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公开(公告)号：US20230077280A1
公开(公告)日：2023-03-09
申请号：US17781349
申请日：2020-12-03
摘要： Embodiments of the disclosure encompass methods of treating insulin resistance in an individual in need thereof by administering one or more STAT3 inhibitors to the individual. In specific aspects, the methods allow for reversing insulin resistance in individuals. The STAT3 inhibitor may be one or more particular small molecules encompassed herein.
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2.发明申请公开(公告)号：US20200331880A1
公开(公告)日：2020-10-22
申请号：US16848661
申请日：2020-04-14
IPC分类号： C07D333/34 , A61K31/47 , A61K31/4406 , A61K31/415 , A61K31/381 , A61K31/357 , A61K31/145 , C07D215/36 , C07D213/71 , C07D231/18 , C07D319/18 , C07C311/08 , C07C311/10 , C07C311/13 , C07C311/21 , C07C311/24 , C07C311/29 , C07C311/44 , C07C323/49 , C07C381/06 , A61K45/06 , A61K31/18 , A61K31/4035 , A61K31/404 , A61K31/4164 , A61K31/4196 , A61K31/42 , A61K31/428 , A61K31/45 , A61K31/454 , A61K31/4704 , A61K31/4709 , A61K31/513
摘要： Embodiments of the invention include methods of treating, preventing, and/or reduce the risk or severity of a condition selected from the group consisting of muscle wasting, muscle weakness, cachexia, and a combination thereof in an individual in need thereof. In some embodiments, particular small molecules are employed for treatment, prevention, and/or reduction in the risk of muscle wasting. In at least particular cases, the small molecules are inhibitors of STAT3.
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公开(公告)号：US20220227750A1
公开(公告)日：2022-07-21
申请号：US17649133
申请日：2022-01-27
申请人： Baylor College of Medicine , The United States of America, as represented by the Secretary, Department of Health and Human Servic
IPC分类号： C07D417/12 , A61K31/18 , A61K31/381 , A61K31/505 , A61K45/06 , A61K31/196 , A61K31/4196 , A61K31/357 , A61K31/415 , A61K31/403 , C07C311/08 , C07C311/21 , C07C311/29 , C07D213/71 , C07D215/36 , C07D239/545 , C07D319/18 , C07D333/34 , C07D401/12 , C07D409/12 , C07D413/12
摘要： Embodiments of the invention include methods of preventing and/or reducing the risk or severity of an allergic reaction in an individual. In some embodiments, particular small molecules are employed for prevention and/or reduction in the risk or severity of anaphylaxis. In at least particular cases, the small molecules are inhibitors of STAT3. In some cases, the small molecule comprises N-(1′,2-dihydroxy-1,2′-binaphthalen-4′-yl)-4-methoxybenzenesulfonamide.
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公开(公告)号：US20150051233A1
公开(公告)日：2015-02-19
申请号：US14335804
申请日：2014-07-18
IPC分类号： C07D417/12 , C07D333/34 , C07D215/06 , C07C317/28 , C07D413/12 , C07D213/71 , C07D231/18 , C07D261/10 , C07D239/60 , C07D409/12 , C07C317/32 , C07C317/30
CPC分类号： C07D417/12 , A61K31/18 , A61K31/343 , A61K31/39 , A61K31/4196 , A61K45/06 , C07C317/28 , C07C317/30 , C07C317/32 , C07D213/71 , C07D215/06 , C07D231/18 , C07D239/60 , C07D261/10 , C07D333/34 , C07D409/12 , C07D413/12
摘要： Embodiments of the invention include methods of treating, preventing, and/or reducing the risk of fibrosis in an individual in need thereof. In some embodiments, particular small molecules are employed for treatment, prevention, and/or reduction of the risk of fibrosis. In at least particular cases, the small molecules are inhibitors of STAT3.
