公开(公告)号：US20140093595A1

公开(公告)日：2014-04-03

申请号：US13906450

申请日：2013-05-31

申请人： Benny ANTONY

发明人： Benny ANTONY

IPC分类号： A61K36/185

CPC分类号： A61K36/185 ,  A61K36/47

摘要： The present disclosure relates to a composition of an extract of fruits of Emblica officinalis selected from the group consisting of liquid juice of fruits of Emblica officinalis, a powder of an alcoholic extract of fruits of Emblica officinalis, a powder of a hydro alcoholic extract of fruits of Emblica officinalis, a powder of a water extract of fruits of Emblica officinalis, a powder of a juice of fruits of Emblica officinalis, a powder of dried fruits of Emblica officinalis, a powder of a water extract of dried fruits of Emblica officinalis, a powder of a pectinase treated water extract of fruits of Emblica officinalis, and combinations thereof; a method of preparing such compositions of extract of fruits of Emblica officinalis, more particularly which has application as a nutraceutical or pharmaceutical for increasing HDL-C levels in patients with memory loss and dementia especially in patients with neurodegenerative diseases like Alzheimer's disease and for the treatment of memory loss especially in Alzheimer's disease.

摘要翻译： 本公开涉及一种选自下列药剂的水果提取物的组合物，所述水果的提取物选自由水芹的果汁的液体汁，水果的酒精提取物的粉末，水果的水提取物的粉末 （Emblica officinalis）的水果提取物的粉末，槟榔果实的果汁的粉末，槟榔干的干果的粉末，水芹的干果的粉末 果胶酶处理水果提取物的粉末及其组合; 更具体地说，这种制备这种组合提取物的方法，尤其是在具有记忆丧失和痴呆症的患者中具有增加HDL-C水平的营养药物或药物的应用，特别是在具有神经变性疾病如阿尔茨海默氏病和治疗的患者中 的记忆丧失，特别是在阿尔茨海默病。

公开(公告)号：US20170326195A1

公开(公告)日：2017-11-16

申请号：US15326450

申请日：2016-10-18

申请人： Benny ANTONY

发明人： Benny ANTONY

IPC分类号： A61K36/81 ,  A61K9/16 ,  A61K9/50 ,  A61K36/21 ,  A61K9/20

CPC分类号： A61K36/81 ,  A61K9/14 ,  A61K9/16 ,  A61K9/2081 ,  A61K9/2846 ,  A61K9/50 ,  A61K9/5026 ,  A61K9/5036 ,  A61K9/5042 ,  A61K36/185 ,  A61K36/21 ,  A61K36/23 ,  A61K36/47 ,  A61K36/48 ,  A61K36/53 ,  A61K36/534 ,  A61K36/54 ,  A61K36/67 ,  A61K36/71 ,  A61K36/82 ,  A61K36/87 ,  A61K36/9066 ,  A61K36/9068 ,  A61K2236/00 ,  A61K2236/13 ,  A61K2236/15 ,  A61K2236/33 ,  A61K2236/331 ,  A61K2236/35 ,  A61K2236/51

摘要： The invention relates to an extract of Ashwagandha that exhibit enhanced bioactivity and bioavailability comprising of enriched withanolide glycosides and saponins; with negligible amount of alkaloids, withanolide aglycones and oligosaccharides. The extract as disclosed prepared from root, stems, leaves and whole plant of Ashwagandha further shows improved immunomodulatory activity, anti-inflammatory activity, anti stress activity, antidiabetic activity and sleep quality. The disclosure also provides a method of improving bioactivity of withanolide glycosides even at lower doses, by the administration of an enteric coaled formulation of extract of Ashwagandha to humans. The enteric coaling protects the composition from hydrolysis in the acidic environment of the stomach to release the withanolide glycoside in neutral/alkaline pH in gastrointestinal tract (GIT) thus enhancing the absorption. Further the process of preparation of the extract of Ashwagandha enriched with withanolide glycosides and saponins are disclosed along with various formulations.

