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公开(公告)号：US20200338096A1
公开(公告)日：2020-10-29
申请号：US16758742
申请日：2018-10-17
发明人： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Matthias Beat WITTWER , Carsten SCHMECK , Pierre WASNAIRE , Heiko SCHIRMER , Hana CERNECKA , Karoline DROEBNER , Hanna TINEL , Anja BUCHMUELLER , Thomas MONDRITZKI , Axel KRETSCHMER , Klemens LUSTIG , Robert FRICKE , Guillaume LEVILAIN , Ursula KRENZ , Norbert WITOWSKI
IPC分类号： A61K31/675 , A61K45/06 , C07F9/6558 , A61P13/12
摘要： The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20210261541A1
公开(公告)日：2021-08-26
申请号：US17161201
申请日：2021-01-28
发明人： Henrik TELLER , Alexandros VAKALOPOULOS , Melissa BOULTADAKIS ARAPINIS , Alexander STRAUB , Hanna TINEL , Markus BRECHMANN , Matthias Beat WITTWER , Maximillian Andreas KULLMANN , Till FREUDENBERGER , Thomas MONDRITZKI , Tobias MARQUARDT
IPC分类号： C07D471/04 , A61P9/06 , A61K31/4375 , A61K31/551 , A61K45/06 , C07D491/107 , C07D519/00 , A61P9/00 , A61P13/00
摘要： The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US20170320854A1
公开(公告)日：2017-11-09
申请号：US15581064
申请日：2017-04-28
发明人： Marie-Pierre COLLIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMÜLLER , Hanna TINEL , Karoline DRÖBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Axel KRETSCHMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA
IPC分类号： C07D401/14 , A61K45/06 , A61K31/4439
CPC分类号： C07D401/14 , A61K31/4439 , A61K45/06
摘要： The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20160122325A1
公开(公告)日：2016-05-05
申请号：US14930157
申请日：2015-11-02
发明人： Carsten SCHMECK , Michael GERISCH , Nils GRIEBENOW , Peter KOLKHOF , Florian KOLLING , Anna ENGELEN , Axel KRETSCHMER , Dieter LANG , Klemens LUSTIG , Thomas MONDRITZKI , Elisabeth POOK , Hartmut BECK , Frank SÜßMEIER , Sonja VOLLMER , Pierre WASNAIRE
IPC分类号： C07D403/06 , A61K45/06 , A61K31/4196
CPC分类号： C07D249/12 , A61K31/4196 , A61K45/06 , C07D403/06
摘要： The present invention relates to novel 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular and renal diseases.
摘要翻译： 本发明涉及新的5-（羟基烷基）-1-苯基-1,2,4-三唑衍生物，制备这些化合物的方法，含有这些化合物的药物组合物，以及这些化合物或组合物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管和肾脏疾病。
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公开(公告)号：US20190161454A1
公开(公告)日：2019-05-30
申请号：US16098266
申请日：2017-05-02
发明人： Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMÜLLER , Hanna TINEL , Karoline DRÖBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Axel KRETSCHMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA
IPC分类号： C07D249/12 , A61K45/06 , A61K31/4196 , A61P9/00 , A61P13/12
摘要： The present invention relates to novel 5-(carboxamide)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20190144423A1
公开(公告)日：2019-05-16
申请号：US16098308
申请日：2017-05-02
发明人： Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMÜLLER , Hanna TINEL , Karoline DRÖBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Axel KRETSCHMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA
IPC分类号： C07D401/14 , A61P13/12 , A61P9/04 , A61P9/10 , A61P3/10
摘要： The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20190119251A1
公开(公告)日：2019-04-25
申请号：US16098262
申请日：2017-05-02
发明人： Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMÜLLER , Hanna TINEL , Karoline DRÖBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA , Axel KRETSCHMER
IPC分类号： C07D401/14 , A61K45/06 , A61K31/4439 , C07D403/14 , A61K31/497 , A61K31/506 , C07D403/06 , A61K31/4196
摘要： The present invention relates to novel 5-(carboxamide)-1-aryl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20200017473A1
公开(公告)日：2020-01-16
申请号：US16579341
申请日：2019-09-23
发明人： Marie-Pierre COLLIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMUELLER , Hanna TINEL , Karoline DROEBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Axel KRETSCHMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA
IPC分类号： C07D401/14 , A61P9/04 , A61P13/12 , A61P3/10 , A61P9/10 , A61K45/06 , A61K31/4439
摘要： The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20190241562A1
公开(公告)日：2019-08-08
申请号：US16317322
申请日：2017-07-04
发明人： Henrik TELLER , Melissa BOULTADAKIS ARAPINIS , Alexandros VAKALOPOULOS , Anne-Sophie REBSTOCK , Alexander STRAUB , Hanna TINEL , Markus BRECHMANN , Matthias Beat WITTWER , Maximillian Andreas KULLMANN , Klaus MÜNTER , Thomas MONDRITZKI , Tobias MARQUARDT
IPC分类号： C07D471/04 , A61P9/04 , A61P13/12 , A61P9/06
摘要： The present application relates to novel 7-substituted 1-pyridylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US20170313665A1
公开(公告)日：2017-11-02
申请号：US15523061
申请日：2015-10-30
发明人： Carsten SCHMECK , Michael GERISCH , Nils GRIEBENOW , Peter KOLKHOF , Florian KÖLLING , Anna ENGELEN , Axel KRETSCHMER , Dieter LANG , Klemens LUSTIG , Thomas MONDRITZKI , Elisabeth POOK , Hartmut BECK , Frank SÜßMEIER , Sonja VOLLMER , Pierre WASNAIRE
IPC分类号： C07D249/12 , A61K45/06 , A61K31/4196
CPC分类号： C07D249/12 , A61K31/4196 , A61K45/06 , C07D403/06
摘要： The present invention relates to novel 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular and renal diseases.
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