12 , C07D405/14
摘要： The invention provides novel cyclic amine azaheterocyclic carboxamide according to Formula (I), Formula (II) and Formula (III) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译： 本发明提供了式（I），式（II）和式（III）的新型环胺氮杂环甲酰胺，其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号：US09586938B2
公开(公告)日：2017-03-07
申请号：US13810860
申请日：2011-07-28
申请人： Bayard R. Huck , Xiaoling Chen , Constantin Neagu , Reinaldo Jones , Yufang Xiao , Igor Mochalkin
发明人： Bayard R. Huck , Xiaoling Chen , Constantin Neagu , Reinaldo Jones , Yufang Xiao , Igor Mochalkin
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04 , A01N43/42 , A61K31/47 , C07D403/12 , C07D233/90 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/12 , C07D405/14 , A61K31/4709 , A61K31/517 , A61K45/06 , C07D403/14
CPC分类号： C07D403/12 , A61K31/4709 , A61K31/517 , A61K45/06 , C07D233/90 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/12 , C07D405/14
摘要： The invention provides novel cyclic amine azaheterocyclic carboxamide according to Formula (I), Formula (II) and Formula (III) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译： 本发明提供了式（I），式（II）和式（III）的新型环胺氮杂环甲酰胺，其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号：US20130137677A1
公开(公告)日：2013-05-30
申请号：US13703276
申请日：2011-07-01
申请人： Bayard R. Huck , Constantin Neagu , Reinaldo Jones , Lizbeth Celeste DeSelm , Yufang Xiao , Srinivasa R. Karra , Ruoxi Lan , Igor Mochalkin , Amanda E. Sutton , Thomas E. Richardson
发明人： Bayard R. Huck , Constantin Neagu , Reinaldo Jones , Lizbeth Celeste DeSelm , Yufang Xiao , Srinivasa R. Karra , Ruoxi Lan , Igor Mochalkin , Amanda E. Sutton , Thomas E. Richardson
IPC分类号： C07D239/94 , A61K45/06 , A61K31/517 , C07D403/12
CPC分类号： C07D239/94 , A61K31/517 , A61K45/06 , C07D239/74 , C07D403/12
摘要： The invention provides novel bicyclic azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译： 本发明提供了根据式（I）的新型双环氮杂杂环甲酰胺化合物，其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号：US08710044B2
公开(公告)日：2014-04-29
申请号：US13703276
申请日：2011-07-01
申请人： Bayard R. Huck , Constantin Neagu , Reinaldo Jones , Lizbeth Celeste DeSelm , Yufang Xiao , Srinivasa R. Karra , Ruoxi Lan , Igor Mochalkin , Amanda E. Sutton , Thomas E. Richardson
发明人： Bayard R. Huck , Constantin Neagu , Reinaldo Jones , Lizbeth Celeste DeSelm , Yufang Xiao , Srinivasa R. Karra , Ruoxi Lan , Igor Mochalkin , Amanda E. Sutton , Thomas E. Richardson
IPC分类号： A61K31/00 , A61K31/519 , C07D239/72
CPC分类号： C07D239/94 , A61K31/517 , A61K45/06 , C07D239/74 , C07D403/12
摘要： The invention provides novel bicyclic azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译： 本发明提供了根据式（I）的新型双环氮杂杂环甲酰胺化合物，其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号：US20130252942A1
公开(公告)日：2013-09-26
申请号：US13989199
申请日：2011-11-11
申请人： Bayard R. Huck , Reinaldo Jones , Yufang Xiao , Constantin Neagu , Donald Bankston , Andreas Goutopoulos
发明人： Bayard R. Huck , Reinaldo Jones , Yufang Xiao , Constantin Neagu , Donald Bankston , Andreas Goutopoulos
IPC分类号： C07D403/12 , A61K45/06 , A61K31/517
CPC分类号： C07D403/12 , A61K31/517 , A61K45/06
摘要： The invention provides novel quinazoline carboxamide azetidine compounds according to Formula (I) and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译： 本发明提供了根据式（I）的新型喹唑啉羧酰胺氮杂环丁烷化合物和用于治疗过度增殖性疾病如癌症的用途。
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公开(公告)号：US08946247B2
公开(公告)日：2015-02-03
申请号：US13989199
申请日：2011-11-11
申请人： Bayard R. Huck , Reinaldo Jones , Yufang Xiao , Constantin Neagu , Donald Bankston , Andreas Goutopoulos
发明人： Bayard R. Huck , Reinaldo Jones , Yufang Xiao , Constantin Neagu , Donald Bankston , Andreas Goutopoulos
IPC分类号： A61K31/517 , C07D239/72
CPC分类号： C07D403/12 , A61K31/517 , A61K45/06
摘要： The invention provides novel quinazoline carboxamide azetidine compounds according to Formula (I) and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译： 本发明提供了根据式（I）的新型喹唑啉羧酰胺氮杂环丁烷化合物和用于治疗过度增殖性疾病如癌症的用途。
