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    METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING O-GLYCOSYLATION
    1.
    发明申请
    METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING O-GLYCOSYLATION 有权
    用于检测和调节O-糖蛋白的方法和组合物

    公开(公告)号：US20100290987A1

    公开(公告)日：2010-11-18

    申请号：US12664559

    申请日：2008-06-13

    申请人： Benjamin Gross ,  Suzanne Kahne Walker ,  Jonathan Swoboda

    发明人： Benjamin Gross ,  Suzanne Kahne Walker ,  Jonathan Swoboda

    IPC分类号： A61K51/08 ,  C07K2/00 ,  C12N9/00 ,  C07K7/06 ,  G01N33/50 ,  A61K38/02 ,  A61K38/08 ,  A61K38/43 ,  C12N5/071 ,  A61P25/28 ,  A61P3/10

    CPC分类号： C12Q1/37 ,  C07K7/06 ,  C07K2319/50 ,  C07K2319/60 ,  C12N9/12 ,  C12Q1/34 ,  G01N2333/924 ,  G01N2440/38 ,  G01N2500/02

    摘要： The invention relates to methods and products for modulating glycosylation of proteins. The invention is useful for identifying therapeutic compounds to treat glycosylation-associated disorders such as neurodegeneration, diabetes, including complications of diabetes such as insulin resistance, nephropathy, microvascular damage, and endothelial dysfunction. The invention is also useful for identifying therapeutic compounds to treat de-glycosylation-associated disorders such as ischemic damage and traumatic injury. The invention also relates in part to assays that are useful for identifying and testing candidate compounds for modulating glycosylation of proteins and also relates in part to compounds to treat glycosylation-associated diseases and disorders.

    摘要翻译： 本发明涉及调节蛋白质糖基化的方法和产品。 本发明可用于鉴定用于治疗糖基化相关疾病如神经变性，糖尿病，包括糖尿病并发症如胰岛素抵抗，肾病，微血管损伤和内皮功能障碍的治疗化合物。 本发明也可用于鉴定治疗化合物以治疗去糖基化相关疾病如缺血性损伤和创伤性损伤。 本发明还部分涉及可用于鉴定和测试用于调节蛋白质糖基化的候选化合物的测定法，并且还部分涉及用于治疗糖基化相关疾病和病症的化合物。

    Heat balance in FCC process and apparatus with downflow reactor riser
    5.
    发明授权
    Heat balance in FCC process and apparatus with downflow reactor riser 失效
    FCC工艺中的热平衡和具有下流式反应器提升管的设备

    公开(公告)号：US4411773A

    公开(公告)日：1983-10-25

    申请号：US403685

    申请日：1982-07-30

    申请人： Benjamin Gross

    发明人： Benjamin Gross

    IPC分类号： B01J8/26 ,  C10G11/18 ,  F27B15/10 ,  F27B15/14 ,  F27B15/16

    CPC分类号： B01J8/26 ,  C10G11/18

    摘要： In a fluid catalytic cracking (FCC) process and apparatus, the heat balance between the reactor and the regenerator of the FCC operation is partially uncoupled by transferring at least a portion of thermal energy from the reactor vessel downflow riser to the regenerator vessel. The transfer of thermal energy results in a higher regenerating temperature. The thermal energy is recirculated to the upstream section of the downflow reactor riser through a regenerated catalyst having higher temperature. Consequently, the outlet of the reactor vessel is maintained at a substantially constant temperature (e.g., 1000.degree. F.) and the rate of conversion of the oil feed and the octane number of gasoline produced in the process are increased.

