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公开(公告)号：US20150274754A1
公开(公告)日：2015-10-01
申请号：US14738148
申请日：2015-06-12
发明人： Markus FOLLMANN , Johannes-Peter STASCH , Gorden REDLICH , Nils GRIEBENOW , Dieter LANG , Frank WUNDER , Walter HÜBSCH , Alexandros VAKALOPOULOS , Adrian TERSTEEGEN
IPC分类号： C07D519/00 , A61K31/53 , A61K45/06 , A61K31/519
CPC分类号： C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06 , C07D471/04
摘要： The present application relates to novel substituted fused pyrimidines and triazines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新颖的取代的稠合嘧啶和三嗪，其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于生产药物用于治疗和/或预防 疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20140309307A1
公开(公告)日：2014-10-16
申请号：US14304171
申请日：2014-06-13
发明人： Michael HAHN , Thomas LAMPE , Johannes-Peter STASCH , Karl-Heinz SCHLEMMER , Frank WUNDER , Volkhart Min-Jian LI , Eva-Maria BECKER , Friederike STOLL , Andreas KNORR , Elisabeth WOLTERING
IPC分类号： C07C233/55 , A61K45/06 , A61K31/196
CPC分类号： C07C231/14 , A61K9/0053 , A61K31/196 , A61K45/06 , C07C233/55 , C07C235/38 , C07C2601/02 , C07C2601/04 , C07C2601/08
摘要： The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
摘要翻译： 本申请涉及在3-位上带有支链或环状烷基取代基的新型3-苯基丙酸衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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3.发明申请BENZIMIDAZOLE AND PYRAZOLOPYRIDINE DERIVATIVES FOR TREATING AND/OR PREVENTING CARDIOVASCULAR DISEASES 审中-公开用于治疗和/或预防心脏血管疾病的苯唑咪唑和吡唑并吡啶衍生物公开(公告)号：US20130303559A1
公开(公告)日：2013-11-14
申请号：US13941967
申请日：2013-07-15
发明人： Alexander STRAUB , Frank SÜßMEIER , Frank WUNDER , Johannes-Peter STASCH , Volkhart Min-Jian LI , Joachim MITTENDORF
IPC分类号： C07D403/04 , A61K31/506 , A61K45/06 , C07D471/04
CPC分类号： C07D403/04 , A61K31/506 , A61K45/06 , C07D403/14 , C07D471/04
摘要： The present application relates to novel fused, heteroatom-bridged pyrazole and imidazole derivatives, to processes for their preparation, to their use, alone or in combination, for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的稠合，杂原子桥连的吡唑和咪唑衍生物，其制备方法，单独或组合用于治疗和/或预防疾病及其用于制备用于治疗的药物的用途 和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20130237551A1
公开(公告)日：2013-09-12
申请号：US13851373
申请日：2013-03-27
发明人： Markus FOLLMANN , Johannes-Peter STASCH , Gorden REDLICH , Jens ACKERSTAFF , Nils GRIEBENOW , Walter KROH , Andreas KNORR , Eva-Maria BECKER , Frank WUNDER , Volkhart Min-Jian LI , Elke HARTMANN , Joachim MITTENDORF , Karl-Heinz SCHLEMMER , Rolf JAUTELAT , Donald BIERER
IPC分类号： A61K31/506 , A61K45/06
CPC分类号： A61K31/506 , A61K45/06 , C07C57/145 , C07C309/04 , C07C309/05 , C07D471/04
摘要： The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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公开(公告)号：US20130210824A1
公开(公告)日：2013-08-15
申请号：US13736692
申请日：2013-01-08
发明人： Markus FOLLMANN , Johannes-Peter STASCH , Gorden REDLICH , Nils GRIEBENOW , Dieter LANG , Frank WUNDER , Holger PAULSEN , Walter Hübsch
IPC分类号： C07D487/04 , A61K31/53 , A61K45/06 , A61K31/519
CPC分类号： C07D487/04 , A61K31/519 , A61K31/53 , A61K45/06 , C07D519/00 , A61K2300/00
摘要： The present application relates to novel substituted fused imidazoles and pyrazoles, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof producing medicaments for the treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
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公开(公告)号：US20190185415A1
公开(公告)日：2019-06-20
申请号：US16230957
申请日：2018-12-21