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公开(公告)号：US08637532B2
公开(公告)日：2014-01-28
申请号：US13148903
申请日：2010-02-04
申请人： Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Stieber , Brian L. Hodous , Hui Qiu , Reinaldo Jones , Brian H. Heasley
发明人： Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Stieber , Brian L. Hodous , Hui Qiu , Reinaldo Jones , Brian H. Heasley
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号： C07D215/04 , A61K31/47 , C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要： The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译： 本发明提供根据式（I）的新型取代的氨基氮杂环甲酰胺化合物，其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号：US08569295B2
公开(公告)日：2013-10-29
申请号：US13388952
申请日：2010-07-28
申请人： Xiaoling Chen , Srinivasa R. Karra , Bayard R. Huck , Ruoxi Lan , Amanda E. Sutton , Andreas Goutopoulos , Brian L. Hodous , Reinaldo Jones
发明人： Xiaoling Chen , Srinivasa R. Karra , Bayard R. Huck , Ruoxi Lan , Amanda E. Sutton , Andreas Goutopoulos , Brian L. Hodous , Reinaldo Jones
IPC分类号： C07D471/04 , C07D498/14 , A61K31/519
CPC分类号： C07D471/04 , C07D498/14
摘要： The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译： 本发明提供根据式（I）的新型取代的氮杂环化合物，其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号：US20120190654A1
公开(公告)日：2012-07-26
申请号：US13388952
申请日：2010-07-28
申请人： Xiaoling Chen , Srinivasa R. Karra , Bayard R. Huck , Ruoxi Lan , Amanda E. Sutton , Andreas Goutopoulos , Brian L. Hodous , Reinaldo Jones
发明人： Xiaoling Chen , Srinivasa R. Karra , Bayard R. Huck , Ruoxi Lan , Amanda E. Sutton , Andreas Goutopoulos , Brian L. Hodous , Reinaldo Jones
IPC分类号： A61K31/519 , C07D498/14 , A61K31/5365 , C07D471/14 , A61K31/5377 , A61K31/635 , A61P35/00 , A61P29/00 , A61P1/18 , A61P13/12 , A61P13/08 , A61P9/00 , A61P17/06 , A61P17/04 , A61P17/00 , A61P3/10 , A61P27/02 , C07D519/00 , C07D471/04
CPC分类号： C07D471/04 , C07D498/14
摘要： The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译： 本发明提供根据式（I）的新型取代的氮杂环化合物，其用于治疗过度增殖性疾病如癌症的制备和用途。
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10.发明授权Compositions and methods for the production of pyrimidine and pyridine compounds with BTK inhibitory activity 有权用BTK抑制活性生产嘧啶和吡啶化合物的组合物和方法公开(公告)号：US09073947B2
公开(公告)日：2015-07-07
申请号：US14112428
申请日：2012-06-10
申请人： Brian L. Hodous , Lesley Liu-Bujalski , Reinaldo Jones , Donald Bankston , Theresa L. Johnson , Igor Mochalkin , Ngan Nguyen , Hui Qiu , Andreas Goutopoulos , Nadia Brugger
发明人： Brian L. Hodous , Lesley Liu-Bujalski , Reinaldo Jones , Donald Bankston , Theresa L. Johnson , Igor Mochalkin , Ngan Nguyen , Hui Qiu , Andreas Goutopoulos , Nadia Brugger
IPC分类号： A61K31/506 , C07D401/12 , C07F5/02 , C07D213/68 , C07D213/73 , C07D213/74 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D495/04 , C07D405/14 , C07D451/02 , C07D471/10
CPC分类号： A61K31/69 , A61K31/44 , A61K31/4545 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/55 , C07D213/68 , C07D213/73 , C07D213/74 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D451/02 , C07D471/10 , C07D495/04 , C07F5/022
摘要： The present invention provides novel pyrimidine and pyridine compounds according to Formula (I), Formula (II), Formula (III), Formula (IV) and Formula (V) their manufacture and use for the treatment of hyperproliferative diseases including, but not limited to, cancer, lupus, allergic disorders, Sjogren's disease and rheumatoid arthritis. In preferred embodiments, the present invention describes irreversible kinase inhibitors including, but not limited to, inhibitors of Bruton's tyrosine kinase.
摘要翻译： 本发明提供了式（I），式（II），式（III），式（IV）和式（V））的新型嘧啶和吡啶化合物用于治疗过度增殖性疾病的制造和用途，包括但不限于 癌症，狼疮，过敏性疾病，干燥病和类风湿性关节炎。 在优选的实施方案中，本发明描述不可逆激酶抑制剂，包括但不限于Bruton酪氨酸激酶的抑制剂。
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