    摘要翻译： 在流化催化裂化（FCC）方法和装置中，FCC操作的反应器和再生器之间的热平衡通过将至少一部分热能从反应器容器向下流入提升管转移到再生器容器而部分解耦。 热能转移导致更高的再生温度。 热能通过具有较高温度的再生催化剂再循环到下流式反应器提升管的上游段。 因此，反应容器的出口保持在基本上恒定的温度（例如1000°F），并且在该方法中产生的油进料的转化率和汽油的辛烷值增加。

    FCC Reactor with a downflow reactor riser
    6.
    发明授权
    FCC Reactor with a downflow reactor riser 失效
    FCC反应器具有下流反应器提升管

    公开(公告)号：US4385985A

    公开(公告)日：1983-05-31

    申请号：US254329

    申请日：1981-04-14

    申请人： Benjamin Gross ,  Michael P. Ramage

    发明人： Benjamin Gross ,  Michael P. Ramage

    IPC分类号： B01J8/18 ,  C10G11/18

    CPC分类号： B01J8/18 ,  C10G11/182

    摘要： A fluid catalytic cracking (FCC) process and apparatus using a riser and a reactor for cracking of petroleum feeds in the presence of a catalyst and a regenerator for regenerating the spent catalyst are improved by providing a downflow riser. The downflow riser assures uniform distribution of the catalyst throughout the feed, decreases contact time of the catalyst with the feed and decreases the amount of coke made in the process.

    摘要翻译： 通过提供下流式提升器，改进了在催化剂和用于再生废催化剂的再生器存在下使用提升管和反应器进行石油进料裂化的流化催化裂化（FCC）方法和装置。 降流提升器确保催化剂在整个进料中的均匀分布，减少催化剂与进料的接触时间，并减少在该方法中制备的焦炭的量。

    FCC Catalyst section control
    7.
    发明授权
    FCC Catalyst section control 失效
    FCC催化剂部分控制

    公开(公告)号：US4211636A

    公开(公告)日：1980-07-08

    申请号：US931573

    申请日：1978-08-07

    申请人： Benjamin Gross ,  Wooyoung Lee

    发明人： Benjamin Gross ,  Wooyoung Lee

    IPC分类号： B01J8/26 ,  C10G11/18

    CPC分类号： B01J8/26 ,  C10G11/187 ,  Y10S208/01

    摘要： In the fluid catalytic cracking process, improved adaptive behavior of the catalyst section with the regenerator operating in the complete CO-burning mode is achieved by including, as elements of control, variable preheat of the oil feed and variable recycle of regenerated catalyst to spent catalyst. In response to excursions of the regenerated catalyst temperature, such as would be caused by change of feedstock, the oil preheat temperature and recycle ratio are altered in a direction to restore the regenerated catalyst temperature to a predetermined value. The improved control system extends the useful control range, and it also diminishes counterproductive changes in severity induced by disturbances such as change of feedstock quality.

    摘要翻译： 在流化催化裂化过程中，催化剂部分与再生器在完全CO燃烧模式下运行的改进的适应行为通过包括作为控制元素的油进料可变预热和再生催化剂可再循环到废催化剂 。 响应于再生催化剂温度的偏移，例如由原料变化引起的油的预热温度和再循环率在一个方向上改变，以将再生催化剂温度恢复到预定值。 改进的控制系统延伸了有用的控制范围，并且还减少了干扰引起的严重性的反作用变化，例如原料质量的变化。

    FCC Catalyst section control
    8.
    发明授权
    FCC Catalyst section control 失效
    FCC催化剂部分控制

    公开(公告)号：US4093537A

    公开(公告)日：1978-06-06

    申请号：US769639

    申请日：1977-02-17

    申请人： Benjamin Gross ,  Wooyoung Lee

    发明人： Benjamin Gross ,  Wooyoung Lee

    IPC分类号： B01J8/26 ,  C10G11/18 ,  C10G13/18

    CPC分类号： B01J8/26 ,  C10G11/187 ,  Y10S208/01

    摘要： In the fluid catalytic cracking process, improved adaptive behavior of the catalyst section with the regenerator operating in the complete CO-burning mode is achieved by including, as elements of control, variable preheat of the air feed and variable recycle of regenerated catalyst to spent catalyst. In response to excursions of the regenerated catalyst temperature, such as would be caused by change of feedstock, the air preheat temperature and recycle ratio are altered in a direction to restore the regenerated catalyst temperature to a predetermined value. The improved control system extends the useful control range, and it also diminishes counterproductive changes in severity induced by disturbances such as change of feedstock quality.

