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1.发明申请公开(公告)号：US20220193669A1
公开(公告)日：2022-06-23
申请号：US17600090
申请日：2021-02-26
发明人： Yongjia GAO , Yingying ZHAO , Hui LIAO , Wenliang YAO , Le GU , Bolin FAN , Yue LI
摘要： Provided are a temperature control system, a detection system and a temperature control method for a micro-fluidic chip. The temperature control system includes a circuit structure in a functional layer of the micro-fluidic chip, corresponding to a reaction zone of the micro-fluidic chip, and including at least two thermistors and an input port and an output port, wherein the input port and the output port are electrically coupled through the thermistors to form an application circuit; and a controller electrically coupled to each port and configured to select a first input port and a first output port, such that the circuit structure is configured to form a first application circuit as a heating device, and to select a second input port and a second output port, such that the circuit structure is configured to form a second application circuit as a temperature sensor.
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2.发明申请公开(公告)号：US20220314216A1
公开(公告)日：2022-10-06
申请号：US17419846
申请日：2020-09-29
发明人： Bolin FAN , Yingying ZHAO , Le GU , Wenliang YAO , Hui LIAO , Yongjia GAO , Qiuxu WEI
摘要： A micro-fluidic chip is provided. The micro-fluidic chip includes: a first base substrate; a first electrode on the first base substrate and electrically coupled to a wire at a driving end; a second electrode on a side of the first electrode away from the first base substrate and spaced apart and electrically insulated from the first electrode, the second electrode including a plurality of sub-blocks of the second electrode, and an orthographic projection of the second electrode on the first base substrate being at least partially overlapped with an orthographic projection of the first electrode on the first base substrate; and voltage-dividing resistors coupled to the plurality of sub-blocks of the second electrode in one-to-one correspondence and electrically coupled to a ground wire.
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公开(公告)号：US20210129139A1
公开(公告)日：2021-05-06
申请号：US16639867
申请日：2019-01-03
发明人： Yue GENG , Yuelei XIAO , Hui LIAO , Peizhi CAI , Jian LI , Shenkang WU
摘要： A patterning method of a film is disclosed. The method including: providing a film including a first surface; forming n etching barrier layers on the first surface of the film, and n is an integer larger than or equal to 2; and performing n etching processes on the film to form a recessed structure on the first surface using the n etching barrier layers as masks, the recessed structure includes n bottom surfaces respectively having different depths. Two adjacent etching processes of the n etching processes include a previous etching process and a subsequent etching process, and after the previous etching process is completed, a part of the n etching barrier layers is removed to form a mask for the subsequent etching process; a material of the part of the n etching barrier layers which is removed is different from a material of the mask of the subsequent etching process.
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公开(公告)号：US20220126287A1
公开(公告)日：2022-04-28
申请号：US17271297
申请日：2020-05-13
发明人： Yue LI , Wenliang YAO , Nan ZHAO , Yongjia GAO , Le GU , Hui LIAO , Bolin FAN , Yingying ZHAO
摘要： Provided is a micro-fluidic chip, including a first substrate and a second substrate opposite to each other. A liquid storage cavity is formed between the first substrate and the second substrate, and a liquid inlet hole penetrating through the first substrate in a thickness direction is formed in the first substrate. The first substrate includes a first electrode layer and a hydrophobic layer that are sequentially disposed in the thickness direction of the first substrate, and the first electrode layer is on a surface of the hydrophobic layer away from the second substrate. The second substrate includes an adjustment layer and a second electrode layer that are sequentially disposed in a thickness direction of the second substrate, and the second electrode layer is on a surface of the adjustment layer away from the first substrate. A micro-fluidic system and a control method of the micro-fluidic chip are also provided.
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5.发明申请公开(公告)号：US20220341925A1
公开(公告)日：2022-10-27
申请号：US17434408
申请日：2021-02-07
发明人： Yue LI , Wenliang YAO , Nan ZHAO , Yongjia GAO , Bolin FAN , Le GU , Hui LIAO , Yingying ZHAO
IPC分类号： G01N33/543 , G01N21/76
摘要： The present disclosure relates to a digital microfluidic chemiluminescence detection chip, a detection method and a detection device. The digital microfluidic chemiluminescence detection chip includes a first baseplate and a second baseplate disposed oppositely. A cavity formed by the first and second baseplate includes a mixing and incubating area for combining an antigen, a magnetic particle antibody and an antibody, a luminescence detection area for chemiluminescence and detecting an optical signal, and a communication path for communicating the mixing and incubating area and the luminescence detection area. The first baseplate is provided with a drive array for driving sample solution to move and an optical sensing array for acquiring a luminescence signal of the sample solution. The drive array corresponds to positions of the mixing and incubating area, the luminescence detection area and the communication path. The optical sensing array corresponds to a position of the luminescence detection area.
