公开(公告)号：US6146409A

公开(公告)日：2000-11-14

申请号：US716788

申请日：1996-09-04

申请人： Bergein F. Overholt ,  Masoud Panjehpour ,  Mike Stonefield

发明人： Bergein F. Overholt ,  Masoud Panjehpour ,  Mike Stonefield

IPC分类号： A61M31/00 ,  A61B17/22 ,  A61B18/00 ,  A61B18/22 ,  A61F2/958 ,  A61M25/00 ,  A61N5/06 ,  A61B17/36

CPC分类号： A61N5/062 ,  A61N5/0601 ,  A61B2017/22058 ,  A61B2017/22059 ,  A61B2017/22087 ,  A61B2018/2261 ,  A61M25/10

摘要： The present invention provides improved methods and devices for delivering light to the surface of a biological column, for example in the treatment of Barrett's esophagus using PDT. The improvement comprises the use of an extended irradiation segment or window. The improved methods of the present invention permits treatment lengths of the biological column to be increased without increasing the incidence of stricture formation.

摘要翻译： 本发明提供了用于将光输送到生物柱的表面的改进的方法和装置，例如在使用PDT治疗巴雷特食管时。 改进之处在于使用延长的辐射段或窗口。 本发明的改进方法允许增加生物柱的处理长度，而不增加狭窄形成的发生。

公开(公告)号：US5579773A

公开(公告)日：1996-12-03

申请号：US316132

申请日：1994-09-30

申请人： Tuan Vo-Dinh ,  Masoud Panjehpour ,  Bergein F. Overholt

发明人： Tuan Vo-Dinh ,  Masoud Panjehpour ,  Bergein F. Overholt

IPC分类号： A61B10/00 ,  A61B1/00 ,  A61B5/00 ,  A61B6/00

CPC分类号： A61B5/0084 ,  A61B5/0071 ,  A61B5/4233 ,  A61B5/0075 ,  A61B5/7239

摘要： An apparatus and method for cancer diagnosis are disclosed. The diagnostic method includes the steps of irradiating a tissue sample with monochromatic excitation light, producing a laser-induced fluorescence spectrum from emission radiation generated by interaction of the excitation light with the tissue sample, and dividing the intensity at each wavelength of the laser-induced fluorescence spectrum by the integrated area under the laser-induced fluorescence spectrum to produce a normalized spectrum. A mathematical difference between the normalized spectrum and an average value of a reference set of normalized spectra which correspond to normal tissues is calculated, which provides for amplifying small changes in weak signals from malignant tissues for improved analysis. The calculated differential normalized spectrum is correlated to a specific condition of a tissue sample.

摘要翻译： 公开了一种用于癌症诊断的装置和方法。 诊断方法包括以下步骤：用单色激发光照射组织样本，通过激发光与组织样本的相互作用产生的发射辐射产生激光诱导荧光光谱，并将激光诱导的每个波长的强度除以 荧光光谱由激光诱导荧光光谱下的积分面积产生归一化光谱。 计算归一化光谱与对应于正常组织的归一化光谱参考组的平均值之间的数学差异，其提供用于扩增来自恶性组织的弱信号的小变化以进行改进的分析。 所计算的差分归一化光谱与组织样品的特定条件相关。