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公开(公告)号：US5006652A
公开(公告)日：1991-04-09
申请号：US230084
申请日：1988-08-08
Applicant: George J. Cullinan , Bennett C. Laguzza , William L. Scott
Inventor： George J. Cullinan , Bennett C. Laguzza , William L. Scott
IPC: C12P21/08 , A61K39/395 , A61K47/48 , A61P35/00 , C07D519/04 , C07K1/113 , C07K14/00 , C07K14/705 , C07K16/00 , C07K19/00
CPC classification number: A61K47/48692 , A61K47/48715
Abstract: A seris of antibody-vinca drug conjugates comprise antibodies which target antigens associated with undesirable cells, so that the cells are controlled or killed by the cytotoxic vinca drug. The drug is linked to the antibody through an organic group comprising a carbonyl at the antibody end, and an alkylidene hydrazide at the vinca end.
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公开(公告)号：US4801688A
公开(公告)日：1989-01-31
申请号：US106756
申请日：1987-10-07
Applicant: Bennett C. Laguzza , Cynthia L. Nichols
Inventor： Bennett C. Laguzza , Cynthia L. Nichols
CPC classification number: A61K47/48392
Abstract: Immunoglobulin conjugates formed by reaction of an antineoplastic indole-dihydroindole vinca alkaloid containing a hydrazine group attached at C-3 or C-4 with an oxidized glycoprotein containing aldehyde groups.
Abstract translation: 通过将含有C-3或C-4连接的肼基的抗肿瘤性吲哚 - 二氢吲哚长春花生物碱与含有醛基的氧化糖蛋白反应形成的免疫球蛋白缀合物。
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3.发明授权2-alkyl(or phenyl)thio-6-N alkyl ergolines and 4-dialkylaminotetrahydrobenz[c,d]indoles 失效2-烷基（或苯基）硫代-6-N烷基高麦角碱和4-二烷基氨基四氢苯并[c，d]吲哚
公开(公告)号：US4683313A
公开(公告)日：1987-07-28
申请号：US747753
申请日：1985-06-24
Applicant: Bennett C. Laguzza , Cynthia L. Nichols , Nicholas J. Bach
Inventor： Bennett C. Laguzza , Cynthia L. Nichols , Nicholas J. Bach
IPC: A61K31/40 , A61K31/403 , A61K31/48 , A61P25/00 , A61P43/00 , C07D209/90 , C07D457/02
CPC classification number: C07D209/90 , C07D457/02
Abstract: D-2-Alkyl(or phenyl)thio-6-n-alkylergolines or .+-.-2-alkyl(or phenyl)thio-4-dialkylaminotetrahydrobenz[c,d]indoles, dopamine D-1 antagonists.
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公开(公告)号：US4622398A
公开(公告)日：1986-11-11
申请号：US748116
申请日：1985-06-24
Applicant: Bennett C. Laguzza
Inventor： Bennett C. Laguzza
IPC: A61K31/505 , A61K31/517 , A61P9/12 , A61P25/00 , A61P43/00 , C07D239/74 , C07D239/78 , C07D239/80 , C07D239/84
CPC classification number: C07D239/78 , C07D239/74 , C07D239/80 , C07D239/84
Abstract: 2-Permissibly-substituted-6-dialkylaminotetrahydroquinazolines, receptor agonists.
Abstract translation: 2-可取代的-6-二烷基氨基四氢喹唑啉，受体激动剂。
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Patent Agency Ranking5.发明授权Cytotoxic antibody conjugates of hydrazide derivatized methotrexate analogs via simple organic linkers 失效通过简单的有机接头，酰肼衍生的甲氨蝶呤类似物的细胞毒性抗体缀合物
公开(公告)号：US5028697A
公开(公告)日：1991-07-02
申请号：US229941
申请日：1988-08-08
Applicant: David A. Johnson , Bennett C. Laguzza , William L. Scott
Inventor： David A. Johnson , Bennett C. Laguzza , William L. Scott
IPC: C12P21/08 , A61K39/395 , A61K47/48 , A61P35/00 , C07D475/08 , C07K1/113 , C07K14/00 , C07K14/705 , C07K16/00 , C07K19/00 , C12R1/91
CPC classification number: A61K47/48692
Abstract: Conjugates of antibodies and cytotoxic methotrexate drugs make use of linkers between the drug and antibody which are simple organic groups, wherein the link to the antibody is an acyl group and the link to the drug is an alkylidene hydrazide.