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公开(公告)号：US20220023865A1
公开(公告)日：2022-01-27
申请号：US16631780
申请日：2019-05-13
发明人： Le GU , Peizhi CAI , Fengchun PANG , Yue GENG , Yingying ZHAO , Haochen CUI , Yuelei XIAO , Hui LIAO , Wenliang YAO , Nan ZHAO
摘要： A microfluidic device and a detection method for the microfluidic device are provided. The microfluidic device includes a driving substrate configured to drive a movement of a droplet; and a position detector configured to detect a position of the droplet on the driving substrate.
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公开(公告)号：US20210268499A1
公开(公告)日：2021-09-02
申请号：US17186186
申请日：2021-02-26
发明人： Hui LIAO , Yingying ZHAO , Bolin FAN , Wenliang YAO , Nan ZHAO , Le GU , Yongjia GAO
IPC分类号： B01L3/00 , G01N33/577 , G01N27/22
摘要： The present disclosure discloses a microfluidic structure, a microfluidic chip and a detection method. The microfluidic structure includes: a first base substrate and a second base substrate opposite to each other, an antibody area located between the first base substrate and the second base substrate and storing an enzyme-labeled first antibody, a cleaning area storing cleaning liquid, a signal substrate area storing a signal substrate solution and a detection area with a second antibody and an ion sensitive film fixed thereon, wherein all channel areas from the antibody area, the cleaning area and the signal substrate area to the detection area each have a driving electrode structure driving liquid drops to move; and the detection area has a thin film transistor connected with the ion sensitive film.
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公开(公告)号：US20200338549A1
公开(公告)日：2020-10-29
申请号：US16768558
申请日：2019-11-13
发明人： Yingying ZHAO , Peizhi CAI , Le GU , Fengchun PANG , Yue GENG , Yuelei XIAO , Haochen CUI , Nan ZHAO , Hui LIAO , Wenliang YAO , Chuncheng CHE
IPC分类号： B01L3/00
摘要： The present disclosure provides a microfluidic chip, including: first base substrate and a second base substrate opposite to each other; first electrode and second electrode between the first base substrate and the second base substrate and configured to control droplet to move between the first base substrate and the second base substrate according to voltages applied on the first electrode and the second electrode; light guide component configured to guide light propagating in the first base substrate to the droplet; shading component and detection component, shading component having light transmission regions spaced from each other, light transmission regions being configured to transmit light passing through the droplet to the detection component, wherein detection component is on second base substrate and is configured to obtain property of the droplet according to an intensity of the light passing through droplet and received from the light transmission regions.
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公开(公告)号：US20210063340A1
公开(公告)日：2021-03-04
申请号：US16632661
申请日：2019-01-02
发明人： Wenliang YAO , Haochen CUI , Peizhi CAI , Fengchun PANG , Yue GENG , Le GU , Nan ZHAO , Yuelei XIAO , Hui LIAO , Yingying ZHAO , Chuncheng CHE
IPC分类号： G01N27/327 , B01L3/00 , H01H29/28
摘要： A chip, a method of operating a chip, and a detection device are provided. The chip includes a detection cavity and a working electrode, the detection cavity is configured to be capable of containing a plurality of droplets, and the working electrode is arranged in the detection cavity and is configured to regularly arrange the plurality of droplets in the detection cavity along an extending direction of the working electrode.
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公开(公告)号：US20210229092A1
公开(公告)日：2021-07-29
申请号：US16644904
申请日：2019-03-11
发明人： Haochen CUI , Jian LI , Yingying ZHAO , Wenliang YAO , Peizhi CAI , Yue GENG , Le GU , Fengchun PANG , Yuelei XIAO , Hui LIAO , Nan ZHAO
IPC分类号： B01L3/00 , H01J31/26 , G01N33/535 , G01N21/76
摘要： A microfluidic chip and a detection method using the microfluidic chip. The microfluidic chip includes: at least one micro-chamber; a photocathode located on a side of the at least one micro-chamber and configured to receive photons emitted from the micro-chamber to generate electrons; a micro-channel plate located on a side of the photocathode away from the micro-chamber and configured to multiply the electrons generated by the photocathode; and a first electrode located on a side of the micro-channel plate away from the photocathode; the micro-channel plate includes a plurality of micro-channels extending substantially in a thickness direction of the micro-channel plate, a secondary electron emission layer is provided on an inner wall of each of the plurality of micro-channels, and the first electrode is configured to detect the electrons that are multiplied by the micro-channel plate.
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