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公开(公告)号：US09512126B2
公开(公告)日：2016-12-06
申请号：US14384828
申请日：2013-03-11
IPC分类号： A01N43/00 , A61K31/33 , C07D487/00 , C07D487/04 , A61K31/5025 , A61K45/06
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06
摘要： The present invention relates to substituted imidazopyridazine compounds of general formula I in which R3, R5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20150104526A1
公开(公告)日：2015-04-16
申请号：US14384828
申请日：2013-03-11
IPC分类号： C07D487/04 , A61K45/06 , A61K31/5025
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06
摘要： The present invention relates to substituted imidazopyridazine compounds of general formula I in which R3, R5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式I的取代的咪唑并哒嗪化合物，其中R3，R5和A如权利要求中所定义，所述化合物的制备方法，药物组合物和包含所述化合物的组合以及所述化合物用于制造 用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物，作为唯一试剂或与其它活性成分组合。
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公开(公告)号：US10730856B2
公开(公告)日：2020-08-04
申请号：US15105832
申请日：2014-12-16
发明人： Olaf Peters , Nico Bräuer , Ulrich Bothe , Marcus Koppitz , Jens Nagel , Gernot Langer
IPC分类号： C07D403/04 , A61K45/06
摘要： The present invention relates to novel benzimidazole derivatives of the general formula (I), to processes for their preparation and to their use for preparing pharmaceutical compositions for the treatment of disorders and indications associated with the EP4 receptor.
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公开(公告)号：US10894784B2
公开(公告)日：2021-01-19
申请号：US16063370
申请日：2016-12-15
发明人： Volker Schulze , Tobias Heinrich , Florian Prinz , Julien Lefranc , Jens Schröder , Anne Mengel , Wilhelm Bone , Joszef Bálint , Antje Margret Wengner , Knut Eis , Horst Irlbacher , Marcus Koppitz , Ulf Bömer , Benjamin Bader , Hans Briem , Philip Lienau , Clara Christ , Detlef Stöckigt , Roman Hillig
IPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D451/14 , C07D471/08 , C07D487/08 , A61P35/00
摘要： The present invention covers heteroarylbenzimidazole compounds of general formula (I) in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative and/or inflammatory disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US09993484B2
公开(公告)日：2018-06-12
申请号：US15501079
申请日：2015-08-03
发明人： Lars Wortmann , Ulrich Lücking , Julien LeFranc , Hans Briem , Marcus Koppitz , Knut Eis , Franz Von Nussbaum , Benjamin Bader , Antje Margret Wengner , Gerhard Siemeister , Wilhelm Bone , Philip Lienau , Joanna Grudzinska-Goebel , Dieter Moosmayer , Uwe Eberspächer , Hans Schick
IPC分类号： C07D471/04 , C07D413/04 , C07D295/02 , C07D403/14 , A61K31/5377 , A61K31/4375 , A61K31/4025 , A61K31/4155 , A61K31/541 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D491/22 , C07D519/00 , C07F9/6561
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (1b), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20160016959A1
公开(公告)日：2016-01-21
申请号：US14771648
申请日：2014-02-25
发明人： Marcus Koppitz , Ulrich Klar , Antje Margret Wengner , Roland Neuhaus , Gerhard Siemeister , Michael Bruning
IPC分类号： C07D487/04 , A61K39/395 , A61K33/24 , A61K31/282 , A61K31/675 , A61K31/7068 , A61K31/52 , A61K38/14 , A61K31/573 , A61K31/704 , A61K31/5025 , A61K31/69
CPC分类号： C07D487/04 , A61K31/282 , A61K31/4188 , A61K31/5025 , A61K31/52 , A61K31/573 , A61K31/675 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K38/14 , A61K39/3955 , A61K2039/505 , C07D237/00
摘要： The present invention relates to substituted imidazopyridazine compounds, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及取代的咪唑并哒嗪化合物，制备所述化合物的方法，药物组合物和包含所述化合物的组合以及所述化合物用于制备药物组合物用于治疗或预防疾病，特别是超级 增殖和/或血管生成障碍，作为唯一的药剂或与其它活性成分组合。
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公开(公告)号：US11529356B2
公开(公告)日：2022-12-20
申请号：US16999832
申请日：2020-08-21
发明人： Lars Wortmann , Ulrich Lücking , Julien Lefranc , Hans Briem , Marcus Koppitz , Knut Eis , Franz Von Nussbaum , Benjamin Bader , Antje Margret Wengner , Gerhard Siemeister , Wilhelm Bone , Philip Lienau , Joanna Grudzinska-Goebel , Dieter Moosmayer , Uwe Eberspächer , Hans Schick
IPC分类号： A61K31/4375 , A61K31/5377 , A61K31/4155 , C07D471/04 , C07D519/00 , C07D413/14 , A61P35/00 , A61P35/02 , A61K31/541 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D491/22 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11319324B2
公开(公告)日：2022-05-03
申请号：US16759262
申请日：2018-10-18
发明人： Marcus Koppitz , Holger Siebeneicher , Nico Bräuer , Elisabeth Pook , Andrea Rotgeri , Roland Neuhaus , Oliver Martin Fischer , Jens Nagel , Adam James Davenport , James Lindsay Carr , Robert James Townsend , Nina Connelly Ursinyova , Shelley Anne Parrott
IPC分类号： C07D487/14
摘要： The present invention covers substituted. Pyrazolo-pyrrolo-pyrimidine-dione (PPPD) compounds of general formula (I): in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neurogenic diseases, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US10729680B2
公开(公告)日：2020-08-04
申请号：US16067830
申请日：2017-01-06
发明人： Ulrich Lücking , Marcus Koppitz , Julien Lefranc , Lars Wortmann , Antje Margret Wengner , Gerhard Siemeister , Ulf Bömer , Benjamin Bader , Philip Lienau , Hans Schick
IPC分类号： A61K31/4375 , A61P35/00 , A61K45/06 , C07D471/04
摘要： The present invention relates to 5-substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
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![[8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones](/abs-image/US/2019/01/01/US10167293B2/abs.jpg.150x150.jpg)
公开(公告)号：US10167293B2
公开(公告)日：2019-01-01
申请号：US15596383
申请日：2017-05-16
发明人： Marcus Koppitz , Holger Siebeneicher , Holger Steuber , Antonius Ter Laak , Reinhard Nubbemeyer , Antje Rottmann , Horst Irlbacher , Benjamin Bader , Michaele Peters , Andrea Wagenfeld , Ildiko Terebesi
IPC分类号： C07D487/08 , A61K31/4995 , A61K45/06
摘要： The present invention covers [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of disorders, in particular of gynecological disorders, hyperproliferative disorders, metabolic disorders, or inflammatory disorders as a sole agent or in combination with other active ingredients.
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