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公开(公告)号：US20150274754A1
公开(公告)日：2015-10-01
申请号：US14738148
申请日：2015-06-12
发明人： Markus FOLLMANN , Johannes-Peter STASCH , Gorden REDLICH , Nils GRIEBENOW , Dieter LANG , Frank WUNDER , Walter HÜBSCH , Alexandros VAKALOPOULOS , Adrian TERSTEEGEN
IPC分类号： C07D519/00 , A61K31/53 , A61K45/06 , A61K31/519
CPC分类号： C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06 , C07D471/04
摘要： The present application relates to novel substituted fused pyrimidines and triazines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新颖的取代的稠合嘧啶和三嗪，其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于生产药物用于治疗和/或预防 疾病，特别是用于治疗和/或预防心血管疾病。
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2.发明申请ALKYLAMINE-SUBSTITUTED DICYANOPYRIDINE AND AMINO ACID ESTER PRODRUGS THEREOF 有权烷基取代的二亚氨基吡啶和氨基酸酯的制备方法公开(公告)号：US20130267700A1
公开(公告)日：2013-10-10
申请号：US13801484
申请日：2013-03-13
发明人： Alexandros VAKALOPOULOS , Daniel MEIBOM , Barbara ALBRECHT-KÜPPER , Katja ZIMMERMANN , Jörg KELDENICH , Hans-Georg LERCHEN , Peter NELL , Frank SÜßMEIER , Ursula KRENZ
IPC分类号： C07D417/14 , C07D417/12
CPC分类号： C07D417/14 , A61K47/64 , C07D417/12 , C07K5/0202 , C07K5/06026 , C07K5/06034 , C07K5/06086 , C07K5/06147 , C07K5/06165
摘要： The present application relates to novel 6-alkylamino-substituted dicyanopyridines, to their amino acid ester prodrugs, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的6-烷基氨基取代的二氰基吡啶，其氨基酸酯前药，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/ 或预防疾病，优选用于治疗和/或预防心血管疾病。
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公开(公告)号：US20140162981A1
公开(公告)日：2014-06-12
申请号：US13893344
申请日：2013-05-14
发明人： Peter NELL , Walter HÜBSCH , Barbara ALBRECHT-KÜPPER , Jorg KELDENICH , Alexandros VAKALOPOULOS , Frank SÜSSMEIER , Katja ZIMMERMANN , Dieter LANG , Daniel MEIBOM
IPC分类号： C07D413/14 , C07D413/12 , C07F7/10 , A61K31/695 , A61K31/4439 , A61K45/06
CPC分类号： A61K31/4439 , A61K31/695 , A61K45/06 , C07D413/12 , C07D413/14 , C07D419/14 , C07F7/10
摘要： The present application relates to novel substituted aryloxazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular and metabolic disorders.
摘要翻译： 本申请涉及新型取代的芳氧唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ /或预防心血管和代谢紊乱。
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公开(公告)号：US20150105374A1
公开(公告)日：2015-04-16
申请号：US14491558
申请日：2014-09-19
发明人： Markus FOLLMANN , Johannes-Peter STASCH , Gorden REDLICH , Nils GRIEBENOW , Dieter LANG , Frank WUNDER , Walter HÜBSCH , Niels LINDNER , Alexandros VAKALOPOULOS , Adrian TERSTEEGEN
IPC分类号： A61K31/519 , A61K45/06 , A61K31/527 , A61K31/5377 , A61K31/5386 , A61K31/541 , C07D519/00 , C07D487/04
CPC分类号： A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/5383 , A61K31/5386 , A61K31/541 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/20 , C07D498/08 , C07D519/00
摘要： The present application relates to novel substituted annellated pyrimidines, methods for production thereof, use thereof alone or in combinations for treating and/or preventing diseases and use thereof for the production of medicinal products for treating and/or preventing diseases, in particular for treating and/or preventing cardiovascular diseases.
