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    Anti-mesothelin immunoconjugates and uses therefor
    3.
    发明授权
    Anti-mesothelin immunoconjugates and uses therefor 有权

    公开(公告)号：US10781263B2

    公开(公告)日：2020-09-22

    申请号：US15923766

    申请日：2018-03-16

    申请人： Bayer Intellectual Property GmbH

    发明人： Antje Kahnert ,  Kerstin Unterschemmann ,  Iring Heisler ,  Charlotte Christine Kopitz ,  Joachim Schuhmacher

    IPC分类号： A61K39/00 ,  C07K16/30 ,  A61K47/68

    摘要： The present invention provides immunoconjugates composed of antibodies, e.g., monoclonal antibodies, or antibody fragments that bind to mesothelin, that are conjugated to cytotoxic agents, e.g., maytansine, or derivatives thereof, and/or co-administered or formulated with one or more additional anti-cancer agents. The immunoconjugates of the invention can be used in the methods of the invention to treat and/or diagnose and/or monitor cancers, e.g. solid tumors, recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells.

    Anti-mesothelin immunoconjugates and uses therefor
    4.
    发明授权
    Anti-mesothelin immunoconjugates and uses therefor 有权

    公开(公告)号：US10647779B2

    公开(公告)日：2020-05-12

    申请号：US15656645

    申请日：2017-07-21

    申请人： Bayer Intellectual Property GmbH

    发明人： Antje Kahnert ,  Kerstin Unterschemmann ,  Iring Heisler ,  Charlotte Kopitz ,  Joachim Schuhmacher

    IPC分类号： A61K39/00 ,  C07K16/30 ,  A61K47/68

    摘要： The present invention provides immunoconjugates composed of antibodies, e.g., monoclonal antibodies, or antibody fragments that bind to mesothelin, that are conjugated to cytotoxic agents, e.g., maytansine, or derivatives thereof, and/or co-administered or formulated with one or more additional anti-cancer agents. The immunoconjugates of the invention can be used in the methods of the invention to treat and/or diagnose and/or monitor cancers, solid tumors, recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells.

    ANTI-MESOTHELIN IMMUNOCONJUGATES AND USES THEREFOR
    5.
    发明申请
    ANTI-MESOTHELIN IMMUNOCONJUGATES AND USES THEREFOR 审中-公开

    公开(公告)号：US20180201690A1

    公开(公告)日：2018-07-19

    申请号：US15923766

    申请日：2018-03-16

    申请人： Bayer Intellectual Property GmbH

    发明人： Antje Kahnert ,  Kerstin Unterschemmann ,  Iring Heisler ,  Charlotte Christine Kopitz ,  Joachim Schuhmacher

    IPC分类号： C07K16/30 ,  A61K47/68

    摘要： The present invention provides immunoconjugates composed of antibodies, e.g., monoclonal antibodies, or antibody fragments that bind to mesothelin, that are conjugated to cytotoxic agents, e.g., maytansine, or derivatives thereof, and/or co-administered or formulated with one or more additional anti-cancer agents. The immunoconjugates of the invention can be used in the methods of the invention to treat and/or diagnose and/or monitor cancers, e.g. solid tumors, recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells.

    N-CARBOXYALKYL-AURISTATIN AND USE THEREOF
    7.
    发明申请
    N-CARBOXYALKYL-AURISTATIN AND USE THEREOF 审中-公开
    N-羧甲基 - 鸟嘌呤及其用途

    公开(公告)号：US20150148298A1

    公开(公告)日：2015-05-28

    申请号：US14615005

    申请日：2015-02-05

    申请人： SEATTLE GENETICS, INC.

    发明人： Hans-Georg LERCHEN ,  Sherif El Sheikh ,  Beatrix Stelet-Ludwig ,  Sven Golfier ,  Joachim Schuhmacher ,  Jean Mark Gnoth ,  Ursula Krenz

    IPC分类号： C07K5/113

    CPC分类号： C07K5/1021 ,  A61K38/00 ,  A61K38/07 ,  A61K38/08 ,  A61K45/06 ,  C07K1/1077 ,  C07K5/0205 ,  C07K7/02

    摘要： The present application relates to new derivatives of monomethylauristatin F, substituted on the N terminus by a carboxyalkyl group, processes for preparing these derivatives, their use for the treatment and/or prevention of diseases and to produce medication for the treatment and/or prevention of diseases, particularly hyperproliferative and/or angiogenic disorders such as cancer disorders, for example. Such treatments can occur as monotherapies or in combination with other medication or further therapeutic measures.

    摘要翻译： 本申请涉及通过羧基烷基在N末端被取代的单甲基海洛定蛋白F的新衍生物，用于制备这些衍生物的方法，其用于治疗和/或预防疾病以及产生用于治疗和/或预防 疾病，特别是过度增生和/或血管发生疾病，例如癌症。 这种治疗可以作为单一疗法发生，或与其他药物或其他治疗措施组合发生。