发明人： Michael HAHN , Thomas LAMPE , Johannes-Peter STASCH , Karl-Heinz SCHLEMMER , Frank WUNDER , Volkhart Min-Jian LI , Eva-Maria BECKER-PELSTER , Friederike STOLL , Andreas KNORR , Elisabeth WOLTERING
IPC分类号： C07C231/14 , A61K9/00 , A61K45/06 , C07C233/55 , A61K31/196 , C07C235/38
CPC分类号： C07C231/14 , A61K9/0053 , A61K31/196 , A61K45/06 , C07C233/55 , C07C235/38 , C07C2601/02 , C07C2601/04 , C07C2601/08
摘要： The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
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公开(公告)号：US20150105374A1
公开(公告)日：2015-04-16
申请号：US14491558
申请日：2014-09-19
发明人： Markus FOLLMANN , Johannes-Peter STASCH , Gorden REDLICH , Nils GRIEBENOW , Dieter LANG , Frank WUNDER , Walter HÜBSCH , Niels LINDNER , Alexandros VAKALOPOULOS , Adrian TERSTEEGEN
IPC分类号： A61K31/519 , A61K45/06 , A61K31/527 , A61K31/5377 , A61K31/5386 , A61K31/541 , C07D519/00 , C07D487/04
CPC分类号： A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/5383 , A61K31/5386 , A61K31/541 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/20 , C07D498/08 , C07D519/00
摘要： The present application relates to novel substituted annellated pyrimidines, methods for production thereof, use thereof alone or in combinations for treating and/or preventing diseases and use thereof for the production of medicinal products for treating and/or preventing diseases, in particular for treating and/or preventing cardiovascular diseases.
摘要翻译： 本申请涉及新颖的取代的环状嘧啶，其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防心血管疾病。
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公开(公告)号：US20150080414A1
公开(公告)日：2015-03-19
申请号：US14552122
申请日：2014-11-24
发明人： Markus FOLLMANN , Johannes-Peter STASCH , Gorden REDLICH , Jens ACKERSTAFF , Nils GRIEBENOW , Walter KROH , Andreas KNORR , Eva-Maria BECKER , Frank WUNDER , Volkhart Min-Jian LI , Elke HARTMANN , Joachim MITTENDORF , Karl-Heinz SCHLEMMER , Rolf JAUTELAT , Donald BIERER
IPC分类号： C07D471/04 , A61K45/06 , A61K31/506
CPC分类号： A61K31/506 , A61K45/06 , C07C57/145 , C07C309/04 , C07C309/05 , C07D471/04
摘要： The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的5-氟-1H-吡唑并吡啶，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及它们用于制备用于治疗和/ 或预防疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20140142069A1
公开(公告)日：2014-05-22
申请号：US14045630
申请日：2013-10-03
发明人： Thomas LAMPE , Michael HAHN , Johannes-Peter STASCH , Karl-Heinz SCHLEMMER , Frank WUNDER , Sherif EL SHEIKH , Volkhart Min-Jian LI , Eva-Maria BECKER-PELSTER , Friederike STOLL , Andreas KNORR
IPC分类号： C07C233/88 , A61K31/655 , C07C231/02 , A61K31/196
CPC分类号： C07C233/88 , A61K31/196 , A61K31/655 , C07C205/38 , C07C231/02 , C07C233/45 , C07C233/55 , C07C255/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D305/06
摘要： The present application relates to novel 3-phenylpropionic acid derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的3-苯基丙酸衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是 治疗和/或预防心血管疾病。
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公开(公告)号：US20180282262A1
公开(公告)日：2018-10-04
申请号：US16001146
申请日：2018-06-06
发明人： Michael HAHN , Thomas LAMPE , Johannes-Peter STASCH , Karl-Heinz SCHLEMMER , Frank WUNDER , Volkhart Min-Jian LI , Eva-Maria BECKER-PELSTER , Friederike STOLL , Andreas KNORR , Elisabeth WOLTERING
IPC分类号： C07C231/14 , A61K31/196 , C07C235/38 , C07C233/55 , A61K45/06 , A61K9/00
CPC分类号： C07C231/14 , A61K9/0053 , A61K31/196 , A61K45/06 , C07C233/55 , C07C235/38 , C07C2601/02 , C07C2601/04 , C07C2601/08
摘要： The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
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