摘要翻译： 本发明的实施方案包括在有需要的个体中治疗，预防和/或降低纤维化风险的方法。 在一些实施方案中，特定的小分子用于治疗，预防和/或降低纤维化风险。 在至少特定情况下，小分子是STAT3的抑制剂。
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公开(公告)号：US20150031714A1
公开(公告)日：2015-01-29
申请号：US14335829
申请日：2014-07-18
申请人： Baylor College of Medicine , THE UNITED STATES OF AMERICA, as represented by The Secretary, Dept. of Health and Human Services
IPC分类号： C07D417/12 , C07C311/29 , C07D333/34 , C07D215/36 , C07D413/12 , C07D319/18 , C07D213/71 , C07D239/545 , C07D401/12 , C07D409/12 , C07C311/21 , C07C311/08
CPC分类号： C07D417/12 , A61K31/18 , A61K31/196 , A61K31/357 , A61K31/381 , A61K31/403 , A61K31/415 , A61K31/4196 , A61K31/505 , A61K45/06 , C07C311/08 , C07C311/21 , C07C311/29 , C07D213/71 , C07D215/36 , C07D239/545 , C07D319/18 , C07D333/34 , C07D401/12 , C07D409/12 , C07D413/12 , A61K2300/00
摘要： Embodiments of the invention include methods of preventing and/or reducing the risk or severity of an allergic reaction in an individual. In some embodiments, particular small molecules are employed for prevention and/or reduction in the risk or severity of anaphylaxis. In at least particular cases, the small molecules are inhibitors of STAT3. In some cases, the small molecule comprises N-(1′,2-dihydroxy-1,2′-binaphthalen-4′-yl)-4-methoxybenzenesulfonamide.
摘要翻译： 本发明的实施方案包括预防和/或降低个体中过敏反应的风险或严重程度的方法。 在一些实施方案中，使用特定的小分子来预防和/或降低过敏反应的风险或严重程度。 在至少特定情况下，小分子是STAT3的抑制剂。 在一些情况下，小分子包含N-（1'，2-二羟基-1,2'-联萘-4'-基）-4-甲氧基苯磺酰胺。
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6.发明授权公开(公告)号：US11161831B2
公开(公告)日：2021-11-02
申请号：US16848661
申请日：2020-04-14
IPC分类号： C07D333/34 , A61K31/47 , A61K31/4406 , A61K31/415 , A61K31/381 , A61K31/357 , A61K31/145 , C07D215/36 , C07D213/71 , C07D231/18 , C07D319/18 , C07C311/08 , C07C311/10 , C07C311/13 , C07C311/31 , C07C311/24 , C07C311/29 , C07C311/44 , C07C311/49 , C07C311/06 , A61K31/06 , A61K31/18 , A61K31/4035 , A61K31/404 , A61K31/4164 , A61K31/4196 , A61K31/42 , A61K31/428 , A61K31/45 , A61K31/454 , A61K31/4704 , A61K31/4709 , A61K31/513 , C07C311/21 , C07C323/49 , C07C381/06 , A61K45/06
摘要： Embodiments of the invention include methods of treating, preventing, and/or reduce the risk or severity of a condition selected from the group consisting of muscle wasting, muscle weakness, cachexia, and a combination thereof in an individual in need thereof. In some embodiments, particular small molecules are employed for treatment, prevention, and/or reduction in the risk of muscle wasting. In at least particular cases, the small molecules are inhibitors of STAT3.
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7.发明授权公开(公告)号：US10676455B2
公开(公告)日：2020-06-09
申请号：US14335853
申请日：2014-07-18
IPC分类号： C07D333/34 , A61K31/47 , A61K31/44 , A61K31/194 , C07C311/21 , C07D215/36 , A61K31/4406 , A61K31/415 , A61K31/381 , A61K31/357 , A61K31/145 , C07D213/71 , C07D231/18 , C07D319/18 , C07C311/08 , C07C311/10 , C07C311/13 , C07C311/24 , C07C311/29 , C07C311/44 , C07C323/49 , C07C381/06 , A61K45/06 , A61K31/18 , A61K31/4035 , A61K31/404 , A61K31/4164 , A61K31/4196 , A61K31/42 , A61K31/428 , A61K31/45 , A61K31/454 , A61K31/4704 , A61K31/4709 , A61K31/513
摘要： Embodiments of the invention include methods of treating, preventing, and/or reduce the risk or severity of a condition selected from the group consisting of muscle wasting, muscle weakness, cachexia, and a combination thereof in an individual in need thereof. In some embodiments, particular small molecules are employed for treatment, prevention, and/or reduction in the risk of muscle wasting. In at least particular cases, the small molecules are inhibitors of STAT3.