摘要翻译： 本申请涉及新颖的取代的环状嘧啶，其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防心血管疾病。
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5.发明申请ALKYLAMINE-SUBSTITUTED DICYANOPYRIDINE AND AMINO ACID ESTER PRODRUGS THEREOF 审中-公开烷基取代的二亚氨基吡啶和氨基酸酯的制备方法公开(公告)号：US20140296515A1
公开(公告)日：2014-10-02
申请号：US14306781
申请日：2014-06-17
发明人： Alexandros VAKALOPOULOS , Daniel MEIBOM , Barbara ALBRECHT-KÜPPER , Katja ZIMMERMANN , Jörg KELDENICH , Hans-Georg LERCHEN , Peter NELL , Frank SÜßMEIER , Ursula KRENZ
IPC分类号： C07D417/14 , C07D417/12
CPC分类号： C07D417/14 , A61K47/64 , C07D417/12 , C07K5/0202 , C07K5/06026 , C07K5/06034 , C07K5/06086 , C07K5/06147 , C07K5/06165
摘要： The present application relates to novel 6-alkylamino-substituted dicyanopyridines, to their amino acid ester prodrugs, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的6-烷基氨基取代的二氰基吡啶，其氨基酸酯前药，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/ 或预防疾病，优选用于治疗和/或预防心血管疾病。
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公开(公告)号：US20140296295A1
公开(公告)日：2014-10-02
申请号：US14304801
申请日：2014-06-13
发明人： Walter HÜBSCH , Daniel MEIBOM , Alexandros VAKALOPOULOS , Barbara ALBRECHT-KÜPPER , Peter NELL , Katja ZIMMERMANN , Frank SÜßMEIER , Joerg KELDENICH
IPC分类号： C07D417/14 , A61K31/4439 , A61K31/44 , A61K45/06 , C07D413/12 , C07D401/12 , C07D213/85 , A61K31/444 , C07D417/12
CPC分类号： A61K31/44 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D213/70 , C07D213/85 , C07D401/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present application relates to novel 2-alkoxy-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的2-烷氧基取代的二氰基吡啶，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于 治疗和/或预防心血管疾病。
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公开(公告)号：US20210261541A1
公开(公告)日：2021-08-26
申请号：US17161201
申请日：2021-01-28
发明人： Henrik TELLER , Alexandros VAKALOPOULOS , Melissa BOULTADAKIS ARAPINIS , Alexander STRAUB , Hanna TINEL , Markus BRECHMANN , Matthias Beat WITTWER , Maximillian Andreas KULLMANN , Till FREUDENBERGER , Thomas MONDRITZKI , Tobias MARQUARDT
IPC分类号： C07D471/04 , A61P9/06 , A61K31/4375 , A61K31/551 , A61K45/06 , C07D491/107 , C07D519/00 , A61P9/00 , A61P13/00
摘要： The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US20170240566A1
公开(公告)日：2017-08-24
申请号：US15503578
申请日：2015-08-25
发明人： Alexandros VAKALOPOULOS , Gaelle VALOT , Markus FOLLMANN , Damian BROCKSCHNIEDER , Johannes-Peter STASCH , Tobias MARQUARDT , Adrian TERSTEEGEN , Frank WUNDER , Lisa DIETZ , Dieter LANG , Ursula KRENZ
IPC分类号： C07D519/00 , A61K31/519 , C07D487/04 , A61K45/06
CPC分类号： C07D519/00 , A61K31/519 , A61K45/06 , C07D487/04
摘要： The present application relates to novel amino-substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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公开(公告)号：US20160002267A1
公开(公告)日：2016-01-07
申请号：US14771542
申请日：2014-02-25
发明人： Markus FOLLMANN , Johannes-Peter STASCH , Gorden REDLICH , Dieter LANG , Alexandros VAKALOPOULOS , Frank WUNDER , Adrian TERSTEEGEN
IPC分类号： C07D519/00 , A61K45/06 , A61K31/519
CPC分类号： C07D519/00 , A61K31/519 , A61K45/06
摘要： The present application relates to novel benzyl-substituted pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的苄基取代的吡唑并吡啶，其制备方法，单独使用或组合用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途 ，特别是用于治疗和/或预防心血管疾病。
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![Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use](/abs-image/US/2014/06/26/US20140179672A1/abs.jpg.150x150.jpg)
公开(公告)号：US20140179672A1
公开(公告)日：2014-06-26
申请号：US14070180
申请日：2013-11-01
发明人： Alexandros VAKALOPOULOS , Markus FOLLMANN , Ingo HARTUNG , Philipp BUCHGRABER , Rolf JAUTELAT , Jorma HAßFELD , Niels LINDNER , Alexey GROMOV , Frank WUNDER , Johannes-Peter STASCH , Gorden REDLICH , Volkhart Min-Jian LI , Eva Maria BECKER-PELSTER , Andreas KNORR
IPC分类号： A61K31/4985 , A61K45/06 , C07D471/04 , A61K31/437 , C07D471/08 , A61K31/439
CPC分类号： A61K31/437 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/04 , C07D471/08 , C07D519/00
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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