    摘要翻译： 在流化催化裂化过程中，催化剂段与采用完全CO燃烧模式工作的再生器的改进的适应行为是通过将作为控制元件的空气进料的可变预热和再生催化剂可再循环到废催化剂 。 响应于再生催化剂温度的偏移，例如由原料变化引起的空气预热温度和再循环比在沿再生催化剂温度恢复到预定值的方向上改变。 改进的控制系统延伸了有用的控制范围，并且还减少了干扰引起的严重性的反作用变化，例如原料质量的变化。

    Visbreaking process
    9.
    发明授权
    Visbreaking process 失效
    减粘裂化过程

    公开(公告)号：US4615791A

    公开(公告)日：1986-10-07

    申请号：US771739

    申请日：1985-09-03

    申请人： Byung C. Choi ,  Benjamin Gross ,  Madhava Malladi

    发明人： Byung C. Choi ,  Benjamin Gross ,  Madhava Malladi

    IPC分类号： C10G9/00 ,  C10G47/32 ,  C10G47/34

    CPC分类号： C10G9/007 ,  C10G47/34

    摘要： Heavy petroleum oils such as resids are subjected to visbreaking in the presence of a hydroaromatic hydrogen donor solvent having an aromatic and alpha-to-aromatic proton content each of at least 20 percent of the total solvent hydrogen. The amount of donor solvent is from 0.1 to 50, preferably 0.1 to 20, weight percent of the heavy oil feed. The visbreaking may be carried out at relatively high severities as the use of the donor solvent reduces coke formation as well as producing a product of reduced viscosity, pour point and sedimentation characteristics. Reaction severity is usually in the range of 250 to 1500 seconds ERT at 800.degree. F. (427.degree. C.) but may range up to 15000 seconds ERT. Suitable solvents may be obtained from catalytic cracking process, for example, FCC cycle oils, slurry oils and main column bottoms.

    摘要翻译： 在油芳族氢供体溶剂存在下，将重质石油油（如残渣）进行减粘裂化，其具有芳族和α-至芳族质子含量，每个都占总溶剂氢的至少20％。 供体溶剂的量为重油进料的0.1-50重量％，优选0.1-20重量％。 减粘裂化可以在相当高的严重程度下进行，因为使用供体溶剂减少焦炭形成，以及生产具有降低粘度，倾点和沉降特性的产物。 反应严重度通常在800°F（427°C）的250至1500秒的ERT范围内，但可能范围高达15000秒ERT。 合适的溶剂可以从催化裂化过程获得，例如FCC循环油，浆料油和主塔底物。

    Increased gasoline octane in FCC reactor
    10.
    发明授权
    Increased gasoline octane in FCC reactor 失效
    FCC反应器中汽油辛烷值增加

    公开(公告)号：US4459203A

    公开(公告)日：1984-07-10

    申请号：US335295

    申请日：1981-12-28

    申请人： James H. Beech ,  Benjamin Gross ,  Michael P. Ramage

    发明人： James H. Beech ,  Benjamin Gross ,  Michael P. Ramage

    IPC分类号： C10G11/18 ,  C10G11/00

    CPC分类号： C10G11/18

    摘要： The operation of FCC apparatus is improved by decreasing oil partial pressure in the FCC reactor riser by about 10 psia, as compared to the normal oil partial pressure in the riser, thereby increasing octane rating of the gasoline produced in the FCC unit. The oil partial pressure may be reduced by injecting a suitable amount of an inert diluent into the riser, or by decreasing throughput of the FCC reactor.

    摘要翻译： 与FCC提升管中的正常油分压相比，通过将FCC反应器提升管中的油分压降低大约10psia，从而提高FCC单元中产生的汽油的辛烷值，可以提高FCC装置的运行。 可以通过将适量的惰性稀释剂注入提升管中，或通过降低FCC反应器的产量来降低油分压。