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6.发明授权2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists without D-2 agonist activity 失效2-烷基（或苯基）硫代-6-正烷基高甘油酯是没有D-2激动剂活性的多巴胺D-1拮抗剂
公开(公告)号：US4801712A
公开(公告)日：1989-01-31
申请号：US60588
申请日：1987-06-11
Applicant: Bennett C. Laguzza , Cynthia L. Nichols , Nicholas J. Bach
Inventor： Bennett C. Laguzza , Cynthia L. Nichols , Nicholas J. Bach
IPC: C07D209/90 , C07D457/02 , A61K31/48
CPC classification number: C07D209/90 , C07D457/02
Abstract: D-2-Alkyl(or phenyl)thio-6-n-alkylergolines or .+-.-2-alkyl(or phenyl)thio-4-dialkylaminotetrahydrobenz[c,d]indoles, dopamine D-1 antagonists.
Abstract translation: D-2-烷基（或苯基）硫代-6-正烷基高甘油或+ / - 2-烷基（或苯基）硫代-4-二烷基氨基四氢苯并[c，d]吲哚，多巴胺D-1拮抗剂。
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公开(公告)号：US5144012A
公开(公告)日：1992-09-01
申请号：US656343
申请日：1991-02-15
Applicant: David A. Johnson , Bennett C. Laguzza , William L. Scott
Inventor： David A. Johnson , Bennett C. Laguzza , William L. Scott
IPC: A61K47/48
CPC classification number: A61K47/48692 , Y10S530/807
Abstract: Conjugates of antibodies and cytotoxic methotrexate drugs make use of liners between the drug and antibody which are simple organic groups, wherein the link to the antibody is an acyl group and the link to the drug is an alkylidene hydrazide.
Abstract translation: 抗体和细胞毒性甲氨蝶呤药物的结合物利用作为简单有机基团的药物和抗体之间的衬垫，其中与抗体的连接是酰基，并且与药物的连接是亚烷基酰肼。
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8.发明授权Cytotoxic antibody conjugates of hydrazide derivatized vinca analogs via simple organic linkers 失效通过简单的有机接头，酰肼衍生的长春花类似物的细胞毒性抗体缀合物
公开(公告)号：US5094849A
公开(公告)日：1992-03-10
申请号：US640792
申请日：1991-01-14
Applicant: George J. Cullinan , Bennett C. Laguzza , William L. Scott
Inventor： George J. Cullinan , Bennett C. Laguzza , William L. Scott
IPC: A61K47/48
CPC classification number: A61K47/48692 , A61K47/48715
Abstract: A series of antibody-vinca drug conjugates comprise antibodies which target antigens associated with undesirable cells, so that the cells are controlled or killed by the cytotoxic vinca drug. The drug is linked to the antibody through an organic group comprising a carbonyl at the antibody end, and an alkylidene hydrazide at the vinca end.
Abstract translation: 一系列抗体 - 长春花药物缀合物包含靶向与不想要的细胞相关的抗原的抗体，使得细胞被细胞毒性长春花药物控制或杀死。 药物通过在抗体末端包含羰基的有机基团和长春花碱末端的亚烷基酰肼与抗体连接。
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公开(公告)号：US4675322A
公开(公告)日：1987-06-23
申请号：US679832
申请日：1984-12-10
Applicant: Bennett C. Laguzza
Inventor： Bennett C. Laguzza
CPC classification number: C07D457/02
Abstract: N-1-substituted-6-n-propyl-8.beta.-methylthio-methylergoline, D-2 agonists without interaction with alpha adrenergic receptors.
Abstract translation: N-1-取代-6-正丙基-8β-甲硫基 - 甲基麦角灵，不与α肾上腺素能受体相互作用的D-2激动剂。
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