公开(公告)号：US20170202785A1

公开(公告)日：2017-07-20

申请号：US15478013

申请日：2017-04-03

申请人： Benny ANTONY

发明人： Benny ANTONY

IPC分类号： A61K31/12 ,  A61K9/00 ,  A61K9/48 ,  A61K36/9066

CPC分类号： A61K31/12 ,  A61K9/0053 ,  A61K9/4825 ,  A61K9/4858 ,  A61K36/9066

摘要： Disclosure provides a formulation of curcuminoid with essential oil of turmeric to enhance the bioavailability of curcumin and to augment the biological activity of curcumin, wherein curcumin is the main constituent of curcuminoid and wherein Ar-turmerone is the main constituent of the essential oil of turmeric. An application of curcuminoid with essential oil of turmeric to enhance the bioavailability of curcumin for oral supplementation against a variety of diseases and method of doing the same is provided.

公开(公告)号：US20140193533A1

公开(公告)日：2014-07-10

申请号：US14206044

申请日：2014-03-12

申请人： Benny ANTONY

发明人： Benny ANTONY

IPC分类号： A61K31/12 ,  A61K36/9066

CPC分类号： A61K31/12 ,  A61K36/9066 ,  A61K2300/00

摘要： A formulation of curcuminoid mixture having curcumin, demethoxycurcumin and bisdemethoxycurcumin and an essential oil of turmeric having 45% Ar-turmerone. The formulation gives enhanced bioavailability of bisdemethoxycurcumin, demethoxycurcumin and curcumin for up to 10 hrs. The curcuminoid mixture has curcumin, demethoxycurcumin and bisdemethoxycurcumin in a weight/weight ratio ranging from about 0.8:1:1 to about 1:1.1:1.2. A process of preparing a formulation of curcuminoid mixture having curcumin, demethoxycurcumin and bisdemethoxycurcumin in 0.8:1:1 to 1:1:1:1.2 weight/weight ratio and an essential oil of turmeric having 45% Ar-turmerone. A formulation for improved biological activity and bioavailability and tissue distribution of curcumin, demethoxycurcumin and bisdemethoxycurcumin.

摘要翻译： 具有姜黄素，脱甲氧基姜黄素和双二甲氧基姜黄素的姜黄素混合物的制剂和具有45％Ar-姜黄酮的姜黄精油。 该配方可提高双二甲氧基姜黄素，去甲氧基姜黄素和姜黄素长达10小时的生物利用度。 姜黄素混合物具有约0.8:1:1至约1:1.1:1.2的重量/重量比的姜黄素，脱甲氧基姜黄素和双二甲氧基姜黄素。 制备姜黄素，脱甲氧基姜黄素和双二甲氧基姜黄素的配方，其配比为0.8:1:1:1:1:1:1:1.2重量/重量比，姜黄素为45％Ar-姜黄酮。 姜黄素，去甲氧基姜黄素和双去甲氧基姜黄素的生物活性和生物利用度以及组织分布的制剂。

公开(公告)号：US20210113646A1

公开(公告)日：2021-04-22

申请号：US17123636

申请日：2020-12-16

申请人： Benny ANTONY

发明人： Benny ANTONY

IPC分类号： A61K36/81 ,  A61K9/16 ,  A61K9/20 ,  A61K9/50 ,  A61K36/21 ,  A61K9/14 ,  A61K9/28 ,  A61K36/185 ,  A61K36/23 ,  A61K36/47 ,  A61K36/48 ,  A61K36/53 ,  A61K36/534 ,  A61K36/54 ,  A61K36/67 ,  A61K36/71 ,  A61K36/82 ,  A61K36/87 ,  A61K36/9066 ,  A61K36/9068

