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14 条记录 (耗时 0.018 秒)

    Process for the production of a hydroxyalkyne by coupling reaction between acetaldehyde and a terminal alkyne
    9.
    发明申请
    Process for the production of a hydroxyalkyne by coupling reaction between acetaldehyde and a terminal alkyne 失效
    通过乙醛和末端炔之间的偶联反应制备羟基亚氨基的方法

    公开(公告)号：US20070004943A1

    公开(公告)日：2007-01-04

    申请号：US10553464

    申请日：2004-04-15

    申请人： Beatriz Dominguez

    发明人： Beatriz Dominguez

    IPC分类号： C07C33/04

    CPC分类号： C07C29/42 ,  C07B2200/07 ,  C07C29/60 ,  C07C33/044 ,  C07C33/042

    摘要： A process for performing, a coupling reaction between acetaldehyde and a terminal alkyne to yield a hydroxyalkyne is described comprising the steps of; (i) reacting without solvent, a terminal alkyne with a Lewis acidic metal salt in tile presence of a alkanolamine ligand and a cyclic amine base to form a metal-alkyne complex, and (ii) adding a solution of acetaldehyde to the metal-alkyne complex.

    摘要翻译： 描述了进行乙醛和末端炔烃之间的偶联反应以产生羟基亚氨基的方法，其包括以下步骤： （i）在不含溶剂的情况下使末端炔与路易斯酸性金属盐在链烷醇胺配体和环胺碱的存在下反应形成金属 - 炔炔络合物，和（ii）向乙炔加入乙醛溶液 复杂。

    Unsaturated derivatives at the 4-position of 6-tert-butyl-1, 1- dimethylindane and their use in human and veterinary medicine and in cosmetics
    10.
    发明授权
    Unsaturated derivatives at the 4-position of 6-tert-butyl-1, 1- dimethylindane and their use in human and veterinary medicine and in cosmetics 失效
    6-叔丁基-1,1-二甲基茚满的4-位不饱和衍生物及其在人兽药和化妆品中的用途

    公开(公告)号：US06180674B2

    公开(公告)日：2001-01-30

    申请号：US09158892

    申请日：1998-09-23

    申请人： Angel De Lera ,  Beatriz Dominguez

    发明人： Angel De Lera ,  Beatriz Dominguez

    IPC分类号： A61K3119

    CPC分类号： C07D333/38 ,  A61K8/31 ,  A61K8/362 ,  A61K8/37 ,  A61K8/4926 ,  A61Q7/00 ,  A61Q19/00 ,  A61Q19/004 ,  C07C57/50 ,  C07C63/66 ,  C07C69/618 ,  C07C69/76

    摘要： 6-tert-Butyl-1,1-dimethylindane derivatives which are unsaturated in the 4-position of formula: X represents: (i) either a radical of formula: and Y represents a radical of formula: (ii) or a radical of formula: and Y represents either a radical of formula (b) or a radical of formula: Z being —O—, —S— or R1 represents —CH3, —(CH2)p—OR4, —(CH2)p—COR5 or —S(O)t—R6, p being 0, 1, 2 or 3, t being 0, 1 or 2, R2 represents H or lower alkyl, R3 represents H, lower alkyl or —COR7, R4 represents H, lower alkyl, —COR7, aryl, aralkyl, mono- or polyhydroxyalkyl, or a polyether radical, R5 represents H, lower alkyl, —OR8 or —N(r′)(r″), R6 represents H or lower alkyl, R7 represents lower alkyl, R8 represents H, alkyl, alkenyl, alkynyl, aryl, aralkyl, mono- or polyhydroxyalkyl, a sugar residue or an amino acid residue, r′ and r″ represent H, lower alkyl, —COR7, aryl, a sugar residue or an amino acid residue or r′ and r″ form a heterocycle, and the salts of the compounds of formula (I). Use in the topical and systemic treatment of dermatological conditions, as well as in cosmetics.

    摘要翻译： 在式X中4-位不饱和的6-叔丁基-1,1-二甲基茚满衍生物表示：（i）下式的基团：Y表示式（ⅱ）的基团或基团 并且Y表示式（b）的基团或式Z的基团是-O - ， - S-或R 1表示-CH 3， - （CH 2）p -OR 4， - （CH 2）p -OR 5或 - S（O）t-R6，p为0,1,2或3，t为0,1或2，R2为H或低级烷基，R3为H，低级烷基或-COR7，R4为H，低级烷基， -COR 7，芳基，芳烷基，单 - 或多羟基烷基或聚醚基，R 5表示H，低级烷基，-OR 8或-N（r'）（r“），R 6表示H或低级烷基，R 7表示低级烷基 R8代表H，烷基，烯基，炔基，芳基，芳烷基，单或多羟基烷基，糖残基或氨基酸残基，r'和r“代表H，低级烷基，-COR7，芳基，糖残基或 氨基酸残基或r'和r“形成杂环，和式（I）化合物的盐。在局部和系统中使用 ic治疗皮肤病学条件，以及化妆品。