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公开(公告)号：US10112933B2
公开(公告)日：2018-10-30
申请号：US14335804
申请日：2014-07-18
IPC分类号： C07D417/12 , A61K31/18 , C07C317/28 , C07C317/30 , C07C317/32 , C07D213/71 , C07D215/06 , C07D231/18 , C07D239/60 , C07D261/10 , C07D333/34 , C07D409/12 , C07D413/12 , A61K31/343 , A61K31/39 , A61K31/4196 , A61K45/06
摘要： Embodiments of the invention include methods of treating, preventing, and/or reducing the risk of fibrosis in an individual in need thereof. In some embodiments, particular small molecules are employed for treatment, prevention, and/or reduction of the risk of fibrosis. In at least particular cases, the small molecules are inhibitors of STAT3.
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9.发明申请METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCLE WASTING, MUSCLE WEAKNESS, AND/OR CACHEXIA 审中-公开用于治疗肌肉损伤，肌肉疲劳和/或慢性病的方法和组合物公开(公告)号：US20150024032A1
公开(公告)日：2015-01-22
申请号：US14335853
申请日：2014-07-18
IPC分类号： C07D333/34 , A61K31/4406 , A61K31/415 , A61K31/381 , A61K31/357 , C07C317/28 , C07D215/36 , C07D213/71 , C07D231/18 , C07D319/18 , C07C317/34 , A61K31/47 , A61K31/145
摘要： Embodiments of the invention include methods of treating, preventing, and/or reduce the risk or severity of a condition selected from the group consisting of muscle wasting, muscle weakness, cachexia, and a combination thereof in an individual in need thereof. In some embodiments, particular small molecules are employed for treatment, prevention, and/or reduction in the risk of muscle wasting. In at least particular cases, the small molecules are inhibitors of STAT3.
摘要翻译： 本发明的实施方案包括在有需要的个体中治疗，预防和/或降低选自肌肉消瘦，肌肉无力，恶病质及其组合的病症的风险或严重程度的方法。 在一些实施方案中，使用特定的小分子来治疗，预防和/或降低肌肉消瘦的风险。 在至少特定情况下，小分子是STAT3的抑制剂。
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公开(公告)号：US20140296270A1
公开(公告)日：2014-10-02
申请号：US14253239
申请日：2014-04-15
发明人： David J. Tweardy , Xuejun Xu , Moses M. Kasembeli
IPC分类号： A61K31/515 , A61K31/427 , C07D417/06 , A61K31/194 , A61K45/06 , A61K31/192 , C07C65/17 , A61K31/37 , C07D311/74 , C07D405/06 , A61K31/357 , C07C311/21
CPC分类号： A61K31/515 , A61K31/19 , A61K31/192 , A61K31/194 , A61K31/275 , A61K31/357 , A61K31/37 , A61K31/427 , A61K45/06 , C07C65/17 , C07C311/21 , C07D311/74 , C07D405/06 , C07D417/06
摘要： Small molecule inhibitors of Stat3 and their derivatives are disclosed. Also described are methods to inhibit cell growth by use of Stat3 inhibitors, and the use of Stat3 inhibitors for the prevention and/or treatment of cancer. Further, inhibitors of Stat3 that also do not inhibit Stat1 are described as well as their derivatives. Methods of screening additional compounds for Stat3 inhibition activity and/or non-inhibition of Stat1 activity are also described herein.
摘要翻译： 公开了Stat3及其衍生物的小分子抑制剂。 还描述了通过使用Stat3抑制剂抑制细胞生长的方法，以及Stat3抑制剂用于预防和/或治疗癌症的方法。 此外，还描述了也不抑制Stat1的Stat3抑制剂及其衍生物。 Stat3抑制活性和/或Stat1活性的非抑制的其他化合物的筛选方法也在此描述。
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