摘要： The invention relates to an extract of Ashwagandha that exhibit enhanced bioactivity and bioavailability comprising of enriched withanolide glycosides and saponins; with negligible amount of alkaloids, withanolide aglycones and oligosaccharides. The extract as disclosed prepared from root, stems, leaves and whole plant of Ashwagandha further shows improved immunomodulatory activity, anti-inflammatory activity, anti stress activity, antidiabetic activity and sleep quality. The disclosure also provides a method of improving bioactivity of withanolide glycosides even at lower doses, by the administration of an enteric coated formulation of extract of Ashwagandha to humans. The enteric coating protects the composition from hydrolysis in the acidic environment of the stomach to release the withanolide glycoside in neutral/alkaline pH in gastrointestinal tract (GIT) thus enhancing the absorption. Further the process of preparation of the extract of Ashwagandha enriched with withanolide glycosides and saponins are disclosed along with various formulations.

公开(公告)号：US20170042833A1

公开(公告)日：2017-02-16

申请号：US15288882

申请日：2016-10-07

申请人： Benny ANTONY

发明人： Benny ANTONY

IPC分类号： A61K31/12 ,  A61K36/9066

CPC分类号： A61K31/12 ,  A61K36/9066 ,  A61K2300/00

摘要： A formulation of curcuminoid mixture having curcumin, demethoxycurcumin and bisdemethoxycurcumin and an essential oil of turmeric having 45% Ar-turmerone. The formulation gives enhanced bioavailability of bisdemethoxycurcumin, demethoxycurcumin and curcumin for up to 10 hrs. The curcuminoid mixture has curcumin, demethoxycurcumin and bisdemethoxycurcumin in a weight/weight ratio ranging from about 0.8:1:1 to about 1:1.1:1.2. A process of preparing a formulation of curcuminoid mixture having curcumin, demethoxycurcumin and bisdemethoxycurcumin in 0.8:1:1 to 1:1.1:1.2 weight/weight ratio and an essential oil of turmeric having 45% Ar-turmerone. A formulation for improved biological activity and bioavailability and tissue distribution of curcumin, demethoxycurcumin and bisdemethoxycurcumin.

摘要翻译： 具有姜黄素，脱甲氧基姜黄素和双二甲氧基姜黄素的姜黄素混合物的制剂和具有45％Ar-姜黄酮的姜黄精油。 该配方可提高双二甲氧基姜黄素，去甲氧基姜黄素和姜黄素长达10小时的生物利用度。 姜黄素混合物具有约0.8:1:1至约1:1.1:1.2的重量/重量比的姜黄素，脱甲氧基姜黄素和双二甲氧基姜黄素。 制备姜黄素，脱甲氧基姜黄素和双二甲氧基姜黄素的姜黄素混合物制剂的方法，其重量比为0.8:1:1:1:1:1:1:1:1:1.1:1.2，重量比为45重量％的姜黄精油。 姜黄素，去甲氧基姜黄素和双去甲氧基姜黄素的生物活性和生物利用度以及组织分布的制剂。

公开(公告)号：US20140093594A1

公开(公告)日：2014-04-03

申请号：US14094725

申请日：2013-12-02

申请人： Benny ANTONY

发明人： Benny ANTONY

IPC分类号： A61K36/9066 ,  A61K31/12

CPC分类号： A61K36/9066 ,  A01N65/48 ,  A61K31/12 ,  A01N25/28

摘要： A composition having a curcuminoid and an essential oil of turmeric. A composition having a curcuminoid and an essential oil of turmeric, wherein the essential oil is present in an amount sufficient to cause an enhancement of bioavailability of curcumin when the composition is administered to a human as compared to bioavailability of curcumin obtained upon administration of a composition prepared without adding essential oil to the curcuminoid. A method to prepare a composition having a curcuminoid and an essential oil of turmeric.

摘要翻译： 具有姜黄素和姜黄精油的组合物。 具有姜黄素和姜黄精油的组合物，其中当组合物施用于人时，所述精油以足以引起姜黄素的生物利用度提高的量存在，与施用组合物时获得的姜黄素的生物利用度相比 准备不添加精油到姜黄素。 一种制备具有姜黄素和姜黄精油的组合物的方法。

公开(公告)号：US20190255138A1

公开(公告)日：2019-08-22

申请号：US16315503

申请日：2017-07-06

申请人： Benny ANTONY

发明人： Benny ANTONY

IPC分类号： A61K36/9066 ,  A61K31/121 ,  A61K36/185 ,  A61K9/14 ,  A61P25/28 ,  A61P25/08 ,  A61P25/16 ,  A61P25/24

摘要： Compositions for inhibiting beta secretase activity are disclosed. Compositions that enhance bioavailability of curcumin, demethoxycurcumin, bisdemethoxycurcumin, α-turmerone, ar-turmerone, or, sesamolin are disclosed. Some compositions include a curcuminoid mixture and essential oil of turmeric having α-turmerone. Some compositions include a curcuminoid mixture and a combination, wherein the combination includes essential oil of turmeric having α-turmerone, and, an extract of sesame oil having sesamolin. Some compositions are a combination of essential oil of turmeric having α-turmerone, and, an extract of sesame oil having sesamolin. Methods of preparing the compositions are disclosed. Methods of treatment of central nervous system or neurological disorders are provided.

公开(公告)号：US20190160132A1

公开(公告)日：2019-05-30

申请号：US16265440

申请日：2019-02-01

申请人： Benny ANTONY

发明人： Benny ANTONY

IPC分类号： A61K36/81 ,  A61K9/20 ,  A61K36/185 ,  A61K36/87 ,  A61K36/21 ,  A61K9/50 ,  A61K9/14 ,  A61K36/9068 ,  A61K36/47 ,  A61K36/534 ,  A61K36/54 ,  A61K9/16 ,  A61K36/9066 ,  A61K9/28 ,  A61K36/48 ,  A61K36/23 ,  A61K36/67 ,  A61K36/53 ,  A61K36/82 ,  A61K36/71

摘要： The invention relates to an extract of Ashwagandha that exhibit enhanced bioactivity and bioavailability comprising of enriched withanolide glycosides and saponins; with negligible amount of alkaloids, withanolide aglycones and oligosaccharides. The extract as disclosed prepared from root, stems, leaves and whole plant of Ashwagandha further shows improved immunomodulatory activity, anti-inflammatory activity, anti stress activity, antidiabetic activity and sleep quality. The disclosure also provides a method of improving bioactivity of withanolide glycosides even at lower doses, by the administration of an enteric coated formulation of extract of Ashwagandha to humans. The enteric coating protects the composition from hydrolysis in the acidic environment of the stomach to release the withanolide glycoside in neutral/alkaline pH in gastrointestinal tract (GIT) thus enhancing the absorption. Further the process of preparation of the extract of Ashwagandha enriched with withanolide glycosides and saponins are disclosed along with various formulations.

公开(公告)号：US20130309339A1

公开(公告)日：2013-11-21

申请号：US13886287

申请日：2013-05-03

申请人： Benny ANTONY

发明人： Benny ANTONY

IPC分类号： A61K36/47

CPC分类号： A61K36/47 ,  A61K36/185 ,  A61K36/78

摘要： A method of producing a product to correct hypercholesterolemia including pulping fruits of Emblica officinalis with demineralized water to create a slurry. The slurry is treated with pectinase. The pectinase-treated slurry is filtered to create a solution. The solution is concentrated to create a product. A product having an extract of Emblica officinalis for prophylactic and for therapeutic treatment of coronary diseases, atherosclerosis, hypothyroidism and hyperthyroidism.

摘要翻译： 一种制备产品以纠正高胆固醇血症的产品的方法，包括用软化水制成的槟榔制浆果实以产生浆液。 浆料用果胶酶处理。 将果胶酶处理的浆料过滤以产生溶液。 该解决方案集中在一个产品上。 一种具有槟榔提取物的产品，用于预防和治疗冠状动脉疾病，动脉粥样硬化，甲状腺功能减退和甲状腺机能亢进。